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Photo of  James Heubi, MD

James Heubi, MD

Professor - Aff

Associate Dean for the Center for Clinical and Translational Science and Training and Professor of Pediatrics

COM Pediatrics Gastroenterology

Education/Credentials
  • Medical Degree: Indiana University School of Medicine
Research Interests

Intestinal Bile Salt Transport, Cholesterol Absorption, Pediatric Bone Disease, Cholestasis 

Contact Information
  • Cincinnati Children's Hospital Medical Center Room 300
  • 240 Albert Sabin Way
  • Cincinnati, Ohio 45229
  • Office 513-636-8046
  • Fax 513-803-1039
  • Email james.heubi@cchmc.org

Peer Reviewed Publications

Dorsey, Jill; Buckley, Donna; Summer, Suzanne; Jandacek, Ronald J; Rider, Therese; Tso, Patrick; Narkewicz, Michael R; Heubi, James E 2010. Fat malabsorption in cystic fibrosis: comparison of quantitative fat assay and a novel assay using fecal lauric/behenic acid. Journal of pediatric gastroenterology and nutrition, 50 4, 441-6

Hommel, Kevin A; McGraw, Kelly L; Ammerman, Robert T; Heubi, James E; Hansen, Molly; Dunlap, Ellen; Beidel, Deborah C 2010. Psychosocial functioning in children and adolescents with gastrointestinal complaints and disorders. Journal of clinical psychology in medical settings, 17 2, 159-66

Burke, Katie T; Horn, Paul S; Tso, Patrick; Heubi, James E; Woollett, Laura A 2009. Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels. American journal of physiology. Gastrointestinal and liver physiology, 297 1, G144-51

Gonzales, Emmanuel; Gerhardt, Marie F; Fabre, Monique; Setchell, Kenneth D R; Davit-Spraul, Anne; Vincent, Isabelle; Heubi, James E; Bernard, Olivier; Jacquemin, Emmanuel 2009. Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy. Gastroenterology, 137 4, 1310-1320.e1-3

Graham, Rose C; Heubi, James E; Cohen, Mitchell B; Li, Buk 2009. Teaching and tomorrow: a novel recruitment program for a pediatric subspecialty. Journal of pediatric gastroenterology and nutrition, 49 5, 594-8

Perman, Marissa J; Lucky, Anne W; Heubi, James E; Azizkhan, Richard G 2009. Severe symptomatic hypocalcemia in a patient with RDEB treated with intravenous zoledronic acid. Archives of dermatology, 145 1, 95-6

Setchell, Kenneth Dr; Zhao, Xueheng; Jha, Pinky; Heubi, James E; Brown, Nadine M 2009. The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers. The American journal of clinical nutrition, 90 4, 1029-37

Steinberg, S J; Snowden, A; Braverman, N E; Chen, L; Watkins, P A; Clayton, P T; Setchell, K D R; Heubi, J E; Raymond, G V; Moser, A B; Moser, H W 2009. A PEX10 defect in a patient with no detectable defect in peroxisome assembly or metabolism in cultured fibroblasts. Journal of inherited metabolic disease, 32 1, 109-19

Wooldridge, Jamie L; Heubi, James E; Amaro-Galvez, Rodolfo; Boas, Steven R; Blake, Kathryn V; Nasr, Samya Z; Chatfield, Barbara; McColley, Susanna A; Woo, Marlyn S; Hardy, Karen A; Kravitz, Richard M; Straforini, Cristina; Anelli, Marco; Lee, Candace 2009. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 8 6, 405-17

Cohran, Valeria C; Griffiths, Mark; Heubi, James E 2008. Bone mineral density in children exposed to chronic glucocorticoid therapy. Clinical pediatrics, 47 5, 469-75

Heubi, James E 2008. Pancreatic enzyme-replacement therapy in CF: considerations for the USA. Expert review of respiratory medicine, 2 5, 589-96

Heubi, James E 2007. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Journal of pediatric gastroenterology and nutrition, 44 4, 513-5

Heubi, James E 2007. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Journal of pediatric gastroenterology and nutrition, 44 4, 513-5

Heubi, James E; Setchell, Kenneth D R; Bove, Kevin E 2007. Inborn errors of bile acid metabolism. Seminars in liver disease, 27 3, 282-94

Yao, Lihang; Horn, Paul S; Heubi, James E; Woollett, Laura A 2007. The liver plays a key role in whole body sterol accretion of the neonatal Golden Syrian hamster. Biochimica et biophysica acta, 1771 4, 550-7

Focht, Dean R; Baker, Raymond C; Heubi, James E; Moyer, M Susan 2006. Variability in the management of childhood constipation. Clinical pediatrics, 45 3, 251-6

Heubi, James E; Finkel, Yigael; Molleston, Jean; Alonsom, Estella; Olivia-Hemker, Maria 2006. The match for US pediatric gastroenterology and nutrition fellowships. Journal of pediatric gastroenterology and nutrition, 43 4, 411-2

Konikoff, Michael R; Blanchard, Carine; Kirby, Cassie; Buckmeier, Bridget K; Cohen, Mitchell B; Heubi, James E; Putnam, Philip E; Rothenberg, Marc E 2006. Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 4 11, 1328-36

Setchell, Kenneth D R; Heubi, James E 2006. Defects in bile acid biosynthesis--diagnosis and treatment. Journal of pediatric gastroenterology and nutrition, 43 Suppl 1 , S17-22

Stark, Lori J; Davis, Ann McGrath; Janicke, David M; Mackner, Laura M; Hommel, Kevin A; Bean, Judy A; Lovell, Daniel; Heubi, James E; Kalkwarf, Heidi J 2006. A randomized clinical trial of dietary calcium to improve bone accretion in children with juvenile rheumatoid arthritis. The Journal of pediatrics, 148 4, 501-7

Wang, Yanwen; Jones, Peter J H; Woollett, Laura A; Buckley, Donna D; Yao, Lihang; Granholm, Norman A; Tolley, Elizabeth A; Heubi, James E 2006. Effects of chenodeoxycholic acid and deoxycholic acid on cholesterol absorption and metabolism in humans. Translational research : the journal of laboratory and clinical medicine, 148 1, 37-45

Woollett, L A; Wang, Y; Buckley, D D; Yao, L; Chin, S; Granholm, N; Jones, P J H; Setchell, K D R; Tso, P; Heubi, J E 2006. Micellar solubilisation of cholesterol is essential for absorption in humans. Gut, 55 2, 197-204

Demmers, Théa A; Jones, Peter J H; Wang, Yanwen; Krug, Susan; Creutzinger, Vivian; Heubi, James E 2005. Effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids among infants until 18 months of age. Pediatrics, 115 6, 1594-601

Miles, L; Heubi, J E; Bove, Kevin E 2005. Hepatocyte glycogen accumulation in patients undergoing dietary management of urea cycle defects mimics storage disease. Journal of pediatric gastroenterology and nutrition, 40 4, 471-6

Setchell, Kenneth D R; Clerici, Carlo; Lephart, Edwin D; Cole, Sidney J; Heenan, Claire; Castellani, Danilo; Wolfe, Brian E; Nechemias-Zimmer, Linda; Brown, Nadine M; Lund, Trent D; Handa, Robert J; Heubi, James E 2005. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. The American journal of clinical nutrition, 81 5, 1072-9

Thomas, Stephen R; Kalkwarf, Heidi J; Buckley, Donna D; Heubi, James E 2005. Effective dose of dual-energy X-ray absorptiometry scans in children as a function of age. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 8 4, 415-22

Guthery, S L; Heubi, J E; Filipovich, A 2004. Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study. Bone marrow transplantation, 33 12, 1235-9

Jandacek, Ronald J; Heubi, James E; Tso, Patrick 2004. A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology, 127 1, 139-44

Woollett, Laura A; Buckley, Donna D; Yao, Lihang; Jones, Peter J H; Granholm, Norman A; Tolley, Elizabeth A; Tso, Patrick; Heubi, James E 2004. Cholic acid supplementation enhances cholesterol absorption in humans. Gastroenterology, 126 3, 724-31

Cheng, Jeffrey B; Jacquemin, Emmanuel; Gerhardt, Marie; Nazer, Hisham; Cresteil, Danièle; Heubi, James E; Setchell, Kenneth D R; Russell, David W 2003. Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease. The Journal of clinical endocrinology and metabolism, 88 4, 1833-41

Cohran, Valeria C.; Heubi, James E. 2003. Treatment of Pediatric Cholestatic Liver Disease. Current treatment options in gastroenterology, 6 5, 403-415

Guthery, Stephen L; Heubi, James E; Bucuvalas, John C; Gross, Thomas G; Ryckman, Frederick C; Alonso, Maria H; Balistreri, William F; Hornung, Richard W 2003. Determination of risk factors for Epstein-Barr virus-associated posttransplant lymphoproliferative disorder in pediatric liver transplant recipients using objective case ascertainment. Transplantation, 75 7, 987-93

Guthery, Stephen L; Pohl, John F; Bucuvalas, John C; Alonso, Maria H; Ryckman, Frederick C; Balistreri, William F; Heubi, James E 2003. Bone mineral density in long-term survivors following pediatric liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 9 4, 365-70

King, Wilson; Levin, Ronald; Schmidt, Rosemary; Oestreich, Alan; Heubi, James E 2003. Prevalence of reduced bone mass in children and adults with spastic quadriplegia. Developmental medicine and child neurology, 45 1, 12-6

Setchell, Kenneth D R; Brown, Nadine Maynard; Desai, Pankaj B; Zimmer-Nechimias, Linda; Wolfe, Brian; Jakate, Abhijeet S; Creutzinger, Vivian; Heubi, James E 2003. Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes. The Journal of nutrition, 133 4, 1027-35

Setchell, Kenneth D R; Heubi, James E; Bove, Kevin E; O'Connell, Nancy C; Brewsaugh, Tracy; Steinberg, Steven J; Moser, Ann; Squires, Robert H 2003. Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy. Gastroenterology, 124 1, 217-32

Woollett, Laura A; Buckley, Donna D; Yao, Lihang; Jones, Peter J H; Granholm, Norman A; Tolley, Elizabeth A; Heubi, James E 2003. Effect of ursodeoxycholic acid on cholesterol absorption and metabolism in humans. Journal of lipid research, 44 5, 935-42

Heubi, James E 2002. Protecting the innocent. Journal of pediatric gastroenterology and nutrition, 34 4, 334-6

Heubi, James E; Heyman, Melvin B; Shulman, Robert J 2002. The impact of liver disease on growth and nutrition. Journal of pediatric gastroenterology and nutrition, 35 Suppl 1 , S55-9

Heubi, James E; Wiechmann, David A; Creutzinger, Vivian; Setchell, Kenneth D R; Squires, Robert; Couser, Robert; Rhodes, Philip 2002. Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease. The Journal of pediatrics, 141 2, 237-42

Kamath, Binita M; Krantz, Ian D; Spinner, Nancy B; Heubi, James E; Piccoli, David A 2002. Monozygotic twins with a severe form of Alagille syndrome and phenotypic discordance. American journal of medical genetics, 112 2, 194-7

Setchell, Kenneth D R; Brown, Nadine M; Zimmer-Nechemias, Linda; Brashear, Wayne T; Wolfe, Brian E; Kirschner, Abby S; Heubi, James E 2002. Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. The American journal of clinical nutrition, 76 2, 447-53

Yao, Lihang; Heubi, James E; Buckley, Donna D; Fierra, Humberto; Setchell, Kenneth D R; Granholm, Norman A; Tso, Patrick; Hui, David Y; Woollett, Laura A 2002. Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. Journal of lipid research, 43 4, 654-60

Guthery, S L; Heubi, J E 2001. Liver involvement in childhood histiocytic syndromes. Current opinion in gastroenterology, 17 5, 474-8

Setchell, K D; Brown, N M; Desai, P; Zimmer-Nechemias, L; Wolfe, B E; Brashear, W T; Kirschner, A S; Cassidy, A; Heubi, J E 2001. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. The Journal of nutrition, 131 4 Suppl, 1362S-75S

McConville, B J; Arvanitis, L A; Thyrum, P T; Yeh, C; Wilkinson, L A; Chaney, R O; Foster, K D; Sorter, M T; Friedman, L M; Brown, K L; Heubi, J E 2000. Pharmacokinetics, tolerability, and clinical effectiveness of quetiapine fumarate: an open-label trial in adolescents with psychotic disorders. The Journal of clinical psychiatry, 61 4, 252-60

Sayad, A E; Farah, R A; Rogers, Z R; Heubi, J E; Buchanan, G R; Squires, R H 1999. Correlation of serum cholylglycine level with hepatic dysfunction in children with sickle cell anemia. Clinical pediatrics, 38 5, 293-6

Dellert, S F; Farrell, M K; Specker, B L; Heubi, J E 1998. Bone mineral content in children with short bowel syndrome after discontinuation of parental nutrition. The Journal of pediatrics, 132 3 Pt 1, 516-9

Heubi, J E; Barbacci, M B; Zimmerman, H J 1998. Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. The Journal of pediatrics, 132 1, 22-7

Setchell, K D; Zimmer-Nechemias, L; Cai, J; Heubi, J E 1998. Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life. The American journal of clinical nutrition, 68 6 Suppl, 1453S-1461S

Dellert, S F; Nowicki, M J; Farrell, M K; Delente, J; Heubi, J E 1997. The 13C-xylose breath test for the diagnosis of small bowel bacterial overgrowth in children. Journal of pediatric gastroenterology and nutrition, 25 2, 153-8

Heubi, J E; Bien, J P 1997. Acetaminophen use in children: more is not better. The Journal of pediatrics, 130 2, 175-7

Heubi, J E; Higgins, J V; Argao, E A; Sierra, R I; Specker, B L 1997. The role of magnesium in the pathogenesis of bone disease in childhood cholestatic liver disease: a preliminary report. Journal of pediatric gastroenterology and nutrition, 25 3, 301-6

Nowicki, M J; Shneider, B L; Paul, J M; Heubi, J E 1997. Glucocorticoids upregulate taurocholate transport by ileal brush-border membrane. The American journal of physiology, 273 1 Pt 1, G197-203

Oelkers, P; Kirby, L C; Heubi, J E; Dawson, P A 1997. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). The Journal of clinical investigation, 99 8, 1880-7

Ploysangam, T; Heubi, J E; Eisen, D; Balistreri, W F; Lucky, A W 1997. Cutaneous Crohn's disease in children. Journal of the American Academy of Dermatology, 36 5 Pt 1, 697-704

Setchell, K D; Zimmer-Nechemias, L; Cai, J; Heubi, J E 1997. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet, 350 9070, 23-7

Dumaswala, R; Berkowitz, D; Heubi, J E 1996. Adaptive response of the enterohepatic circulation of bile acids to extrahepatic cholestasis. Hepatology (Baltimore, Md.), 23 3, 623-9

Kalkwarf, H J; Specker, B L; Heubi, J E; Vieira, N E; Yergey, A L 1996. Intestinal calcium absorption of women during lactation and after weaning. The American journal of clinical nutrition, 63 4, 526-31

Alfaro, M P; Siegel, R M; Baker, R C; Heubi, J E 1995. Resting energy expenditure and body composition in pediatric HIV infection. Pediatric AIDS and HIV infection, 6 5, 276-80

Argao, E A; Balistreri, W F; Hollis, B W; Ryckman, F C; Heubi, J E 1994. Effect of orthotopic liver transplantation on bone mineral content and serum vitamin D metabolites in infants and children with chronic cholestasis. Hepatology (Baltimore, Md.), 20 3, 598-603

Dumaswala, R; Berkowitz, D; Setchell, K D; Heubi, J E 1994. Effect of fasting on the enterohepatic circulation of bile acids in rats. The American journal of physiology, 267 5 Pt 1, G836-42

Higgins, J V; Paul, J M; Dumaswala, R; Heubi, J E 1994. Downregulation of taurocholate transport by ileal BBM and liver BLM in biliary-diverted rats. The American journal of physiology, 267 4 Pt 1, G501-7

Nowicki, M J; Ahmad, N; Heubi, J E; Kuramoto, I K; Baroudy, B M; Balistreri, W F 1994. The prevalence of hepatitis C virus (HCV) in infants and children after liver transplantation. Digestive diseases and sciences, 39 10, 2250-4

Peclet, M H; Ryckman, F C; Pedersen, S H; Dittrich, V S; Heubi, J E; Farrell, M; Balistreri, W F; Ziegler, M M 1994. The spectrum of bile duct complications in pediatric liver transplantation. Journal of pediatric surgery, 29 2, 214-9; discussion 21

Specker, B L; Vieira, N E; O'Brien, K O; Ho, M L; Heubi, J E; Abrams, S A; Yergey, A L 1994. Calcium kinetics in lactating women with low and high calcium intakes. The American journal of clinical nutrition, 59 3, 593-9

Argao, E A; Heubi, J E 1993. Fat-soluble vitamin deficiency in infants and children. Current opinion in pediatrics, 5 5, 562-6

Argao, E A; Specker, B L; Heubi, J E 1993. Bone mineral content in infants and children with chronic cholestatic liver disease. Pediatrics, 91 6, 1151-4

Daugherty, C C; Setchell, K D; Heubi, J E; Balistreri, W F 1993. Resolution of liver biopsy alterations in three siblings with bile acid treatment of an inborn error of bile acid metabolism (delta 4-3-oxosteroid 5 beta-reductase deficiency). Hepatology (Baltimore, Md.), 18 5, 1096-101

Heubi, J E 1993. Promising new treatment for type I tyrosinemia. Journal of pediatric gastroenterology and nutrition, 17 3, 340-1

Sokol, R J; Butler-Simon, N; Conner, C; Heubi, J E; Sinatra, F R; Suchy, F J; Heyman, M B; Perrault, J; Rothbaum, R J; Levy, J 1993. Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Gastroenterology, 104 6, 1727-35

Argao, E A; Heubi, J E; Hollis, B W; Tsang, R C 1992. d-Alpha-tocopheryl polyethylene glycol-1000 succinate enhances the absorption of vitamin D in chronic cholestatic liver disease of infancy and childhood. Pediatric research, 31 2, 146-50

Cohen, M B; A-Kader, H H; Lambers, D; Heubi, J E 1992. Complications of percutaneous liver biopsy in children. Gastroenterology, 102 2, 629-32

Heubi, J E; O'Connell, N C; Setchell, K D 1992. Ileal resection/dysfunction in childhood predisposes to lithogenic bile only after puberty. Gastroenterology, 103 2, 636-40

Bucuvalas, J C; Cutfield, W; Horn, J; Sperling, M A; Heubi, J E; Campaigne, B; Chernausek, S D 1990. Resistance to the growth-promoting and metabolic effects of growth hormone in children with chronic liver disease. The Journal of pediatrics, 117 3, 397-402

Bucuvalas, J C; Heubi, J E; Specker, B L; Gregg, D J; Yergey, A L; Vieira, N E 1990. Calcium absorption in bone disease associated with chronic cholestasis during childhood. Hepatology (Baltimore, Md.), 12 5, 1200-5

Burton, E M; Babcock, D S; Heubi, J E; Gelfand, M J 1990. Neonatal jaundice: clinical and ultrasonographic findings. Southern medical journal, 83 3, 294-302

Heubi, J E; Daugherty, C C 1990. Neonatal cholestasis: an approach for the practicing pediatrician. Current problems in pediatrics, 20 5, 233-95

Heubi, J E; Fellows, J L 1990. Absence of relationship between the postnatal development of ileal active taurocholate transport and microvillus membrane fluidity. Journal of developmental physiology, 13 3, 135-9

Heubi, J E; Hollis, B W; Tsang, R C 1990. Bone disease in chronic childhood cholestasis. II. Better absorption of 25-OH vitamin D than vitamin D in extrahepatic biliary atresia. Pediatric research, 27 1, 26-31

Heubi, J E; Sokol, R J; McGraw, C A 1990. Comparison of total serum lipids measured by two methods. Journal of pediatric gastroenterology and nutrition, 10 4, 468-72

Heubi, J E; Hollis, B W; Specker, B; Tsang, R C 1989. Bone disease in chronic childhood cholestasis. I. Vitamin D absorption and metabolism. Hepatology (Baltimore, Md.), 9 2, 258-64

Muñoz, S J; Heubi, J E; Balistreri, W F; Maddrey, W C 1989. Vitamin E deficiency in primary biliary cirrhosis: gastrointestinal malabsorption, frequency and relationship to other lipid-soluble vitamins. Hepatology (Baltimore, Md.), 9 4, 525-31

Sokol, R J; Butler-Simon, N; Heubi, J E; Iannaccone, S T; McClung, H J; Accurso, F; Hammond, K; Heyman, M; Sinatra, F; Riely, C 1989. Vitamin E deficiency neuropathy in children with fat malabsorption. Studies in cystic fibrosis and chronic cholestasis. Annals of the New York Academy of Sciences, 570 , 156-69

Sokol, R J; Kim, Y S; Hoofnagle, J H; Heubi, J E; Jones, E A; Balistreri, W F 1989. Intestinal malabsorption of vitamin E in primary biliary cirrhosis. Gastroenterology, 96 2 Pt 1, 479-86

Daugherty, C C; Gartside, P S; Heubi, J E; Saalfeld, K; Snyder, J 1987. A morphometric study of Reye's syndrome. Correlation of reduced mitochondrial numbers and increased mitochondrial size with clinical manifestations. The American journal of pathology, 129 2, 313-26

Sokol, R J; Heubi, J E; Butler-Simon, N; McClung, H J; Lilly, J R; Silverman, A 1987. Treatment of vitamin E deficiency during chronic childhood cholestasis with oral d-alpha-tocopheryl polyethylene glycol-1000 succinate. Gastroenterology, 93 5, 975-85

Heubi, J E 1986. Role of thyroxine on postnatal development of ileal active bile salt transport. The American journal of physiology, 251 2 Pt 1, G237-42

Moyer, M S; Heubi, J E; Goodrich, A L; Balistreri, W F; Suchy, F J 1986. Ontogeny of bile acid transport in brush border membrane vesicles from rat ileum. Gastroenterology, 90 5 Pt 1, 1188-96

Daugherty, C C; Heubi, J E 1985. Reye's syndrome associated with adenovirus infections. American journal of diseases of children (1960), 139 11, 1076

Heubi, J E; Fellows, J L 1985. Postnatal development of intestinal bile salt transport. Relationship to membrane physico-chemical changes. Journal of lipid research, 26 7, 797-805

Heubi, J E; Gunn, T D 1985. The role of glucocorticoids in the postnatal development of ileal active bile salt transport. Pediatric research, 19 11, 1147-51

Rennebohm, R M; Heubi, J E; Daugherty, C C; Daniels, S R 1985. Reye syndrome in children receiving salicylate therapy for connective tissue disease. The Journal of pediatrics, 107 6, 877-80

Sokol, R J; Guggenheim, M A; Heubi, J E; Iannaccone, S T; Butler-Simon, N; Jackson, V; Miller, C; Cheney, M; Balistreri, W F; Silverman, A 1985. Frequency and clinical progression of the vitamin E deficiency neurologic disorder in children with prolonged neonatal cholestasis. American journal of diseases of children (1960), 139 12, 1211-5

Sokol, R J; Guggenheim, M A; Iannaccone, S T; Barkhaus, P E; Miller, C; Silverman, A; Balistreri, W F; Heubi, J E 1985. Improved neurologic function after long-term correction of vitamin E deficiency in children with chronic cholestasis. The New England journal of medicine, 313 25, 1580-6

Heubi, J E; Daugherty, C C; Partin, J S; Partin, J C; Schubert, W K 1984. Grade I Reye's syndrome--outcome and predictors of progression to deeper coma grades. The New England journal of medicine, 311 24, 1539-42

Merk, P F; Heubi, J E 1984. Diagnosis, evaluation and treatment of the child with a simple febrile seizure. Indiana medicine : the journal of the Indiana State Medical Association, 77 9, 673-5

Norman, E J; Heubi, J E; Gelfand, M J; Dan, P; Matthews, D E 1984. Chenodeoxycholic acid pool size determination from children using isotope dilution mass spectrometry. Biomedical mass spectrometry, 11 6, 269-72

Sokol, R J; Heubi, J E; Iannaccone, S T; Bove, K E; Balistreri, W F 1984. Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis. The New England journal of medicine, 310 19, 1209-12

Balistreri, W F; Heubi, J E; Suchy, F J 1983. Immaturity of the enterohepatic circulation in early life: factors predisposing to "physiologic" maldigestion and cholestasis. Journal of pediatric gastroenterology and nutrition, 2 2, 346-54

Balistreri, W F; Heubi, J E; Suchy, F J 1983. Bile acid metabolism: relationship of bile acid malabsorption and diarrhea. Journal of pediatric gastroenterology and nutrition, 2 1, 105-21

Heubi, J E; Burstein, S; Sperling, M A; Gregg, D; Subbiah, M T; Matthews, D E 1983. The role of human growth hormone in the regulation of cholesterol and bile acid metabolism. The Journal of clinical endocrinology and metabolism, 57 5, 885-91

Heubi, J E; Partin, J C; Schubert, W K 1983. Hypocalcemia and steatorrhea--clues to etiology. Digestive diseases and sciences, 28 2, 124-8

Lichtenstein, P K; Heubi, J E; Daugherty, C C; Farrell, M K; Sokol, R J; Rothbaum, R J; Suchy, F J; Balistreri, W F 1983. Grade I Reye's syndrome. A frequent cause of vomiting and liver dysfunction after varicella and upper-respiratory-tract infection. The New England journal of medicine, 309 3, 133-9

Sokol, R J; Bove, K E; Heubi, J E; Iannaccone, S T 1983. Vitamin E deficiency during chronic childhood cholestasis: presence of sural nerve lesion prior to 2 1/2 years of age. The Journal of pediatrics, 103 2, 197-204

Sokol, R J; Farrell, M K; Heubi, J E; Tsang, R C; Balistreri, W F 1983. Comparison of vitamin E and 25-hydroxyvitamin D absorption during childhood cholestasis. The Journal of pediatrics, 103 5, 712-7

Sokol, R J; Heubi, J E; Balistreri, W F 1983. Vitamin E deficiency in cholestatic liver disease. The Journal of pediatrics, 103 4, 663-4

Sokol, R J; Heubi, J E; Balistreri, W F 1983. Intrahepatic "cholestasis facies": is it specific for Alagille syndrome? The Journal of pediatrics, 103 2, 205-8

Sokol, R J; Heubi, J E; Balistreri, W F 1983. Kasai procedure and vitamin E. Pediatrics, 71 4, 668-9

Sokol, R J; Heubi, J E; Iannaccone, S; Bove, K E; Balistreri, W F 1983. Mechanism causing vitamin E deficiency during chronic childhood cholestasis. Gastroenterology, 85 5, 1172-82

Fondacaro, J D; Heubi, J E; Kellogg, F W 1982. Intestinal bile acid malabsorption in cystic fibrosis: a primary mucosal cell defect. Pediatric research, 16 6, 494-8

Heubi, J E 1982. Serum bile acids as markers of liver disease in childhood. Journal of pediatric gastroenterology and nutrition, 1 4, 457-8

Heubi, J E; Balistreri, W F; Fondacaro, J D; Partin, J C; Schubert, W K 1982. Primary bile acid malabsorption: defective in vitro ileal active bile acid transport. Gastroenterology, 83 4, 804-11

Heubi, J E; Balistreri, W F; Suchy, F J 1982. Bile salt metabolism in the first year of life. The Journal of laboratory and clinical medicine, 100 1, 127-36

Heubi, J E; Fondacaro, J D 1982. Postnatal development of intestinal bile salt transport in the guinea pig. The American journal of physiology, 243 3, G189-94

Heubi, J E; Soloway, R D; Balistreri, W F 1982. Biliary lipid composition in healthy and diseased infants, children, and young adults. Gastroenterology, 82 6, 1295-9

Balistreri, W F; Suchy, F J; Farrell, M K; Heubi, J E 1981. Pathologic versus physiologic cholestasis: elevated serum concentration of a secondary bile acid in the presence of hepatobiliary disease. The Journal of pediatrics, 98 3, 399-402

Heubi, J E; Farrell, M K; Partin, J C 1981. The effect of continuous enteral feeding on cholic acid kinetics in a child. The American journal of clinical nutrition, 34 6, 1139-44

Merk, P F; Heubi, J E 1981. Management of the acute ingestion of poison in children. The Journal of the Indiana State Medical Association, 74 1, 23-7

Suchy, F J; Balistreri, W F; Heubi, J E; Searcy, J E; Levin, R S 1981. Physiologic cholestasis: elevation of the primary serum bile acid concentrations in normal infants. Gastroenterology, 80 5 pt 1, 1037-41

Balistreri, W F; Suchy, F J; Heubi, J E 1980. Serum bile acid response to a test meal stimulus: a sensitive test of ileal function. The Journal of pediatrics, 96 3 Pt 2, 582-9

Heubi, J E; Balistreri, W F 1980. Bile salt metabolism in infants and children after protracted infantile diarrhea. Pediatric research, 14 8, 943-6

Heubi, J E; Balistreri, W F; Partin, J C; Schubert, W K; Suchy, F J 1980. Enterohepatic circulation of bile acids in infants and children with ileal resection. The Journal of laboratory and clinical medicine, 95 2, 231-40

Heubi, J E; Balistreri, W F; Partin, J C; Schubert, W K; McGraw, C A 1979. Refractory infantile diarrhea due to primary bile acid malabsorption. The Journal of pediatrics, 94 4, 546-51

Heubi, J E; Fondacaro, J D; Balistreri, W F 1979. Essential hypertension in childhood. The Journal of pediatrics, 95 6, 1085-7

Heubi, J E; Partin, J C; Schubert, W K; McGraw, C A 1979. Small intestinal mucosal fatty acid uptake and esterification in infants and children. Pediatric research, 13 6, 781-2

Heubi, J E; Tsang, R C; Steichen, J J; Chan, G M; Chen, I W; DeLuca, H F 1979. 1,25-Dihydroxyvitamin D3 in childhood hepatic osteodystrophy. The Journal of pediatrics, 94 6, 977-82

Gaebler, J W; Heubi, J E 1975. Acute otitis media - diagnosis and treatment. The Journal of the Indiana State Medical Association, 68 1, 40-1

Bove, K E; Daugherty, C C; Tyson, W; Mierau, G; Heubi, J E; Balistreri, W F; Setchell, K D . Bile acid synthetic defects and liver disease. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 3 1, 1-16

Bove, Kevin E; Heubi, James E; Balistreri, William F; Setchell, Kenneth D R . Bile acid synthetic defects and liver disease: a comprehensive review. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 7 4, 315-34

Heubi, J E . Whenever possible, use the gut! Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology, 21 2, 88-90

Heubi, J E; Partin, J C; Partin, J S; Schubert, W K . Reye's syndrome: current concepts. Hepatology (Baltimore, Md.), 7 1, 155-64

Oestreich, A E; Sokol, R J; Suchy, F J; Heubi, J E . Renal abnormalities in arteriohepatic dysplasia and nonsyndromic intrahepatic biliary hypoplasia. Annales de radiologie, 26 2-3, 203-9

Sokol, R J; Heubi, J E; McGraw, C; Balistreri, W F . Correction of vitamin E deficiency in children with chronic cholestasis. II. Effect on gastrointestinal and hepatic function. Hepatology (Baltimore, Md.), 6 6, 1263-9