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Department of

Environmental Health

Photo of  Ying Xia, PHD

Ying Xia, PHD

  • BS: Wuhan University
  • MS: National Institute of Vaccine and Serum
  • PHD: UT Southwestern Medical Center

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Peer Reviewed Publications

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Chen, Liang; Mongan, Maureen; Meng, Qinghang; Wang, Qin; Kao, Winston; Xia, Ying 2016. Corneal Wound Healing Requires IKB kinase ? Signaling in Keratocytes. PloS one, 11 3, e0151869

Chen, Liang; Peng, Zhimin; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Sartor, Maureen; Chen, Jing; Niu, Liang; Medvedovic, Mario; Kao, Winston; Xia, Ying 2016. Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop. Protein & cell, 7 5, 338-50

Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro 2016. Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells. Stem cells (Dayton, Ohio), 34 12, 2825-2839

Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult. PloS one, 10 11, e0142440

Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes. Toxicological sciences : an official journal of the Society of Toxicology, 147 2, 425-35

Mongan, Maureen; Meng, Qinghang; Wang, Jingjing; Kao, Winston W-Y; Puga, Alvaro; Xia, Ying 2015. Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis. The Journal of biological chemistry, 290 32, 19770-9

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, Andrew; Xia, Ying; Puga, Alvaro 2015. Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice. Toxicological sciences : an official journal of the Society of Toxicology, 146 1, 52-64

Yousaf, Rizwan; Meng, Qinghang; Hufnagel, Robert B; Xia, Ying; Puligilla, Chandrakala; Ahmed, Zubair M; Riazuddin, Saima 2015. MAP3K1 function is essential for cyto-architecture of mouse organ of Corti and survival of auditory hair cells. Disease models & mechanisms, ,

Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro 2014. Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells. Stem cell research, 12 1, 296-308

Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro 2014. The Ah Receptor Recruits IKK? to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. Toxicological sciences : an official journal of the Society of Toxicology, 139 1, 121-32

Meng, Qinghang; Jin, Chang; Chen, Yinglei; Chen, Jing; Medvedovic, Mario; Xia, Ying 2014. Expression of signaling components in embryonic eyelid epithelium. PloS one, 9 2, e87038

Meng, Qinghang; Mongan, Maureen; Carreira, Vinicius; Kurita, Hisaka; Liu, Chia-Yang; Kao, Winston; Xia, Ying 2014. Eyelid closure in embryogenesis is required for ocular adnexa development. Investigative ophthalmology & visual science, ,

Meng, Qinghang; Mongan, Maureen; Wang, Jingjing; Tang, Xiaofang; Zhang, Jinling; Kao, Winston; Xia, Ying 2014. Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Developmental biology, 395 1, 29-37

Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene. Toxicology, 316 , 14-24

Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure. PloS one, 9 5, e97849

Jin, Chang; Chen, Jing; Meng, Qinghang; Carreira, Vinicius; Tam, Neville N C; Geh, Esmond; Karyala, Saikumar; Ho, Shuk-Mei; Zhou, Xiangtian; Medvedovic, Mario; Xia, Ying 2013. Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Developmental biology, 374 1, 96-107

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro 2013. Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells. PloS one, 8 11, e80558

Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying 2012. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. The Journal of biological chemistry, 287 4, 2787-97

Wang, Jingcai; Xia, Ying 2012. Assessing developmental roles of MKK4 and MKK7 in vitro. Communicative & integrative biology, 5 4, 319-24

Chen, Liang; Meng, Qinghang; Kao, Winston; Xia, Ying 2011. I?B kinase ? regulates epithelium migration during corneal wound healing. PloS one, 6 1, e16132

Deng, Maoxian; Ding, Wei; Min, Xuewen; Xia, Ying 2011. MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells. Cytoskeleton (Hoboken, N.J.), 68 3, 139-49

Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54

Meng, Qinghang; Xia, Ying 2011. c-Jun, at the crossroad of the signaling network. Protein & cell, 2 11, 889-98

Mongan, Maureen; Wang, Jingcai; Liu, Hongshan; Fan, Yunxia; Jin, Chang; Kao, Winston Y-W; Xia, Ying 2011. Loss of MAP3K1 enhances proliferation and apoptosis during retinal development. Development (Cambridge, England), 138 18, 4001-12

Warr, Nick; Bogani, Debora; Siggers, Pam; Brixey, Rachel; Tateossian, Hilda; Dopplapudi, Asha; Wells, Sara; Cheeseman, Michael; Xia, Ying; Ostrer, Harry; Greenfield, Andy 2011. Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. PloS one, 6 5, e19572

Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro 2010. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer research, 70 1, 212-20

Meng, Qinghang; Peng, Zhimin; Chen, Liang; Si, Jutong; Dong, Zhongyun; Xia, Ying 2010. Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells. Cancer letters, 299 1, 45-53

Peng, Zhimin; Geh, Esmond; Chen, Liang; Meng, Qinghang; Fan, Yunxia; Sartor, Maureen; Shertzer, Howard G; Liu, Zheng-Gang; Puga, Alvaro; Xia, Ying 2010. Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Molecular pharmacology, 77 5, 784-92

Zhu, Yu-Jia; Xia, Ying; Ren, Guan-Jun; Wang, Meng-Zhao; Zeng, Xuan; Zhang, Li 2010. Efficacy and clinical/molecular predictors of erlotinib monotherapy for Chinese advanced non-small cell lung cancer. Chinese medical journal, 123 22, 3200-5

Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying 2009. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environmental health perspectives, 117 7, 1124-30

Kao, Winston W-Y; Xia, Ying; Liu, Chia-Yang; Saika, Shizuya 2008. Signaling pathways in morphogenesis of cornea and eyelid. The ocular surface, 6 1, 9-23

Malthankar-Phatak, Gauri H; Patel, Anant B; Xia, Ying; Hong, Soonsun; Chowdhury, Golam M I; Behar, Kevin L; Orina, Isaac A; Lai, James C K 2008. Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons. Brain research, 1229 , 147-54

Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, Alvaro 2008. The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Molecular biology of the cell, 19 8, 3263-71

Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, George; Xia, Ying 2008. Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicological sciences : an official journal of the Society of Toxicology, 104 2, 405-11

Takatori, Atsushi; Geh, Esmond; Chen, Liang; Zhang, Lin; Meller, Jarek; Xia, Ying 2008. Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development (Cambridge, England), 135 1, 23-32

Peng, Zhimin; Peng, Li; Fan, Yunxia; Zandi, Ebrahim; Shertzer, Howard G; Xia, Ying 2007. A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. The Journal of biological chemistry, 282 29, 21487-96

Deng, Maoxian; Chen, Wei-Li; Takatori, Atsushi; Peng, Zhimin; Zhang, Lin; Mongan, Maureen; Parthasarathy, Ranjani; Sartor, Maureen; Miller, Marian; Yang, Jianhua; Su, Bing; Kao, Winston W-Y; Xia, Ying 2006. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Molecular biology of the cell, 17 8, 3446-55

Kao, Winston W-Y; Funderburgh, James L; Xia, Ying; Liu, Chia-Yang; Conrad, Gary W 2006. Focus on molecules: lumican. Experimental eye research, 82 1, 3-4

Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicological sciences : an official journal of the Society of Toxicology, 87 2, 365-84

Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro 2005. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Molecular pharmacology, 68 2, 336-46

Puga, Alvaro; Tomlinson, Craig R; Xia, Ying 2005. Ah receptor signals cross-talk with multiple developmental pathways. Biochemical pharmacology, 69 2, 199-207

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5

Gao, Min; Labuda, Tord; Xia, Ying; Gallagher, Ewen; Fang, Deyu; Liu, Yun-Cai; Karin, Michael 2004. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (New York, N.Y.), 306 5694, 271-5

Tan, Zongqing; Huang, Mingya; Puga, Alvaro; Xia, Ying 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicological sciences : an official journal of the Society of Toxicology, 82 1, 80-7

Xia, Ying; Kao, Winston W-Y 2004. The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype. Biochemical pharmacology, 68 6, 997-1001

Xia, Ying; Karin, Michael 2004. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends in cell biology, 14 2, 94-101

Zhang, Lu; Lou, Danwen; Jiao, Hongyuan; Zhang, Dongsheng; Wang, Xinkang; Xia, Ying; Zhang, Jianhua; Xu, Ming 2004. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 13, 3344-54

Khoo, Shih; Griffen, Steven C; Xia, Ying; Baer, Richard J; German, Michael S; Cobb, Melanie H 2003. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. The Journal of biological chemistry, 278 35, 32969-77

Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D 2003. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The EMBO journal, 22 19, 5079-89

Zhang, Lin; Deng, Maoxian; Kao, Candace W C; Kao, Winston W Y; Xia, Ying 2003. MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis. Molecular vision, 9 , 584-93

Zhang, Lin; Wang, Wei; Hayashi, Yasuhito; Jester, James V; Birk, David E; Gao, Min; Liu, Chia-Yang; Kao, Winston W-Y; Karin, Michael; Xia, Ying 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. The EMBO journal, 22 17, 4443-54

Puga, Alvaro; Xia, Ying; Elferink, Cornelis 2002. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chemico-biological interactions, 141 1-2, 117-30

Roy, Sanjit K; Hu, Junbo; Meng, Qingjun; Xia, Ying; Shapiro, Paul S; Reddy, Sekhar P M; Platanias, Leonidas C; Lindner, Daniel J; Johnson, Peter F; Pritchard, Catrin; Pagés, Gilles; Pouyssegur, Jacques; Kalvakolanu, Dhananjaya V 2002. MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America, 99 12, 7945-50

Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying 2002. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochemical pharmacology, 64 5-6, 771-80

Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; Medvedovic, Mario; Puga, Alvaro . Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis. Environmental health perspectives, 121 11-12, 1334-43