George Thomas, MD

Carnevalli, Larissa S; Masuda, Kouhei; Frigerio, Francesca; Le Bacquer, Olivier; Um, Sung Hee; Gandin, Valentina; Topisirovic, Ivan; Sonenberg, Nahum; Thomas, George; Kozma, Sara C 2010. S6K1 plays a critical role in early adipocyte differentiation. Developmental cell, 18 5, 763-74

Dikeakos, Jimmy D; Atkins, Katelyn M; Thomas, Laurel; Emert-Sedlak, Lori; Byeon, In-Ja L; Jung, Jinwon; Ahn, Jinwoo; Wortman, Matthew D; Kukull, Ben; Saito, Masumichi; Koizumi, Hirokazu; Williamson, Danielle M; Hiyoshi, Masateru; Barklis, Eric; Takiguchi, Masafumi; Suzu, Shinya; Gronenborn, Angela M; Smithgall, Thomas E; Thomas, Gary 2010. Small Molecule Inhibition of HIV-1-Induced MHC-I Downregulation Identifies a Temporally Regulated Switch in Nef Action. Molecular biology of the cell, ,

Kalender, Adem; Selvaraj, Anand; Kim, So Young; Gulati, Pawan; Brûlé, Sophie; Viollet, Benoit; Kemp, Bruce E; Bardeesy, Nabeel; Dennis, Patrick; Schlager, John J; Marette, André; Kozma, Sara C; Thomas, George 2010. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell metabolism, 11 5, 390-401

Selvaraj, Anand; Thomas, George 2010. Phosphatase 2A puts the brakes on mTORC1 nutrient signaling. Cell metabolism, 11 4, 245-7

Plas, David R; Thomas, George 2009. Tubers and tumors: rapamycin therapy for benign and malignant tumors. Current opinion in cell biology, 21 2, 230-6

Gulati, Pawan; Gaspers, Lawrence D; Dann, Stephen G; Joaquin, Manel; Nobukuni, Takahiro; Natt, Francois; Kozma, Sara C; Thomas, Andrew P; Thomas, George 2008. Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell metabolism, 7 5, 456-65

Johansson, Gunnar; Mahller, Yonatan Y; Collins, Margaret H; Kim, Mi-Ok; Nobukuni, Takahiro; Perentesis, John; Cripe, Timothy P; Lane, Heidi A; Kozma, Sara C; Thomas, George; Ratner, Nancy 2008. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Molecular cancer therapeutics, 7 5, 1237-45

Dann, Stephen G; Selvaraj, Anand; Thomas, George 2007. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends in molecular medicine, 13 6, 252-9

Gulati, P; Thomas, G 2007. Nutrient sensing in the mTOR/S6K1 signalling pathway. Biochemical Society transactions, 35 Pt 2, 236-8

Nobukuni, Takahiro; Kozma, Sara C; Thomas, George 2007. hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Current opinion in cell biology, 19 2, 135-41

Cota, Daniela; Proulx, Karine; Smith, Kathi A Blake; Kozma, Sara C; Thomas, George; Woods, Stephen C; Seeley, Randy J 2006. Hypothalamic mTOR signaling regulates food intake. Science (New York, N.Y.), 312 5775, 927-30

Dann, Stephen G; Thomas, George 2006. The amino acid sensitive TOR pathway from yeast to mammals. FEBS letters, 580 12, 2821-9

Franz, David Neal; Leonard, Jennifer; Tudor, Cynthia; Chuck, Gail; Care, Marguerite; Sethuraman, Gopalan; Dinopoulos, Argirios; Thomas, George; Crone, Kerry R 2006. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Annals of neurology, 59 3, 490-8

Um, Sung Hee; D'Alessio, David; Thomas, George 2006. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell metabolism, 3 6, 393-402

Gangloff, Yann-Gaël; Mueller, Matthias; Dann, Stephen G; Svoboda, Petr; Sticker, Melanie; Spetz, Jean-Francois; Um, Sung Hee; Brown, Eric J; Cereghini, Silvia; Thomas, George; Kozma, Sara C 2004. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Molecular and cellular biology, 24 21, 9508-16

Craig, A J; Cualing, H; Thomas, G; Lamerson, C; Smith, R 1998. Cytophagic histiocytic panniculitis--a syndrome associated with benign and malignant panniculitis: case comparison and review of the literature. Journal of the American Academy of Dermatology, 39 5 Pt 1, 721-36

Frohman, L A; Downs, T R; Kelijman, M; Clarke, I J; Thomas, G 1990. Somatostatin secretion and action in the regulation of growth hormone secretion. Metabolism: clinical and experimental, 39 9 Suppl 2, 43-5

Kashiwagi, S; Tew, J M; van Loveren, H R; Thomas, G 1988. Trapping of giant basilar trunk aneurysms. Report of two cases. Journal of neurosurgery, 69 3, 442-5