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Department of Internal Medicine

Hematology & Oncology

Photo of  El Mustapha Bahassi, PhD

El Mustapha Bahassi, PhD

Assistant Professor of Medicine

  • Doctoral Degree: University of Brussels
  • Master's Degree: University of Brussels
  • Fellowship: University of Texas Southwestern Medical Center Department of Molecular Oncology

Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0508
  • Cincinnati, Ohio 45267
  • Office 513-558-6116
  • Fax 513-558-6703
  • Email

Peer Reviewed Publications

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Koncar, Robert F; Chu, Zhengtao; Romick-Rosendale, Lindsey E; Wells, Susanne I; Chan, Timothy A; Qi, Xiaoyang; Bahassi, El Mustapha 2017. PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas. Oncotarget, 8 9, 15827-15837

Koncar, Robert F; Feldman, Rebecca; Bahassi, El Mustapha; Hashemi Sadraei, Nooshin 2017. Comparative molecular profiling of HPV-induced squamous cell carcinomas. Cancer medicine, ,

Lu, Fanghui; Chen, Ying; Zhao, Chuntao; Wang, Haibo; He, Danyang; Xu, Lingli; Wang, Jincheng; He, Xuelian; Deng, Yaqi; Lu, Ellen E; Liu, Xue; Verma, Ravinder; Bu, Hong; Drissi, Rachid; Fouladi, Maryam; Stemmer-Rachamimov, Anat O; Burns, Dennis; Xin, Mei; Rubin, Joshua B; Bahassi, El Mustapha; Canoll, Peter; Holland, Eric C; Lu, Q Richard 2016. Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer cell, 29 5, 669-683

Bahassi, El Mustapha; Li, Ya-Qin; Wise-Draper, Trisha M; Deng, Li; Wang, Jiang; Darnell, Colleen N; Wilson, Keith M; Wells, Susanne I; Stambrook, Peter J; Rixe, Olivier 2013. A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer. European journal of cancer (Oxford, England : 1990), 49 10, 2345-55

Furgason JM, Li W, Milholland B, Bahassi EM 2013. Whole genome sequencing of glioblastoma DNAs: Overexpression of EGFR and downstream effectors is mediated by gene amplification, suppressor loss, and multiple mutational events. PLoS One, ,

Furgason, John M; Bahassi, El Mustapha 2013. Targeting DNA repair mechanisms in cancer. Pharmacology & therapeutics, 137 3, 298-308

Salkeni, Mohamad A; Zarzour, Ahmad; Ansay, Tracy Y; McPherson, Christopher M; Warnick, Ronald E; Rixe, Olivier; Bahassi, El Mustapha 2013. Detection of EGFRvIII mutant DNA in the peripheral blood of brain tumor patients. Journal of neuro-oncology, 115 1, 27-35

Furgason J.M. and Bahassi E.M. 2012. Targeting DNA repair mechanisms in cancer. Pharmacol Ther. , 2012 Oct 27 ,

Bahassi EM 2011. Polo-like kinases and DNA damage checkpoint: beyond the traditional mitotic functions. Exp Biol Med (Maywood), 236 , 648-57

Bahassi EM, Moying Yin, Yaqin Li, Deborah G. Conrady, Rhett A Kovall, Andrew B. Herr and Peter J. Stambrook. 2011. A point mutation in the β-TRCP-dependent degradation motif of Cdc25A leads to increased ASK-1-mediated apoptosis, impaired meiosis and early embryonic lethality in a knock-in mouse model. Cell Div., 2011 Feb 10;6(1):4,

Bahassi, El Mustapha 2011. Polo-like kinases and DNA damage checkpoint: beyond the traditional mitotic functions. Experimental biology and medicine (Maywood, N.J.), 236 6, 648-57

Bahassi, El Mustapha; Yin, Moying; Robbins, Susan B; Li, Ya-Qin; Conrady, Deborah G; Yuan, Zhenyu; Kovall, Rhett A; Herr, Andrew B; Stambrook, Peter J 2011. A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis. Cell division, 6 1, 4

Dai, Bojie; Zhao, X Frank; Mazan-Mamczarz, Krystyna; Hagner, Patrick; Corl, Sharon; Bahassi, El Mustapha; Lu, Song; Stambrook, Peter J; Shapiro, Paul; Gartenhaus, Ronald B 2011. Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma. Nature communications, 2 , 402

Myer, David L; Robbins, Susan B; Yin, Moying; Boivin, Gregory P; Liu, Yang; Greis, Kenneth D; Bahassi, El Mustapha; Stambrook, Peter J 2011. Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors. Mutation research, ,

Andrysik, Zdenek; Bernstein, William Z; Deng, Li; Myer, David L; Li, Ya-Qin; Tischfield, Jay A; Stambrook, Peter J; Bahassi, El Mustapha 2010. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Nucleic acids research, 38 9, 2931-43

Meyer, Sara E; Peace, Belinda E; Bahassi, El Mustapha; Kavanaugh, Gina M; Wagh, Purnima K; Robbins, Susan B; Yin, Moying; Wells, Susanne I; Zinser, Glendon M; Stambrook, Peter J; Waltz, Susan E 2010. Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice. Cancer letters, 296 2, 186-93

Bahassi, El Mustapha; Robbins, Susan B; Yin, Moying; Boivin, Gregory P; Kuiper, Raoul; van Steeg, Harry; Stambrook, Peter J 2009. Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias. Proceedings of the National Academy of Sciences of the United States of America, 106 40, 17111-6

LaPensee, Elizabeth W; Schwemberger, Sandy J; LaPensee, Christopher R; Bahassi, El Mustapha; Afton, Scott E; Ben-Jonathan, Nira 2009. Prolactin confers resistance against cisplatin in breast cancer cells by activating glutathione-S-transferase. Carcinogenesis, 30 8, 1298-304

Bahassi EM, Jerald L. Ovessen, Ashley C. Riesenberg, William L. Bernstein and Peter J. Stambrook 2008. The checkpoint kinases Chk1 and Chk2 regulate the interaction between hBRCA2 and Rad51 in response to DNA damage. Oncogene, 27 , 3977-85

Bahassi, E M; Ovesen, J L; Riesenberg, A L; Bernstein, W Z; Hasty, P E; Stambrook, P J 2008. The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. Oncogene, 27 28, 3977-85

Bahassi EM and Stambrook PJ. 2007. Cell Cycle Regulation, Cell Division and Cancer. Medical Cell Biology, 3rd Edition ,

Bahassi, El Mustapha; Penner, C Gail; Robbins, Susan B; Tichy, Elisia; Feliciano, Estrella; Yin, Moying; Liang, Li; Deng, Li; Tischfield, Jay A; Stambrook, Peter J 2007. The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model. Mutation research, 616 1-2, 201-9

Bahassi, El Mustapha; Myer, David L; McKenney, Richard J; Hennigan, Robert F; Stambrook, Peter J 2006. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutation research, 596 1-2, 166-76

Myer, David L; Bahassi, El Mustapha; Stambrook, Peter J 2005. The Plk3-Cdc25 circuit. Oncogene, 24 2, 299-305

Bahassi, El Mustapha; Hennigan, Robert F; Myer, David L; Stambrook, Peter J 2004. Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. Oncogene, 23 15, 2658-63

Bahassi, El Mustapha; Karyala, Saikumar; Tomlinson, Craig R; Sartor, Maureen A; Medvedovic, Mario; Hennigan, Robert F 2004. Critical regulation of genes for tumor cell migration by AP-1. Clinical & experimental metastasis, 21 4, 293-304

Bahassi, El Mustapha; Conn, Christopher W; Myer, David L; Hennigan, Robert F; McGowan, Clare H; Sanchez, Yolanda; Stambrook, Peter J 2002. Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. Oncogene, 21 43, 6633-40

Bahassi EM and Hennigan RF 2001. The functional significance of the Polo-like Kinase Family. Cancer Research Alert, 2:133-144 ,

Bahassi EM, O'Dea MH, Allali N, Messens J, Gellert M, Couturier M. 1999. Interactions of CcdB with DNA gyrase. Inactivation of gyrA, poisoning of the gyrase-DNA complex, and the antidote action of CdcA. J Biol Chem, 274: , 10936-44

Butow A.R. and Bahassi EM 1999. Orchestrating mitochondrial biogenesis. Curr Biol., 9: , 767-9

Loris R, Dao-Thi MH, Bahassi EM, Van Melderen L, Poortmans F, Liddington R, Couturier M, Wyns L. 1999. Crystal structure of CcdB, a topoisomerase poison from E. coli J Mol Biol, 285: , 1667-77

Couturier M, Bahassi EM, Van Melderen L. 1998. Bacterial death by DNA gyrase poisoning Trends Microbiol, 6: , 269-75

Dao-Thi MH, Wyns, L, Poortmans F, Bahassi EM, Couturier M, Loris R. 1998. Crystalization of ccdB Acta Crystallogr D Biol Crystallogr, 54: , 975-81

Bahassi EM, Salmon MA, Van Meldern L, Bernard P, Couturier M 1995. F plasmid CcdB killer protein: ccdB gene mutants coding for non-cytotoxic proteins which retain their regulatory functions Mol Microbiol, 15: , 1031-7

Bernard P, Gabant P, Bahassi EM, Couturier M. 1994. Positive-selection vectors using the F plasmid ccdB killer gene Gene, 148: , 71-4