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Department of Internal Medicine

Infectious Diseases

Photo of  George Deepe, MD

George Deepe, MD

Professor of Clinical Medicine

Education/Credentials
  • Bachelor's Degree: Kenyon College
  • Medical Degree: University of Cincinnati College of Medicine
  • Residency: Southern Illinois School of Medicine
  • Fellowship : University of Kentucky College of Medicine
  • Fellowship : University of Cincinnati College of Medicine

Research/Clinical Interests

I have been involved in the study of the host response to the pathogenic fungus, Histoplasma capsulatum for over 25 years. I have devoted the large majority of our work on the role of the innate and adaptive immune response to this fungus. The laboratory has made several notable observations that have distinguished the interaction of this intracellular pathogen from that of other microbes. Moreover, some of these finding can be linked to the clinical spectrum, especially our observations regarding the role of tumor necrosis factor-?. Other contributions include the study of the role of regulatory T cells and histoplasmosis, the role chemokines in this disease, and the study of metal regulation by colony stimulating factors. We are exceedingly interested in how zinc regulation dictates the functional attributes of macrophages infected with H. capsulatum. We use a variety of techniques to examine the role of zinc. We have partnered with the Department of Chemistry and bioinformaticians to pursue how zinc and zinc binding proteins shape the biological activity of macrophages. We have extended our work into the examination of transcription factor regulation of macrophages and dendritic cells. For the former hypoxia-inducing factor (HIF) is required for an intact innate immune response to challenge with this organism. We have demonstrated that the absence of HIF-1? in macrophages causes collapse of the immune system. This detrimental effect is caused by elevated interleukin-10 production. For dendritic cells, we have discovered that Krüppel-like factor (KLF) 2 is necessary for these cells to regulate the emergence of T helper type 2 cells that produce interleukin-4 which is detrimental in both intracellular infections and in asthma. When dendritic cells lack KLF2 they upregulate a Notch ligand, Jagged 2, on dendritic cells. This ligand drives the emergence of Th2. The impact of KLF2 is via HIF-1?.

Board Certifications & Licenses
  • Board Certified Diplomate American Board of Internal Medicine, 1979
  • Board Certified Diplomate American Board of Internal Medicine, Certification in Infectious Diseases, 1982
Contact Information
  • Medical Sciences Building
  • Room 6152
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0560
  • Office 513-558-4704
  • Fax 513-558-2089
  • Email george.deepe@uc.edu

Peer Reviewed Publications

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Donnell, Anna M; Lewis, Stephanie; Abraham, Sami; Subramanian, Kavitha; Figueroa, Julio Landero; Deepe, George S; Vonderheide, Anne P 2017. Investigation of an optimal cell lysis method for the study of the zinc metalloproteome of Histoplasma capsulatum. Analytical and bioanalytical chemistry, ,

Friedrich, Dirk; Fecher, Roger A; Rupp, Jan; Deepe, George S 2017. Impact of HIF-1? and hypoxia on fungal growth characteristics and fungal immunity. Microbes and infection, 19 3, 204-209

Horwath, Michael C; Bell-Horwath, Tiffany R; Lescano, Victor; Krishnan, Karthik; Merino, Edward J; Deepe, George S 2017. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem : a European journal of chemical biology, ,

Dade, Jessica; DuBois, Juwen C; Pasula, Rajamouli; Donnell, Anna M; Caruso, Joseph A; Smulian, A George; Deepe, George S 2016. HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo. Medical mycology, 54 8, 865-75

Fecher, Roger A; Horwath, Michael C; Friedrich, Dirk; Rupp, Jan; Deepe, George S 2016. Inverse Correlation between IL-10 and HIF-1? in Macrophages Infected with Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 197 2, 565-79

George, Mariam Mathew; Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Caruso, Joseph A; Deepe, George S 2016. Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance. Journal of immunology (Baltimore, Md. : 1950), 197 5, 1864-76

Hsieh, Heidi; Vignesh, Kavitha Subramanian; Deepe, George S; Choubey, Divaker; Shertzer, Howard G; Genter, Mary Beth 2016. Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora. Toxicology in vitro : an international journal published in association with BIBRA, 35 , 24-30

Sterkel, Alana K; Lorenzini, Jenna L; Fites, J Scott; Subramanian Vignesh, Kavitha; Sullivan, Thomas D; Wuthrich, Marcel; Brandhorst, Tristan; Hernandez-Santos, Nydiaris; Deepe, George S; Klein, Bruce S 2016. Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Cell host & microbe, 19 3, 361-74

Subramanian Vignesh, Kavitha; Deepe, George S 2016. Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Archives of biochemistry and biophysics, 611 , 66-78

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Divanovic, Senad; Caruso, Joseph A; Deepe, George S 2016. IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages. Cell reports, 16 12, 3232-46

Xiong, Ye; Lingrel, Jerry B; Wüthrich, Marcel; Klein, Bruce S; Vasudevan, Neelakantan T; Jain, Mukesh K; George, Mariam; Deepe, George S 2016. Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1?/Jagged2/Notch Axis. mBio, 7 3,

Horwath, Michael C; Fecher, Roger A; Deepe, George S 2015. Histoplasma capsulatum, lung infection and immunity. Future microbiology, 10 6, 967-75

Figueroa, Julio A Landero; Vignesh, Kavitha Subramanian; Deepe, George S; Caruso, Joseph 2014. Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells. Metallomics : integrated biometal science, 6 2, 301-15

Figueroa, Julio A Landero; Vignesh, Kavitha Subramanian; Deepe, George S; Caruso, Joseph 2014. Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells. Metallomics : integrated biometal science, 6 2, 301-15

Figueroa, Julio A Landero; Vignesh, Kavitha Subramanian; Deepe, George S; Caruso, Joseph 2014. Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells. Metallomics : integrated biometal science, 6 2, 301-15

Verma, A; Kroetz, D N; Tweedle, J L; Deepe, G S 2014. Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. Mucosal immunology, ,

Verma, Akash; Wüthrich, Marcel; Deepe, George; Klein, Bruce 2014. Adaptive Immunity to Fungi. Cold Spring Harbor perspectives in medicine, ,

Cole, Garry T; Hung, Chiung-Yu; Sanderson, Sam D; Hurtgen, Brady J; Wüthrich, Marcel; Klein, Bruce S; Deepe, George S; Ostroff, Gary R; Levitz, Stuart M 2013. Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS pathogens, 9 12, e1003768

Cole, Garry T; Hung, Chiung-Yu; Sanderson, Sam D; Hurtgen, Brady J; Wüthrich, Marcel; Klein, Bruce S; Deepe, George S; Ostroff, Gary R; Levitz, Stuart M 2013. Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS pathogens, 9 12, e1003768

Cole, Garry T; Hung, Chiung-Yu; Sanderson, Sam D; Hurtgen, Brady J; Wüthrich, Marcel; Klein, Bruce S; Deepe, George S; Ostroff, Gary R; Levitz, Stuart M 2013. Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS pathogens, 9 12, e1003768

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS pathogens, 9 12, e1003815

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS pathogens, 9 12, e1003815

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS pathogens, 9 12, e1003815

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Deepe, G. S., Jr.; Buesing, W. R. 2012. Deciphering the pathways of death of , 188 1 , 334-44

Deepe, George S 2012. NADPH oxidase regulates efficacy of vaccination in aspergillosis. The Journal of clinical investigation, 122 5, 1608-11

Deepe, George S; Buesing, William R 2012. Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. Journal of immunology (Baltimore, Md. : 1950), 188 1, 334-44

Kroetz, D. N.; Deepe, G. S. 2012. The role of cytokines and chemokines in Cytokine, 58 1 , 112-7

Kroetz, D. N.; Deepe, G. S., Jr. 2012. CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor J Immunol, 205 6 , 955-63

Kroetz, Danielle N; Deepe, George S 2012. The role of cytokines and chemokines in Histoplasma capsulatum infection. Cytokine, 58 1, 112-7

Kroetz, Danielle N; Deepe, George S 2012. CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor ? antagonism in murine histoplasmosis. The Journal of infectious diseases, 205 6, 955-63

Wüthrich, Marcel; Deepe, George S; Klein, Bruce 2012. Adaptive immunity to fungi. Annual review of immunology, 30 , 115-48

Kroetz, D. N.; Deepe, G. S., Jr. 2011. An aberrant thymus in CCR5 J Immunol, 186 10 , 5949-55

Kroetz, Danielle N; Deepe, George S 2011. An Aberrant Thymus in CCR5-/- Mice Is Coupled with an Enhanced Adaptive Immune Response in Fungal Infection. Journal of immunology (Baltimore, Md. : 1950), 186 10, 5949-55

Mora-Montes, Héctor M; Netea, Mihai G; Ferwerda, Gerben; Lenardon, Megan D; Brown, Gordon D; Mistry, Anita R; Kullberg, Bart Jan; O'Callaghan, Chris A; Sheth, Chirag C; Odds, Frank C; Brown, Alistair J P; Munro, Carol A; Gow, Neil A R; Deepe, G S 2011. Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin. Infection and immunity, 79 5, 1961-70

Deepe, G. S., Jr. 2010. Histoplasma capsulatum , 2 , 3305-3318

Kroetz, D. N.; Deepe, G. S., Jr. 2010. CCR5 dictates the equilibrium of proinflammatory IL-17 J Immunol, 184 9 , 5224-31

Kroetz, Danielle N; Deepe, George S 2010. CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection. Journal of immunology (Baltimore, Md. : 1950), 184 9, 5224-31

Szymczak, W. A.; Deepe, G. S., Jr. 2010. Antigen-presenting dendritic cells rescue CD4-depleted CCR2 Infect Immun, 78 5 , 2125-37

Szymczak, Wendy A; Deepe, George S 2010. Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection. Infection and immunity, 78 5, 2125-37

Winters, M. S.; Chan, Q.; Caruso, J. A.; Deepe, G. S., Jr. 2010. Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses J Infect Dis, 202 7 , 1136-45

Winters, Michael S; Chan, Qilin; Caruso, Joseph A; Deepe, George S 2010. Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses. The Journal of infectious diseases, 202 7, 1136-45

Deepe, George S; Gibbons, Reta S 2009. Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. The Journal of infectious diseases, 200 1, 142-51

Szymczak, W. A.; Deepe, G. S., Jr. 2009. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity J Immunol, 183 3 , 1964-74

Szymczak, Wendy A; Deepe, George S 2009. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity. Journal of immunology (Baltimore, Md. : 1950), 183 3, 1964-74

Chagas, Ronney Fernandes; Bailão, Alexandre Melo; Pereira, Maristela; Winters, Michael S; Smullian, Alan George; Deepe, George S; de Almeida Soares, Célia Maria 2008. The catalases of Paracoccidioides brasiliensis are differentially regulated: protein activity and transcript analysis. Fungal genetics and biology : FG & B, 45 11, 1470-8

de Bastos Ascenço Soares, Renata; Gomez, Francisco J; de Almeida Soares, Célia Maria; Deepe, George S 2008. Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection. Infection and immunity, 76 9, 4214-21

Deepe, George S; Gibbons, Reta S 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 180 2, 1088-97

Deepe, George S; Gibbons, Reta S; Smulian, A George 2008. Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs. Journal of leukocyte biology, 84 3, 669-78

Medeiros, Alexandra I; Sá-Nunes, Anderson; Turato, Walter M; Secatto, Adriana; Frantz, Fabiani G; Sorgi, Carlos A; Serezani, Carlos H; Deepe, George S; Faccioli, Lúcia H 2008. Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. Journal of immunology (Baltimore, Md. : 1950), 181 12, 8544-51

Winters, Michael S; Spellman, Daniel S; Chan, Qilin; Gomez, Francisco J; Hernandez, Margarita; Catron, Brittany; Smulian, Alan G; Neubert, Thomas A; Deepe, George S 2008. Histoplasma capsulatum proteome response to decreased iron availability. Proteome science, 6 , 36

Cutler, Jim E; Deepe, George S; Klein, Bruce S 2007. Advances in combating fungal diseases: vaccines on the threshold. Nature reviews. Microbiology, 5 1, 13-28

Dann, Frank J; Gottlieb, Alice B; Deepe, George S; Flynn, JoAnne L; Wallis, Robert S; Thompson, Elizabeth H Z; Louie, James S 2007. Structural-functional relationships of TNF-alpha antagonists: next steps. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 12 1, 46-7

Deepe, George S 2007. Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 27 6, 471-80

Deepe, George S 2007. Tumor necrosis factor-alpha and host resistance to the pathogenic fungus, Histoplasma capsulatum. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 12 1, 34-7

Smulian, A George; Gibbons, Reta S; Demland, Jeffery A; Spaulding, Deborah T; Deepe, George S 2007. Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum. Eukaryotic cell, 6 11, 2066-71

Wüthrich, Marcel; Filutowicz, Hanna I; Allen, Holly L; Deepe, George S; Klein, Bruce S 2007. V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis. Infection and immunity, 75 1, 193-200

Allen, Holly L; Deepe, George S 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 177 3, 1763-71

Deepe, George S; Gibbons, Reta S 2006. T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum. The Journal of infectious diseases, 193 2, 322-30

Deepe, George S; McGuinness, Michael 2006. Interleukin-1 and host control of pulmonary histoplasmosis. The Journal of infectious diseases, 194 6, 855-64

Scheckelhoff, Mark R; Deepe, George S 2006. Pulmonary V beta 4+ T cells from Histoplasma capsulatum-infected mice respond to a homologue of Sec31 that confers a protective response. The Journal of infectious diseases, 193 6, 888-97

Allen, Holly L; Deepe, George S 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. The Journal of clinical investigation, 115 10, 2875-85

Borges, Clayton L; Pereira, Maristela; Felipe, Maria S S; de Faria, Fabrícia P; Gomez, Francisco J; Deepe, George S; Soares, Célia M A 2005. The antigenic and catalytically active formamidase of Paracoccidioides brasiliensis: protein characterization, cDNA and gene cloning, heterologous expression and functional analysis of the recombinant protein. Microbes and infection / Institut Pasteur, 7 1, 66-77

Deepe, George S 2005. Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 Suppl 3 , S204-7

Deepe, George S; Smelt, Sara; Louie, James S 2005. Tumor necrosis factor inhibition and opportunistic infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 Suppl 3 , S187-8

Deepe, George S; Wüthrich, Marcel; Klein, Bruce S 2005. Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity. Medical mycology : official publication of the International Society for Human and Animal Mycology, 43 5, 381-9

Scheckelhoff, Mark; Deepe, George S 2005. A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum. Infection and immunity, 73 4, 2129-34

Barton, Lance F; Runnels, Herbert A; Schell, Todd D; Cho, Yunjung; Gibbons, Reta; Tevethia, Satvir S; Deepe, George S; Monaco, John J 2004. Immune defects in 28-kDa proteasome activator gamma-deficient mice. Journal of immunology (Baltimore, Md. : 1950), 172 6, 3948-54

Deepe, George S 2004. Preventative and therapeutic vaccines for fungal infections: from concept to implementation. Expert review of vaccines, 3 6, 701-9

Deepe, George S; Gibbons, Reta S 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. Journal of immunology (Baltimore, Md. : 1950), 171 10, 5353-62

Gildea, Lucy A; Gibbons, Reta; Finkelman, Fred D; Deepe, George S 2003. Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum. Infection and immunity, 71 7, 3787-93

Guedes, Herbert Leonel de Matos; Guimarães, Allan Jefferson; Muniz, Mauro de Medeiros; Pizzini, Claudia Vera; Hamilton, Andrew John; Peralta, José Mauro; Deepe, George S; Zancopé-Oliveira, Rosely M 2003. PCR assay for identification of histoplasma capsulatum based on the nucleotide sequence of the M antigen. Journal of clinical microbiology, 41 2, 535-9

Huffnagle, Gary B; Deepe, George S 2003. Innate and adaptive determinants of host susceptibility to medically important fungi. Current opinion in microbiology, 6 4, 344-50

McCormack, Francis X; Gibbons, Reta; Ward, Susan R; Kuzmenko, Alexander; Wu, Huixing; Deepe, George S 2003. Macrophage-independent fungicidal action of the pulmonary collectins. The Journal of biological chemistry, 278 38, 36250-6

Nosanchuk, Joshua D; Steenbergen, Judith N; Shi, Li; Deepe, George S; Casadevall, Arturo 2003. Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum. The Journal of clinical investigation, 112 8, 1164-75

Wuthrich, Marcel; Filutowicz, Hanna I; Warner, Tom; Deepe, George S; Klein, Bruce S 2003. Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts. The Journal of experimental medicine, 197 11, 1405-16

Barton, Lance F; Cruz, Miguel; Rangwala, Reshma; Deepe, George S; Monaco, John J 2002. Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection. Journal of immunology (Baltimore, Md. : 1950), 169 6, 3046-52

Costa, Alessandra A; Gómez, Francisco J; Pereira, Maristela; Felipe, M Sueli S; Jesuino, Rosália S A; Deepe, George S; de Almeida Soares, Célia M 2002. Characterization of a gene which encodes a mannosyltransferase homolog of Paracoccidioides brasiliensis. Microbes and infection / Institut Pasteur, 4 10, 1027-34

Cunha, Daniela A; Zancopé-Oliveira, Roseli M; Sueli, M; Felipe, S; Salem-Izacc, Silvia M; Deepe, George S; Soares, Célia M A 2002. Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis. Clinical and diagnostic laboratory immunology, 9 2, 374-7

Deepe, George S; Gibbons, Reta S 2002. Functional properties of the T cell receptor repertoire in responding to the protective domain of heat-shock protein 60 from Histoplasma capsulatum. The Journal of infectious diseases, 186 6, 815-22

Deepe, George S; Gibbons, Reta S 2002. Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum. Infection and immunity, 70 7, 3759-67

Deepe, George S; Gibbons, Reta S; Ward, Susan R 2002. Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum. Infection and immunity, 70 3, 1648-52

Scheckelhoff, Mark; Deepe, George S 2002. The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells. Journal of immunology (Baltimore, Md. : 1950), 169 10, 5818-26

Deepe, G S; Gibbons, R 2001. V beta 6+ T cells are obligatory for vaccine-induced immunity to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 167 4, 2219-26

Deepe, G S; Gibbons, R 2001. Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosis. Infection and immunity, 69 5, 3128-34

Gomez, F J; Woodward, E O; Pilcher-Roberts, R; Gibbons, R S; Deepe, G S 2001. V beta 6+ and V beta 4+ T cells exert cooperative activity in clearance of secondary infection with Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 166 4, 2855-62

Izacc, S M; Gomez, F J; Jesuino, R S; Fonseca, C A; Felipe, M S; Deepe, G S; Soares, C M 2001. Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis. Medical mycology : official publication of the International Society for Human and Animal Mycology, 39 5, 445-55

Allendoerfer, R; Deepe, G S 2000. Regulation of infection with Histoplasma capsulatum by TNFR1 and -2. Journal of immunology (Baltimore, Md. : 1950), 165 5, 2657-64

Cain, J A; Deepe, G S 2000. Interleukin-12 neutralization alters lung inflammation and leukocyte expression of CD80, CD86, and major histocompatibility complex class II in mice infected with Histoplasma capsulatum. Infection and immunity, 68 4, 2069-76

Deepe, G S 2000. Immune response to early and late Histoplasma capsulatum infections. Current opinion in microbiology, 3 4, 359-62

Deepe, G S; Gibbons, R 2000. Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice. Antimicrobial agents and chemotherapy, 44 12, 3328-36

Deepe, G S; Romani, L; Calich, V L; Huffnagle, G; Arruda, C; Molinari-Madlum, E E; Perfect, J R 2000. Knockout mice as experimental models of virulence. Medical mycology : official publication of the International Society for Human and Animal Mycology, 38 Suppl 1 , 87-98

Retallack, D M; Deepe, G S; Woods, J P 2000. Applying in vivo expression technology (IVET) to the fungal pathogen Histoplasma capsulatum. Microbial pathogenesis, 28 3, 169-82

Allendörfer, R; Brunner, G D; Deepe, G S 1999. Complex requirements for nascent and memory immunity in pulmonary histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 162 12, 7389-96

Deepe, G S; Gibbons, R; Woodward, E 1999. Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 163 9, 4985-93

Fisher, K L; Deepe, G S; Woods, J P 1999. Histoplasma capsulatum strain variation in both H antigen production and beta-glucosidase activity and overexpression of HAG1 from a telomeric linear plasmid. Infection and immunity, 67 7, 3312-6

Retallack, D M; Heinecke, E L; Gibbons, R; Deepe, G S; Woods, J P 1999. The URA5 gene is necessary for histoplasma capsulatum growth during infection of mouse and human cells. Infection and immunity, 67 2, 624-9

Zancopé-Oliveira, R M; Reiss, E; Lott, T J; Mayer, L W; Deepe, G S 1999. Molecular cloning, characterization, and expression of the M antigen of Histoplasma capsulatum. Infection and immunity, 67 4, 1947-53

Allendoerfer, R; Deepe, G S 1998. Infection with Histoplasma capsulatum: Host-fungus interface. Revista iberoamericana de micología : órgano de la Asociación Española de Especialistas en Micología, 15 4, 256-60

Allendoerfer, R; Deepe, G S 1998. Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. Journal of immunology (Baltimore, Md. : 1950), 160 12, 6072-82

Batanghari, J W; Deepe, G S; Di Cera, E; Goldman, W E 1998. Histoplasma acquisition of calcium and expression of CBP1 during intracellular parasitism. Molecular microbiology, 27 3, 531-9

Cain, J A; Deepe, G S 1998. Evolution of the primary immune response to Histoplasma capsulatum in murine lung. Infection and immunity, 66 4, 1473-81

Dixon, D M; Casadevall, A; Klein, B; Mendoza, L; Travassos, L; Deepe, G S 1998. Development of vaccines and their use in the prevention of fungal infections. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 Suppl 1 , 57-67

Gomez, F J; Cain, J A; Gibbons, R; Allendoerfer, R; Deepe, G S 1998. Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis. The Journal of clinical investigation, 102 5, 984-95

Matthews, R C; Maresca, B; Burnie, J P; Cardona, A; Carratu, L; Conti, S; Deepe, G S; Florez, A M; Franceschelli, S; Garcia, E; Gargano, L S; Kobayashi, G S; McEwen, J G; Ortiz, B L; Oviedo, A M; Polonelli, L; Ponton, J; Restrepos, A; Storlazzi, A 1998. Stress proteins in fungal diseases. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 Suppl 1 , 45-51

Mounts, A; Deepe, G S 1998. Simultaneous infection with Blastomyces dermatitidis and Cryptococcus neoformans. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 1, 47-50

Murphy, J W; Bistoni, F; Deepe, G S; Blackstock, R A; Buchanan, K; Ashman, R B; Romani, L; Mencacci, A; Cenci, E; Fè d'Ostiani, C; Del Sero, G; Calich, V L; Kashino, S S 1998. Type 1 and type 2 cytokines: from basic science to fungal infections. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 Suppl 1 , 109-18

Allendoerfer, R; Biovin, G P; Deepe, G S 1997. Modulation of immune responses in murine pulmonary histoplasmosis. The Journal of infectious diseases, 175 4, 905-14

Allendoerfer, R; Deepe, G S 1997. Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice. Infection and immunity, 65 7, 2564-9

Deepe, G S 1997. Prospects for the development of fungal vaccines. Clinical microbiology reviews, 10 4, 585-96

Healy, D P; Dansereau, R J; Dunn, A B; Clendening, C E; Mounts, A W; Deepe, G S 1997. Reduced tetracycline bioavailability caused by magnesium aluminum silicate in liquid formulations of bismuth subsalicylate. The Annals of pharmacotherapy, 31 12, 1460-4

Allendoerfer, R; Maresca, B; Deepe, G S 1996. Cellular immune responses to recombinant heat shock protein 70 from Histoplasma capsulatum. Infection and immunity, 64 10, 4123-8

Deepe, G S; Gibbons, R; Brunner, G D; Gomez, F J 1996. A protective domain of heat-shock protein 60 from Histoplasma capsulatum. The Journal of infectious diseases, 174 4, 828-34

Deepe, G S; Durose, G G 1995. Immunobiological activity of recombinant H antigen from Histoplasma capsulatum. Infection and immunity, 63 8, 3151-7

Gomez, F J; Allendoerfer, R; Deepe, G S 1995. Vaccination with recombinant heat shock protein 60 from Histoplasma capsulatum protects mice against pulmonary histoplasmosis. Infection and immunity, 63 7, 2587-95

Deepe, G S 1994. Role of CD8+ T cells in host resistance to systemic infection with Histoplasma capsulatum in mice. Journal of immunology (Baltimore, Md. : 1950), 152 7, 3491-500

Deepe, G S 1994. The immune response to Histoplasma capsulatum: unearthing its secrets. The Journal of laboratory and clinical medicine, 123 2, 201-5

Newman, S L; Gootee, L; Brunner, G; Deepe, G S 1994. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. The Journal of clinical investigation, 93 4, 1422-9

Allendoerfer, R; Magee, D M; Deepe, G S; Graybill, J R 1993. Transfer of protective immunity in murine histoplasmosis by a CD4+ T-cell clone. Infection and immunity, 61 2, 714-8

Deepe, G S 1993. Histoplasma capsulatum and V beta a mice: cellular immune responses and susceptibility patterns. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 31 3, 181-8

Rossi, S J; Healy, D P; Savani, D V; Deepe, G 1993. High-dose ciprofloxacin in the treatment of a renal cyst infection. The Annals of pharmacotherapy, 27 1, 38-9

Rossi, S J; Healy, D P; Savani, D V; Deepe, G 1993. High-dose ciprofloxacin in the treatment of a renal cyst infection. The Annals of pharmacotherapy, 27 1, 38-9

Rossi, S J; Healy, D P; Savani, D V; Deepe, G 1993. High-dose ciprofloxacin in the treatment of a renal cyst infection. The Annals of pharmacotherapy, 27 1, 38-9

Domer, J E; Murphy, J W; Deepe, G S; Franco, M 1992. Immunomodulation in the mycoses. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 30 Suppl 1 , 157-66

Gomez, F J; Gomez, A M; Deepe, G S 1992. An 80-kilodalton antigen from Histoplasma capsulatum that has homology to heat shock protein 70 induces cell-mediated immune responses and protection in mice. Infection and immunity, 60 7, 2565-71

Henderson, H M; Deepe, G S 1992. Recognition of Histoplasma capsulatum yeast-cell antigens by human lymphocytes and human T-cell clones. Journal of leukocyte biology, 51 5, 432-6

Gómez, A M; Rhodes, J C; Deepe, G S 1991. Antigenicity and immunogenicity of an extract from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infection and immunity, 59 1, 330-6

Gomez, F J; Gomez, A M; Deepe, G S 1991. Protective efficacy of a 62-kilodalton antigen, HIS-62, from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infection and immunity, 59 12, 4459-64

Deepe, G S; Brunner, G D 1990. Functional analysis of Histoplasma capsulatum-reactive T-cell hybridomas. Infection and immunity, 58 6, 1538-44

Deepe, G S; Bullock, W E 1990. Immunological aspects of fungal pathogenesis. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 9 8, 567-79

Deepe, G S; Bullock, W E 1989. Correlative studies of blastogenic responses and interleukin 1 production by mononuclear cells from patients with zoopathogenic fungal infections. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 27 3, 159-68

Harris, J E; Deepe, G S 1989. Requirements for histoplasmin presentation by accessory cells to a Histoplasma capsulatum-reactive T-cell line. Journal of leukocyte biology, 45 2, 105-13

Deepe, G S 1988. Protective immunity in murine histoplasmosis: functional comparison of adoptively transferred T-cell clones and splenic T cells. Infection and immunity, 56 9, 2350-5

Gomez, A M; Bullock, W E; Taylor, C L; Deepe, G S 1988. Role of L3T4+ T cells in host defense against Histoplasma capsulatum. Infection and immunity, 56 7, 1685-91

Hagler, D N; Deepe, G S; Pogue, C L; Walzer, P D 1988. Blastogenic responses to Pneumocystis carinii among patients with human immunodeficiency (HIV) infection. Clinical and experimental immunology, 74 1, 7-13

Harris, J E; Deepe, G S 1988. Characterization of antigenic determinants in histoplasmin that stimulate Histoplasma capsulatum-reactive T cells in vitro. Infection and immunity, 56 9, 2343-9

Deepe, G S; Smith, J G; Sonnenfeld, G; Denman, D; Bullock, W E 1986. Development and characterization of Histoplasma capsulatum-reactive murine T-cell lines and clones. Infection and immunity, 54 3, 714-22

Deepe, G S; Taylor, C L; Harris, J E; Bullock, W E 1986. Modulation of cellular immune responses in mice with disseminated histoplasmosis by recombinant interleukin-2. Infection and immunity, 53 1, 6-12

Deepe, G S; Taylor, C L; Bullock, W E 1985. Evolution of inflammatory response and cellular immune responses in a murine model of disseminated blastomycosis. Infection and immunity, 50 1, 183-9

Deepe, G S; Taylor, C L; Srivastava, L; Bullock, W E 1985. Impairment of granulomatous inflammatory response to Histoplasma capsulatum by inhibitors of angiotensin-converting enzyme. Infection and immunity, 48 2, 395-401

Deepe, G S; Watson, S R; Bullock, W E 1984. Cellular origins and target cells of immunoregulatory factors in mice with disseminated histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 132 4, 2064-71

Bullock, W E; Deepe, G S 1983. Medical mycology in crisis. The Journal of laboratory and clinical medicine, 102 5, 685-93

Deepe, G S; Kravitz, G R; Bullock, W E 1983. Pharmacological modulation of suppressor cell activity in mice with disseminated histoplasmosis. Infection and immunity, 41 1, 114-20

Deepe, G S; MacMillan, B G; Linnemann, C C 1982. Unexplained fever in burn patients due to cytomegalovirus infection. JAMA : the journal of the American Medical Association, 248 18, 2299-301

Deepe, G S; Watson, S R; Bullock, W E 1982. Generation of disparate immunoregulatory factors in two inbred strains of mice with disseminated histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 129 5, 2186-91

Deepe, G S; Capparell, R; Coonrod, J D 1980. Atypical mycobacterial lymphadenitis in an adult. Chest, 78 6, 882-3

Deepe, G S; Coonrod, J D 1980. Fulminant wound infection with Aeromonas hydrophila. Southern medical journal, 73 11, 1546-7

Deepe, G S; Eagleton, L E 1980. Resolution of influenzal pneumonia. IMJ. Illinois medical journal, 158 2, 76-8

Deepe, G S; Seder, R A . Molecular and cellular determinants of immunity to Histoplasma capsulatum. Research in immunology, 149 4-5, 397-406; discussion

Huaman, Moises A; Deepe, George S; Fichtenbaum, Carl J . Elevated Circulating Concentrations of Interferon-Gamma in Latent Tuberculosis Infection. Pathogens & immunity, 1 2, 291-303