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Department of

Environmental Health

Photo of  Changchun Xie, PhD

Changchun Xie, PhD

Associate Professor of Biostatistics

Education/Credentials
  • Ph.D.: University of Guelph
  • M.S.: Dalhousie University
  • M.S.: Zhejiang University
  • B.S.: Hunan Normal University

Research/Clinical Interests

My research interests include 1) clinical trials, 2) statistical genetics: next generation sequencing, Genome-wide association study, NDA methylation, gene environmental interaction, 3) statistical methodology: survival models, multiple testing, hierarchical generalized linear models, nonparametric methods, longitudinal data and multivariate statistical analysis.

Contact Information
  • Division of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati
  • 104 Kettering Lab, 160 Panzeca Way
  • Cincinnati, Ohio 45267
  • Office (513)-558-0229
  • Email xiecn@ucmail.uc.edu

Peer Reviewed Publications

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Lindsley, Andrew W; Saal, Howard M; Burrow, Thomas A; Hopkin, Robert J; Shchelochkov, Oleg; Khandelwal, Pooja; Xie, Changchun; Bleesing, Jack; Filipovich, Lisa; Risma, Kimberly; Assa'ad, Amal H; Roehrs, Phillip A; Bernstein, Jonathan A 2016. Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome. The Journal of allergy and clinical immunology, 137 1, 179-187.e10

Chen, Aimin; Xu, Fan; Xie, Changchun; Wu, Tianying; Vuong, Ann M; Miao, Maohua; Yuan, Wei; DeFranco, Emily A 2015. Gestational Weight Gain Trend and Population Attributable Risks of Adverse Fetal Growth Outcomes in Ohio. Paediatric and perinatal epidemiology, 29 4, 346-50

Li, Yue; Xie, Changchun; Murphy, Susan K; Skaar, David; Nye, Monica; Vidal, Adriana C; Cecil, Kim M; Dietrich, Kim N; Puga, Alvaro; Jirtle, Randy L; Hoyo, Cathrine 2015. Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. Environmental health perspectives, ,

Wang, Ke-Sheng; Zuo, Lingjun; Pan, Yue; Xie, Changchun; Luo, Xingguang 2015. Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. Journal of psychiatric research, 71 , 1-7

Bailey, Swneke D; Xie, Changchun; Paré, Guillaume; Montpetit, Alexandre; Mohan, Viswanathan; Yusuf, Salim; Gerstein, Hertzel; Engert, James C; Anand, Sonia S 2014. Variation at the DPP4 locus influences apolipoprotein B levels in South Asians and exhibits heterogeneity in Europeans related to BMI. Diabetologia, 57 4, 738-45

Chen, Yaolong; Yang, Kehu; Jing, Tao; Tian, Jinhui; Shen, Xiping; Xie, Changchun; Ma, Bin; Liu, Yali; Yao, Liang; Cao, Xiaoyuan 2014. Use of text messages to communicate clinical recommendations to health workers in rural China: a cluster-randomized trial. Bulletin of the World Health Organization, 92 7, 474-81

Tang, Zhe; Zhou, Tao; Luo, Yanxia; Xie, Changchun; Huo, Da; Tao, Lixin; Pan, Lei; Sun, Fei; Zhu, Huiping; Yang, Xinghua; Wang, Wei; Yan, Aoshuang; Li, Xia; Guo, Xiuhua 2014. Risk factors for cerebrovascular disease mortality among the elderly in Beijing: a competing risk analysis. PloS one, 9 2, e87884

Xie, Changchun 2014. Relations among Three Parametric Multiple Testing Methods for Correlated Tests. Journal of statistical computation and simulation, 84 4, 812-818

Zhou, Tao; Li, Xia; Tang, Zhe; Xie, Changchun; Tao, Lixin; Pan, Lei; Huo, Da; Sun, Fei; Luo, Yanxia; Wang, Wei; Yan, Aoshuang; Guo, Xiuhua 2014. Risk factors of CVD mortality among the elderly in Beijing, 1992 - 2009: an 18-year cohort study. International journal of environmental research and public health, 11 2, 2193-208

Anand, Sonia S; Meyre, David; Pare, Guillaume; Bailey, Swneke D; Xie, Changchun; Zhang, Xiaohe; Montpetit, Alexandre; Desai, Dipika; Bosch, Jackie; Mohan, Viswanathan; Diaz, Rafael; McQueen, Matthew J; Cordell, Heather J; Keavney, Bernard; Yusuf, Salim; Gaudet, Daniel; Gerstein, Hertzel; Engert, James C 2013. Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study. Diabetes care, 36 9, 2836-42

Kirsh, Elliana R; van Leer, Eva; Phero, Heidi J; Xie, Changchun; Khosla, Sid 2013. Factors associated with singers' perceptions of choral singing well-being. Journal of voice : official journal of the Voice Foundation, 27 6, 786.e25-32

Xie, Changchun; Chen, Ding-Geng 2013. Letter to the editor. Biometrical journal. Biometrische Zeitschrift, 55 2, 264-5

Yamanaka, Osamu; Yuan, Yong; Coulson-Thomas, Vivien Jane; Gesteira, Tarsis Ferreira; Call, Mindy K; Zhang, Yujin; Zhang, Jianhua; Chang, Shao-Hsuan; Xie, Changchun; Liu, Chia-Yang; Saika, Shizuya; Jester, James V; Kao, Winston W-Y 2013. Lumican binds ALK5 to promote epithelium wound healing. PloS one, 8 12, e82730

Xie, Changchun 2012. Weighted multiple testing correction for correlated tests. Statistics in medicine, 31 4, 341-52

Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, A Darlene; Miller, Ruby; Lanktree, Matthew B; Saleheen, Danish; Danesh, John; Yusuf, Salim; Engert, James C; Hegele, Robert A; Anand, Sonia S 2012. BRCA2 variants and cardiovascular disease in a multi-ethnic study. BMC medical genetics, 13 , 56

Chow, Clara K; Islam, Shofiqul; Bautista, Leonelo; Rumboldt, Zvonko; Yusufali, Afzal; Xie, Changchun; Anand, Sonia S; Engert, James C; Rangarajan, Sumathy; Yusuf, Salim 2011. Parental history and myocardial infarction risk across the world: the INTERHEART Study. Journal of the American College of Cardiology, 57 5, 619-27

Do, Ron; Xie, Changchun; Zhang, Xiaohe; Männistö, Satu; Harald, Kennet; Islam, Shofiqul; Bailey, Swneke D; Rangarajan, Sumathy; McQueen, Matthew J; Diaz, Rafael; Lisheng, Liu; Wang, Xingyu; Silander, Kaisa; Peltonen, Leena; Yusuf, Salim; Salomaa, Veikko; Engert, James C; Anand, Sonia S 2011. The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. PLoS medicine, 8 10, e1001106

Mercuri, Mathew; Mehta, Shamir; Xie, Changchun; Valettas, Nicholas; Velianou, James L; Natarajan, Madhu K 2011. Radial artery access as a predictor of increased radiation exposure during a diagnostic cardiac catheterization procedure. JACC. Cardiovascular interventions, 4 3, 347-52

Assimes, Themistocles L; Hólm, Hilma; Kathiresan, Sekar; Reilly, Muredach P; Thorleifsson, Gudmar; Voight, Benjamin F; Erdmann, Jeanette; Willenborg, Christina; Vaidya, Dhananjay; Xie, Changchun; Patterson, Chris C; Morgan, Thomas M; Burnett, Mary Susan; Li, Mingyao; Hlatky, Mark A; Knowles, Joshua W; Thompson, John R; Absher, Devin; Iribarren, Carlos; Go, Alan; Fortmann, Stephen P; Sidney, Stephen; Risch, Neil; Tang, Hua; Myers, Richard M; Berger, Klaus; Stoll, Monika; Shah, Svati H; Thorgeirsson, Gudmundur; Andersen, Karl; Havulinna, Aki S; Herrera, J Enrique; Faraday, Nauder; Kim, Yoonhee; Kral, Brian G; Mathias, Rasika A; Ruczinski, Ingo; Suktitipat, Bhoom; Wilson, Alexander F; Yanek, Lisa R; Becker, Lewis C; Linsel-Nitschke, Patrick; Lieb, Wolfgang; König, Inke R; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Reinhard, Wibke; Winogradow, Janina; Grassl, Martina; Grosshennig, Anika; Preuss, Michael; Schreiber, Stefan; Wichmann, H-Erich; Meisinger, Christa; Yee, Jean; Friedlander, Yechiel; Do, Ron; Meigs, James B; Williams, Gordon; Nathan, David M; MacRae, Calum A; Qu, Liming; Wilensky, Robert L; Matthai, William H; Qasim, Atif N; Hakonarson, Hakon; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Knouff, Christopher W; Waterworth, Dawn M; Walker, Max C; Mooser, Vincent E; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Martinelli, Nicola; Olivieri, Oliviero; Trabetti, Elisabetta; Malerba, Giovanni; Pignatti, Pier Franco; Guiducci, Candace; Mirel, Daniel; Parkin, Melissa; Hirschhorn, Joel N; Asselta, Rosanna; Duga, Stefano; Musunuru, Kiran; Daly, Mark J; Purcell, Shaun; Eifert, Sandra; Braund, Peter S; Wright, Benjamin J; Balmforth, Anthony J; Ball, Stephen G ; Ouwehand, Willem H; Deloukas, Panos; Scholz, Michael; Cambien, Francois; Huge, Andreas; Scheffold, Thomas; Salomaa, Veikko; Girelli, Domenico; Granger, Christopher B; Peltonen, Leena; McKeown, Pascal P; Altshuler, David; Melander, Olle; Devaney, Joseph M; Epstein, Stephen E; Rader, Daniel J; Elosua, Roberto; Engert, James C; Anand, Sonia S; Hall, Alistair S; Ziegler, Andreas; O'Donnell, Christopher J; Spertus, John A; Siscovick, David; Schwartz, Stephen M; Becker, Diane; Thorsteinsdottir, Unnur; Stefansson, Kari; Schunkert, Heribert; Samani, Nilesh J; Quertermous, Thomas 2010. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. Journal of the American College of Cardiology, 56 19, 1552-63

Bailey, Swneke D; Xie, Changchun; Do, Ron; Montpetit, Alexandre; Diaz, Rafael; Mohan, Viswanathan; Keavney, Bernard; Yusuf, Salim; Gerstein, Hertzel C; Engert, James C; Anand, Sonia 2010. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes care, 33 10, 2250-3

, ; Kathiresan, Sekar; Voight, Benjamin F; Purcell, Shaun; Musunuru, Kiran; Ardissino, Diego; Mannucci, Pier M; Anand, Sonia; Engert, James C; Samani, Nilesh J; Schunkert, Heribert; Erdmann, Jeanette; Reilly, Muredach P; Rader, Daniel J; Morgan, Thomas; Spertus, John A; Stoll, Monika; Girelli, Domenico; McKeown, Pascal P; Patterson, Chris C; Siscovick, David S; O'Donnell, Christopher J; Elosua, Roberto; Peltonen, Leena; Salomaa, Veikko; Schwartz, Stephen M; Melander, Olle; Altshuler, David; Ardissino, Diego; Merlini, Pier Angelica; Berzuini, Carlo; Bernardinelli, Luisa; Peyvandi, Flora; Tubaro, Marco; Celli, Patrizia; Ferrario, Maurizio; Fetiveau, Raffaela; Marziliano, Nicola; Casari, Giorgio; Galli, Michele; Ribichini, Flavio; Rossi, Marco; Bernardi, Francesco; Zonzin, Pietro; Piazza, Alberto; Mannucci, Pier M; Schwartz, Stephen M; Siscovick, David S; Yee, Jean; Friedlander, Yechiel; Elosua, Roberto; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Kathiresan, Sekar; Meigs, James B; Williams, Gordon; Nathan, David M; MacRae, Calum A; O'Donnell, Christopher J; Salomaa, Veikko; Havulinna, Aki S; Peltonen, Leena; Melander, Olle; Berglund, Goran; Voight, Benjamin F; Kathiresan, Sekar; Hirschhorn, Joel N; Asselta, Rosanna; Duga, Stefano; Spreafico, Marta; Musunuru, Kiran; Daly, Mark J; Purcell, Shaun; Voight, Benjamin F; Purcell, Shaun; Nemesh, James; Korn, Joshua M; McCarroll, Steven A; Schwartz, Stephen M; Yee, Jean; Kathiresan, Sekar; Lucas, Gavin; Subirana, Isaac; Elosua, Roberto; Surti, Aarti; Guiducci, Candace; Gianniny, Lauren; Mirel, Daniel; Parkin, Melissa; Burtt, Noel; Gabriel, Stacey B; Samani, Nilesh J; Thompson, John R; Braund, Peter S; Wright, Benjamin J; Balmforth, Anthony J; Ball, Stephen G; Hall, Alistair S ; Schunkert, Heribert; Erdmann, Jeanette; Linsel-Nitschke, Patrick; Lieb, Wolfgang; Ziegler, Andreas; König, Inke; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Grosshennig, Anika; Preuss, Michael; Wichmann, H-Erich; Schreiber, Stefan; Schunkert, Heribert; Samani, Nilesh J; Erdmann, Jeanette; Ouwehand, Willem; Hengstenberg, Christian; Deloukas, Panos; Scholz, Michael; Cambien, Francois; Reilly, Muredach P; Li, Mingyao; Chen, Zhen; Wilensky, Robert; Matthai, William; Qasim, Atif; Hakonarson, Hakon H; Devaney, Joe; Burnett, Mary-Susan; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Knouff, Christopher W; Waterworth, Dawn M; Walker, Max C; Mooser, Vincent; Epstein, Stephen E; Rader, Daniel J; Scheffold, Thomas; Berger, Klaus; Stoll, Monika; Huge, Andreas; Girelli, Domenico; Martinelli, Nicola; Olivieri, Oliviero; Corrocher, Roberto; Morgan, Thomas; Spertus, John A; McKeown, Pascal; Patterson, Chris C; Schunkert, Heribert; Erdmann, Erdmann; Linsel-Nitschke, Patrick; Lieb, Wolfgang; Ziegler, Andreas; König, Inke R; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Grosshennig, Anika; Preuss, Michael; Wichmann, H-Erich; Schreiber, Stefan; Hólm, Hilma; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari; Engert, James C; Do, Ron; Xie, Changchun; Anand, Sonia; Kathiresan, Sekar; Ardissino, Diego; Mannucci, Pier M; Siscovick, David; O'Donnell, Christopher J; Samani, Nilesh J; Melander, Olle; Elosua, Roberto; Peltonen, Leena; Salomaa, Veikko; Schwartz, Stephen M; Altshuler, David 2009. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nature genetics, 41 3, 334-41

Anand, Sonia S; Xie, Changchun; Paré, Guillaume; Montpetit, Alexandre; Rangarajan, Sumathy; McQueen, Matthew J; Cordell, Heather J; Keavney, Bernard; Yusuf, Salim; Hudson, Thomas J; Engert, James C 2009. Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study. Circulation. Cardiovascular genetics, 2 1, 16-25

Mercuri, Mat; Natarajan, Madhu K; Holder, Douglas H; Xie, Changchun; Gafni, Amiram 2009. Insight into capacity planning for cardiac catheterization services: policy lessons learned from "Looking in the Mirror" over a decade. Health policy (Amsterdam, Netherlands), 91 3, 314-20

Mercuri, Mathew; Xie, Changchun; Levy, Michael; Valettas, Nicholas; Natarajan, Madhu K 2009. Predictors of increased radiation dose during percutaneous coronary intervention. The American journal of cardiology, 104 9, 1241-4

de Koning, Lawrence; Merchant, Anwar T; Hegele, Robert A; Xie, Changchun; Vuksan, Vlad; Teo, Koon; Yusuf, Salim; Anand, Sonia S 2008. Association of the FABP2 T54 variant with plasma triglycerides and insulin resistance in a multiethnic population. Clinical chemistry, 54 10, 1742-4

Xavier, Denis; Pais, Prem; Devereaux, P J; Xie, Changchun; Prabhakaran, D; Reddy, K Srinath; Gupta, Rajeev; Joshi, Prashant; Kerkar, Prafulla; Thanikachalam, S; Haridas, K K; Jaison, T M; Naik, Sudhir; Maity, A K; Yusuf, Salim 2008. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet, 371 9622, 1435-42

, ; Anand, Sonia; Yusuf, Salim; Xie, Changchun; Pogue, Janice; Eikelboom, John; Budaj, Andrzej; Sussex, Bruce; Liu, Lisheng; Guzman, Randy; Cina, Claudio; Crowell, Richard; Keltai, Matyas; Gosselin, Gilbert 2007. Oral anticoagulant and antiplatelet therapy and peripheral arterial disease. The New England journal of medicine, 357 3, 217-27

Eikelboom, John W; Mehta, Shamir R; Anand, Sonia S; Xie, Changchun; Fox, Keith A A; Yusuf, Salim 2006. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation, 114 8, 774-82

Schwalm, Jon-David Reid; Ahmad, Mayraj; Velianou, James L; Xie, Changchun; Natarajan, Madhu K 2006. Primary and rescue percutaneous coronary intervention with paclitaxel-eluting stent implantation in ST-elevation myocardial infarction. The American journal of cardiology, 97 9, 1308-10

Mehta, Shamir R; Yusuf, Salim; Díaz, Rafael; Zhu, Jun; Pais, Prem; Xavier, Denis; Paolasso, Ernesto; Ahmed, Rashid; Xie, Changchun; Kazmi, Khawar; Tai, Javed; Orlandini, Andrés; Pogue, Janice; Liu, Lisheng 2005. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA, 293 4, 437-46

Yusuf, Salim; Mehta, Shamir R; Xie, Changchun; Ahmed, Rashid J; Xavier, Denis; Pais, Prem; Zhu, Jun; Liu, Lisheng 2005. Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation. JAMA, 293 4, 427-35

Yusuf, Salim; Mehta, Shamir R; Díaz, Rafael; Paolasso, Ernesto; Pais, Prem; Xavier, Denis; Xie, Changchun; Ahmed, Rashid J; Khazmi, Khawar; Zhu, Jun; Liu, Lisheng 2004. Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction. American heart journal, 148 6, 1068-78

Anand, Sonia S; Davis, A Darlene; Ahmed, Rashid; Jacobs, Ruby; Xie, Changchun; Hill, Amber; Sowden, Joon; Atkinson, Stephanie; Blimkie, Cameron; Brouwers, Melissa; Morrison, Katherine; de Koning, Larry; Gerstein, Hertzel; Yusuf, Salim . A family-based intervention to promote healthy lifestyles in an aboriginal community in Canada. Canadian journal of public health = Revue canadienne de santé publique, 98 6, 447-52

Natarajan, Madhu K; Strauss, Bradley H; Rokoss, Michael; Buller, Christopher E; Mancini, G B John; Xie, Changchun; Sheth, Tej N; Goodhart, David; Cohen, Eric A; Seidelin, Peter; Harper, William; Gerstein, Hertzel C . Randomized trial of insulin versus usual care in reducing restenosis after coronary intervention in patients with diabetes. the STent Restenosis And Metabolism (STREAM) study. Cardiovascular revascularization medicine : including molecular interventions, 13 2, 95-100