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Department of Internal Medicine

Cardiovascular Health and Disease

Photo of Yukitaka Shizukuda

Yukitaka Shizukuda

Professor of Clinical Medicine

Education/Credentials
  • Medical Degree: Sapporo Medical University
  • Internship: SUNY Health Science Center at Brooklyn
  • Residency: SUNY Health Science Center at Brooklyn
  • Research Fellowship: University of North Texas Health Science Center
  • Clinical Cardiology Fellowship : Albert Einstein College of Medicine
  • Molecular Cardiology Fellowship : Albert Einstein College of Medicine

Board Certifications & Licenses
  • Certification American Board of Internal Medicine, 1995
  • Certification Board of Cardiovascular Diseases of American Board of Internal Medicine, 1998
  • Passed examination of special competency of adult echocardiography 2003
  • Ohio License 2006
Contact Information
  • Medical Sciences Building
  • 231 Albert Sabin Way, ML 0542
  • Cincinnati, Ohio 45267
  • Office 513-558-4272
  • Fax 513-558-6899
  • Email yukitaka.shizukuda@uc.edu

Peer Reviewed Publications

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Ahmad, Saad; Bhatti, Sabha; Shizukuda, Yukitaka 2013. Functional assessment of donor and recipient left atrium in heart transplant patients using full-volume three-dimensional echocardiography. Echocardiography (Mount Kisco, N.Y.), 30 2, 191-5

Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M 2013. Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis. American journal of respiratory and critical care medicine, 188 9, 1167-70

Bhatti, Sabha; Hakeem, Abdul; Yousuf, Mian Atif; Al-Khalidi, Hussein R; Mazur, Wojciech; Shizukuda, Yukitaka 2011. Diagnostic performance of computed tomography angiography for differentiating ischemic vs nonischemic cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 18 3, 407-20

Abdul-Waheed, Mohammad; Yousuf, Mian; Kelly, Stephanie J; Arena, Ross; Ying, Jun; Naz, Tehmina; Dunlap, Stephanie H; Shizukuda, Yukitaka 2010. Does left atrial volume affect exercise capacity of heart transplant recipients? Journal of cardiothoracic surgery, 5 , 113

Gujja, Pradeep; Rosing, Douglas R; Tripodi, Dorothy J; Shizukuda, Yukitaka 2010. Iron overload cardiomyopathy: better understanding of an increasing disorder. Journal of the American College of Cardiology, 56 13, 1001-12

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka 2010. Characteristics of exercise-induced intrapulmonary arteriovenous fistula in patients with unexplained exertional dyspnea. Echocardiography (Mount Kisco, N.Y.), 27 8, 908-13

Kelly, Stephanie J; Singhal, Shalabh; Elwing, Jean M; Shizukuda, Yukitaka 2010. Characteristics of Exercise-Induced Intrapulmonary Arteriovenous Fistula in Patients with Unexplained Exertional Dyspnea. Echocardiography (Mount Kisco, N.Y.), ,

Shizukuda, Yukitaka; Bhatti, Sabha; Munjal, Jitender; Hu, Yuhing L; Harrelson, Allan 2010. Personalized echocardiography: clinical applications of advanced echocardiography and future directions. Future cardiology, 6 6, 833-44

Shizukuda, Yukitaka; Plummer, Sandra L; Harrelson, Allan 2010. Customized exercise echocardiography: beyond detection of coronary artery disease. Echocardiography (Mount Kisco, N.Y.), 27 2, 186-94

Harrelson, Allan; Shizukuda, Yukitaka 2009. Left ventricular volume with three-dimensional echocardiography: all vendors the same? Echocardiography (Mount Kisco, N.Y.), 26 5, 622; author reply 62

Rahman, Shahid; Abdul-Waheed, Mohammed; Helmy, Tarek; Huffman, Lynn C; Koshal, Vipin; Guitron, Julian; Merrill, Walter H; Lewis, David F; Dunlap, Stephanie; Shizukuda, Yukitaka; Weintraub, Neal L; Meyer, Christopher; Cilingiroglu, Mehmet 2009. Spontaneous left main coronary artery dissection complicated by pseudoaneurysm formation in pregnancy: role of CT coronary angiography. Journal of cardiothoracic surgery, 4 , 15

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Sachdev, Vandana; Nguyen, Tammy T; Botello, Gilberto; Yau, Yu-Ying; Sidenko, Stanislav; Inez, Ernst; Ali, Mir I; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R 2009. Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis? Echocardiography (Mount Kisco, N.Y.), 26 10, 1153-8

Singhal, Shalabh; Yousuf, Mian A; Weintraub, Neal L; Shizukuda, Yukitaka 2009. Use of bicycle exercise echocardiography for unexplained exertional dyspnea. Clinical cardiology, 32 6, 302-6

Sachdev, Vandana; Machado, Roberto F; Shizukuda, Yukitaka; Rao, Yesoda N; Sidenko, Stanislav; Ernst, Inez; St Peter, Marilyn; Coles, Wynona A; Rosing, Douglas R; Blackwelder, William C; Castro, Oswaldo; Kato, Gregory J; Gladwin, Mark T 2007. Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease. Journal of the American College of Cardiology, 49 4, 472-9

Shizukuda, Yukitaka; Bolan, Charles D; Nguyen, Tammy T; Botello, Gilberto; Tripodi, Dorothy J; Yau, Yu-Ying; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R 2007. Oxidative stress in asymptomatic subjects with hereditary hemochromatosis. American journal of hematology, 82 3, 249-50

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Arena, Ross; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R 2007. Exercise capacity of cardiac asymptomatic hereditary hemochromatosis subjects. Medicine and science in sports and exercise, 39 1, 3-7

Taveira-DaSilva, Angelo M; Hathaway, Olanda M; Sachdev, Vandana; Shizukuda, Yukitaka; Birdsall, Charles W; Moss, Joel 2007. Pulmonary artery pressure in lymphangioleiomyomatosis: an echocardiographic study. Chest, 132 5, 1573-8

Sachdev, Vandana; Aletras, Anthony H; Padmanabhan, Sriram; Sidenko, Stanislav; Rao, Yesoda N; Brenneman, Cynthia L; Shizukuda, Yukitaka; Lie, Glenn R; Vincent, Pamela S; Waclawiw, Myron A; Arai, Andrew E 2006. Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 19 1, 34-9

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Nguyen, Tammy T; Botello, Gilberto; Sachdev, Vandana; Sidenko, Stanislav; Ernst, Inez; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R 2006. Significance of left atrial contractile function in asymptomatic subjects with hereditary hemochromatosis. The American journal of cardiology, 98 7, 954-9

Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Sachdev, Vandana; Birdsall, Charles W; Sidenko, Stanislav; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R 2006. Left ventricular systolic function during stress echocardiography exercise in subjects with asymptomatic hereditary hemochromatosis. The American journal of cardiology, 98 5, 694-8

Shizukuda, Yukitaka; Tripodi, Dorothy J; Smith, Kevin P; Arena, Ross; Waclawiw, Myron A; Rosing, Douglas R 2006. Can we use heart rate recovery information generated by supine ergometry exercise? The American journal of cardiology, 98 9, 1297-8

Matoba, Satoaki; Hwang, Paul M; Nguyen, Tammy; Shizukuda, Yukitaka 2005. Evaluation of pulsed Doppler tissue velocity imaging for assessing systolic function of murine global heart failure. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 18 2, 148-54

Sachdev, Vandana; Shizukuda, Yukitaka; Brenneman, Cynthia L; Birdsall, Charles W; Waclawiw, Myron A; Arai, Andrew E; Mohiddin, Saidi A; Tripodi, Dorothy; Fananapazir, Lameh; Plehn, Jonathan F 2005. Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy. American heart journal, 149 4, 730-6

Shizukuda, Yukitaka; Matoba, Satoaki; Mian, Omar Y; Nguyen, Tammy; Hwang, Paul M 2005. Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice. Molecular and cellular biochemistry, 273 1-2, 25-32

Shizukuda, Yukitaka; Piekarz, Richard L; Bates, Susan E; Sachdev, Vandana; Finkel, Toren; Rosing, Douglas R 2005. Effect of a histone deacetylase inhibitor on human cardiac mass. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 19 1, 89-90

Gladwin, Mark T; Sachdev, Vandana; Jison, Maria L; Shizukuda, Yukitaka; Plehn, Jonathan F; Minter, Karin; Brown, Bernice; Coles, Wynona A; Nichols, James S; Ernst, Inez; Hunter, Lori A; Blackwelder, William C; Schechter, Alan N; Rodgers, Griffin P; Castro, Oswaldo; Ognibene, Frederick P 2004. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. The New England journal of medicine, 350 9, 886-95

Patino, Willmar D; Mian, Omar Y; Shizukuda, Yukitaka; Hwang, Paul M 2003. Current and future applications of SAGE to cardiovascular medicine. Trends in cardiovascular medicine, 13 4, 163-8

Shizukuda, Yukitaka; Buttrick, Peter M 2002. Oxygen free radicals and heart failure: new insight into an old question. American journal of physiology. Lung cellular and molecular physiology, 283 2, L237-8

Shizukuda, Yukitaka; Buttrick, Peter M 2002. Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. Journal of molecular and cellular cardiology, 34 7, 823-31

Shizukuda, Yukitaka; Buttrick, Peter M 2002. Isoprotrenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation, 105 2, E9

Shizukuda, Yukitaka; Buttrick, Peter M 2002. Coronary flow reserve or brachial artery flow to assess endothelial dysfunction: is it time to look at the heart again? The American journal of cardiology, 89 1, 113

Shizukuda, Yukitaka; Buttrick, Peter M 2002. Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. American journal of physiology. Heart and circulatory physiology, 282 1, H320-7

Shizukuda, Yukitaka; Reyland, Mary E; Buttrick, Peter M 2002. Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. American journal of physiology. Heart and circulatory physiology, 282 5, H1625-34

Shizukuda, Y; Buttrick, P M 2001. Protein kinase C(epsilon) modulates apoptosis induced by beta -adrenergic stimulation in adult rat ventricular myocytes via extracellular signal-regulated kinase (ERK) activity. Journal of molecular and cellular cardiology, 33 10, 1791-803

Shizukuda, Y; Helisch, A; Yokota, R; Ware, J A 1999. Downregulation of protein kinase cdelta activity enhances endothelial cell adaptation to hypoxia. Circulation, 100 18, 1909-16

Shizukuda, Y; Tang, S; Yokota, R; Ware, J A 1999. Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity. Circulation research, 85 3, 247-56

Shizukuda, Y; Buttrick, P M; Geenen, D L; Borczuk, A C; Kitsis, R N; Sonnenblick, E H 1998. beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. The American journal of physiology, 275 3 Pt 2, H961-8

Shizukuda, Y; Iwamoto, T; Mallet, R T; Downey, H F 1993. Hypoxic preconditioning attenuates stunning caused by repeated coronary artery occlusions in dog heart. Cardiovascular research, 27 4, 559-64

Lee, S C; Mallet, R T; Shizukuda, Y; Williams, A G; Downey, H F 1992. Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. The American journal of physiology, 262 4 Pt 2, H955-60

Shizukuda, Y; Mallet, R T; Lee, S C; Downey, H F 1992. Hypoxic preconditioning of ischaemic canine myocardium. Cardiovascular research, 26 5, 534-42

Miura, T; Shizukuda, Y; Ogawa, S; Ishimoto, R; Iimura, O 1991. Effects of early and later reperfusion on healing speed of experimental myocardial infarct. The Canadian journal of cardiology, 7 3, 146-54

Shizukuda, Y; Miura, T; Ishimoto, R; Itoya, M; Iimura, O 1991. Effect of prednisolone on myocardial infarct healing: characteristics and comparison with indomethacin. The Canadian journal of cardiology, 7 10, 447-54

Matsuda, K; Shimamoto, K; Ura, N; Ogata, H; Shizukuda, Y; Iwakura, M; Nozawa, A; Kikuchi, K; Iimura, O 1989. A case of primary aldosteronism with chronic renal failure undergoing hemodialysis treatment. Endocrinologia japonica, 36 5, 681-6

Miura, T; Downey, J M; Ooiwa, H; Ogawa, S; Adachi, T; Noto, T; Shizukuda, Y; Iimura, O 1989. Progression of myocardial infarction in a collateral flow deficient species. Japanese heart journal, 30 5, 695-708

Miura, T; Ogawa, S; Ooiwa, H; Adachi, T; Noto, T; Shizukuda, Y; Iimura, O 1989. Human superoxide dismutase failed to limit the size of myocardial infarct after 20-, 30-, or 60-minute ischemia and 72-hour reperfusion in the rabbit. Japanese circulation journal, 53 7, 786-94

Ooiwa, H; Miura, T; Downey, J M; Matsuki, T; Shizukuda, Y; Adachi, T; Tsuchida, A; Iwamoto, T; Ogawa, T; Iimura, O 1989. The effect of inotropic dose of dobutamine during reperfusion on myocardial infarct size. Japanese circulation journal, 53 12, 1511-20

Shizukuda, Y; Tsuchihashi, K; Ogata, H; Hikita, N; Kamei, F; Yonekura, S; Hashimoto, A; Tanaka, S; Iimura, O; Hamagami, Y 1989. [A case of intra-ventricular dissociation with dual ventricular tachycardia]. Kokyu to junkan. Respiration & circulation, 37 5, 579-83

Shizukuda, Y; Murakami, H; Iwakura, M; Hashimoto, A; Tsuchihashi, K; Yonekura, S; Tanaka, S; Shimamoto, K; Sato, M; Iimura, O 1988. Siblings with left ventricular diverticulum and hypertrophic cardiomyopathy. Journal of cardiology, 18 3, 867-74

Arena, Ross; Shizukuda, Yukitaka; Bolan, Charles D; Tripodi, Dorothy J; Yau, Yu-Ying; Smith, Kevin P; Waclawiw, Myron A; Leitman, Susan F; Rosing, Douglas R . Heart rate recovery is lower following supine exercise in asymptomatic hereditary hemochromatosis subjects compared with healthy controls. Journal of cardiopulmonary rehabilitation and prevention, 27 3, 157-60

Shizukuda, Y; Sonnenblick, E H; Le Jemtel, T H; Forman, R . Coronary flow reserve of nonischemic heart failure. Congestive heart failure (Greenwich, Conn.), 5 5, 208-215

Shizukuda, Y; Yonekura, S; Tsuchihashi, K; Tanaka, S; Komatsu, S; Iimura, O . A case of a right coronary artery to left ventricle fistula observed over twenty years. Japanese journal of medicine, 28 4, 510-4

Shizukuda, Yukitaka; Muth, James; Chaney, Curtis; Attari, Mehran . Anomalous ridge on the left atrial side of the atrial septum. Annals of cardiac anaesthesia, 15 2, 161-2

Shizukuda, Yukitaka; Sachdev, Vandana; Fananapazir, Lameh; Tripodi, Dorothy; Mohiddin, Saidi A; Arai, Andrew E; Waclawiw, Myron A; Plehn, Jonathan F . Is functional capacity related to left atrial contractile function in nonobstructive hypertrophic cardiomyopathy? Congestive heart failure (Greenwich, Conn.), 11 5, 234-40