Today is Sunday, Nov. 19, 2017

Department of

Internal Medicine - Cystic Fibrosis Clinical Research Laboratory

Dr. Patricia Joseph-- Clinical Research: 

I dedicate most of my clinical and research time to cystic fibrosis care, CF clinical trials and quality improvement.  I am currently the principal investigator on multiple CF-related clinical trials with more planned for the near future. Our team is involved with several new investigational drugs designed to correct the defect in CF. Other studies include trials designed to improve lung function in CF patients, to evaluate patient methods of coping with chronic illness or to review aminoglycoside dosing and complications in CF. Our Adult CF program has a long history of involvement in quality improvement, and we have recently received a grant from the Cystic Fibrosis Foundation to identify components of our CF care delivery that can be altered to increase patient engagement and improve health outcomes.

I collaborate with John P. Clancy, MD; Lisa Burns, MD; Veronica Indihar, MD; Bruce Trapnell, MD; Christopher Droege, PharmD, on CF clinical trials; Daniel Grossoehme, UC associate professor and chaplain in the Division of Pulmonary Medicine at Cincinnati Children’s Hospital Medical Center, on coping with chronic disease; and with Mark Eckman, MD, on patient-centered outcomes research.

Potential projects for students and fellows: 

Potential project: Evaluate Pulmonary Therapies using CF Registry Data—query existing data provided by CFF to look for patterns in adult outcomes.
Research skills acquired: Clinical data management, statistics and epidemiology
Training required or time delay: Citi Training for human subjects research; add to IRB (4-8 weeks)

Potential project: Shared decision making and Personal Health Monitoring Device (PHMD) use in adult CF patients to improve outcomes.
Research skills acquired: Patient centered outcomes, analytical hierarchy process, electronic medical records, shared decision making (SDM)
Training required or time delay: Citi Training for human subjects research; add to IRB (4-8 weeks).  Study is in development; patients have not yet been recruited.  Short term project would only focus on implementation and SDM.

Potential project:  improving patient engagement by optimizing utilization of EPIC
Research skills acquired:  Quality improvement processes, patient centered outcomes, analytical hierarchy process, electronic medical records,
Training required or time delay: Citi Training for human subjects research; add to IRB (4-8 weeks).  Study is in development; patient recruitment will be based on the portion of true project chosen.  Short term project would focus on implementation, optimizing enrollment, addressing obstacles to utilization.

In addition, I have opportunities available to participate in clinical trials, a Lifespan project, and other ideas for research.