Today is Tuesday, Jan. 23, 2018

Department of

Environmental Health

Photo of  Mary Beth Genter, PhD

Mary Beth Genter, PhD


  • PhD: Duke University
  • BS: St. Lawrence University

Board Certifications & Licenses
  • Diplomate American Board of Toxicology, 1992, Diplomate, American Board of Toxicology
  • Fellow Academy of Toxicological Sciences, 2012, Fellow, ATS
Contact Information
  • Kettering 144 (lab); 158 (lab)
  • 160 Panzeca Way
  • Cincinnati, Ohio 45267-0056
  • Office (513)558-6266
  • Fax (513)558-4397
  • Email

Peer Reviewed Publications

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Genter, Mary Beth 2014. Editor's Note. International journal of toxicology, 33 4, 267

Hsieh, H; Amlal, H; Genter, Mb 2014. Evaluation of the toxicity of zinc in the rat olfactory neuronal cell line, Odora. Human & experimental toxicology, ,

Dong, Hongbin; Shertzer, Howard G; Genter, Mary Beth; Gonzalez, Frank J; Vasiliou, Vasilis; Jefcoate, Colin; Nebert, Daniel W 2013. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochemical and biophysical research communications, 435 4, 727-32

Sasso, Alan F; Schlosser, Paul M; Kedderis, Gregory L; Genter, Mary Beth; Snawder, John E; Li, Zheng; Rieth, Susan; Lipscomb, John C 2013. Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice. Toxicological sciences : an official journal of the Society of Toxicology, 131 2, 360-74

Shertzer, Howard G; Krishan, Mansi; Genter, Mary Beth 2013. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neuroscience letters, 548 , 159-64

Barchowsky, Aaron; Buckley, Lorrene A; Carlson, Gary P; Fitsanakis, Vanessa A; Ford, Sue M; Genter, Mary Beth; Germolec, Dori R; Leavens, Teresa L; Lehman-McKeeman, Lois D; Safe, Stephen H; Sulentic, Courtney E W; Eidemiller, Betty J 2012. The Toxicology Education Summit: building the future of toxicology through education. Toxicological sciences : an official journal of the Society of Toxicology, 127 2, 331-8

Curran, Christine P; Vorhees, Charles V; Williams, Michael T; Genter, Mary Beth; Miller, Marian L; Nebert, Daniel W 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicological sciences : an official journal of the Society of Toxicology, 119 1, 189-208

Genter, Mary Beth 2011. Editor's Note. International journal of toxicology, 30 4, 383

Shertzer, Howard G; Woods, Sally E; Krishan, Mansi; Genter, Mary Beth; Pearson, Kevin J 2011. Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. The Journal of nutrition, 141 4, 582-7

Genter, Mary Beth; Krishan, Mansi; Augustine, Lisa M; Cherrington, Nathan J 2010. Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb. Drug metabolism and disposition: the biological fate of chemicals, 38 10, 1644-7

Hopf, Nancy Brenna; Kirkeleit, Jorunn; Kramer, Stacy L; Moen, Bente; Succop, Paul; Genter, Mary Beth; Carreón, Tania; Mack, James; Talaska, Glenn 2010. Urinary 1-hydroxypyrene levels in offshore workers. International archives of occupational and environmental health, 83 1, 55-9

Genter, M B; Warner, B M; Medvedovic, M; Sartor, M A 2009. Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 47 6, 1051-7

Genter, Mary Beth; Kendig, Eric L; Knutson, Mitchell D 2009. Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Annals of the New York Academy of Sciences, 1170 , 623-8

Shertzer, Howard G; Schneider, Scott N; Kendig, Eric L; Clegg, Deborah J; D'Alessio, David A; Johansson, Elisabet; Genter, Mary Beth 2009. Tetrahydroindenoindole inhibits the progression of diabetes in mice. Chemico-biological interactions, 177 1, 71-80

Kendig, Eric L; Schneider, Scott N; Clegg, Deborah J; Genter, Mary Beth; Shertzer, Howard G 2008. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochemical pharmacology, 76 2, 216-24

Shertzer, Howard G; Genter, Mary B; Talaska, Glenn; Curran, Christine P; Nebert, Daniel W; Dalton, Timothy P 2007. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis, 28 6, 1371-8

Genter, Mary Beth; Clay, Corey D; Dalton, Timothy P; Dong, Hongbin; Nebert, Daniel W; Shertzer, Howard G 2006. Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochemical and biophysical research communications, 342 4, 1375-81

Genter, Mary Beth; Marlowe, Jennifer; Kevin Kerzee, J; Dragin, Nadine; Puga, Alvaro; Dalton, Timothy P; Nebert, Daniel W 2006. Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochemical and biophysical research communications, 348 1, 120-3

Shertzer, Howard G; Genter, Mary Beth; Shen, Dongxiao; Nebert, Daniel W; Chen, Ying; Dalton, Timothy P 2006. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone. Toxicology and applied pharmacology, 217 3, 363-74

Genter, Mary Beth; Warner, Blake M; Krell, Hans-Willi; Bolon, Brad 2005. Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653. Toxicologic pathology, 33 5, 593-9

Genter, Mary Beth 2004. Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities. Journal of biochemical and molecular toxicology, 18 4, 239-44

Ling, Guoyu; Gu, Jun; Genter, Mary Beth; Zhuo, Xiaoliang; Ding, Xinxin 2004. Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chemico-biological interactions, 147 3, 247-58

Shertzer, Howard G; Clay, Corey D; Genter, Mary Beth; Chames, Mark C; Schneider, Scott N; Oakley, Greg G; Nebert, Daniel W; Dalton, Timothy P 2004. Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. Free radical biology & medicine, 36 5, 618-31

Zhang, Jianhua; Moseley, Amy; Jegga, Anil G; Gupta, Ashima; Witte, David P; Sartor, Maureen; Medvedovic, Mario; Williams, Sarah S; Ley-Ebert, Cathy; Coolen, Lique M; Egnaczyk, Gregory; Genter, Mary Beth; Lehman, Michael; Lingrel, Jerry; Maggio, John; Parysek, Linda; Walsh, Ryan; Xu, Ming; Aronow, Bruce J 2004. Neural system-enriched gene expression: relationship to biological pathways and neurological diseases. Physiological genomics, 18 2, 167-83

Genter, Mary Beth; Apparaju, Sandhya; Desai, Pankaj B 2002. Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of biochemical and molecular toxicology, 16 3, 128-34

Genter, Mary Beth; Burman, Dawn M; Vijayakumar, Soundarapandian; Ebert, Cathy L; Aronow, Bruce J 2002. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiological genomics, 12 1, 35-45

Senft, Albert P; Dalton, Timothy P; Nebert, Daniel W; Genter, Mary Beth; Puga, Alvaro; Hutchinson, Richard J; Kerzee, J Kevin; Uno, Shigeyuki; Shertzer, Howard G 2002. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free radical biology & medicine, 33 9, 1268-78

Uno, S; Dalton, T P; Shertzer, H G; Genter, M B; Warshawsky, D; Talaska, G; Nebert, D W 2001. Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochemical and biophysical research communications, 289 5, 1049-56

Dalton, T P; Dieter, M Z; Matlib, R S; Childs, N L; Shertzer, H G; Genter, M B; Nebert, D W 2000. Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochemical and biophysical research communications, 267 1, 184-9

Wetmore, B A; Mitchell, A D; Meyer, S A; Genter, M B 1999. Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat. Toxicological sciences : an official journal of the Society of Toxicology, 49 2, 202-12

Genter, M B; Liang, H C; Gu, J; Ding, X; Negishi, M; McKinnon, R A; Nebert, D W 1998. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. Biochemical pharmacology, 55 11, 1819-26

Gu, J; Zhang, Q Y; Genter, M B; Lipinskas, T W; Negishi, M; Nebert, D W; Ding, X 1998. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. The Journal of pharmacology and experimental therapeutics, 285 3, 1287-95

Millhorn, D E; Conforti, L; Beitner-Johnson, D; Zhu, W; Raymond, R; Filisko, T; Kobayashi, S; Peng, M; Genter, M B 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line. Advances in experimental medicine and biology, 410 , 135-42

Genter, M B; Owens, D M; Deamer, N J 1995. Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants. Chemical senses, 20 4, 385-92

Deamer, N J; O'Callaghan, J P; Genter, M B 1994. Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse. Neurotoxicology, 15 2, 287-93

Genter, M B; Deamer, N J; Cao, Y; Levi, P E 1994. Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat. Journal of biochemical toxicology, 9 1, 31-9

Genter, M B; Recio, L 1994. Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: relevance to butadiene-induced bone marrow toxicity. Fundamental and applied toxicology : official journal of the Society of Toxicology, 22 3, 469-73

Genter, M B; Szakál-Quin, G; Anderson, C W; Anthony, D C; Graham, D G 1987. Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy. Toxicology and applied pharmacology, 87 2, 351-62

Rosenberg, C K; Genter, M B; Szakál-Quin, G; Anthony, D C; Graham, D G 1987. dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat. Toxicology and applied pharmacology, 87 2, 363-73

Crofton, K M; Zhao, X; Sayre, L M; Genter, M B . Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats. Neurotoxicology and teratology, 18 3, 297-303

Deshpande, V S; Genter, M B; Jung, C; Desai, P B . Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery. European journal of drug metabolism and pharmacokinetics, 24 2, 177-82

Genter, M B; Deamer, N J; Blake, B L; Wesley, D S; Levi, P E . Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicologic pathology, 23 4, 477-86

Genter, Mary Beth . I am amazed at how time flies, and that we are now reading the fifth issue of International Journal of Toxicology for 2009! International journal of toxicology, 28 5, 339-40

Genter, Mary Beth; Goss, Kathleen H; Groden, Joanna . Strain-specific of alachlor on murine olfactory mucosal responses. Toxicologic pathology, 32 6, 719-25

Genter-St.Clair . , ,