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Department of Internal Medicine

Hematology & Oncology

Photo of  Xiaoyang Qi, PhD

Xiaoyang Qi, PhD

Professor of Medicine, Co-Division Chief for Basic Science Research

Education/Credentials
  • Bachelor's Degree: Nanjing University
  • Doctoral Degree: Oklahoma Sate University
  • Research Fellowship : Cincinnati Children's Hospital Medical Center

Research/Clinical Interests

My research is focused on developing a new saposin C (SapC) coupled dioleoylphosphatidylserine (DOPS) nanovesicle which has the potential to offer a targeted, potent, broad, and safe therapeutic agent for cancer patients. In preclinical studies, these stable nanovesicles (average diameter of 200 nm) have shown tumor-specific targeting activity and cancer-selective killing efficacy with significant inhibition of tumor growth in various animal tumor models. SapC-DOPS has striking absence of toxicity and adverse side effects in animals. In addition, these vesicles can deliver hydrophilic imaging probes, proteins, and RNA/DNA for cancer-selective targeting though specific binding of the surface exposed PS of tumor cell and vessels. Platform development of SapC-DOPS technology is my ongoing effort for cancer detection and therapy.

Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue, Room 1314
  • ML 0508
  • Cincinnati, Ohio 45267
  • Office 513-558-4025
  • Fax 513-558-6703
  • Email xiaoyang.qi@uc.edu

Peer Reviewed Publications

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Koncar, Robert F; Chu, Zhengtao; Romick-Rosendale, Lindsey E; Wells, Susanne I; Chan, Timothy A; Qi, Xiaoyang; Bahassi, El Mustapha 2017. PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas. Oncotarget, 8 9, 15827-15837

Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E 2017. mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment. Molecular cancer therapeutics, ,

Blanco, Víctor M; Chu, Zhengtao; LaSance, Kathleen; Gray, Brian D; Pak, Koon Yan; Rider, Therese; Greis, Kenneth D; Qi, Xiaoyang 2016. Optical and nuclear imaging of glioblastoma with phosphatidylserine-targeted nanovesicles. Oncotarget, 7 22, 32866-75

Davis, Harold W; Hussain, Nida; Qi, Xiaoyang 2016. Detection of cancer cells using SapC-DOPS nanovesicles. Molecular cancer, 15 1, 33

Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y 2016. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget, 7 18, 25264-75

Barber, Latorya A; Palascak, Mary B; Qi, Xiaoyang; Joiner, Clinton H; Franco, Robert S 2015. Activation of protein kinase C by phorbol ester increases red blood cell scramblase activity and external phosphatidylserine. European journal of haematology, 95 5, 405-10

Blanco, Víctor M; Curry, Richard; Qi, Xiaoyang 2015. SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastoma. Oncoscience, 2 2, 102-10

Blanco, Victor M; Latif, Tahir; Chu, Zhengtao; Qi, Xiaoyang 2015. Imaging and Therapy of Pancreatic Cancer with Phosphatidylserine-Targeted Nanovesicles. Translational oncology, 8 3, 196-203

Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B 2015. Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Molecular cancer therapeutics, 14 4, 857-64

Sulaiman, Mahaboob K; Chu, Zhengtao; Blanco, Victor M; Vallabhapurapu, Subrahmanya D; Franco, Robert S; Qi, Xiaoyang 2015. SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas. Molecular cancer, 14 , 78

Vallabhapurapu, Subrahmanya D; Blanco, Víctor M; Sulaiman, Mahaboob K; Vallabhapurapu, Swarajya Lakshmi; Chu, Zhengtao; Franco, Robert S; Qi, Xiaoyang 2015. Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium. Oncotarget, 6 33, 34375-88

Winter, Patrick M; Pearce, John; Chu, Zhengtao; McPherson, Christopher M; Takigiku, Ray; Lee, Jing-Huei; Qi, Xiaoyang 2015. Imaging of brain tumors with paramagnetic vesicles targeted to phosphatidylserine. Journal of magnetic resonance imaging : JMRI, 41 4, 1079-87

Zhao, Shuli; Chu, Zhengtao; Blanco, Victor M; Nie, Yunzhong; Hou, Yayi; Qi, Xiaoyang 2015. SapC-DOPS nanovesicles as targeted therapy for lung cancer. Molecular cancer therapeutics, 14 2, 491-8

Zhou, Xiaolai; Sun, Lirong; Bastos de Oliveira, Francisco; Qi, Xiaoyang; Brown, William J; Smolka, Marcus B; Sun, Ying; Hu, Fenghua 2015. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. The Journal of cell biology, 210 6, 991-1002

Blanco, Víctor M; Chu, Zhengtao; Vallabhapurapu, Subrahmanya D; Sulaiman, Mahaboob K; Kendler, Ady; Rixe, Olivier; Warnick, Ronald E; Franco, Robert S; Qi, Xiaoyang 2014. Phosphatidylserine-selective targeting and anticancer effects of SapC-DOPS nanovesicles on brain tumors. Oncotarget, 5 16, 7105-18

Chu, Zhengtao; LaSance, Kathleen; Blanco, Victor; Kwon, Chang-Hyuk; Kaur, Balveen; Frederick, Malinda; Thornton, Sherry; Lemen, Lisa; Qi, Xiaoyang 2014. In vivo optical imaging of brain tumors and arthritis using fluorescent SapC-DOPS nanovesicles. Journal of visualized experiments : JoVE, 87,

Olowokure, Olugbenga; Qi, Xiaoyang 2014. Pancreatic cancer: current standards, working towards a new therapeutic approach. Expert review of anticancer therapy, 14 5, 495-7

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y 2014. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. International journal of cancer, 134 1, 9-20

Wojton, Jeffrey; Meisen, Walter Hans; Jacob, Naduparambil K; Thorne, Amy Haseley; Hardcastle, Jayson; Denton, Nicholas; Chu, Zhengtao; Dmitrieva, Nina; Marsh, Rachel; Van Meir, Erwin G; Kwon, Chang-Hyuk; Chakravarti, Arnab; Qi, Xiaoyang; Kaur, Balveen 2014. SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma. Oncotarget, 5 20, 9703-9

A. Liu and X. Qi 2012. Molecular dynamics simulations of DOPC lipid bilayers: effect of Lennard-Jones parameters of the hydrocarbon chains Comput. Mol. Biosci, 2 , 78-82

Abu-Baker, Shadi; Chu, Zhengtao; Stevens, Ashley M; Li, Jie; Qi, Xiaoyang 2012. Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles. Journal of cancer therapy, 3 4, 321-326

Liu, Anping; Qi, Xiaoyang 2012. Molecular Dynamics Simulations of DOPC Lipid Bilayers: The Effect of Lennard-Jones Parameters of Hydrocarbon Chains. Computational molecular bioscience, 2 3, 78-82

Qi, Xiaoyang; Flick, Matthew J; Frederick, Malinda; Chu, Zhengtao; Mason, Rachel; DeLay, Monica; Thornton, Sherry 2012. Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity. PloS one, 7 3, e33966

S. Abu-Baker, Z. Chu, A.M. Stevens, J. Li, and X. Qi 2012. Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles J. Cancer Ther, 3 , 321-326

X. Qi, M.J. Flick, M. Frederick, Z. Chu, R. Mason, M. Delay, and S. Thornton, 2012. Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity PLoS One, 7 , e33966

Lu, Kaihua; Zhao, Guangfeng; Lu, Hongna; Zhao, Shuli; Song, Yuxian; Qi, Xiaoyang; Hou, Yayi 2011. Toll-like receptor 4 can recognize SapC-DOPS to stimulate macrophages to express several cytokines. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 60 2, 153-61

Kaimal, Vinod; Chu, Zhengtao; Mahller, Yonatan Y; Papahadjopoulos-Sternberg, Brigitte; Cripe, Timothy P; Holland, Scott K; Qi, Xiaoyang 2010. Saposin C Coupled Lipid Nanovesicles Enable Cancer-Selective Optical and Magnetic Resonance Imaging. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, ,

Qi, Xiaoyang; Chu, Zhengtao; Mahller, Yonatan Y; Stringer, Keith F; Witte, David P; Cripe, Timothy P 2009. Cancer-selective targeting and cytotoxicity by liposomal-coupled lysosomal saposin C protein. Clinical cancer research : an official journal of the American Association for Cancer Research, 15 18, 5840-51

Nieh, Mu-Ping; Katsaras, John; Qi, Xiaoyang 2008. Controlled release mechanisms of spontaneously forming unilamellar vesicles. Biochimica et biophysica acta, 1778 6, 1467-71

Abu-Baker, Shadi; Qi, Xiaoyang; Lorigan, Gary A 2007. Investigating the interaction of saposin C with POPS and POPC phospholipids: a solid-state NMR spectroscopic study. Biophysical journal, 93 10, 3480-90

Yuan, Weiming; Qi, Xiaoyang; Tsang, Pansy; Kang, Suk-Jo; Illarionov, Petr A; Illaniorov, Petr A; Besra, Gurdyal S; Gumperz, Jenny; Cresswell, Peter 2007. Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules. Proceedings of the National Academy of Sciences of the United States of America, 104 13, 5551-6

Nieh, Mu-Ping; Pencer, Jeremy; Katsaras, John; Qi, Xiaoyang 2006. Spontaneously forming ellipsoidal phospholipid unilamellar vesicles and their interactions with helical domains of saposin C. Langmuir : the ACS journal of surfaces and colloids, 22 26, 11028-33

Abu-Baker, Shadi; Qi, Xiaoyang; Newstadt, Justin; Lorigan, Gary A 2005. Structural changes in a binary mixed phospholipid bilayer of DOPG and DOPS upon saposin C interaction at acidic pH utilizing 31P and 2H solid-state NMR spectroscopy. Biochimica et biophysica acta, 1717 1, 58-66

Chu, Zhengtao; Sun, Ying; Kuan, Chia Yi; Grabowski, Gregory A; Qi, Xiaoyang 2005. Saposin C: neuronal effect and CNS delivery by liposomes. Annals of the New York Academy of Sciences, 1053 , 237-46

Chu, Zhengtao; Witte, David P; Qi, Xiaoyang 2005. Saposin C-LBPA interaction in late-endosomes/lysosomes. Experimental cell research, 303 2, 300-7

Liu, Anping; Wenzel, Nathan; Qi, Xiaoyang 2005. Role of lysine residues in membrane anchoring of saposin C. Archives of biochemistry and biophysics, 443 1-2, 101-12

Ryan, Marnie A; Qi, Xiaoyang; Serrano, Alicia G; Ikegami, Machiko; Perez-Gil, Jesus; Johansson, Jan; Weaver, Timothy E 2005. Mapping and analysis of the lytic and fusogenic domains of surfactant protein B. Biochemistry, 44 3, 861-72

Qi, Xiaoyang; Chu, Zhengtao 2004. Fusogenic domain and lysines in saposin C. Archives of biochemistry and biophysics, 424 2, 210-8

You, Hong Xing; Qi, Xiaoyang; Yu, Lei 2004. Direct AFM observation of saposin C-induced membrane domains in lipid bilayers: from simple to complex lipid mixtures. Chemistry and physics of lipids, 132 1, 15-22

Zhou, Dapeng; Cantu, Carlos; Sagiv, Yuval; Schrantz, Nicolas; Kulkarni, Ashok B; Qi, Xiaoyang; Mahuran, Don J; Morales, Carlos R; Grabowski, Gregory A; Benlagha, Kamel; Savage, Paul; Bendelac, Albert; Teyton, Luc 2004. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science (New York, N.Y.), 303 5657, 523-7

Sun, Ying; Qi, Xiaoyang; Grabowski, Gregory A 2003. Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation. The Journal of biological chemistry, 278 34, 31918-23

Wang, Ying; Grabowski, Gregory A; Qi, Xiaoyang 2003. Phospholipid vesicle fusion induced by saposin C. Archives of biochemistry and biophysics, 415 1, 43-53

You, Hong Xing; Qi, Xiaoyang; Grabowski, Gregory A; Yu, Lei 2003. Phospholipid membrane interactions of saposin C: in situ atomic force microscopic study. Biophysical journal, 84 3, 2043-57

Qi, Xiaoyang; Kondoh, Keiji; Yin, Hulian; Wang, Mei; Ponce, Elvira; Sun, Ying; Grabowski, Gregory A 2002. Ex vivo localization of the mouse saposin C activation region for acid beta-glucosidase. Molecular genetics and metabolism, 76 3, 189-200

Sun, Ying; Qi, Xiaoyang; Witte, David P; Ponce, Elvira; Kondoh, Keiji; Quinn, Brian; Grabowski, Gregory A 2002. Prosaposin: threshold rescue and analysis of the "neuritogenic" region in transgenic mice. Molecular genetics and metabolism, 76 4, 271-86

Aichinger M.; Besra G.; Cerundolo V.; Cox L.; Cresswell P.; Cypen J.; Dushek O.; Ghadbane H.; Gileadi U.; Napolitani G.; Qi X.; Salio M.; Shepherd D.; Van Der Merwe P.; Veerapen N.; Wojno J.; Yuan W. 12-03-2013. Saposins modulate human invariant natural killer t cells self-Reactivity and facilitate lipid exchan Proceedings of the National Academy of Sciences of the United States of America, 110 49,

Besra G.; Cresswell P.; Gumperz J.; Illaniorov P.; Kang S.; Qi X.; Tsang P.; Yuan W. 05-22-2007. Erratum: Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules (P Proceedings of the National Academy of Sciences of the United States of America, 104 21, 9099

Blanco V.; Chu Z.; Frederick M.; Kaur B.; Kwon C.; LaSance K.; Lemen L.; Qi X.; Thornton S. 05-02-2014. In vivo optical imaging of brain tumors and arthritis using fluorescent SapC-DOPS nanovesicles Journal of Visualized Experiments, 87,

Bindloss C.; Chang M.; Grabowski G.; Hopwood J.; Meikle P.; Qi X.; Winchester B. 03-01-2000. Saposins A, B, C, and D in plasma of patients with lysosomal storage disorders Clinical Chemistry, 46 2, 167-174

Aronow B.; Bogdanov V.; Boody R.; Davis H.; Elnakat Thomas H.; Green L.; Hisada Y.; Karve A.; Lewis C.; Lucas F.; Mackman N.; Matiash K.; Mercer C.; Orr-Asman M.; Qi X.; Versteeg H. 01-01-2019. mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumo Journal of Thrombosis and Haemostasis, 17 1, 169-182

Barrett W.; Chu Z.; Davis H.; Franco R.; Kassing W.; Mierzwa M.; Qi X.; Vallabhapurapu S. 01-01-2019. Enhanced phosphatidylserine-selective cancer therapy with irradiation and SapC-DOPS nanovesicles Oncotarget, 10 8, 856-868

Chang L.; Chen C.; Cheng W.; Hsieh-Wilson L.; Hung Y.; Jan C.; Lin P.; Liu L.; Liu S.; Qi X.; Wang S.; Wang Y.; Zhang X. 01-01-2019. Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransfer International Journal of Cancer, ,

Bahassi E.; Chan T.; Chu Z.; Koncar R.; Qi X.; Romick-Rosendale L.; Wells S. 01-01-2017. PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas Oncotarget, 8 9, 15827-15837

Blanco V.; Chu Z.; Latif T.; Qi X. 01-01-2015. Imaging and therapy of pancreatic cancer with phosphatidylserine-targeted nanovesicles Translational Oncology, 8 3, 196-203

Blanco V.; Curry R.; Qi X. 01-01-2015. SapC-DOPS nanovesicles: A novel targeted agent for the imaging and treatment of glioblastoma Oncoscience, 2 2, 102-110

Bourdeau T.; Chow L.; Chu Z.; Denton N.; Franco R.; Kaur B.; Kwon C.; Mathsyaraja H.; Meisen W.; Ostrowski M.; Palascak M.; Qi X.; Thornton S.; Wojton J. 01-01-2013. Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma Molecular Therapy, 21 8, 1517-1525

Cheng, Yizong; Liu, Anping; Guo, Yuping; Qi, Xiaoyang . Computational models for the helix tilt angle. Journal of chemical information and computer sciences, 44 6, 1952-60

Woehrer, Adelheid; Lau, Ching C; Prayer, Daniela; Bauchet, Luc; Rosenfeld, Myrna; Capper, David; Fisher, Paul G; Kool, Marcel; Müller, Martin; Kros, Johan M; Kruchko, Carol; Wiemels, Joseph; Wrensch, Margaret; Danysh, Heather E; Zouaoui, Sonia; Heck, Julia E; Johnson, Kimberly J; Qi, Xiaoyang; O'Neill, Brian P; Afzal, Samina; Scheurer, Michael E; Bainbridge, Matthew N; Nousome, Darryl; Bahassi, El Mustapha; Hainfellner, Johannes A; Barnholtz-Sloan, Jill S . Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014. Clinical neuropathology, 34 1, 40-6