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Robert McCullumsmith

Associate Professor of Psychiatry and Behavioral Neuroscience, Associate Vice Chair of Translational Research and Research Education

Education/Credentials
  • Medical Degree, Doctoral Degree : University of Michigan
Board Certifications & Licenses

American Board of Psychiatry and Neurology (Psychiatry) (Certification Date: 20030912) - (Recertification Date: 20130218)

Research Interests

Cognitive Disorders Research Laboratory
The Cognitive Disorders Research Laboratory was started when Robert McCullumsmith, MD/PhD, joined the University of Cincinnati in 2013.  The CDRL is a basic science lab in the Department of Psychiatry and Behavioral Neuroscience.  Our mission is to understand the cellular and molecular etiology of neuropsychiatric conditions with cognitive deficits.  The lab utilizes a wide spectrum of genomic and proteomic techniques.  Hu...

Contact Information

Clinical Interests

Psychiatry

Peer Reviewed Publications

Dorsett, Christopher R; McGuire, Jennifer L; DePasquale, Erica A K; Gardner, Amanda E; Floyd, Candace L; McCullumsmith, Robert E 2017. Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury. Journal of neurotrauma, 34 2, 263-272

Dorsett, Christopher R; McGuire, Jennifer L; Niedzielko, Tracy L; DePasquale, Erica A K; Meller, Jaroslaw; Floyd, Candace L; McCullumsmith, Robert E 2017. Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression. Journal of neurotrauma, 34 1, 220-234

Funk, Adam J; Mielnik, Catharine A; Koene, Rachael; Newburn, Erin; Ramsey, Amy J; Lipska, Barbara K; McCullumsmith, Robert E 2017. Postsynaptic Density-95 Isoform Abnormalities in Schizophrenia. Schizophrenia bulletin, ,

LaCrosse, Amber L; O'Donovan, Sinead M; Sepulveda-Orengo, Marian T; McCullumsmith, Robert E; Reissner, Kathryn J; Schwendt, Marek; Knackstedt, Lori A 2017. Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 37 24, 5809-5821

Heaven, M R; Funk, A J; Cobbs, A L; Haffey, W D; Norris, J L; McCullumsmith, R E; Greis, K D 2016. Systematic evaluation of data-independent acquisition for sensitive and reproducible proteomics-a prototype design for a single injection assay. Journal of mass spectrometry : JMS, 51 1, ii

Heaven, Michael R; Funk, Adam J; Cobbs, Archie L; Haffey, Wendy D; Norris, Jeremy L; McCullumsmith, Robert E; Greis, Kenneth D 2016. Systematic evaluation of data-independent acquisition for sensitive and reproducible proteomics-a prototype design for a single injection assay. Journal of mass spectrometry : JMS, 51 1, 1-11

McCollum, Lesley A; McCullumsmith, Robert E; Roberts, Rosalinda C 2016. Tyrosine hydroxylase localization in the nucleus accumbens in schizophrenia. Brain structure & function, ,

McCullumsmith, R E; O'Donovan, S M; Drummond, J B; Benesh, F S; Simmons, M; Roberts, R; Lauriat, T; Haroutunian, V; Meador-Woodruff, J H 2016. Shaping plasticity: Alterations in glutamate transporter localization as a pathophysiological mechanism in severe mental illness. Molecular psychiatry, 21 6, 723

Pinner, Anita L; Tucholski, Janusz; Haroutunian, Vahram; McCullumsmith, Robert E; Meador-Woodruff, James H 2016. Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia. Schizophrenia research, ,

Dean, Brian; Gibbons, Andrew S; Boer, Simone; Uezato, Akihito; Meador-Woodruff, James; Scarr, Elizabeth; McCullumsmith, Robert E 2015. Changes in cortical N-methyl-d-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide. The Australian and New Zealand journal of psychiatry, ,

Lindberg, D; Shan, D; Ayers-Ringler, J; Oliveros, A; Benitez, J; Prieto, M; McCullumsmith, R; Choi, D-S 2015. Purinergic signaling and energy homeostasis in psychiatric disorders. Current molecular medicine, 15 3, 275-95

McCullumsmith, R E; O'Donovan, S M; Drummond, J B; Benesh, F S; Simmons, M; Roberts, R; Lauriat, T; Haroutunian, V; Meador-Woodruff, J H 2015. Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons? Molecular psychiatry, ,

McCullumsmith, Robert E 2015. Evidence for schizophrenia as a disorder of neuroplasticity. The American journal of psychiatry, 172 4, 312-3

McCullumsmith, Robert E; Hammond, John H; Shan, Dan; Meador-Woodruff, James H 2015. Postmortem brain: an underutilized substrate for studying severe mental illness. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40 5, 1307

McCullumsmith, Robert E; Sanacora, Gerard 2015. Regulation of extrasynaptic glutamate levels as a pathophysiological mechanism in disorders of motivation and addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40 1, 254-5

McMeekin, Laura J; Lucas, Elizabeth K; Meador-Woodruff, James H; McCullumsmith, Robert E; Hendrickson, Robert C; Gamble, Karen L; Cowell, Rita M 2015. Cortical PGC-1?-Dependent Transcripts are Reduced in Postmortem Tissue From Patients With Schizophrenia. Schizophrenia bulletin, ,

O'Donovan, S M; Hasselfeld, K; Bauer, D; Simmons, M; Roussos, P; Haroutunian, V; Meador-Woodruff, J H; McCullumsmith, R E 2015. Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia. Translational psychiatry, 5 , e579

Sullivan, Courtney R; Funk, Adam J; Shan, Dan; Haroutunian, Vahram; McCullumsmith, Robert E 2015. Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. PloS one, 10 3, e0123158

Funk, Adam J; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2014. Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia. Schizophrenia research, 159 1, 130-5

Marballi, Ketan K; McCullumsmith, Robert E; Yates, Stefani; Escamilla, Michael A; Leach, Robin J; Raventos, Henriette; Walss-Bass, Consuelo 2014. Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches. Journal of neural transmission (Vienna, Austria : 1996), 121 5, 479-90

McCullumsmith, Robert E; Hammond, John H; Shan, Dan; Meador-Woodruff, James H 2014. Postmortem brain: an underutilized substrate for studying severe mental illness. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39 1, 65-87

McGuire, Jennifer L; Hammond, John H; Yates, Stefani D; Chen, Dongquan; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2014. Altered serine/threonine kinase activity in schizophrenia. Brain research, 1568 , 42-54

Roberts, R C; Roche, J K; McCullumsmith, R E 2014. Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: a light and electron microscopic study. Neuroscience, 277 , 522-40

Shan, Dan; Mount, Daniel; Moore, Stephen; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2014. Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia. Schizophrenia research, 154 1-3, 1-13

Eid, Tore; Lee, Tih-Shih W; Wang, Yue; Perez, Edgar; Peréz, Edgar; Drummond, Jana; Lauritzen, Fredrik; Bergersen, Linda H; Meador-Woodruff, James H; Spencer, Dennis D; de Lanerolle, Nihal C; McCullumsmith, Robert E 2013. Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy. Epilepsia, 54 2, 228-38

Shan, Dan; Lucas, Elizabeth K; Drummond, Jana B; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2013. Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia. Schizophrenia research, 144 1-3, 1-8

Tucholski, Janusz; Simmons, Micah S; Pinner, Anita L; Haroutunian, Vahram; McCullumsmith, Robert E; Meador-Woodruff, James H 2013. Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia. Schizophrenia research, 146 1-3, 177-83

Funk, Adam J; McCullumsmith, Robert E; Haroutunian, Vahram; Meador-Woodruff, James H 2012. Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37 4, 896-905

Hammond, John C; Meador-Woodruff, James H; Haroutunian, Vahram; McCullumsmith, Robert E 2012. AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia. PloS one, 7 6, e39190

McCullumsmith, Robert E; Hammond, John; Funk, Adam; Meador-Woodruff, James H 2012. Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia. Current pharmaceutical biotechnology, 13 8, 1535-42

Moehle, Mark S; Luduena, Richard F; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2012. Regional differences in expression of ?-tubulin isoforms in schizophrenia. Schizophrenia research, 135 1-3, 181-6

Shan, D; Yates, S; Roberts, R C; McCullumsmith, R E 2012. Update on the neurobiology of schizophrenia: a role for extracellular microdomains. Minerva psichiatrica, 53 3, 233-249

Shan, Dan; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2012. Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia. Neuroreport, 23 4, 224-7

Hammond, John C; McCullumsmith, Robert E; Haroutunian, Vahram; Meador-Woodruff, James H 2011. Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia. Schizophrenia research, 130 1-3, 260-5

McCullumsmith, Robert E; Meador-Woodruff, James H 2011. Novel approaches to the study of postmortem brain in psychiatric illness: old limitations and new challenges. Biological psychiatry, 69 2, 127-33

Sodhi, Monsheel S; Simmons, Micah; McCullumsmith, Robert; Haroutunian, Vahram; Meador-Woodruff, James H 2011. Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia. Biological psychiatry, 70 7, 646-54

Bauer, Deborah; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2010. Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia. Schizophrenia research, 117 1, 92-8

Hammond, John C; McCullumsmith, Robert E; Funk, Adam J; Haroutunian, Vahram; Meador-Woodruff, James H 2010. Evidence for abnormal forward trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35 10, 2110-9

Bauer, Deborah Elaine; Haroutunian, Vahram; McCullumsmith, Robert E; Meador-Woodruff, James H 2009. Expression of four housekeeping proteins in elderly patients with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996), 116 4, 487-91

Funk, Adam J; Rumbaugh, Gavin; Harotunian, Vahram; McCullumsmith, Robert E; Meador-Woodruff, James H 2009. Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. Neuroreport, 20 11, 1019-22

Uezato, Akihito; Meador-Woodruff, James H; McCullumsmith, Robert E 2009. Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia. Bipolar disorders, 11 7, 711-25

Bauer, Deborah; Gupta, Daya; Harotunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2008. Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia. Schizophrenia research, 104 1-3, 108-20

Massie, Ann; Cnops, Lieselotte; Smolders, Ilse; McCullumsmith, Robert; Kooijman, Ron; Kwak, Shin; Arckens, Lutgarde; Michotte, Yvette 2008. High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain. The Journal of comparative neurology, 511 2, 155-72

Oni-Orisan, Akin; Kristiansen, Lars V; Haroutunian, Vahram; Meador-Woodruff, James H; McCullumsmith, Robert E 2008. Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia. Biological psychiatry, 63 8, 766-75

Steffek, Amy E; McCullumsmith, Robert E; Haroutunian, Vahram; Meador-Woodruff, James H 2008. Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia. Schizophrenia research, 103 1-3, 71-82

Beneyto, Monica; Kristiansen, Lars V; Oni-Orisan, Akinwunmi; McCullumsmith, Robert E; Meador-Woodruff, James H 2007. Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32 9, 1888-902

McCullumsmith, Robert E; Gupta, Daya; Beneyto, Monica; Kreger, Emily; Haroutunian, Vahram; Davis, Kenneth L; Meador-Woodruff, James H 2007. Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia. Schizophrenia research, 90 1-3, 15-27

McCullumsmith, Robert E; Kristiansen, Lars V; Beneyto, Monica; Scarr, Elizabeth; Dean, Brian; Meador-Woodruff, James H 2007. Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder. Brain research, 1127 1, 108-18

Huerta, Ibone; McCullumsmith, Robert E; Haroutunian, Vahram; Giménez-Amaya, José Manuel; Meador-Woodruff, James H 2006. Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia. Synapse (New York, N.Y.), 59 7, 394-402

Bruneau, Emile G; McCullumsmith, Robert E; Haroutunian, Vahram; Davis, Kenneth L; Meador-Woodruff, James H 2005. Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia. Schizophrenia research, 75 1, 27-34

Gupta, Daya S; McCullumsmith, Robert E; Beneyto, Monica; Haroutunian, Vahram; Davis, Kenneth L; Meador-Woodruff, James H 2005. Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia. Synapse (New York, N.Y.), 57 3, 123-31

McCullumsmith, Robert E; Clinton, Sarah M; Meador-Woodruff, James H 2004. Schizophrenia as a disorder of neuroplasticity. International review of neurobiology, 59 , 19-45

McCullumsmith, Robert E; Semins, Michelle J; Meador-Woodruff, James H 2004. Effects of 6-cyano-7-nitroquinoxaline-2,3-dione on nicotinic receptor subunit transcript expression in the rat brain. Synapse (New York, N.Y.), 52 1, 62-72

Davidkova, Genoveva; McCullumsmith, Robert E; Meador-Woodruff, James H 2003. Expression of ARHGEF11 mRNA in schizophrenic thalamus. Annals of the New York Academy of Sciences, 1003 , 375-7

Gharaee-Kermani, Mehrnaz; McCullumsmith, Robert E; Charo, Israel F; Kunkel, Steven L; Phan, Sem H 2003. CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis. Cytokine, 24 6, 266-76

McCullumsmith, Robert E; Meador-Woodruff, James H 2003. Expression of transcripts for the vesicular glutamate transporters in the human medial temporal lobe. Annals of the New York Academy of Sciences, 1003 , 438-42

McCullumsmith, Robert E; Stincic, Todd L; Agrawal, Smriti M; Meador-Woodruff, James H 2003. Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat. European journal of pharmacology, 477 2, 101-12

Meador-Woodruff, James H; Clinton, Sarah M; Beneyto, Monica; McCullumsmith, Robert E 2003. Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia. Annals of the New York Academy of Sciences, 1003 , 75-93

McCullumsmith, Robert E; Meador-Woodruff, James H 2002. Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 26 3, 368-75