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Photo of  Ricky Y.K. Leung, PhD

Ricky Y.K. Leung, PhD

Research Assistant Professor, Department of Environmental Health, UC College of Medicine

  • PhD: The Chinese University of Hong Kong (Biochemistry, Molecular Toxicology)
  • MPhil: The Chinese University of Hong Kong (Biochemistry, Biochemical Toxicology)
  • BSc: The Chinese University of Hong Kong (Biochemistry)
Contact Information
  • UC Institute Member Seal
Research Interests

Dr. Leung’s research has focused upon estrogen signaling in hormone-related cancers. Estrogen receptors in breast cancer are relatively well-studied but their roles in prostate cancer remains controversial. Dr. Leung has discovered several estrogen receptor isoforms and helped clarify the functions of the receptors during prostate carcinogenesis. His recent findings revealed their potential prognostic values in prostate cancer. 

Dr. Leung is also interested in studying how post-t...

Peer Reviewed Publications

Ho, Shuk-Mei; Cheong, Ana; Lam, Hung-Ming; Hu, Wen-Yang; Shi, Guang-Bin; Zhu, Xuegong; Chen, Jing; Zhang, Xiang; Medvedovic, Mario; Leung, Yuet-Kin; Prins, Gail S 2015. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. Endocrinology, 156 11, 3984-95

Panchanathan, Ravichandran; Liu, Hongzhu; Leung, Yuet-Kin; Ho, Shuk-Mei; Choubey, Divaker 2015. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Molecular and cellular endocrinology, 415 , 45-55

Zhou, Zilan; Badkas, Apurva; Stevenson, Max; Lee, Joo-Youp; Leung, Yuet-Kin 2015. Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery. International journal of pharmaceutics, 487 1-2, 81-90

Knower, Kevin C; To, Sarah Q; Leung, Yuet-Kin; Ho, Shuk-Mei; Clyne, Colin D 2014. Endocrine disruption of the epigenome: a breast cancer link. Endocrine-related cancer, 21 2, T33-55

Langevin, Scott M; Pinney, Susan M; Leung, Yuet-Kin; Ho, Shuk-Mei 2014. Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics, 6 4, 367-9

Leung, Yuet-Kin; Chan, Queeny Kwan-Yi; Ng, Chi-Fai; Ma, Fanny Man-Ting; Tse, Ho-Man; To, Ka-Fai; Maranchie, Jodi; Ho, Shuk-Mei; Lau, Kin-Mang 2014. Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer. PloS one, 9 5, e98037

Yang, Won Seok; Chadalapaka, Gayathri; Cho, Sung-Gook; Lee, Syng-Ook; Jin, Un-Ho; Jutooru, Indira; Choi, Kwangmin; Leung, Yuet-Kin; Ho, Shuk-Mei; Safe, Stephen; Kim, Kyounghyun 2014. The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis. Neoplasia (New York, N.Y.), 16 12, 1059-69

Brunst, Kelly J; Leung, Yuet-Kin; Ryan, Patrick H; Khurana Hershey, Gurjit K; Levin, Linda; Ji, Hong; Lemasters, Grace K; Ho, Shuk-Mei 2013. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. The Journal of allergy and clinical immunology, 131 2, 592-4.e1-3

Lee, Ming-Tsung; Ho, Shuk-Mei; Tarapore, Pheruza; Chung, Irving; Leung, Yuet-Kin 2013. Estrogen receptor beta isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia (New York, N.Y.), 15 11, 1262-71

Lee, Ming-Tsung; Leung, Yuet-Kin; Chung, Irving; Tarapore, Pheruza; Ho, Shuk-Mei 2013. Estrogen receptor beta (ERbeta1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. The Journal of biological chemistry, 288 35, 25038-52

Lee, Ming-Tsung; Ouyang, Bin; Ho, Shuk-Mei; Leung, Yuet-Kin 2013. Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation. Molecular and cellular endocrinology, 376 1-2, 125-35

Ho, Shuk-Mei; Johnson, Abby; Tarapore, Pheruza; Janakiram, Vinothini; Zhang, Xiang; Leung, Yuet-Kin 2012. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR journal / National Research Council, Institute of Laboratory Animal Resources, 53 3-4, 289-305

Lam, Hung-Ming; Suresh Babu, C V; Wang, Jiang; Yuan, Yong; Lam, Ying-Wai; Ho, Shuk-Mei; Leung, Yuet-Kin 2012. Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion. Molecular and cellular endocrinology, 358 1, 27-35

Leung, Yuet-Kin; Lee, Ming-Tsung; Lam, Hung-Ming; Tarapore, Pheruza; Ho, Shuk-Mei 2012. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids, 77 7, 727-37

Ho, Shuk-Mei; Lee, Ming-Tsung; Lam, Hung-Ming; Leung, Yuet-Kin 2011. Estrogens and prostate cancer: etiology, mediators, prevention, and management. Endocrinology and metabolism clinics of North America, 40 3, 591-614, ix

Leung, Yuet-Kin; Ho, Shuk-Mei 2011. Estrogen receptor beta: switching to a new partner and escaping from estrogen. Science signaling, 4 168, pe19

Ouyang, Bin; Leung, Yuet-Kin; Wang, Vinson; Chung, Ethan; Levin, Linda; Bracken, Bruce; Cheng, Liang; Ho, Shuk-Mei 2011. ?-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology, 77 1, 249.e1-7

Haynes, Erin N; Heckel, Pamela; Ryan, Patrick; Roda, Sandy; Leung, Yuet-Kin; Sebastian, Kelly; Succop, Paul 2010. Environmental manganese exposure in residents living near a ferromanganese refinery in Southeast Ohio: a pilot study. Neurotoxicology, 31 5, 468-74

Leung, Yuet-Kin; Lam, Hung-Ming; Wu, Shulin; Song, Dan; Levin, Linda; Cheng, Liang; Wu, Chin-Lee; Ho, Shuk-Mei 2010. Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocrine-related cancer, 17 3, 675-89

Zhang, Xiang; Wu, Mengchu; Xiao, Hong; Lee, Ming-Tsung; Levin, Linda; Leung, Yuet-Kin; Ho, Shuk-Mei 2010. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. The Prostate, 70 7, 765-76

Hess-Wilson, Janet K; Webb, Siobhan L; Daly, Hannah K; Leung, Yuet-Kin; Boldison, Joanne; Comstock, Clay E S; Sartor, Maureen A; Ho, Shuk-Mei; Knudsen, Karen E 2007. Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environmental health perspectives, 115 11, 1646-53

Zhang, X; Leung, Y-K; Ho, S-M 2007. AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. Oncogene, 26 52, 7346-54

Ho, Shuk-Mei; Leung, Yuet-Kin; Chung, Irving 2006. Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer. Annals of the New York Academy of Sciences, 1089 , 177-93

Leung, Yuet-Kin; Gao, Ying; Lau, Kin-Mang; Zhang, Xiang; Ho, Shuk-Mei 2006. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Neoplasia (New York, N.Y.), 8 4, 242-9

Leung, Yuet-Kin; Ho, John W 2006. Deciphering signaling control by phosphoproteome using mass spectrometry. Protein and peptide letters, 13 5, 467-9

Leung, Yuet-Kin; Mak, Paul; Hassan, Sazzad; Ho, Shuk-Mei 2006. Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proceedings of the National Academy of Sciences of the United States of America, 103 35, 13162-7

Mak, Paul; Leung, Yuet-Kin; Tang, Wan-Yee; Harwood, Charlotte; Ho, Shuk-Mei 2006. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia (New York, N.Y.), 8 11, 896-904

Ho, John W; Song, Jing Zheng; Leung, Yuet Kin 2005. Activation of p53 by specific agents in potential cancer therapy. Current medicinal chemistry. Anti-cancer agents, 5 2, 131-5

Leung, Yuet-Kin; Lau, Kin-Mang; Mobley, James; Jiang, Zhong; Ho, Shuk-Mei 2005. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer research, 65 9, 3726-34

Leung, Yuet Kin; Wong, Kwong Fai; Lee, Hung Kay; Ho, John W 2004. Cloning and characterization of chironomidae ferrochelatase: copper activation of the purified ferrochelatase. Molecular and cellular biochemistry, 262 1-2, 225-31

Zhu, Xuegong; Leav, Irwin; Leung, Yuet-Kin; Wu, Mengchu; Liu, Qin; Gao, Ying; McNeal, John E; Ho, Shuk-Mei 2004. Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. The American journal of pathology, 164 6, 2003-12

Ho, J.W., Leung, Y.K., and Chan, C.P. 2003. Potential of medicinal herbs in the treatment of liver disorders. Trends in Comparative Biochemistry & Physiology , 9 , 269

Lau, Kin-Mang; Tam, Neville N C; Thompson, Christopher; Cheng, Robert Y S; Leung, Yuet-Kin; Ho, Shuk-Mei 2003. Age-associated changes in histology and gene-expression profile in the rat ventral prostate. Laboratory investigation; a journal of technical methods and pathology, 83 5, 743-57

Leung, Yuet Kin; Ng, Tzi Bun; Ho, John W 2003. Transcriptional regulation of fosl-1 by licorice in rat Clone 9 cells. Life sciences, 73 24, 3109-21

Tam, Neville N C; Gao, Ying; Leung, Yuet-Kin; Ho, Shuk-Mei 2003. Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. The American journal of pathology, 163 6, 2513-22

Ho, John W; Leung, Yuet Kin; Chan, Chun Pong 2002. Herbal medicine in the treatment of cancer. Current medicinal chemistry. Anti-cancer agents, 2 2, 209-14

Leung, Yuet Kin; Ho, John W 2002. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Biochemical pharmacology, 63 4, 767-75

Leung, Y K; Ho, J W 2001. Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes. Archives of physiology and biochemistry, 109 2, 175-9

Leung, Y K; Ho, J W 2001. Purification and properties of ferrochelatase from Chironomidae larvae. Molecular and cellular biochemistry, 220 1-2, 161-7

Leung, Y K; Ho, J W 1999. Modulation of reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by vitamin C-palmitate. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 124 4, 451-6

Leung, Y K; Ho, J W 1998. Inhibitory effect of nicotine and its metabolites on tolbutamide hydroxylation in rat liver microsomes. Journal of biochemical and biophysical methods, 36 2-3, 87-94