Education/CredentialsFellowship: University of Cincinnati (Genome Research Institute )Doctoral Degree: Wright State University (Molecular Biology and Biochemistry)Internship : The Community Hospital (Medical Technology )Bachelor's Degree: Wittenberg University (Biology (Cum Laude)) Contact Information Research InterestsmTOR/S6K pathway in diabetes, mTOR signaling in hepatocellular carcinogenesis, Hematology Oncology Peer Reviewed Publications Donati, Giulio; Peddigari, Suresh; Mercer, Carol A; Thomas, George 2013. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint. Cell reports, 4 1, 87-98Teng, Teng; Thomas, George; Mercer, Carol A 2013. Growth control and ribosomopathies. Current opinion in genetics & development, 23 1, 63-71Thomas, Hala Elnakat; Mercer, Carol A; Carnevalli, Larissa S; Park, Jongsun; Andersen, Jesper B; Conner, Elizabeth A; Tanaka, Kazuhiro; Matsutani, Tomoo; Iwanami, Akio; Aronow, Bruce J; Manway, Liu; Maira, S Michel; Thorgeirsson, Snorri S; Mischel, Paul S; Thomas, George; Kozma, Sara C 2012. mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma. Science translational medicine, 4 139, 139ra84Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97McFarland-Mancini, Molly M; Funk, Holly M; Paluch, Andrew M; Zhou, Mingfu; Giridhar, Premkumar Vummidi; Mercer, Carol A; Kozma, Sara C; Drew, Angela F 2010. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. Journal of immunology (Baltimore, Md. : 1950), 184 12, 7219-28Dennis, Patrick B; Mercer, Carol A 2009. The GST-BHMT assay and related assays for autophagy. Methods in enzymology, 452 , 97-118Mercer, Carol A; Kaliappan, Alagammai; Dennis, Patrick B 2009. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy, 5 5, 649-62Mercer, Carol A; Kaliappan, Alagammai; Dennis, Patrick B 2008. Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization. Autophagy, 4 2, 185-94Robinson-Smith, Toni M; Isaacsohn, Idit; Mercer, Carol A; Zhou, Mingfu; Van Rooijen, Nico; Husseinzadeh, Nader; McFarland-Mancini, Molly M; Drew, Angela F 2007. Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice. Cancer research, 67 12, 5708-16Caserta TM, Kommagani R, Yuan Z, Robbins DJ, Mercer CA, Kadakia MP 2006. p63 overexpression induces the expression of Sonic Hedgehog Molecular Cancer Research, 4(10):759-68 ,
Research InterestsmTOR/S6K pathway in diabetes, mTOR signaling in hepatocellular carcinogenesis, Hematology Oncology
Peer Reviewed Publications Donati, Giulio; Peddigari, Suresh; Mercer, Carol A; Thomas, George 2013. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint. Cell reports, 4 1, 87-98Teng, Teng; Thomas, George; Mercer, Carol A 2013. Growth control and ribosomopathies. Current opinion in genetics & development, 23 1, 63-71Thomas, Hala Elnakat; Mercer, Carol A; Carnevalli, Larissa S; Park, Jongsun; Andersen, Jesper B; Conner, Elizabeth A; Tanaka, Kazuhiro; Matsutani, Tomoo; Iwanami, Akio; Aronow, Bruce J; Manway, Liu; Maira, S Michel; Thorgeirsson, Snorri S; Mischel, Paul S; Thomas, George; Kozma, Sara C 2012. mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma. Science translational medicine, 4 139, 139ra84Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97McFarland-Mancini, Molly M; Funk, Holly M; Paluch, Andrew M; Zhou, Mingfu; Giridhar, Premkumar Vummidi; Mercer, Carol A; Kozma, Sara C; Drew, Angela F 2010. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. Journal of immunology (Baltimore, Md. : 1950), 184 12, 7219-28Dennis, Patrick B; Mercer, Carol A 2009. The GST-BHMT assay and related assays for autophagy. Methods in enzymology, 452 , 97-118Mercer, Carol A; Kaliappan, Alagammai; Dennis, Patrick B 2009. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy, 5 5, 649-62Mercer, Carol A; Kaliappan, Alagammai; Dennis, Patrick B 2008. Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization. Autophagy, 4 2, 185-94Robinson-Smith, Toni M; Isaacsohn, Idit; Mercer, Carol A; Zhou, Mingfu; Van Rooijen, Nico; Husseinzadeh, Nader; McFarland-Mancini, Molly M; Drew, Angela F 2007. Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice. Cancer research, 67 12, 5708-16Caserta TM, Kommagani R, Yuan Z, Robbins DJ, Mercer CA, Kadakia MP 2006. p63 overexpression induces the expression of Sonic Hedgehog Molecular Cancer Research, 4(10):759-68 ,
Donati, Giulio; Peddigari, Suresh; Mercer, Carol A; Thomas, George 2013. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint. Cell reports, 4 1, 87-98Teng, Teng; Thomas, George; Mercer, Carol A 2013. Growth control and ribosomopathies. Current opinion in genetics & development, 23 1, 63-71Thomas, Hala Elnakat; Mercer, Carol A; Carnevalli, Larissa S; Park, Jongsun; Andersen, Jesper B; Conner, Elizabeth A; Tanaka, Kazuhiro; Matsutani, Tomoo; Iwanami, Akio; Aronow, Bruce J; Manway, Liu; Maira, S Michel; Thorgeirsson, Snorri S; Mischel, Paul S; Thomas, George; Kozma, Sara C 2012. mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma. Science translational medicine, 4 139, 139ra84Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97McFarland-Mancini, Molly M; Funk, Holly M; Paluch, Andrew M; Zhou, Mingfu; Giridhar, Premkumar Vummidi; Mercer, Carol A; Kozma, Sara C; Drew, Angela F 2010. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. Journal of immunology (Baltimore, Md. : 1950), 184 12, 7219-28Dennis, Patrick B; Mercer, Carol A 2009. The GST-BHMT assay and related assays for autophagy. Methods in enzymology, 452 , 97-118Mercer, Carol A; Kaliappan, Alagammai; Dennis, Patrick B 2009. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy, 5 5, 649-62Mercer, Carol A; Kaliappan, Alagammai; Dennis, Patrick B 2008. Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization. Autophagy, 4 2, 185-94Robinson-Smith, Toni M; Isaacsohn, Idit; Mercer, Carol A; Zhou, Mingfu; Van Rooijen, Nico; Husseinzadeh, Nader; McFarland-Mancini, Molly M; Drew, Angela F 2007. Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice. Cancer research, 67 12, 5708-16Caserta TM, Kommagani R, Yuan Z, Robbins DJ, Mercer CA, Kadakia MP 2006. p63 overexpression induces the expression of Sonic Hedgehog Molecular Cancer Research, 4(10):759-68 ,