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Photo of  Randal E. Morris, PhD

Randal E. Morris, PhD

Education/Credentials
  • Doctoral Degree: Emory University
  • Master's Degree: Northern Illinois University
  • Bachelor's Degree: Aurora College
Contact Information
Research Interests

My research interest over the past 20 years has focused on endocytosis, i.e. the binding, internalization, and intracellular routing of ligands by eucaryotic cells. To monitor these events my colleagues and I have employed a variety of techniques, both biochemical and morphological. My forte is electron microscopy; more specifically, I use immunohistochemical techniques at the ultrastructural level toanswer questions central to cell biology.One of the 2 systems in which I am interested is the interaction ...

Peer Reviewed Publications

Newman, Simon L; Gootee, Lisa; Hilty, Jeremy; Morris, Randall E 2006. Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 176 3, 1806-13

Gildea, Lucy A; Ciraolo, Georgianne M; Morris, Randal E; Newman, Simon L 2005. Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion. Infection and immunity, 73 10, 6803-11

Jubinsky, Paul T; Short, Mary K; Mutema, George; Morris, Randal E; Ciraolo, Georgianne M; Li, Maomi 2005. Magmas expression in neoplastic human prostate. Journal of molecular histology, 36 1-2, 69-75

Newman, Simon L; Bhugra, Bindu; Holly, Angela; Morris, Randal E 2005. Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion. Infection and immunity, 73 2, 770-7

Smith, Justin W; Koshoffer, Amy; Morris, Randal E; Boissy, Raymond E 2005. Membranous complexes characteristic of melanocytes derived from patients with Hermansky-Pudlak syndrome type 1 are macroautophagosomal entities of the lysosomal compartment. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 18 6, 417-26

Belecky-Adams, Teri; Holmes, Michael; Shan, Yuqing; Tedesco, C Susan; Mascari, Carla; Kaul, Ajay; Wight, David C; Morris, Randal E; Sussman, Mark; Diamond, Jack; Parysek, Linda M 2003. An intact intermediate filament network is required for collateral sprouting of small diameter nerve fibers. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 28, 9312-9

Long, Kristin H; Gomez, Francisco J; Morris, Randall E; Newman, Simon L 2003. Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. Journal of immunology (Baltimore, Md. : 1950), 170 1, 487-94

Gildea, L A; Morris, R E; Newman, S L 2001. Histoplasma capsulatum yeasts are phagocytosed via very late antigen-5, killed, and processed for antigen presentation by human dendritic cells. Journal of immunology (Baltimore, Md. : 1950), 166 2, 1049-56

Jubinsky, P T; Messer, A; Bender, J; Morris, R E; Ciraolo, G M; Witte, D P; Hawley, R G; Short, M K 2001. Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction. Experimental hematology, 29 12, 1392-402

Sherry, A M; Malinowska, D H; Morris, R E; Ciraolo, G M; Cuppoletti, J 2001. Localization of ClC-2 Cl- channels in rabbit gastric mucosa. American journal of physiology. Cell physiology, 280 6, C1599-606

Howell, M L; Alsabbagh, E; Ma, J F; Ochsner, U A; Klotz, M G; Beveridge, T J; Blumenthal, K M; Niederhoffer, E C; Morris, R E; Needham, D; Dean, G E; Wani, M A; Hassett, D J 2000. AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide. Journal of bacteriology, 182 16, 4545-56

Morris, R E 2000. The use of nonparametric statistics in quantitative electron microscopy. Journal of electron microscopy, 49 4, 545-9

Ochoa, A L; Mitchner, N A; Paynter, C D; Morris, R E; Ben-Jonathan, N 2000. Vascular endothelial growth factor in the rat pituitary: differential distribution and regulation by estrogen. The Journal of endocrinology, 165 2, 483-92

Elhalwagi, B M; Zhang, M; Ikegami, M; Iwamoto, H S; Morris, R E; Miller, M L; Dienger, K; McCormack, F X 1999. Normal surfactant pool sizes and inhibition-resistant surfactant from mice that overexpress surfactant protein A. American journal of respiratory cell and molecular biology, 21 3, 380-7

Strasser, J E; Newman, S L; Ciraolo, G M; Morris, R E; Howell, M L; Dean, G E 1999. Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 162 10, 6148-54

Morris, R E; Ciraolo, G M 1997. A universal post-embedding protocol for immunogold labelling of osmium-fixed, epoxy resin-embedded tissue. Journal of electron microscopy, 46 4, 315-9

Rodeberg, D A; Morris, R E; Babcock, G F 1997. Azurophilic granules of human neutrophils contain CD14. Infection and immunity, 65 11, 4747-53

Korfhagen, T R; Bruno, M D; Ross, G F; Huelsman, K M; Ikegami, M; Jobe, A H; Wert, S E; Stripp, B R; Morris, R E; Glasser, S W; Bachurski, C J; Iwamoto, H S; Whitsett, J A 1996. Altered surfactant function and structure in SP-A gene targeted mice. Proceedings of the National Academy of Sciences of the United States of America, 93 18, 9594-9

Gao, K; Morris, R E; Wei, C 1995. Epipolarization microscopic immunogold assay: a combination of immunogold silver staining, enzyme-linked-immunosorbent assay and epipolarization microscopy. Biotechnic & histochemistry : official publication of the Biological Stain Commission, 70 4, 211-6

Ross, G F; Morris, R E; Ciraolo, G; Huelsman, K; Bruno, M; Whitsett, J A; Baatz, J E; Korfhagen, T R 1995. Surfactant protein A-polylysine conjugates for delivery of DNA to airway cells in culture. Human gene therapy, 6 1, 31-40

Gao, K; Giffin, B F; Morris, R E; Cardell, E L; Cardell, R R 1994. Optimal visualization of immunogold-silver staining of hepatic PEPCK with epipolarized light microscopy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 42 6, 823-6

Ikeda, K; Clark, J C; Bachurski, C J; Wikenheiser, K A; Cuppoletti, J; Mohanti, S; Morris, R E; Whitsett, J A 1994. Immortalization of subpopulations of respiratory epithelial cells from transgenic mice bearing SV40 large T antigen. The American journal of physiology, 267 3 Pt 1, L309-17

Saelinger, C B; Morris, R E 1994. Uptake and processing of toxins by mammalian cells. Methods in enzymology, 235 , 705-17

Gao, K; Morris, R E; Giffin, B F; Cardell, R R 1993. Immunogold-silver staining and epipolarized light microscopic detection of phosphoenolpyruvate carboxykinase and glycogen phosphorylase in rat liver. Histochemistry, 99 5, 341-6

Giffin, B F; Drake, R L; Morris, R E; Cardell, R R 1993. Hepatic lobular patterns of phosphoenolpyruvate carboxykinase, glycogen synthase, and glycogen phosphorylase in fasted and fed rats. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 41 12, 1849-62

Giffin, B F; Gao, K; Morris, R E; Cardell, R R 1993. Enhancement of antigenic site detection with gold labeled secondary and tertiary antibodies using the immunogold-silver staining method. Biotechnic & histochemistry : official publication of the Biological Stain Commission, 68 6, 309-15

Kounnas, M Z; Morris, R E; Thompson, M R; FitzGerald, D J; Strickland, D K; Saelinger, C B 1992. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. The Journal of biological chemistry, 267 18, 12420-3

Morris, R E; Ciraolo, G M; Saelinger, C B 1992. Validation of the biotinyl ligand-avidin-gold technique. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 40 5, 711-21

Thorkelsson, T; Ciraolo, G M; Ross, G F; Whitsett, J A; Morris, R E 1992. Lectin activity of the major surfactant protein (SP-A) may participate in, but is not required for, binding to rat type II cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 40 5, 643-9

Forristal, J J; Thompson, M R; Morris, R E; Saelinger, C B 1991. Mouse liver contains a Pseudomonas aeruginosa exotoxin A-binding protein. Infection and immunity, 59 9, 2880-4

Morris, R E; Ciraolo, G M; Saelinger, C B 1991. Gold enhancement of gold-labeled probes: gold-intensified staining technique (GIST). The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 39 11, 1585-91

Thompson, M R; Forristal, J; Kauffmann, P; Madden, T; Kozak, K; Morris, R E; Saelinger, C B 1991. Isolation and characterization of Pseudomonas aeruginosa exotoxin A binding glycoprotein from mouse LM cells. The Journal of biological chemistry, 266 4, 2390-6

Morris, R E; Saelinger, C B 1990. Visualization of intracellular trafficking of proteins. Methods in enzymology, 184 , 379-88

Ryan, R M; Morris, R E; Rice, W R; Ciraolo, G; Whitsett, J A 1989. Binding and uptake of pulmonary surfactant protein (SP-A) by pulmonary type II epithelial cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 37 4, 429-40

O'Reilly, M A; Gazdar, A F; Morris, R E; Whitsett, J A 1988. Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line. Biochimica et biophysica acta, 970 2, 194-204

Saelinger, C B; Morris, R E 1987. Intracellular trafficking of Pseudomonas exotoxin A. Antibiotics and chemotherapy, 39 , 149-59

Morris, R E; Saelinger, C B 1986. Problems in the production and use of 5 nm avidin-gold colloids. Journal of microscopy, 143 Pt 2, 171-6

Morris, R E; Saelinger, C B 1986. Reduced temperature alters Pseudomonas exotoxin A entry into the mouse LM cell. Infection and immunity, 52 2, 445-53

Morris, R E; Gerstein, A S; Bonventre, P F; Saelinger, C B 1985. Receptor-mediated entry of diphtheria toxin into monkey kidney (Vero) cells: electron microscopic evaluation. Infection and immunity, 50 3, 721-7

Morris, R E; Saelinger, C B 1985. Route of pseudomonas and diphtheria toxin entry into mammalian cells: basis for susceptibility to toxin. Survey and synthesis of pathology research, 4 1, 34-43

Saelinger, C B; Morris, R E; Foertsch, G 1985. Trafficking of Pseudomonas exotoxin A in mammalian cells. European journal of clinical microbiology, 4 2, 170-4

Cohen, D A; Morris, R E; Bubel, H C 1984. Abortive ectromelia virus infection in peritoneal macrophages activated by Corynebacterium parvum. Journal of leukocyte biology, 35 2, 179-92

Manhart, M D; Morris, R E; Bonventre, P F; Leppla, S; Saelinger, C B 1984. Evidence for pseudomonas exotoxin A receptors on plasma membrane of toxin-sensitive lm fibroblasts. Infection and immunity, 45 3, 596-603

Morris, R E; Saelinger, C B 1984. Visualization of intracellular trafficking: use of biotinylated ligands in conjunction with avidin-gold colloids. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 32 1, 124-8

Barnett, J H; Estes, S A; Wirman, J A; Morris, R E; Staneck, J L 1983. Erysipeloid. Journal of the American Academy of Dermatology, 9 1, 116-23

Bentley, D M; Watson, S R; Morris, R E 1983. Age-related loss of Lyt-1,2 cells in C58 mice results in susceptibility to lactic dehydrogenase virus-induced polioencephalomyelitis. Infection and immunity, 41 3, 1389-90

Morris, R E; Manhart, M D; Saelinger, C B 1983. Receptor-mediated entry of Pseudomonas toxin: methylamine blocks clustering step. Infection and immunity, 40 2, 806-11

Morris, R E; Saelinger, C B 1983. Diphtheria toxin does not enter resistant cells by receptor-mediated endocytosis. Infection and immunity, 42 2, 812-7

Bentley, D M; Guckian, V A; Stinnett, J D; Morris, R E 1982. Failure to demonstrate a role for line Ib tumor-associated surface antigen in the etiology of age-dependent polioencephalomyelitis. Molecular immunology, 19 8, 983-9

Bentley, D M; Morris, R E 1982. T cell subsets required for protection against age-dependent polioencephalomyelitis of C58 mice. Journal of immunology (Baltimore, Md. : 1950), 128 2, 530-4

Fitzgerald, D; Morris, R E; Saelinger, C B 1982. Essential role of calcium in cellular internalization of Pseudomonas toxin. Infection and immunity, 35 2, 715-20

Mbuy, G N; Morris, R E; Bubel, H C 1982. Inhibition of cellular protein synthesis by vaccinia virus surface tubules. Virology, 116 1, 137-47

Morris, R E; David, C S; Manhart, M D 1982. Tumor and histocompatibility antigen interaction: direct visualization by a double-label bridging technique for immuno-electron microscopy. Molecular immunology, 19 8, 973-82

Morris, R E; Saelinger, C B 1982. Combined use of immunoferritin and immunocolloidal gold for the simultaneous demonstration of two antigens by immuno-electron microscopy. Stain technology, 57 4, 225-37

Morris, R E; Saelinger, C B 1982. A simple reliable method for producing electron dense markers of uniform size for use in immunoelectron microscopy. Journal of immunological methods, 49 3, 237-46

Gelman, B B; Davis, M H; Morris, R E; Gruenstein, E 1981. Structural changes in lysosomes from cultured human fibroblasts in Duchenne's muscular dystrophy. The Journal of cell biology, 88 2, 329-37

Morris, R E; Bentley, D M; Ciraolo, G M 1981. Quantitation of tumor antigen expression on the surface of malignant line Ib lymphocytes by immuno-electron microscopy. Journal of the National Cancer Institute, 66 1, 111-9

FitzGerald, D; Morris, R E; Saelinger, C B 1980. Receptor-mediated internalization of Pseudomonas toxin by mouse fibroblasts. Cell, 21 3, 867-73

Morris, R E; Ciraolo, G M; Cohen, D A; Bubel, H C 1980. In situ fixation of cultured mouse peritoneal exudate cells: comparison of fixation methods. In vitro, 16 2, 136-46

Hale, T L; Morris, R E; Bonventre, P F 1979. Shigella infection of henle intestinal epithelial cells: role of the host cell. Infection and immunity, 24 3, 887-94

Morris, R E; Murphy, W H 1978. Immunogenicity and paralytogenicity of antigen solubilized from line Ib malignant lymphocytes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 157 2, 330-5

Morris, R E; Fritz, R B 1976. Expression of virion and tumor-specific antigens on the surface of chick embryo cells infected with strain MC29 avian leukosis virus. Cancer research, 36 2 Pt 1, 414-9

Morris, R E; Fritz, R B 1975. Ultrastructural visualization of virus-induced surface antigens. Comparative studies of three immunohistochemical techniques. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 23 11, 855-62

Broomall, K R; Morris, R E; Walzer, P D; Smulian, A G . Zymolyase treatment exposes p55 antigen of Pneumocystis carinii. The Journal of eukaryotic microbiology, 45 3, 284-9

FitzGerald, D; Morris, R E; Saelinger, C B . Inhibition of the activity of pseudomonas toxin by methylamine. Reviews of infectious diseases, 5 Suppl 5 , S985-91

Kaneshiro, E S; Reuter, S F; Quattrone, F J; Morris, R E . Sustained food vacuole formation by axenic Paramecium tetraurelia and the inhibition of membrane recycling by Alcian Blue. The Journal of protozoology, 39 6, 713-8