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Department of Internal Medicine

Digestive Diseases

Photo of  Ralph Giannella, MD

Ralph Giannella, MD

Professor of Digestive Diseases

Education/Credentials
  • Bachelor's Degree: Cornell University
  • Medical Degree: The Albany Medical College
  • Medical Internship : Boston City Hospital
  • Assistant Resident: Boston City Hospital
  • Senior Resident: Boston VA Hospital
  • Chief Resident: The Mallory Gastrointestinal Service, Boston City Hospital
  • American Cancer Society Summer Fellowship: The Albany Medical College
  • Teaching Fellow: Tufts University School of Medicine
  • NIH Research Fellowship: Mallory Gastrointestinal Laboratory Thorndike Memorial Laboratory, Boston City Hospital

Board Certifications & Licenses
  • National Board of Medical Examiners, 1965
  • American Board of Internal Medicine, 1971, Diplomate
  • American Board of Gastroenterology, 1972, Diplomate
  • License District of Columbia (inactive)
  • License Massachusetts (inactive)
  • License Kentucky (inactive)
  • Ohio
Contact Information
  • Medical Sciences Building 7th Floor
  • 231 Albert Sabin Way
  • PO Box 670595, ML 0595
  • Cincinnati, Ohio 670595
  • Office 513-558-5244
  • Fax 513-558-1744
  • Email giannera@ucmail.uc.edu

Peer Reviewed Publications

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Roberts M and Giannella RA: 2008. AGA PAC: an essential tool to advance Gastroenterology. Gastroenterology , 134: , 908-912

Sellers ZM, Mann E, Smith A, Dong KH, Giannella R, Cohen MB, Barrett KE, Dong H. 2008. Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3 secretion via a novel GC-C and CFTR-independent pathway. FASEB, 22 , 1-11

Albano F, De Marco G, Berni Canani R, Cirillo P, Buccigrossi V, Giannella RA, Guarion A. 2005. Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with the basolateral compartment of rat and human colonic cells. Ped Research , 58 , 159-163

Mann EA, Steinbrecher KA, Stroup C, Witte DP, Cohen MB, Giannella RA: 2005. Lack of guanylyl cyclase C, the receptor for E. coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model. Int J Cancer, 116: , 500-505

Carrithers SL, Ott CE, Hill MJ, Johnson BR, Cai W, Chang JJ, Shah RG, Sun C, Mann EA, Fonteles MC, Forte LR, Jackson BA, Giannella RA, Greenberg RN: 2004. Guanylin and uroguanylin induce natriuresis in mice ladcking guanylyl cyclase-C receptor. Kidney International, 65: , 40-53

Morelli MS, Rouster SD, Giannella RA, Sherman KE: 2004. Clinical application of polymerase chain reaction to diagnose Clostridium difficile in hospitalized patients with diarrhea. Clin Gastroenterol Hepatol, 2: , 669-674

Rao SP, Sellers Z, Crombie DL, Hogan DL, Mann EA, Childs D, Keely S, Sheil-Puopolo M, Giannella RA, Barrett KE, Isenberg JI, Pratha VS: 2004. A role for Guanylate cyclase C (GC-C) in acid-stimulated duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol, 286: , 95-101

Cohen MB, Giannella RA, Bean J, Taylor D, Parker S, Hoeper A, Wowk S, Hawkins J, Schiff G, Killeen KP: 2002. Randomized, controlled human challenge study of the safety, immunogenicity and protective efficacy of a single dose of Peru-15, live oral cholera vaccine. Infec Immun, 70: , 1965-1970

Albano F, Brasitus T, Mann EA, Guarion A, Giannella RA: 2001. Colonocyte basolateral membranes contain E. coli heat-stable enterotoxin receptors. Biochem Biophys Res Comm., 284: , 331-334

Charney AN, Egnor RW, Alexander-Chacko JT, Zaharia V, Mann EA, Giannella RA: 2001. Effect of E. coli heat-atable enterotoxin on colonic electrolyte transport in guanylyl cyclase-C receptor-deficient mice. Amer J Physiol , 380: , G216-G221

Roy N, Guruprasas MR, Kondaiah P, Mann EA, Giannella RA, Visweshariah SS: 2001. Protein kinase C regulates transcription of the human guanylyl cyclase C gene. Eur J Biochem, 268: , 1-13

Shah RJ, Fenoglio-Preiser C, Bleau BL, Giannella RA: 2001. Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea. Amer J Gastro, 96 , 1091-1095

Steinbrecher KA, Mann EA, Giannella RA, Cohen MB 2001. Increases in guanylin and uroguanylin levels in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. Gastroenterology, 121: , 1191

McRorie J, Zorich N, Riccardi K, Bishop L, Filloon T, Wason S, and Giannella RA: 2000. Effects of olestra and sorbitol consumption on objective measures of diarrhea: impact of stool viscosity on common gastrointestinal symptoms. Reg Toxicol Pharmacol, 31: , 59-67

Aranda-Michel J, Giannella RA: 1999. Acute diarrhea: A practical review. Amer J Med, 106: , 670-676

Carrithers SL, Hill MJ, Johnson BR, O'Hara SM, Jackson BA, Ott CE, Lorenz J, Mann EA, Giannella RA, Forte Lr, Greenberg RN: 1999. Renal effects of uroguanylin and guanylin in vivo. Braz J Med Biol Res, 32: , 1337-1344

Charney AN, Giannella RA, Egnor RW: 1999. Effect of short-chain fatty acids on cGMP-medicated colonic secretion. Comparative Biochemistry Physiology, 124: , 169-178

Cohen MB, Giannella RA, Losonsky GA, Lang DR, Parker S, Hawkins JA, Gunther C, Schiff GA: 1999. Validation and characterization of a human volunteer challenge model for cholera using frozen bacteria of the new epidemic serotype, V. cholerae 0139. Infec Immun, 67: , 6346-6349

Fischer DR, Nussbaum MS, Pritts TA, Gilinsky NH, Weesner RE, Martin SP, Giannella RA: 1999. Use of omeprazole in the management of giant duodenal ulcer: results of a prospective study. Surgery, 126: , 643-649

Flagella M, Clarke LL, Miller ML, Erway LC, Giannella RA, Andringa A, Gawenis LR, Dramer J, Duffy JJ, Doetschman T, Lorenz JN, Yamoah EN, Cardell EL, Shull GE: 1999. Mice lacking the basolateral Na-K-2C1 cotransporter have impaired intestinal epithelial chloride secretion and are profundly deaf. J Biol Chem, 274: , 26946-26955

Swenson ES, Mann EA, Giannella RA: 1999. Intestinal expression of guanylyl cyclase C, the guanylin/heat-stable enterotoxin receptor, is regulated by hepatocyte nuclear factor 4. Amer J Physiol., 276 , G728-736

Tacket CO, Cohen MB, Wasserman SS, Losonsky G, Livio S, Kotloff K, Edelman R, Kaper JB, Cryz SJ, Giannella RA, Schiff G, Lang DR, Levine MM: 1999. Randomized, double-blind, placebo-controlled, multi-centered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challnge with vibrio cholerae 01 E1 Tor, Inaba three months after vaccination. Infec Immun, 67: , 6341-6345

Sack DA, Tacket CO, Cohen MB, Sack RB, Losonsky GA, Shimko J, Nataro JP, Edelman R, Levine MM, Giannella RA, Schiff G, Lang D: 1998. Validation of a volunteer model of cholera using frozen bacteria as the challenge. Infec Immun, 66: , 1968-1972

Mann EA, Jump ML, Wu J, Yee E, and Giannella RA: 1997. Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion. Biochem Biophys Res Comm, 239: , 463-466

Mann EA, Jump ML, Giannella RA: 1996. Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene. Biochim Biophys Acta (Gene Stucture and Expression ). 1305:, 7-10 ,

Mann EA, Swenson ES, Copeland NG, Gilbert DJ, Jenkins NA, Taguchi T, Testa JR, Giannella RA: 1996. Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12. Genomics, 34: 265-267,

Swenson ES, Mann EA, Jump ML, Witte DP, Giannella RA: 1996. The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine. Biochem Biophys Res Comm, 225: , 1009-1014

Giannella RA: 1995. E. coli heat-stable enterotoxins, guanylins and their receptors: what are they and what are they doing? J Lab Clin Med, 125: , 173-181

Heck JE, Staneck JL, Cohen MB, Weckbach LS, Giannella RA, Hawkins J, Tosiello R: 1994. Prevention of Traveler's diarrhea: ciprofloxacin vs trimethoprim/sulfamethoxazole in adult volunteers workin in Latin America and the Caribbean. J Trav Med, 1: , 136-142

Cohen MB, Jensen NJ, Hawkins JA, Thompson MR, Lentze 1993. Receptors for Escherichia coli heat-stable enterotoxin in human intestine and in a human intestinal cell line (CACO-2). J Cell Physiol, 156: , 138-144

Giannella RA, Orlowski J, Jump M Lynn, Lingrel JB: 1993. Na,K-ATPase gene expression in rat intestine and CaCo2 cells: Response to thyroid hormone. Am J Physiol, 265: , G775-782

Giannella RA: 1993. Enteric infections: 50 years of progress. Gastroenterology, 104: , 1589-1594

Mann EA, Cohen MB, Giannella RA: 1993. Comparison of receptors for E. coli heat-stable enterotoxin: Novel receptor present in IEC-6 cells. Amer J Physiol., 264: , G172-G178

Wolf DC, Giannella RA: 1993. Antibiotic therapy for bacterial enterocolitis: A comprehensive review. Amer J Gastroent, 88: , 1667-1683

Cohen MB, Giannella RA: 1992. Jejunal Toxin Inactivation regulates susceptibility of the immature rat to STa. Gastroenterology, 102: , 1988-1996

Cohen MB, Mann EA, Lau C. Henning SJ, Giannella RA: 1992. A gradient in expression of the E. coli heat-stable enterotoxin receptor along the villus-to-crypt axis of rat small intestine. Biochem Biophys Res Comm, 186: , 483-490

Laney DW, Mann EA, Dellon SC, Perkins DR, Giannella RA, Cohen MB: 1992. Novel sites for expression of an E. coli heat-stable enterotoxin receptor in the developing rat. Amer J Physiol, 263: , G816-G821

Mezoff AG, Giannella RA, Eade MN, Cohen MB: 1992. E. coli enterotoxin binds to receptors, stimulates guanyl cyclase and impairs absorption in rat colon. Gastroenterology, 102: , 816-822

Park SI, Giannella RA: 1992. Evaluation and treatment of acute infectious diarrhea. Prac Gastroent., 16: , 27-41

Romeo DP, Weesner RE, Giannella RA: 1990. Misdiagnosis of Zollinger-Ellison syndrome due to hyperlipidemia. Gastroenterology, 99: , 1511-1513

Thompson MR, Giannella RA: 1990. Different crosslinking agents identify distinctly different putative E. coli heat-stable enterotoxin rat intestinal cell receptor proteins. J Receptor Research, 10: , 97-117

Thompson MR, Luttrell M, Giannella RA: 1990. Preparation of stable 125-I-cyclic GMP tyrosine methyl ester suitable for 3', 5'cyclic GMP radioimmunoassay by HPLC.` J Immunoassay , 11: , 97-108

Cohen MB, Thompson MR, Giannella RA: 1989. Differences in jejunal and ileal response to E. coli enterotoxin: Possible mechanisms. Amer J Physiol, 275: , G118-G123

Guarino A, Giannella RA, Thompson M: 1989. Citrobacter freundii produces and 18 amino acid heat-stable enterotoxin identical to Escherchia coli ST la. Infect Immun, 57: , 649-652

Cohen MB, Guarino A, Giannella RA: 1988. Age-related differences in receptors for E. coli heat-stable enterotoxin in the small and large intestine of children. Gastroenterology, 94: , 367-373

Huott PA, Liu W, McRoberts JA, Giannella RA, Dharmsathaphorn K: 1988. The mechanism of action of E. coli heat-stable enterotoxin in a human colonic cell line. J Clin Invest, 82: , 514-523

Saxe J, Giannella RA: 1988. Bacterial and traveler's diarrhea: Diagnosis and management. Prac Gastroent, 12: , 20-28

Weesner RE, Kolinjivadi J, Giannella RA, Huitger-O'Connor T, Genta RM: 1988. The effect of Strongyloides ratti on small bowel function in the normal and immunosuppressed host. Dig Dis Sci, 33: , 1316-1321

Cohen MB, Thompson MR, Overman GJ, Giannella RA: 1987. Association and dissociation of E. coli heat-stable enterotoxin from rat brush border membrane receptors. Infect Immun, 55: , 329-334

Guarino A, Cohen MD, Giannella RA: 1987. Small and large intestinal guanylate cyclase in children: Effect of age and stimulation by E. coli heat-stable enterotoxin. Pediatric Res, 21: , 551-555

Guarino A, Cohen MD, Overmann G, Thompson MR, Giannella RA: 1987. Binding of E. coli heat-stable enterotoxin to rat intestinal brush borders and to basolateral membranes. Dig Dis Sci, 32: , 1017-1026

Guarion A, Cohen MB, Thompson M, Dharmsathaphorn K, Giannella RA: 1987. T84-cell receptor binding and guanylate cyclase activation by E. coli heat-stable enterotoxin. Amer J Physiol, 16: , G775-G780

Peterson JH, Weesner RE, Giannella RA: 1987. E. coli peritonitis following left-sided colonoscopy in a patient on continuous ambulatory peritoneal dialysis. Am J Gastro, 82: , 171-172

Cohen MB, Moyer MS, Luttrell M, Giannella RA: 1986. The immature rat small intestine exhibits and increased sensitivity and response to E. coli heat-stable enterotoxin. Pediatric Res, 20: , 555-560

Epstein SA, Giannella RA, Brandwein HJ: 1986. Activation of guanylate cyclase by E. coli heat-stable enterotoxin (STa): Modulation by NAD and Pertussis toxin. FEBS Lett, 203: 44-48,

Giannella RA: 1986. Chronic diarrhea of the traveler: Diagnostic and therapeutic considerations. Rev Infec Dis, 8: , 5223-5226

King K, Genta RM, Giannella RA, Weesner RE: 1986. Congential hepatic fibrosis and cerebral aneurysm in a 32 year-old woman. J Ped Gastro Nutr, 5: , 481-484

Thompson MR, Jordan RL, Luttrell MA, Brandwein H, Kaper JB, Levine MM, Giannella RA: 1986. A blinded, two laboratory comparative analysis of E. coli STa production using monoclonal antibody ELISA, radioimmunoassay, suckling mouse assay, and gene probe analysis. J Clin Micro, 24: , 753-758

Brandwein H, Deutsch A, Thompson MR, Giannella RA: 1985. Production of neutralizing monoclonal antibodies to E. coli heat-stable enterotoxin. Infect Immun, 47: , 242-246

Thompson MR, Giannella RA: 1985. Revised amino acid sequence for a heat-stable enterotoxin produced by a E. coli strain (18D) pathogenic for humans. Infect Immun, 47 , 834-836

Thompson MR, Luttrell M, Overmann G, Giannella RA: 1985. Biological and immunological characteristics of 125I-E. coli heat-stable enterotoxin species purified by HPLC. Anal Biochem, 148: , 26-36

Thompson MR, Brandwein H, LaBine-Racke M, Giannella RA: 1984. A simple and reliable ELISA assay for E. coli STa using monoclonal antibodies. J Clin Micro, 20: , 59-64

Bongiovanni G, Giannella RA: 1983. Newer causes of infectious diarrheas. Diagnosis, 5: , 117-121

Giannella RA, Luttrell M, Thompson MR: 1983. Binding of E. coli heat-stable enterotoxin to receptors on rat intestinal cells. Amer J Physiol, 245: , G492-G498

Giannella RA: 1983. E. coli heat-stable enterotoxin: Biochemical and physiological effects on the intestine Prog Fd Nutr Sci, 7: , 140-145

Moon HW, Baetz AL, Giannella RA: 1983. Immunization of swine with heat-stable E. coli enterotoxin coupled to a carrier protein does not protect suckling pigs against and E. coli strain that produces heat-stable enterotoxin. Infect Immun, 39: , 990-992

Moon HW, Whipp SC, Argenzio RA, Levine MM, Giannella RA: 1983. Attaching and effacing activities of rabbit and human enteropathogenic E. coli in pig and rabbit intestines. Infect Immun, 41: , 1340-1351

Mathias JF, Nogueira J, Martin JE, Carlson GM, Giannella RA: 1982. E. coli heat-stable enterotoxin: Its effect on the motility of the small intestine. Amer J Physiol, 245: , G360-G363

Rothbaum R, McAdams AJ, Giannella R, Partin JC: 1982. A clinicopathologic study of enterocyte-adherent E. coli: A cause of protracted diarrhea in infants. Gastroenterology, 83: , 441-454

Banwell JG, Kistler LA, Giannella RA, Weber FL, Lieber A, Powell DE: 1981. Clinical conference: Small intestinal bacterial overgrowth syndrome. Gastroenterology, 80: , 834-845

Chan SK, Giannella RA: 1981. Amino acid sequence of heat-stable enterotoxin produced by E. coli pathogenic for man. J Biol Chem, 256: , 7744-7746

Giannella RA, Drake KW, Luttrell M: 1981. Development of radioimmunoassay for E. coli heat-stable enterotoxin: Comparison with the suckling mouse bioassay. Infect Immun, 33: , 186-192

Giannella RA, Serumaga J, Walls D, Drake KW: 1981. Effect of clindamycin on intestinal water and glucose transport in the rat. Gastroenterology, 80: , 907-913

Rao MC, Orellana SA, Field M, Robertson DC, Giannella RA: 1981. Comparison of the biological actions of three purified heat-stable enterotoxins: Effects of ion transport and guanylate cyclase activity in rabbit ileum in vitro. Infect Immun, 33: , 165-170

Kistler LA, Giannella RA: 1980. Relationship of intestinal bacteria to malabsorption. Practical Gastroenterology, 4: , 24-44

Staples SJ, Asher S, Giannella RA: 1980. Purification and characterization of heat-stable enterotoxin produced by a strain of E. coli pathogenic for man. J Biol Chem, 255: , 4716-4721

Giannella RA, Brasile L: 1979. A hospital food-borne outbreak of diarrhea caused by Bacillus cereus: Clinical, epidemiologic, and microbiologis studies. J Infect Dis, 139: , 366-370

Giannella RA, Drake KW: 1979. Effect of purified E. coli heat-stable enterotoxin on intestinal cyclic nuucleotide metabolism and fluid secretion. Infect Immun, 24: , 19-23

Giannella RA: 1979. Importance of the intestinal inflammatory reaction in salmonella-mediated intestinal secretion. Infect Immun, 23: , 140-145

Giannella RA, Rout WR, Formal SB: 1977. Effect of indomethacin on intestinal water transport in salmonella-infected Rhesus monkeys. Infect Immun, 17: , 136-139

Charney AN, Gots RE, Formal SB, Giannella RA: 1976. Activation of intestinal mucosal adenylate cyclase by Shigella dysenteriae I enterotoxin. Gastroenterology, 70 , 1085-1090

Giannella RA, Rout WR, Formal SB, Collins H: 1976. The role of plasma filtration in the intestinal fluid secretion mediated by infection with Salmonella typhimurium. Infect Immun, 13: , 470-474

Giannella RA, Toskes PP: 1976. Gastrointestinal bleeding and iron absorption in the experimental blind loop syndrome. Amer J Clin Nutr, 29 , 754-757

Giannella RA: 1976. Management of massive upper gastrointestinal bleeding. J Kentucky Med Assoc, 74 , 30-33

Giannella RA: 1976. The suckling mouse model for the detection of heate-stable Escherichia coli enterotoxin: Characteristics of the model. Infect Immun, 14 , 95-99

Kinsey MD, Dammin GJ, Formal SB, Giannella RA: 1976. The role of altered intestinal permeability in the pathogenesis of salmonella diarrhea in the Rhesus monkey. Gastroenterology, 71: , 429-434

Kinsey MD, Formal SB, Dammin GJ, Giannella RA: 1976. Fluid and electrolyte transport in Rhesus monkeys challenged intracecally with Shigella flexneri 2a. Infect Immun, 14: , 368-371

Charney AN, Kinsey MD, Giannella RA, Myers L, Gots, RE: 1975. Sodium-potassium-activated adenosine triphosphatase and intestinal electrolyte transport: Effect of adrenal steroids. J Clin Invest, 56 , 653-660

Giannella RA, Gots RE, Charney AN, Greenough WB, Formal SB: 1975. Pathogenesis of Salmonella-mediated intestinal fluid secretion: Activation of adenylate cyclase and inhibition by indomethacin. Gastroenterology, 69: , 1238-1245

Rout WR, Formal SB, Giannella RA, Dammin GJ: 1975. Pathophysilogy of Shigella diarrhea in the Rhesus monkey: Intestinal transport, morphological and bacteriological studies. Gastroenterology, 68 , 270-278

Toskes PP, Giannella RA, Rout WR, Jervis H, Takeuchi A: 1975. Small intestinal mucosal cell injury in the experimental blind loop syndrome: Light, electron microscopic, and histochemical studies. Gastroenterology, 68 , 1193-1203

Charney AN, Gots RE, Giannella RA: 1974. (Na+-K+)-stimulated adenosine triphosphatase in isolated intestinal villus tip and crypt cells. Biochim Biophys Acta, 367 , 256-270

Fromm D, Giannella RA, Formal SB, Quijano R, Collins H: 1974. Ion transport across isolated ileal mucosa invaded by salmonella. Gastroenterology, 66 , 215-225

Giannella RA, Rout WR, Toskes PP: 1974. Jejunal brush border injury and impaired sugar and amino acid uptake in the blind loop syndromes. Gastroenterology, 67 , 965-974

Giannella RA: 1974. Acute bacterial diarrhea. J Kentucky Med Assoc, 72 , 667-671

Gots RE, Formal SB, Giannella RA: 1974. Indomethacin inhibition of Salmonella typhimurium, Shigella flexneri, and cholera mediated rabbit ileal secretion. J Infect Dis, 130: , 280-284

Rout WR, Formal SB, Dammin GJ, Giannella RA: 1974. Pathophysiology of salmonella diarrhea in the Rhesus monkey: Intestinal Transport, morphological and bacteriological studies. Gastroenterology, 67 , 59-70

Toskes PP, Smith G, Bensinger T, Giannella RA, Conrad M: 1974. Folic acid abnormalities in iron deficiency: Mechanism of decreased serum folate levels in rats. Amer J Clin Nutr, 27 , 355-361

Giannella RA, Broitman SA, Zamcheck N: 1973. The influence of gastric acidity on bacterial and parasitic enteric infections. A perspective. Annals Int Med, 78 , 271-276

Giannella RA, Formal SB, Dammin GJ, Collins H: 1973. Pathogenesis of salmonellosis: Studies of fluid secretion, mucosal invasion, and morphologic reaction in the rabbit ileum. J Clin Invest, 52 , 441-453

Giannella RA, Washington O, Gemski P, Formal S: 1973. Invasion of HeLa cells by Salmonella typhimurium: A model for the study of salmonella "invasiveness." J Infect Dis, 128 , 69-75

Formal SB, Gemski P, Giannella RA, Austin S: 1972. Mechanisms of Shigella pathogenesis. Amer J Clin Nutr, 15 , 1427-1432

Giannella RA, Broitman SA, Zamcheck N: 1972. Competition between bacteria and intrinsic factor for vitamin B12: Implications for vitamin B12 malabsorption in intestinal bacterial overgrowth. Gastroenterology, 62 , 255-260

Giannella RA, Broitman SA, Zamcheck N: 1972. Gastric acid barrier to ingested microorganisms in man: In vivo and in vitro studies Gut, 13 , 251-256

Giannella RA, Broitman SA, Zamcheck N: 1971. Vitamin B12 uptake by intestinal microorganisms: mechanism and relevance to syndromes of intestinal bacterial overgrowth. J Clin Invest, 50 , 1100-1107

Giannella RA, Broitman SA, Zamcheck N: 1971. Salmonella enteritis I. Role of reduced gastric secretion in pathogenesis. Amer J Dig Dis, 16 , 1000-1006

Giannella RA, Broitman SA, Zamcheck N: 1971. Salmonella enteritis II. Fulminant diarrhea and its effects on the small intestine. Amer J Dig Dis, 16 , 1007-1013

Published Abstracts

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Mann EA, Shanmukhappa K, Giannella RA, Bexerra J, Cohen MB: 2006. Hepatocyte proliferation after carbon tetrachloride injury is impaired in Guanylate Cyclase C (GC-C) receptor null mice. Hepatology, 44: suppl.1. , 385A


Mann EA, Stroup C, Giannella RA 2004. Lack of Guanylyl Cyclase C affects both polyp number and apoptosis in APC/min mice. Gastroenterology, ,


Mann EA, Giannella RA: 2002. Guanylyl cyclase C, the guanylin/uroguanylin receptor, is transcriptionally regulated by B-catenin/TCF. Gastroenterology, 122: , A402-403


Hogan DL, Crombie DL, Keely SJ, Mann EA, Sheil-Puopolo, Giannella RA, Barrett KE, JI Isenberg, VSK Pratha: 2001. Guanylate cyclase C (GC-C) mediates acid-stimulated duodenal mucosal bicarbonate secretion. Gastroenterology, 120: , A527.


Mann EA, Steinbrecher KA, Witte D, Cohen MB, Giannella, RA: 2001. Lack of guanylate cyclase C (GC-C0 leade to reduction of adenoma formation in murine model of intestinal cancer. Gastroenterology, 120: , A298.


Steinbrecher KA, Mann EA, Giannella RA, Cohen MB: 2001. A hypertonic diet increases mouse guanylin and uroguanylin levels via a guanylate cyclase-C independent mechanism. Gastroenterology, 120: , A679


Charney AN, Egnor RW, Zaharia V, Mann EA, Giannella RA: 2000. Action of STa on colonic ion transport in guanylate cyclase C deficient mice. Gastroenterology, aa8: , A288.


Giannella RA: 2000. Molecular pathogenesis of E. coli diarrhea. German Journal of Gastroenterology, 38:Suppl S3. , p 6.


Mann EA, Sheil-Puopolo MP, Giannella RA: 2000. Guanylyl cyclase C deficient mice have more severe carbon tetrachloride induced liver injury than wild-type controls. Gastroenterology, aa8: , A292.


Zhou RH, Hogan DL, Pratha VS, Mann EA, Giannella RA, Isenberg JL. 2000. Guanylate cyclase C(GC-C)mediates calcium-activated duodenal mucosal bicarbonate secretion. Gastroenterology, 118: , A35.


Cohen MB, Giannella RA, Lang D, Parker S, Brunner L, Hawkins J, Gunther C, Schiff GM: 1999. Development of a human volunteer challenge model for cholera using frozen bacteria of the new epidemic serotype, V. cholerae 0139. Gastroenterology, 116: , A683


Giannella RA and Mann EA 1999. Consequences of ablation of the guanylate cyclase C gene. FASEB J, 13: , A725


Mann EA, Giannella RA: 1999. Intestinal heat-stable enterotoxin (ST) receptors: persistence of binding activity in the guanylyl cyclase C (GC-C) receptor knockout mouse. Gastroenterology, 116: , A906


Mann EA, Sheil MP, Keaton N, Giannella RA: 1999. Regulation of the guanylyl cyclase C (GC-C) gene: importance of both cdx-2, a caudal-related transcription factor, and hepatocyte nuclear factor 4 (HNF-4. Gastroenterology, 116: , A564


Shah RJ, Bleau B, Giannella RA: 1999. Usefullness of colonoscopy with ileoscopy and biopsy in the evaluation of patients with chronic diarrhea. Gastroenterology, 116: , A930


Zhou RH, Pratha VA, Hogan DL, Steinbach JH, Mann EA, Giannella RA, Isenberg JI 1999. Gunaylate cyclase C (GC-C) plays a major role in duodenal mucosal bicarbonate secretion. Gastroenterology, 116: A , 890


Charney AN, Egnor RW, Giannella RA: 1998. SCFA's prevent and reverse cGmp (ST Toxin)-induced colonic C1 secretion. Gastroenterology, 114: , G1463


Giannella R, Zorich N, Riccardi K, Filloon T, McRorie J: 1998. Reports of diarrhea: when is stool water output clinically meaningful? A randomized, controlled trial of Olestra and sorbitol. Gastroenterology, 114: , G1520


McRorie J, Zorich N, Giannella R. 1998. Reports of abdominal cramping pain and urgency are correlated with changes in stool viscosity. Gastroenterology, 114: , G1616


Swenson S, Mann EA, Jump ML, Giannella RA: 1998. Transcriptional regulation by hepatocyte nuclear factor 4 is critical for intestinal expression of guanylyl cyclase C. Gastroenterology, 114: , G3729


Charney AN, Giannella RA: 1997. SCFA's but not intracellular bicarponate inhibit cyclic GMP-mediated secretion. Gastroenterology, 112: , 353


Mann EA, Swenson ES, Jump ML, Giannella RA: 1996. Cloning of the mouse guanylyl cyclase C promoter and functional analysis in the CaCo-2 intestinal cell line. Gastroenterology, 110: , 345


Mann EA, Jump ML, Giannella RA: 1995. Cloning and transcriptional analysis of the human gene for a guanylin/STa receptor. Gastroenterology , 106: , A329


Dellon SC, Mann EA, Giannella RA: 1993. Thyroid hormone modulates the STa-guanylin receptor in the rat jejunum and colon. Gastroenterology, 104: , A241


Cohen MB, Mann EA, Lau C, Henning SJ, Giannella RA: 1992. A gradient in expression of the E. coli heat-stable enterotoxin (STa)receptor along the villus to crypt axis in the rat intestine. Gastroenterology, 102: , A205


Mann EA, Cohen MB, Giannella RA: 1992. Molecular cloning and characterization of the human enterocyte receptor for E. coli heat-stable enterotoxin and expression in CAC02 cells. Gastroenterology, 102: , A224


Giannella R, Orlowski J, Lingrel JB: 1991. Hormonal regulation of NA,K-ATPase gene expression in CAC02 cells. Gastroenterology, 100: , A212


Giannella R, Orlowski J, Lingrel JB: 1991. NA,K-ATPase gene expression in rat and human intestine. Gastroenterology, 100: , A212


Sturbaum CV, Cha JH, Boyette TR, Giannella RA, Powell DW: 1991. Cholera toxin and E. coli ST toxin stimulated rat colonic cyclic nucleotide pools. Gastroenterology, 100: , A843


Cohen MB, Jensen NJ, Thompson Mr, Lentze MJ, Giannella RA: 1990. Identification of the human intestinal receptor for E. coli heat-stable enterotoxin. Pediatr Res, 27: , 541


Mezoff AG, Giannella RA, Eade MN, Cohen MB: 1990. The colon plays a significant role in E. coli heat-stable enterotoxin (STa)-mediated diarrheal disease. Pediatr Res, 27: , 541


Cohen MB, Conti TR, Ritter M, Thompson MR, Giannella RA: 1989. Intestinal defense against E. coli heat-stable enterotoxin (ST): Components of the ST inactivation process. Gastroenterology , 96: , A92


Cohen MB, Thompson MR, Giannella RA: 1988. Failure of inactivation of E. coli heat-stable enterotoxin. A mechanism to prolong and increase the secretory response in the suckling rat jejunum. Gastroenterology, 94: , A72


Cohen MB, Filaccio ML, Giannella RA: 1987. Regional differences in survival of E.coli heat-stable enterotoxin in rat intestine. Gastroenterology, 92: , 1349


Giannella RA, Huott P, Dharmsathaphorn K: 1987. Reversal of E. coli heat-stable enterotoxin-induced secretion and guanylate cyclase activation by anti-ST monoclonal antibody. Gastroenterology , 92: , 1403


Weesner R, Kolinjavadi J, Giannella R, Huitger-O'Connor T, Genta R: 1987. Strongyloides ratti effect on small bowel function in the normal and immunosuppressed host. Gastroenterology, 92: , 1687


Cohen MB, Guarino A, Bove K, Giannella RA: 1986. Development of E.coli heat-stable enterotoxin receptors in human small intestine and colon. Gastroenterology, 90: , 1375


Guarino A, Overmann G, Cohen M, Thompson M, Giannella R: 1986. Specific binding of and guanyl cyclase activation by E.coli heat-stable interotoxin in a human intestinal cell line. Gastroenterology, 90: , 1441


Cohen MB, Luttrell M. Giannella RA: 1985. Increased response and sensitivity of the immature rat jejunum to E.coli heat-stable enterotoxin. Clin Res, 33: , 906


Cohen MB, Moyer MS, Luttrell M, Giannella RA: 1985. Mechanism of increased sensitivity of the weanling rat small intestine to E.coli heat-stable toxin. Gastroenterology, 88: , 1352


Cohen MB, Thompson MR, Overmann G, Giannella RA: 1985. Reversibility of binding of E.coli heat-stable enterotoxin (STa): Resolution of a controversy. Accepted for presentation at the 21st US-Japan Cholera Conference, Bethesda, Maryland, Octioer, 1985. , ,


Giannella RA, Luttrell M, Thompson M: 1985. Receptor occupancy and intestinal secretion induced by E.coli heat-stable enterotoxin. Gastroenterology, 88: , 1392


Thompson MR, Giannella RA: 1985. Preparation by C-18 HPLC and characterization of 12 5I-4 TYR and - 19 TYR monoidinated Escherichia coli heat-stable enterotoxin tracers. Presented at Fifth International Symposium on HPLC of Proteins, Peptides, and Polynucleotides, November 4-6. , ,


Thompson MR, Giannella RA: 1985. Binding of monoiodinated 125I 4-TYR and 18-TYR E.coli Sta to rat enterocyte receptors and anti-STa antibodies. , ,


Thompson MR, Jordan RL, Luttrell M, Kaper JB, Levine MM, Giannella RA: 1985. A blinded, two laboratory comparative analysis of E.coli STa production using monoclonal antibody ELISA, radioimmunoassay, suckling mouse assay and gene probe analysis. , ,


Thompson MR, LaBine-Racke M, Giannella RA: 1985. Characterization of solubilized rat enterocyte brush border E.coli heat-stable enterotoxin (STa) receptors using a monoiodinated STa probe. , ,


Merritt Am, Burrows CF, Beckett R, Martin J, Giannella RA: 1984. Effect of E.coli STa on piglet jejunal myoelectrical activity. Gastroenterology, 86: , 1182


Thompson Mr, Brandwein H, Deutsch A, Luttrell M, LaBine-Racke M, Giannella RA: 1984. Characterization of monoclonal antibodies against E.coli heat-stable enterotoxins (ST) and their use in a simple reliable ELISA. Gastroenterology, 86: , 1281


Giannella RA, Thompson MR, Luttrell M, Overmann G: 1983. E.coli heat-stable enterotoxin: Structural determinants for ligand and receptor in the binding of ST to its enterocyte receptor. Gastroenterology, 84: , 1165


Mathias JR, Sninsky CA, Martin JL, Giannella RA: 1983. Effect of prostaglandin E2 on myoelectric activity in rabbit small intestine. Clin Res, 31: , 286


Weesner RE, Mendenhall CL, Giannella RA, Sperling MI, Maxon HR, Chen IW: 1983. A comparison of serum elastase I, trypsin and pancreatic isoamylase in patients with acute pancreatitis and chronic alcoholism. Dig Dis Sci, 28: , 952


Giannella RA, Luttrell M: 1982. Binding of E.coli heat-stable enterotoxin in to small intestinal brush border receptors. Gastroenterology, 82: , 1065


Giannella RA, Drake KW, Luttrell M: 1981. Possible role of prostaglandins in salmonella-mediated intestinal secretion. Gastroenterology, 80: , 1155


Rothbaum RJ, Partin JC, McAdams AJ, Shah DB, Giannella RA: 1981. Enterocyte adherent E.coli 0119:B14: A novel mechanism of infant diarrhea. Gastroenterology, 80: , 1065


Giannella RA, Drake KW: 1980. Development of a sensitive radioimmunoassay for E.coli heat-stable enterotoxin. Gastroenterology, 78: , 1172


Giannella RA, Luttrell M, Drake KW: 1980. Binding of pure E.coli heat-stable enterotoxin to isolated rat intestinal villus cells. Clin Res, 28: , 764


Mathias J. Martin J, Carlson G, Nogueira J, Giannella R: 1980. Repetitive burstss of action potentials in response to E.coli heat-stable interotoxin: A defense mechanism of the bacterium? Clin Res, 28: , 281


Giannella RA, Serumaga J: 1979. Alteration in intestinal water transport induced by clindamycin. Gastroenterology, 76: , 1137


Giannella RA, Walls D: 1979. Abnormalities of intestinal water and glucose transport in the experimental blind loop syndrome. Gastroenterology, 76: , 1138


Giannella RA: 1979. Intestinal transport abnormalities in the experimental blind loop syndrome. Clin Res, 27: , 683


Eade MN, Giannella RA: 1978. Effect of purified E.coli heat-stable enterotoxin on intestinal transport and possible mechanism of action. Gastroenterology, 74:,


Giannella RA: 1978. Purification of the heat-stable enterotoxin on intestinal transport and possible mechanism of action. Gastroenterology, 74: , 1124


Banwell JG, Giannella RA, Benenson AS, Wilson D, Burke J: 1977. A study of the prevalence and incidence of enterotoxigenic E.coli diarrheal disease in several Kentucky communities. Gastroenterology, 72: , 1027


Giannella RA, Brasile L: 1977. A hospital foodborne outbreak of diarrhea due to Bacillus cereus. Clin Res, 25: , 618


Giannella RA: 1977. Specificity of the suckling mouse assay for heat-stable E.coli enterotoxin and mode of action of the toxin. Gastroenterology, 72: , 1062


Giannella RA: 1977. The importance of the intestinal inflammatory response in salmonella-mediated intestinal secretion. Gastroenterology, 72: , 1062


Banwell JG, Hanke D, Lepot A, Giannella RA: 1976. Characteristics of polymyxin binding to brush boader membranes and its relationship to intestinal adenylate cyclase. Gastroenterology, 70: , 108


Giannella RA: 1976. The suckling mouse assay for E.coli enterotoxin. Characteristics fo the model. Gastroenterology, 70% , 112


Kinsey MD, Formal SB, Dammin GJ, Giannella ra: 1976. The importance of oral inoculation in the pathogenesis of shigella diarrhea. Gastroenterology, 70: , 44


Charney AN, Gots RE, Formal SB, Giannella RA: 1975. Activation of intestinal mucosal adenylate cyclase by shigella dysenteriae 1 enterotoxin. Clin Res , 23: , 480


Charney AN, Kinsey MD, Myers L, Giannella RA, Gots RE: 1975. Role of Na-K-Atpase in intestinal electrolyte transport after adrenal steroids. Clin Res, 23: , 247


Giannella RA: 1975. Differences in the salmonella and cholera toxin activation of intestinal adenyl cyclase: Differential effects of indomethacin. Clin Res, 23; , 518


Kinsey MD, Formal SB, Giannella RA: 1975. Role of altered permeability in the pathogenesis of salmonella diarrhea. Gastroenterology, 68: , 926


Charney AN, Gots R, Giannella RA: 1974. Na-K-ATPase in isolated intestinal villus tip and crypt cells. Gastroenterology, 66: , 673


Charney An, Kinsey MD, Myers L, Giannella RA, Gots RE: 1974. Intestinal Na+-K+-ATPase and electrolyte transport after adrenal steroids. Clin Res, 22: , 692


Giannella RA, Rout WR, Formal SB, Dammin GJ: 1974. The pathophysiology of Shigella diarrhea and dysentery in the Rhesus monkey. Gastroenterology, 66 , 698


Gots RE, Formal SB, Giannella RA: 1974. Salmonella-mediated ileal secretion: stimulation of adenyl cyclase, inhibition by indomethacin and possible participation of prostaglandins. Clin Res, 22: , 358


Formal SB, Gemski P, Giannella RA, Rout WR: 1973. Immuno Symposium: Pathophysiology and immunology of gram negative infections. Vienna, Austria 28-30 September, ,


Formal SB, Gemski P, Giannella RA: 1973. Pathogenesis of bacillary dysentery. First International Congress for Bacteriology, 1: , 156


Fromm D, Giannella RA, Formal S, Quijano R, Collins C: 1973. Active ion transport across isolated ileum invaded by salmonella. Gastroenterology, 64: , 729


Giannella RA, Toskes P, Rout R, Jervis H, Takeuchi A: 1973. Jejunal brush border and intracellular injury in the blind loop syndrome:A light histochemical, and electron microscopic study. Gastroenterology, 64: , 733


Giannella RA, Toskes P, Rout R: 1973. Reversible brush border injury and impaired sugar and amino acid uptake in the blind loop syndrome. Clin Res, 21: , 50


Gots R, Formal S, Giannella R: 1973. Indomethacin inhibition of salmonella, shigella, and cholera toxin mediated rabbit ileal fluid secretion. Clin Res, 21: , 975


Rout R, Giannella RA, Formal S, Dammin G: 1973. The pathophysiology of shigella diarrhea and dysentery. Clin Res, 21: , 964


Rout R, Giannella RA, Formal S, Dammin G: 1973. The pathophysiology of salmonella diarrhea in Rhesus monkeys. Gastroenterology, 64: , 793


Toskes P, Bensinger T, Giannella RA, Conrad M: 1973. Ineffective erythropoiesis with increased folate utilization secondary to iron deficiency. Clin Res, 21: , 569


Toskes P, Bensinger T, Giannella RA, Conrad M: 1973. Folic acid abnormalities in the blind loop syndrome. Clin Res, 21: , 55


Toskes P, Rout R, Giannella RA: 1973. Antibiotic-reversible brush border damage in the blind loop syndrome. Clin Res, 21: , 527


Giannella RA, Formal S, Dammin G: 1972. Pathogenesis of salmonella diarrhea. Clin Res, 20: , 880


Giannella RA, Formal S, Dammin G: 1972. Secretory, morphologic and invasive characteristics of Salmonella typhimurium infection of the rabbit ileum. Gastroenterology, 62: , 752


Toskes P, Smith G, Giannella RA, Bensinger T, Conrad M: 1972. The relationship of iron deficiency to serum folate levels.. Gastroenterology, 62: , 861


Giannella RA, Broitman SA, Zamcheck N: 1971. Salmonelloiis: Relevance of reduced gastric secretion to severity of diarrhea and effects in the small bowel. Gastroenterology, 60: , 666


Giannella RA, Broitman SA, Zamcheck N: 1971. Gastric acid barrier to microorganisms in the human stomach. Clin Res, 19: ,


Giannella RA, Broitman SA, Zamcheck N: 1970. Mechanism of vitamin B12 uptake by intestinal bacteria. Gastroenterology, 58: , 1042


Giannella RA, Broitman SA, Zamcheck N: 1970. Competition between bacteria and intrinsic factor for vitamin B12 Clin Res, 18: , 380


Giannella RA, Broitman SA, Zamcheck N: 1970. Cholera-like diarrhea in salmonella enteritis: Role of reduced gastric acid in pathogenesis. Clin Res., 18: , 679


Giannella RA, Broitman SA, Zamcheck N: 1969. Vitamin B12 uptake by intestinal bacteria. I. Demonstration of two stage uptake. Clin Res, 17: , 594


Giannella RA, Broitman SA, Zamcheck N: 1969. Bacterial impairment of vitamin B12 binding by intrinsic factor. Clin Res, 17: , 594


Carrithers SL, Mann EA, Hill M, Johnson BR, Giannella RA, Greenberg RN: . Renal effects of Escherichia coli heat-stable enterotoxin (ST) in wildtype and guanylyl cyclase-C (GC-C) deficient mice. , ,


Cohen MB, Bean J, Giannella RA, Taylor D, Parker S, Hoeper A, Wowk S, Hawkins J, Schiff G, Killeen K: . Randomized, double-blind placebo-controlled trial of a single dose of live oral cholera vaccine Peru-15 in preventing cholera following a challenge with Vibrio cholerae 01 El Tor Inaba approximately three months after vaccination. , ,


Liu W, Huott P, Giannella RA, Dharmsathaphorn K: . The mechanism of action of E.coli heat-stable enterotoxin (ST) in a human colonic cell line. Gastroenterology, 90: , 1795:


London RM, Mann EA, Giannella RA, Krause WJ, Forte LR: . Identification of a potential kidney receptor for guanylin expressed in GC-C null mice. Submitted to FASEB. , ,


Mann Ea, Albano F, Brasitus, Berni Canani R, Bisceglia M. Guarino A, Giannella RA: . A novel intestinal receptor for E. coli heat-stable enterotoxin (STa): stimulation of short circuit current by a non-guanylyl cyclase mechanism. Submitted to US-Japan Cholera conference. , ,


Pitisuttithum P, Cohen MB, Phonrat B, Suthirarnsuntorn U, Budsalatid V, Phumratatanapraprin Looareesuwan S, Giannella RA, Schiff GM, Ivanoff B, Lang D: . Validation of a human volunteer challenge model using frozen bacteria of the new epidemic serotype, V. cholerae 0139:comparison of the inoculum does-response between North American and Thai volunteers. , ,


Tacket CO, Cohen MB, Wasserman SS, Losonsky G, Livio S, Kotloff K, Edelman R, Cryz SJ, Giannella RA, Schiff G, Levine MM: . Randomized, double-blind, placebo-controlled trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-hgR in preventing cholera following challenge with Vibrio cholerae 01 El Tor, Inaba. Submitted to US-Japan Cholera Conference. , ,