Institutes & Centers / UC Center for Cardiovascular Research / Facilities & Cores / Comprehensive Cardiovascular Phenotyping Lab

Comprehensive Cardiovascular Phenotyping Lab (CCPL)

Consolidated laboratories to provide in-depth, sophisticated analyses of cardiovascular function in health and disease for investigators inside and outside the University of Cincinnati College of Medicine

Disease Model

  • Pressure overload - TAC
  • Myocardial ischemia - IR, PO
  • Aneurysm — AAA
  • Hypertension
  • Diabetes/Metabolic disease

Mutant Mouse

Echocardiography

Function in Awake Mice

  • BP, ECG telemetry
  • Tail cuff BP
  • Exercise/stress tolerance

Terminal Assessment

  • LV Pressure/Volume
  • Regional Blood Flow
  • Cardiac Output
  • Atrial Pacing
  • Cardiac EP

Ex vivo Organ/Tissue

  • Langendorff/lsolated Heart
  • Muscle length-tension
  • Muscle Ca sensitivity
  • Atrial Pacing
  • Smooth muscle bath

Single Cell

  • Myocte length/tension
  • Myocte Ca sensitivity
  • Myocte calcium

One Shop for All

CCPL is a specialized facility dedicated to the comprehensive assessment and characterization of cardiovascular function and health in animal models. The lab employs a wide range of tools and techniques to provide detailed insights into the cardiovascular system. Here are some of the primary uses and purposes of such a lab:

  • Research and Discovery
  • Cardiovascular Disease Studies
  • Phenotyping Animal Models
  • Drug and Intervention Testing
  • Teaching and Training
  • Advanced Imaging and Diagnostics
  • Genetic and Molecular Studies
  • Cardiovascular Risk Assessment

Some of our collaborators from pharmaceutical companies

Recent Publications:

A complete list of publications can be found at:  NIH NCBI CCPL Pubs

Contact Information

Intranet Login

Contact Us

UC Center for Cardiovascular Research

Cardiovascular Center
231 Albert Sabin Way
PO Box 670542
Cincinnati, OH 45267-0542
Mail Location: 0542
Email:
centerforcvresearch@ucmail.uc.edu
Nicole Held
Phone: 513-558-1035