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Department of Internal Medicine

Cardiovascular Health and Disease

Photo of  Mohamed Effat, MD

Mohamed Effat, MD

Professor of Clinical Medicine; Chief, Interventional Cardiology Section; Director, Interventional Cardiology Fellowship Program

Education/Credentials
  • Medical Degree: Cairo University Faculty of Medicine
  • Transitional Residency : University of South Dakota
  • Internal Medicine Residency : University of South Dakota
  • Cardiovascular Disease Fellowship : Lahey Clinic
  • Interventional Cardiology Fellowship : University of Cincinnati

Research/Clinical Interests

Physiological assessment of coronary artery disease in the cardiac catherization laboratory.

Board Certifications & Licenses
  • American Board of Internal Medicine (Cardiovascular Disease) 11/03/1999
  • American Board of Internal Medicine 08/21/1996
  • American Board of Internal Medicine (Interventional Cardiology) 11/10/2008
Contact Information
  • Medical Sciences Building
  • 231 Albert Sabin Way, ML 0542
  • Cincinnati, Ohio 45267
  • Office 513-558-4272
  • Fax 513-558-6899
  • Email mohamed.effat@uc.edu

Peer Reviewed Publications

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Robbins N, Gilbert M, Kumar M, McNamara JW, Daly P, Koch SE, Conway G, Effat M, Woo JG, Sadayappan S, Rubinstein J. 2018. Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. J Am Heart Assoc, 13 7, 2

Hebbar UU, Effat MA, Peelukhana SV, Arif I, Banerjee RK. 2017. Delineation of epicardial stenosis in patients with microvascular disease using pressure drop coefficient: A pilot outcome study. World J Cardiol, 26 9, 813

Peelukhana SV, Banerjee RK, van de Hoef TP, Kolli KK, Effat M, Helmy T, Leesar M, Kerr H, Piek JJ, Succop P, Back L, Arif I. 2017. Evaluation of lesion flow coefficient for the detection of coronary artery disease in patient groups from two academic medical centers. Cardiovasc Revasc Med, S1553 17, 30340

Effat MA, Peelukhana SV, Banerjee RK. 2016. Clinical outcomes of combined flow-pressure drop measurements using newly developed diagnostic endpoint: Pressure drop coefficient in patients with coronary artery dysfunction. World J Cardiol, 26 8, 283

Kolli KK, van de Hoef TP, Effat MA, Banerjee RK, Peelukhana SV, Succop P, Leesar MA, Imran A, Piek JJ, Helmy TA. 2016. Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A patient-level analysis Catheter Cardiovasc Interv, 87 2, 273

Yeh, Robert W; Secemsky, Eric A; Kereiakes, Dean J; Normand, Sharon-Lise T; Gershlick, Anthony H; Cohen, David J; Spertus, John A; Steg, Philippe Gabriel; Cutlip, Donald E; Rinaldi, Michael J; Camenzind, Edoardo; Wijns, William; Apruzzese, Patricia K; Song, Yang; Massaro, Joseph M; Mauri, Laura 2016. Development and Validation of a Prediction Rule for Benefit and Harm of Dual Antiplatelet Therapy Beyond 1 Year After Percutaneous Coronary Intervention. JAMA, 315 16, 1735-49

Abo-Salem E, Alsidawi S, Jamali H, Effat M, Helmy T. 2015. Optimal Duration of Dual Antiplatelet Therapy after Drug-Eluting Stents: Meta-Analysis of Randomized Trials. Cardiovasc Ther, 33 5, 253

Alsidawi, Said; Effat, Mohamed; Rahman, Shahid; Abdallah, Mouhamad; Leesar, Massoud 2015. The role of vascular imaging in guiding routine Percutaneous Coronary Interventions: A meta-analysis of Bare Metal Stent and Drug-Eluting Stent trials. Cardiovascular therapeutics, ,

Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators 2015. Long-term use of ticagrelor in patients with prior myocardial infarction N Engl J Med, 372 19, 1791

Cannon, Christopher P; Blazing, Michael A; Giugliano, Robert P; McCagg, Amy; White, Jennifer A; Theroux, Pierre; Darius, Harald; Lewis, Basil S; Ophuis, Ton Oude; Jukema, J Wouter; De Ferrari, Gaetano M; Ruzyllo, Witold; De Lucca, Paul; Im, KyungAh; Bohula, Erin A; Reist, Craig; Wiviott, Stephen D; Tershakovec, Andrew M; Musliner, Thomas A; Braunwald, Eugene; Califf, Robert M 2015. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. The New England journal of medicine, 372 25, 2387-97

Kereiakes, Dean J; Yeh, Robert W; Massaro, Joseph M; Driscoll-Shempp, Priscilla; Cutlip, Donald E; Steg, P Gabriel; Gershlick, Anthony H; Darius, Harald; Meredith, Ian T; Ormiston, John; Tanguay, Jean Francois; Windecker, Stephan; Garratt, Kirk N; Kandzari, David E; Lee, David P; Simon, Daniel I; Iancu, Adrian Corneliu; Trebacz, Jaroslaw; Mauri, Laura 2015. Antiplatelet therapy duration following bare metal or drug-eluting coronary stents: the dual antiplatelet therapy randomized clinical trial. JAMA, 313 11, 1113-21

Kolli, Kranthi K; van de Hoef, Tim P; Effat, Mohamed A; Banerjee, Rupak K; Peelukhana, Srikara V; Succop, Paul; Leesar, Massoud A; Imran, Arif; Piek, Jan J; Helmy, Tarek A 2015. Diagnostic cutoff for pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve: A Patient-Level Analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, ,

Peelukhana SV, Banerjee R, Kolli KK, Fernandez-Ulloa M, Arif I, Effat M, Helmy T, Kerr H. 2015. Benefit of ECG-gated rest and stress N-13 cardiac PET imaging for quantification of LVEF in ischemic patients. Nucl Med Commun, 36 10, 968

Peelukhana, Srikara V; Effat, Mohamed; Kolli, Kranthi K; Arif, Imran; Helmy, Tarek; Leesar, Massoud; Kerr, Hanan; Back, Lloyd H; Banerjee, Rupak 2015. Lesion flow coefficient: a combined anatomical and functional parameter for detection of coronary artery disease--a clinical study. The Journal of invasive cardiology, 27 1, 54-64

Alsidawi, Said; Effat, Mohamad 2014. Peri-procedural management of anti-platelets and anticoagulation in patients undergoing MitraClip procedure. Journal of thrombosis and thrombolysis, ,

Alsidawi, Said; Effat, Mohamed; Helmy, Tarek 2014. Advances in interventional cardiology: MitraClip. Journal of thrombosis and thrombolysis, 38 2, 260-8

Kolli, Kranthi K; Arif, Imran; Peelukhana, Srikara V; Succop, Paul; Back, Lloyd H; Helmy, Tarek A; Leesar, Massoud A; Effat, Mohamed A; Banerjee, Rupak K 2014. Diagnostic performance of pressure drop coefficient in relation to fractional flow reserve and coronary flow reserve. The Journal of invasive cardiology, 26 5, 188-95

Kolli, Kranthi K; Effat, M A; Peelukhana, Srikara V; Succop, Paul; Back, Lloyd H; Leesar, M A; Helmy, T A; Imran, Arif; Banerjee, R K 2014. Hyperemia-free delineation of epicardial and microvascular impairments using a Basal index. Annals of biomedical engineering, 42 8, 1681-90

Kolli, Kranthi K; Helmy, Tarek A; Peelukhana, Srikara V; Arif, Imran; Leesar, Massoud A; Back, Lloyd H; Banerjee, Rupak K; Effat, Mohamed A 2014. Functional diagnosis of coronary stenoses using pressure drop coefficient: a pilot study in humans. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 83 3, 377-85

Mauri, Laura; Kereiakes, Dean J; Yeh, Robert W; Driscoll-Shempp, Priscilla; Cutlip, Donald E; Steg, P Gabriel; Normand, Sharon-Lise T; Braunwald, Eugene; Wiviott, Stephen D; Cohen, David J; Holmes, David R; Krucoff, Mitchell W; Hermiller, James; Dauerman, Harold L; Simon, Daniel I; Kandzari, David E; Garratt, Kirk N; Lee, David P; Pow, Thomas K; Ver Lee, Peter; Rinaldi, Michael J; Massaro, Joseph M 2014. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. The New England journal of medicine, 371 23, 2155-66

Peelukhana, Srikara V; Kerr, Hanan; Kolli, Kranthi K; Fernandez-Ulloa, Mariano; Gerson, Myron; Effat, Mohamed; Arif, Imran; Helmy, Tarek; Banerjee, Rupak 2014. Benefit of cardiac N-13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease: a pilot study. Annals of nuclear medicine, ,

Peelukhana, Srikara Viswanath; Kolli, Kranthi K; Leesar, Massoud A; Effat, Mohamed A; Helmy, Tarek A; Arif, Imran; Schneeberger, Eric W; Succop, Paul; Banerjee, Rupak K 2014. Effect of myocardial contractility on hemodynamic end points under concomitant microvascular disease in a porcine model. Heart and vessels, 29 1, 97-109

Effat M; Alsidawi S 2013. The Role of Bivalirudin in Percutaneous Coronary Interention. Cardiol Pharmacol, Dec 2 , e120

Kolli, Kranthi K; Paul, Anup K; Back, Lloyd H; Effat, Mohamed A; Banerjee, Rupak K 2013. Optimization of balloon obstruction for simulating equivalent pressure drop in physiological stenoses. Biorheology, 50 5-6, 257-68

Rahman, Shahid; Leesar, Tara; Cilingiroglu, Mehmet; Effat, Mohamed; Arif, Imran; Helmy, Tarek; Leesar, Massoud A 2013. Impact of kissing balloon inflation on the main vessel stent volume, area, and symmetry after side-branch dilation in patients with coronary bifurcation lesions: a serial volumetric intravascular ultrasound study. JACC. Cardiovascular interventions, 6 9, 923-31

Effat, Mohamad; Leesar, Massoud A 2012. Left main coronary stenosis and acute myocardial infarction: stent or surgery? An evolving perspective. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 79 6, 988-9

Kolli, Kranthi K; Banerjee, R K; Peelukhana, Srikara V; Effat, M A; Leesar, M A; Arif, Imran; Schneeberger, E W; Succop, Paul; Gottliebson, W M; Helmy, Tarek A 2012. Effect of changes in contractility on pressure drop coefficient and fractional flow reserve in a porcine model. The Journal of invasive cardiology, 24 1, 6-12

Peelukhana, S V; Banerjee, R K; Kolli, K K; Effat, M A; Helmy, T A; Leesar, M A; Schneeberger, E W; Succop, P; Gottliebson, W; Irif, A 2012. Effect of heart rate on hemodynamic endpoints under concomitant microvascular disease in a porcine model. American journal of physiology. Heart and circulatory physiology, 302 8, H1563-73

Hakeem, Abdul; Helmy, Tarek; Munsif, Siddharth; Bhatti, Sabha; Mazraeshahi, Reza; Cilingiroglu, Mehmet; Effat, Mohamed; Leesar, Massoud; Arif, Imran 2011. Safety and efficacy of drug eluting stents compared with bare metal stents for saphenous vein graft interventions: a comprehensive meta-analysis of randomized trials and observational studies comprising 7,994 patients. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 77 3, 343-55

Kolli, Kranthi K; Banerjee, R K; Peelukhana, Srikara V; Helmy, T A; Leesar, M A; Arif, Imran; Schneeberger, E W; Hand, Dwight; Succop, Paul; Gottliebson, W M; Effat, M A 2011. Influence of heart rate on fractional flow reserve, pressure drop coefficient, and lesion flow coefficient for epicardial coronary stenosis in a porcine model. American journal of physiology. Heart and circulatory physiology, 300 1, H382-7

Banerjee, Rupak K; Ashtekar, Koustubh D; Effat, Mohamed A; Helmy, Tarek A; Kim, Edward; Schneeberger, Eric W; Sinha, Roy A; Gottliebson, William M; Back, Lloyd H 2009. Concurrent assessment of epicardial coronary artery stenosis and microvascular dysfunction using diagnostic endpoints derived from fundamental fluid dynamics principles. The Journal of invasive cardiology, 21 10, 511-7

Hakeem, Abdul; Khan, Faisal M; Bhatti, Sabha; Samad, Zainab; Effat, Mohamed A; Eckman, Mark H; Helmy, Tarek 2009. Provisional vs. complex stenting strategy for coronary bifurcation lesions: meta-analysis of randomized trials. The Journal of invasive cardiology, 21 11, 589-95

Banerjee, Rupak K; Ashtekar, Koustubh D; Helmy, Tarek A; Effat, Mohamed A; Back, Lloyd H; Khoury, Saeb F 2008. Hemodynamic diagnostics of epicardial coronary stenoses: in-vitro experimental and computational study. Biomedical engineering online, 7 , 24

Effat, M A 1995. Pathophysiology of ischemic heart disease: an overview. AACN clinical issues, 6 3, 369-74

Hakeem, Abdul; Bhatti, Sabha; Arif, Imran; Effat, Mohamed; Cilingiroglu, Mehmet . Fibrinolytic therapy for very late stent thrombosis--is it a viable option? Cardiovascular revascularization medicine : including molecular interventions, 11 4, 264.e13-5