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Photo of  Carolyn M. Price, PhD

Carolyn M. Price, PhD

  • Postdoctoral fellowship: University of Colorado ( Telomere biology )
  • Doctoral Degree: University of Colorado Medical Center (Biochemistry)
  • Bachelor's Degree: St Andrews University (Biochemistry)
Contact Information
Research Interests

Dr. Price studies the structure and function of telomeres, the DNA-protein complexes that cap the ends of chromosomes. Telomeres are essential for genome stability as defects in their structure and/or failure to fully replicate the telomeric DNA leads to chromosome shortening and end-to-end fusion of chromosomes. Telomere shortening due to mutations in the telomere maintenance enzyme, telomerase, limits stem cell proliferation and causes the heritable syndrome dyskeratosis congenita, while up-regulation o...

Peer Reviewed Publications

Zhang, Miaomiao; Wang, Bing; Li, Tingfang; Liu, Rui; Xiao, Yingnan; Geng, Xin; Li, Guang; Liu, Qiang; Price, Carolyn M; Liu, Yang; Wang, Feng 2019. Mammalian CST averts replication failure by preventing G-quadruplex accumulation. Nucleic acids research, ,

Adams, Shannel R; Maezawa, So; Alavattam, Kris G; Abe, Hironori; Sakashita, Akihiko; Shroder, Megan; Broering, Tyler J; Sroga Rios, Julie; Thomas, Michael A; Lin, Xinhua; Price, Carolyn M; Barski, Artem; Andreassen, Paul R; Namekawa, Satoshi H 2018. RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes. PLoS genetics, 14 2, e1007233

Feng, Xuyang; Hsu, Shih-Jui; Bhattacharjee, Anukana; Wang, Yongyao; Diao, Jiajie; Price, Carolyn M 2018. CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells. Nature communications, 9 1, 2827

Bhattacharjee, Anukana; Wang, Yongyao; Diao, Jiajie; Price, Carolyn M 2017. Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST. Nucleic acids research, 45 21, 12311-12324

Feng, Xuyang; Hsu, Shih-Jui; Kasbek, Christopher; Chaiken, Mary; Price, Carolyn M 2017. CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance. Nucleic acids research, 45 8, 4281-4293

Bhattacharjee, Anukana; Stewart, Jason; Chaiken, Mary; Price, Carolyn M 2016. STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function. PLoS genetics, 12 9, e1006342

Cranert, S, Heyse, S, Linger, BR, Lescasse, R, Price, CM 2014. Tetrahymena Pot2 is a developmentally regulated paralog of Pot1 that localizes to chromosome breakage sites but not to telomeres Eukaryot. Cell, 13 , 1519-1529

Premkumar VL, Cranert S, Linger BR, Morin GB, Minium S, Price, CM 2014. The 3’ overhangs at Tetrahymena telomeres are packaged by four proteins: Pot1a, Tpt1, Pat1 and Pat2 Eukaryot. Cell, 13 2, 240-245

Wang, Feng; Stewart, Jason; Price, Carolyn M 2014. Human CST abundance determines recovery from diverse forms of DNA damage and replication stress. Cell cycle (Georgetown, Tex.), 13 22, 3488-3498

Kasbek, Christopher; Wang, Feng; Price, Carolyn M 2013. Human TEN1 maintains telomere integrity and functions in genome-wide replication restart. The Journal of biological chemistry, 288 42, 30139-50

Price, Carolyn M 2012. Telomere flip-flop: an unfolding passage to senescence. EMBO reports, 13 1, 5-6

Stewart, Jason A; Chaiken, Mary F; Wang, Feng; Price, Carolyn M 2012. Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutation research, 730 1-2, 12-9

Stewart, Jason A; Wang, Feng; Chaiken, Mary F; Kasbek, Christopher; Chastain, Paul D; Wright, Woodring E; Price, Carolyn M 2012. Human CST promotes telomere duplex replication and general replication restart after fork stalling. The EMBO journal, 31 17, 3537-49

Wang, Feng; Stewart, Jason A; Kasbek, Christopher; Zhao, Yong; Wright, Woodring E; Price, Carolyn M 2012. Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell reports, 2 5, 1096-103

Linger, Benjamin R; Morin, Gregg B; Price, Carolyn M 2011. The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in Tetrahymena. Molecular biology of the cell, 22 21, 4161-70

Price, Christine M 2011. Beacons of change: focusing on the future. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses / American Society of PeriAnesthesia Nurses, 26 2, 69-71

Price, Carolyn M; Boltz, Kara A; Chaiken, Mary F; Stewart, Jason A; Beilstein, Mark A; Shippen, Dorothy E 2010. Evolution of CST function in telomere maintenance. Cell cycle (Georgetown, Tex.), 9 16, 3157-65

Price, Carolyn M 2009. Antics at the telomere: uncoupled polymerases solve the end replication problem. The EMBO journal, 28 7, 795-6

Surovtseva, Yulia V; Churikov, Dmitri; Boltz, Kara A; Song, Xiangyu; Lamb, Jonathan C; Warrington, Ross; Leehy, Katherine; Heacock, Michelle; Price, Carolyn M; Shippen, Dorothy E 2009. Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Molecular cell, 36 2, 207-18

Churikov, Dmitri; Price, Carolyn M 2008. Pot1 and cell cycle progression cooperate in telomere length regulation. Nature structural & molecular biology, 15 1, 79-84

Jacob, Naduparambil K; Lescasse, Rachel; Linger, Benjamin R; Price, Carolyn M 2007. Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint. Molecular and cellular biology, 27 5, 1592-601

Price, Carolyn M 2007. wRAPing up the end to prevent telomere fusions. Molecular cell, 26 4, 463-4

Churikov, Dmitri; Wei, Chao; Price, Carolyn M 2006. Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Molecular and cellular biology, 26 18, 6971-82

Price, Carolyn M 2006. Stirring the POT1: surprises in telomere protection. Nature structural & molecular biology, 13 8, 673-4

De Rycker, Manu; Price, Carolyn M 2004. Tankyrase polymerization is controlled by its sterile alpha motif and poly(ADP-ribose) polymerase domains. Molecular and cellular biology, 24 22, 9802-12

Jacob, Naduparambil K; Stout, Angela R; Price, Carolyn M 2004. Modulation of telomere length dynamics by the subtelomeric region of tetrahymena telomeres. Molecular biology of the cell, 15 8, 3719-28

Wei, Chao; Price, Carolyn M 2004. Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1. Molecular and cellular biology, 24 5, 2091-102

De Rycker, Manu; Venkatesan, Ranga N; Wei, Chao; Price, Carolyn M 2003. Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization. The Biochemical journal, 372 Pt 1, 87-96

Jacob, Naduparambil K; Kirk, Karen E; Price, Carolyn M 2003. Generation of telomeric G strand overhangs involves both G and C strand cleavage. Molecular cell, 11 4, 1021-32

Tan, Ming; Jahn, Carolyn L; Price, Carolyn M 2003. Origin usage during euplotes ribosomal DNA amplification. Eukaryotic cell, 2 1, 115-22

Tan, Ming; Wei, Chao; Price, Carolyn M 2003. The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes. Gene, 323 , 1-10

Ray, Saugata; Karamysheva, Zemfira; Wang, Libin; Shippen, Dorothy E; Price, Carolyn M 2002. Interactions between telomerase and primase physically link the telomere and chromosome replication machinery. Molecular and cellular biology, 22 16, 5859-68

Wei, Chao; Skopp, Rose; Takata, Minoru; Takeda, Shunichi; Price, Carolyn M 2002. Effects of double-strand break repair proteins on vertebrate telomere structure. Nucleic acids research, 30 13, 2862-70

Jacob, N K; Skopp, R; Price, C M 2001. G-overhang dynamics at Tetrahymena telomeres. The EMBO journal, 20 15, 4299-308

Price, C M 1999. Telomeres and telomerase: broad effects on cell growth. Current opinion in genetics & development, 9 2, 218-24

Ray, S; Jahn, C; Tebeau, C M; Larson, M N; Price, C M 1999. Differential expression of linker histone variants in Euplotes crassus. Gene, 231 1-2, 15-20

Klobutcher, L A; Gygax, S E; Podoloff, J D; Vermeesch, J R; Price, C M; Tebeau, C M; Jahn, C L 1998. Conserved DNA sequences adjacent to chromosome fragmentation and telomere addition sites in Euplotes crassus. Nucleic acids research, 26 18, 4230-40

Carlson, D L; Skopp, R; Price, C M 1997. DNA-Binding properties of the replication telomere protein. Biochemistry, 36 50, 15900-8

Fan, X; Price, C M 1997. Coordinate regulation of G- and C strand length during new telomere synthesis. Molecular biology of the cell, 8 11, 2145-55

Price, C M 1997. Synthesis of the telomeric C-strand. A review. Biochemistry. Biokhimii?a, 62 11, 1216-23

Shippen, D E; Blackburn, E H; Price, C M 1994. DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases. Proceedings of the National Academy of Sciences of the United States of America, 91 1, 405-9

Vermeesch, J R; Price, C M 1994. Telomeric DNA sequence and structure following de novo telomere synthesis in Euplotes crassus. Molecular and cellular biology, 14 1, 554-66

Price, C M 1993. Telomere structure and function. Indian journal of biochemistry & biophysics, 30 2, 77-82

Vermeesch, J R; Williams, D; Price, C M 1993. Telomere processing in Euplotes. Nucleic acids research, 21 23, 5366-71

Price, C M 1992. Centromeres and telomeres. Current opinion in cell biology, 4 3, 379-84

Price, C M; Skopp, R; Krueger, J; Williams, D 1992. DNA recognition and binding by the Euplotes telomere protein. Biochemistry, 31 44, 10835-43

Thomas, L L; Price, C M 1992. Cellular uptake, distribution, and degradation of phosphorothioate oligonucleotides in Euplotes crassus. Annals of the New York Academy of Sciences, 660 , 328-30

Thomas, L L; Price, C M 1992. Cellular uptake and degradation of phosphorothioate oligonucleotides by marine and freshwater ciliates. Antisense research and development, 2 3, 251-6

Gray, J T; Celander, D W; Price, C M; Cech, T R 1991. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell, 67 4, 807-14

Hicke, B J; Celander, D W; MacDonald, G H; Price, C M; Cech, T R 1990. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proceedings of the National Academy of Sciences of the United States of America, 87 4, 1481-5

Price, C M 1990. Telomere structure in Euplotes crassus: characterization of DNA-protein interactions and isolation of a telomere-binding protein. Molecular and cellular biology, 10 7, 3421-31

Price, C M; Cech, T R 1989. Properties of the telomeric DNA-binding protein from Oxytricha nova. Biochemistry, 28 2, 769-74

Price, C M; Cech, T R 1987. Telomeric DNA-protein interactions of Oxytricha macronuclear DNA. Genes & development, 1 8, 783-93

Price, C M; Pettijohn, D E 1986. Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly. Properties of purified NuMA protein. Experimental cell research, 166 2, 295-311

Price, C M; McCarty, G A; Pettijohn, D E 1984. NuMA protein is a human autoantigen. Arthritis and rheumatism, 27 7, 774-9

Linger, Benjamin R; Price, Carolyn M . Conservation of telomere protein complexes: shuffling through evolution. Critical reviews in biochemistry and molecular biology, 44 6, 434-46

Price, C M; Adams, A K; Vermeesch, J R . Accumulation of telomerase RNA and telomere protein transcripts during telomere synthesis in Euplotes. The Journal of eukaryotic microbiology, 41 3, 267-75