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Department of Internal Medicine

Digestive Diseases

Photo of  Mohamed Tarek Shata, MD, PhD

Mohamed Tarek Shata, MD, PhD

Associate Professor of Medicine

Education/Credentials
  • Bachelor's Degree: Cairo University, Faculty of Medicine
  • Master's Degree: Assiut University, Faculty of Medicine
  • Doctoral Degree: University of Maryland, School of Medicine
  • Post-doctoral fellowship: University of California

Contact Information
  • Internal Medicine
  • Medical Sciences Building Room 6360
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0595
  • Office 513-558-6110
  • Fax 513-558-1744
  • Email mohamed.shata@uc.edu

Peer Reviewed Publications

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Shata, Mohamed Tarek M; Abdel-Hameed, Enass A; Rouster, Susan D; Yu, Li; Liang, Meina; Song, Esther; Esser, Mark T; Shire, Norah; Sherman, Kenneth E 2019. HBV and HIV/HBV Infected Patients Have Distinct Immune Exhaustion and Apoptotic Serum Biomarker Profiles. Pathogens & immunity, 4 1, 39-65

Sherman, Kenneth E; Abdel-Hameed, Enass; Rouster, Susan D; Shata, Mohamed Tarek M; Blackard, Jason T; Safaie, Parham; Kroner, Barbara; Preiss, Liliana; Horn, Paul S; Kottilil, Shyam 2018. Improvement in Hepatic Fibrosis Biomarkers Associated with Chemokine Receptor Inactivation through Mutation or Therapeutic Blockade. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ,

Sherman, Kenneth E; Rouster, Susan D; Kong, Ling X; Shata, Tarek M; Archampong, Timothy; Kwara, Awewura; Aliota, Matthew T; Blackard, Jason T 2018. Zika Virus Exposure in an HIV-Infected Cohort in Ghana. Journal of acquired immune deficiency syndromes (1999), 78 5, e35-e38

Nady, S; Shata, M T M; Mohey, M A; El-Shorbagy, A 2017. Protective role of IL-22 against Schistosoma mansoni soluble egg antigen-induced granuloma in Vitro. Parasite immunology, 39 1,

Abdel-Hameed, Enass A; Ji, Hong; Shata, Mohamed Tarek 2016. HIV-Induced Epigenetic Alterations in Host Cells. Advances in experimental medicine and biology, 879 , 27-38

Abdel-Hameed, Enass A; Rouster, Susan D; Ji, Hong; Ulm, Ashley; Hetta, Helal F; Anwar, Nadeem; Sherman, Kenneth E; Shata, Mohamed Tarek M 2016. Evaluating the Role of Cellular Immune Responses in the Emergence of HCV NS3 Resistance Mutations During Protease Inhibitor Therapy. Viral immunology, 29 4, 252-8

Hetta, Helal F; Mekky, Mohamed A; Khalil, Nasr K; Mohamed, Wegdan A; El-Feky, Mohamed A; Ahmed, Shabaan H; Daef, Enas A; Medhat, Ahmed; Nassar, Mahmoud I; Sherman, Kenneth E; Shata, Mohamed Tarek M 2016. Extra-hepatic infection of hepatitis C virus in the colon tissue and its relationship with hepatitis C virus pathogenesis. Journal of medical microbiology, 65 8, 703-12

Mehta, Minesh; Hetta, Helal F; Abdel-Hameed, Enass A; Rouster, Susan D; Hossain, MdMonir; Mekky, Mohamed A; Khalil, Nasr K; Mohamed, Wegdan A; El-Feky, Mohamed A; Ahmed, Shabaan H; Daef, Enas A; El-Mokhtar, Mohamed A; Abdelwahab, Sayed F; Medhat, Ahmed; Sherman, Kenneth E; Shata, Mohamed Tarek M 2016. Association between IL28B rs12979860 single nucleotide polymorphism and the frequency of colonic Treg in chronically HCV-infected patients. Archives of virology, 161 11, 3161-9

Nady, Soad; Ezz, Asmaa; El-Shorbagy, Ayatollah; Esmat, Gamal; Mt, Shata 2016. HCV Infection Amplified Th2 Bias and Th17 Responses In Schistosoma-Infected Patients. The Egyptian journal of immunology, 23 1, 87-96

Hetta, Helal F; Mekky, Mohamed A; Khalil, Nasr K; Mohamed, Wegdan A; El-Feky, Mohamed A; Ahmed, Shabaan H; Daef, Enas A; Nassar, Mahmoud I; Medhat, Ahmed; Sherman, Kenneth E; Shata, Mohamed Tarek M 2015. Association of colonic regulatory T cells with hepatitis C virus pathogenesis and liver pathology. Journal of gastroenterology and hepatology, 30 10, 1543-51

Moon, Changsuk; Zhang, Weiqiang; Ren, Aixia; Arora, Kavisha; Sinha, Chandrima; Yarlagadda, Sunitha; Woodrooffe, Koryse; Schuetz, John D; Valasani, Koteswara Rao; de Jonge, Hugo R; Shanmukhappa, Shiva Kumar; Shata, Mohamed Tarek M; Buddington, Randal K; Parthasarathi, Kaushik; Naren, Anjaparavanda P 2015. Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea. The Journal of biological chemistry, 290 18, 11246-57

Blackard, Jason T; Ma, Gang; Sengupta, Satarupa; Martin, Christina M; Powell, Eleanor A; Shata, M Tarek; Sherman, Kenneth E 2014. Evidence of distinct populations of hepatitis C virus in the liver and plasma of patients co-infected with HIV and HCV. Journal of medical virology, 86 8, 1332-41

Sherman, K E; Terrault, N; Barin, B; Rouster, S D; Shata, M T 2014. Hepatitis E infection in HIV-infected liver and kidney transplant candidates. Journal of viral hepatitis, 21 8, e74-7

Sherman, Kenneth E; Guedj, Jeremie; Shata, Mohamed Tarek; Blackard, Jason T; Rouster, Susan D; Castro, Mario; Feinberg, Judith; Sterling, Richard K; Goodman, Zachary; Aronow, Bruce J; Perelson, Alan S 2014. Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients. Science translational medicine, 6 246, 246ra98

Abdel-Hameed, Enass A; Ji, Hong; Sherman, Kenneth E; Shata, Mohamed Tarek M 2013. Epigenetic modification of FOXP3 in patients with chronic HIV infection. Journal of acquired immune deficiency syndromes (1999), ,

El-Kamary, Samer S; Hashem, Mohamed; Saleh, Doaa A; Abdelwahab, Sayed F; Sobhy, Maha; Shebl, Fatma M; Shardell, Michelle D; Strickland, G Thomas; Shata, Mohamed Tarek 2013. Hepatitis C virus-specific cell-mediated immune responses in children born to mothers infected with hepatitis C virus. The Journal of pediatrics, 162 1, 148-54

Raza, Ali; Shata, Mohamed T 2013. New perspectives of an old cytokine. Inflammatory bowel diseases, 19 3, E39-40

Shata, Mohamed Tarek M; Abdel-Hameed, Enass A; Hetta, Helal F; Sherman, Kenneth E 2013. Immune activation in HIV/HCV-infected patients is associated with low-level expression of liver expressed antimicrobial peptide-2 (LEAP-2). Journal of clinical pathology, 66 11, 967-75

Kong, Ling; Cardona Maya, Walter; Moreno-Fernandez, Maria E; Ma, Gang; Shata, Mohamed T; Sherman, Kenneth E; Chougnet, Claire; Blackard, Jason T 2012. Low-level HIV infection of hepatocytes. Virology journal, 9 , 157

Martin, C M; Welge, J A; Rouster, S D; Shata, M T; Sherman, K E; Blackard, J T 2012. Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro. Journal of viral hepatitis, 19 10, 716-23

Raza, A; Shata, M T 2012. Letter: pathogenicity of Th17 cells may differ in ulcerative colitis compared with Crohn's disease. Alimentary pharmacology & therapeutics, 36 2, 204; author reply 20

Raza, Ali; Yousaf, Wajeeha; Giannella, Ralph; Shata, Mohamed Tarek 2012. Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease. Expert review of clinical immunology, 8 2, 161-8

Shata, Mohamed T; Daef, Enas A; Zaki, Maysaa E; Abdelwahab, Sayed F; Marzuuk, Naglaa M; Sobhy, Maha; Rafaat, Marwa; Abdelbaki, Liala; Nafeh, Mohamed A; Hashem, Mohamed; El-Kamary, Samer S; Shardell, Michelle D; Mikhail, Nabiel N; Strickland, George T; Sherman, Kenneth E 2012. Protective role of humoral immune responses during an outbreak of hepatitis E in Egypt. Transactions of the Royal Society of Tropical Medicine and Hygiene, 106 10, 613-8

Blackard, Jason T; Ma, Gang; Martin, Christina M; Rouster, Susan D; Shata, M Tarek; Sherman, Kenneth E 2011. HIV Variability in the Liver and Evidence of Possible Compartmentalization. AIDS research and human retroviruses, ,

Hashem, Mohamed; El-Karaksy, Hanaa; Shata, Mohamed T; Sobhy, Maha; Helmy, Heba; El-Naghi, Suzan; Galal, Gehan; Ali, Zainab Z; Esmat, Gamal; Abdelwahab, Sayed F; Strickland, G Thomas; El-Kamary, Samer S 2011. Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children. The Journal of infectious diseases, 203 6, 854-61

Ibrahim, E H; Abdelwahab, S F; Nady, S; Hashem, M; Galal, G; Sobhy, M; Saleh, A S; Shata, M T 2011. Prevalence of anti-HEV IgM among blood donors in Egypt. The Egyptian journal of immunology / Egyptian Association of Immunologists, 18 2, 47-58

Eldin, Salwa S Seif; Seddik, Ismail; Daef, Enas A; Shata, M T; Raafat, Marwa; Abdel Baky, Laila; Nafeh, M A 2010. Risk factors and immune response to hepatitis E viral infection among acute hepatitis patients in Assiut, Egypt. The Egyptian journal of immunology / Egyptian Association of Immunologists, 17 1, 73-86

Martin, C M; Welge, J A; Shire, N J; Rouster, S D; Shata, M T; Sherman, K E; Blackard, J T 2010. Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals. Journal of viral hepatitis, 17 8, 588-97

Subbramanian, Ramu A; Basha, Saleem; Brady, Rebecca C; Hazenfeld, Staci; Shata, Mohamed T; Bernstein, David I 2010. Age-related changes in magnitude and diversity of cross-reactive CD4(+) T-cell responses to the novel pandemic H1N1 influenza hemagglutinin. Human immunology, ,

Subbramanian, Ramu A; Basha, Saleem; Shata, Mohamed T; Brady, Rebecca C; Bernstein, David I 2010. Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine, 28 52, 8258-67

Atiq, Muslim; Shire, Norah J; Barrett, Anna; Rouster, Susan D; Sherman, Kenneth E; Shata, Mohamed T 2009. Hepatitis E virus antibodies in patients with chronic liver disease. Emerging infectious diseases, 15 3, 479-81

Blackard, Jason T; Rouster, Susan D; Nady, Soad; Galal, Gehan; Marzuuk, Naglaa; Rafaat, Marwaa M; Daef, Enas; El Din, Salwa Seif; Purcell, Robert H; Emerson, Suzanne U; Sherman, Kenneth E; Shata, M Tarek 2009. Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 46 2, 140-4

Martin, Christina M; Welge, Jeffrey A; Shire, Norah J; Shata, Mohamed T; Sherman, Kenneth E; Blackard, Jason T 2009. Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals. Cytokine, 47 3, 194-8

Nady, Soad; Ignatz-Hoover, James; Shata, Mohamed T 2009. Interleukin-12 is the optimum cytokine to expand human Th17 cells in vitro. Clinical and vaccine immunology : CVI, 16 6, 798-805

Blackard, Jason T; Shata, M Tarek; Shire, Norah J; Sherman, Kenneth E 2008. Acute hepatitis C virus infection: a chronic problem. Hepatology (Baltimore, Md.), 47 1, 321-31

Navaneethan, Udayakumar; Al Mohajer, Mayar; Shata, Mohamed T 2008. Hepatitis E and pregnancy: understanding the pathogenesis. Liver international : official journal of the International Association for the Study of the Liver, 28 9, 1190-9

Shata, Mohamed T; Navaneethan, Udayakumar 2008. The mystery of hepatitis E seroprevalence in developed countries: is there subclinical infection due to hepatitis E virus? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 47 8, 1032-4

Velilla, P A; Shata, M T; Lages, C S; Ying, J; Fichtenbaum, C J; Chougnet, C 2008. Effect of low-dose IL-2 immunotherapy on frequency and phenotype of regulatory T cells and NK cells in HIV/HCV-coinfected patients. AIDS research and human retroviruses, 24 1, 52-61

Youn, Jin-Won; Hu, Yu-Wen; Tricoche, Nancy; Pfahler, Wolfram; Shata, Mohamed Tarek; Dreux, Marlene; Cosset, François-Loic; Folgori, Antonella; Lee, Dong-Hun; Brotman, Betsy; Prince, Alfred M 2008. Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus. Journal of virology, 82 21, 10896-905

Shata, M T; Barrett, A; Shire, N J; Abdelwahab, S F; Sobhy, M; Daef, E; El-Kamary, S S; Hashem, M; Engle, R E; Purcell, R H; Emerson, S U; Strickland, G T; Sherman, K E 2007. Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay. Journal of immunological methods, 328 1-2, 152-61

Shata, Mohamed Tarek M; Pfahler, Wolfram; Brotman, Betsy; Lee, Dong-Hun; Tricoche, Nancy; Murthy, Krishna; Prince, Alfred M 2006. Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load. Journal of medical primatology, 35 3, 165-71

Yao, Zhi Qiang; Shata, Mohamed Tarek; Tricoche, Nancy; Shan, Mei Mei; Brotman, Betsy; Pfahler, Wolfram; Hahn, Young S; Prince, Alfred M 2006. gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection. Virology, 346 2, 324-37

Al-Sherbiny, Maged; Osman, Ahmed; Mohamed, Nahla; Shata, Mohamed Tarek; Abdel-Aziz, Fatma; Abdel-Hamid, Mohamed; Abdelwahab, Sayed F; Mikhail, Nabiel; Stoszek, Sonia; Ruggeri, Lionello; Folgori, Antonella; Nicosia, Alfredo; Prince, Alfred M; Strickland, G Thomas 2005. Exposure to hepatitis C virus induces cellular immune responses without detectable viremia or seroconversion. The American journal of tropical medicine and hygiene, 73 1, 44-9

Farid, A; Al-Sherbiny, M; Osman, A; Mohamed, N; Saad, A; Shata, M T; Lee, D-H; Prince, A M; Strickland, G T 2005. Schistosoma infection inhibits cellular immune responses to core HCV peptides. Parasite immunology, 27 5, 189-96

Prince, Alfred M; Brotman, Betsy; Lee, Dong-Hun; Pfahler, Wolfram; Tricoche, Nancy; Andrus, Linda; Shata, Mohamed T 2005. Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model. The Journal of infectious diseases, 192 10, 1701-9

Youn, Jin-Won; Park, Su-Hyung; Lavillette, Dimitri; Cosset, Francois-Loic; Yang, Se-Hwan; Lee, Chang Geun; Jin, Hyun-Tak; Kim, Chang-Min; Shata, Mohamed Tarek M; Lee, Dong-Hun; Pfahler, Wolfram; Prince, Alfred M; Sung, Young Chul 2005. Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee. Hepatology (Baltimore, Md.), 42 6, 1429-36

Prince, A M; Pawlotsky, J-M; Soulier, A; Tobler, L; Brotman, B; Pfahler, W; Lee, D-H; Li, Liping; Shata, M T 2004. Hepatitis C virus replication kinetics in chimpanzees with self-limited and chronic infections. Journal of viral hepatitis, 11 3, 236-42

Sun, Jiaren; Li, Kui; Shata, Mohamed Tarek; Chan, Teh-sheng 2004. The immunologic basis for hepatitis C infection. Current opinion in gastroenterology, 20 6, 598-602

Talal, Andrew H; Shata, M Tarek; Markatou, Marianthi; Dorante, Gary; Chadburn, Amy; Koch, Robert; Neumann, Avidan U; Ribeiro, Ruy M; Perelson, Alan S 2004. Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV. Journal of acquired immune deficiency syndromes (1999), 35 2, 103-13

Bagley, K C; Shata, M T; Onyabe, D Y; DeVico, A L; Fouts, T R; Lewis, G K; Hone, D M 2003. Immunogenicity of DNA vaccines that direct the coincident expression of the 120 kDa glycoprotein of human immunodeficiency virus and the catalytic domain of cholera toxin. Vaccine, 21 23, 3335-41

Fouts, T R; DeVico, A L; Onyabe, D Y; Shata, M T; Bagley, K C; Lewis, G K; Hone, D M 2003. Progress toward the development of a bacterial vaccine vector that induces high-titer long-lived broadly neutralizing antibodies against HIV-1. FEMS immunology and medical microbiology, 37 2-3, 129-34

Shata, Mohamed Tarek; Shan, Mei Mei; Tricoche, Nancy; Talal, Andrew; Perkus, Marion; Prince, Alfred 2003. Optimization of recombinant vaccinia-based ELISPOT assay. Journal of immunological methods, 283 1-2, 281-9

Shata, Mohamed Tarek; Tricoche, Nancy; Perkus, Marion; Tom, Darley; Brotman, Betsy; McCormack, Patricia; Pfahler, Wolfram; Lee, Dong-Hun; Tobler, Leslie H; Busch, Michael; Prince, Alfred M 2003. Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzees. Virology, 314 2, 601-16

Wang, Xinhai; Hone, David M; Haddad, Asmahan; Shata, Mohamed T; Pascual, David W 2003. M cell DNA vaccination for CTL immunity to HIV. Journal of immunology (Baltimore, Md. : 1950), 171 9, 4717-25

Agwale, S M; Shata, M T; Reitz, M S; Kalyanaraman, V S; Gallo, R C; Popovic, M; Hone, D M 2002. A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice. Proceedings of the National Academy of Sciences of the United States of America, 99 15, 10037-41

Devico, Anthony L; Fouts, Timothy R; Shata, Mohamed T; Kamin-Lewis, Roberta; Lewis, George K; Hone, David M 2002. Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1. Vaccine, 20 15, 1968-74

Shata, M T; Anthony, D D; Carlson, N L; Andrus, L; Brotman, B; Tricoche, N; McCormack, P; Prince, A 2002. Characterization of the immune response against hepatitis C infection in recovered, and chronically infected chimpanzees. Journal of viral hepatitis, 9 6, 400-10

Prince, A M; Shata, M T 2001. Immunoprophylaxis of hepatitis C virus infection. Clinics in liver disease, 5 4, 1091-103

Shata, M T; Hone, D M 2001. Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8(+) T cells and antiviral protective immunity. Journal of virology, 75 20, 9665-70

Shata, M T; Reitz, M S; DeVico, A L; Lewis, G K; Hone, D M 2001. Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector. Vaccine, 20 3-4, 623-9

Shata, M T; Stevceva, L; Agwale, S; Lewis, G K; Hone, D M 2000. Recent advances with recombinant bacterial vaccine vectors. Molecular medicine today, 6 2, 66-71

Hassan, M M; Medhat, A; Makhlouf, M M; Shata, T; Nafeh, M A; Osman, O A; Deaf, E A; Galal, N; Fouad, Y M 1998. Detection of circulating antigens in patients with active Schistosoma haematobium infection. The American journal of tropical medicine and hygiene, 59 2, 295-301

Medhat, A; Zarzour, A; Nafeh, M; Shata, T; Sweifie, Y; Attia, M; Helmy, A; Shehata, M; Zaki, S; Mikhail, N; Ibrahim, S; King, C; Strickland, G T 1997. Evaluation of an ultrasonographic score for urinary bladder morbidity in Schistosoma haematobium infection. The American journal of tropical medicine and hygiene, 57 1, 16-9

King, C L; Medhat, A; Malhotra, I; Nafeh, M; Helmy, A; Khaudary, J; Ibrahim, S; El-Sherbiny, M; Zaky, S; Stupi, R J; Brustoski, K; Shehata, M; Shata, M T 1996. Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. Journal of immunology (Baltimore, Md. : 1950), 156 12, 4715-21

King, C L; Hakimi, J; Shata, M T; Medhat, A 1995. IL-12 regulation of parasite antigen-driven IgE production in human helminth infections. Journal of immunology (Baltimore, Md. : 1950), 155 1, 454-61

Shata, M T; Faltynek, C R; Lewis, G K; Kamin-Lewis, R M 1995. Absence of high-affinity binding sites for interferon alpha/beta in variant murine CD4+ T lymphocytes not expressing the T cell antigen receptor. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 15 4, 291-6

Faltynek, C R; Princler, G L; Schwabe, M; Shata, M T; Lewis, G K; Kamin-Lewis, R M 1990. Characterization of the binding of radioiodinated hybrid recombinant IFN-alpha A/D to murine and human lymphoid cell lines. Journal of interferon research, 10 1, 55-64