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Department of

Environmental Health

Photo of Kim Cecil, PhD

Kim Cecil, PhD

Spectroscopist, Professor of Radiology, Pediatrics, Neuroscience and Environmental Health, Radiology Department Interim Scientific Director for Research, University of Cincinnati College of Medicine

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Peer Reviewed Publications

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Hoskinson, Kristen R; Wolfe, Kelly R; Yeates, Keith Owen; Mahone, E Mark; Cecil, Kim M; Ris, M Douglas 2017. Predicting changes in adaptive functioning and behavioral adjustment following treatment for a pediatric brain tumor: A report from the Brain Radiation Investigative Study Consortium. Psycho-oncology, ,

Li, Yue; Xie, Changchun; Murphy, Susan K; Skaar, David; Nye, Monica; Vidal, Adriana C; Cecil, Kim M; Dietrich, Kim N; Puga, Alvaro; Jirtle, Randy L; Hoyo, Cathrine 2016. Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. Environmental health perspectives, 124 5, 666-73

Raghubar, Kimberly P; Mahone, E Mark; Yeates, Keith Owen; Cecil, Kim M; Makola, Monwabisi; Ris, M Douglas 2016. Working memory and attention in pediatric brain tumor patients treated with and without radiation therapy. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, , 1-13

Cecil, Kim M; Mulkey, Sarah B; Ou, Xiawei; Glasier, Charles M 2015. Brain ketones detected by proton magnetic resonance spectroscopy in an infant with Ohtahara syndrome treated with ketogenic diet. Pediatric radiology, 45 1, 133-7

Clark, Joseph F; Cecil, Kim M 2015. Diagnostic methods and recommendations for the cerebral creatine deficiency syndromes. Pediatric research, 77 3, 398-405

Lindquist, Diana M; Beckwith, Travis; Cecil, Kim M; Sánchez-Martín, Francisco Javier; Landero-Figueroa, Julio; Puga, Alvaro 2015. Prenatal and early postnatal lead exposure in mice: neuroimaging findings. Quantitative imaging in medicine and surgery, 5 4, 511-8

Robinson, Kristen E; Wolfe, Kelly R; Yeates, Keith O; Mahone, E Mark; Cecil, Kim M; Ris, M Douglas 2015. Predictors of adaptive functioning and psychosocial adjustment in children with pediatric brain tumor: a report from the Brain Radiation Investigative Study Consortium. Pediatric blood & cancer, 62 3, 509-16

Sánchez-Martín, Francisco Javier; Lindquist, Diana M; Landero-Figueroa, Julio; Zhang, Xiang; Chen, Jing; Cecil, Kim M; Medvedovic, Mario; Puga, Alvaro 2015. Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead. Neurotoxicology, 46 , 92-100

Cecil, Kim M 2013. Proton magnetic resonance spectroscopy: technique for the neuroradiologist. Neuroimaging clinics of North America, 23 3, 381-92

Pearce, John M; Mahoney, Mary C; Lee, Jing-Huei; Chu, Wen-Jang; Cecil, Kim M; Strakowski, Stephen M; Komoroski, Richard A 2013. 1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer. Magma (New York, N.Y.), 26 3, 337-43

Maugans, Todd A; Farley, Chad; Altaye, Mekibib; Leach, James; Cecil, Kim M 2012. Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics, 129 1, 28-37

Cecil, Kim M; Dietrich, Kim N; Altaye, Mekibib; Egelhoff, John C; Lindquist, Diana M; Brubaker, Christopher J; Lanphear, Bruce P 2011. Proton magnetic resonance spectroscopy in adults with childhood lead exposure. Environmental health perspectives, 119 3, 403-8

Lindquist, Diana M; Dunn, R Scott; Cecil, Kim M 2011. Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study. Schizophrenia research, 128 1-3, 83-90

Brubaker, Christopher J; Dietrich, Kim N; Lanphear, Bruce P; Cecil, Kim M 2010. The influence of age of lead exposure on adult gray matter volume. Neurotoxicology, 31 3, 259-66

Brubaker, Christopher J; Schmithorst, Vincent J; Haynes, Erin N; Dietrich, Kim N; Egelhoff, John C; Lindquist, Diana M; Lanphear, Bruce P; Cecil, Kim M 2009. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology, 30 6, 867-75

Kurowski, Brad; Wade, Shari L; Cecil, Kim M; Walz, Nicolay C; Yuan, Weihong; Rajagopal, Akila; Holland, Scott K 2009. Correlation of diffusion tensor imaging with executive function measures after early childhood traumatic brain injury. Journal of pediatric rehabilitation medicine, 2 4, 273-83

Cecil, Kim M; Brubaker, Christopher J; Adler, Caleb M; Dietrich, Kim N; Altaye, Mekibib; Egelhoff, John C; Wessel, Stephanie; Elangovan, Ilayaraja; Hornung, Richard; Jarvis, Kelly; Lanphear, Bruce P 2008. Decreased brain volume in adults with childhood lead exposure. PLoS medicine, 5 5, e112

Patel, Nick C; Cecil, Kim M; Strakowski, Stephen M; Adler, Caleb M; DelBello, Melissa P 2008. Neurochemical alterations in adolescent bipolar depression: a proton magnetic resonance spectroscopy pilot study of the prefrontal cortex. Journal of child and adolescent psychopharmacology, 18 6, 623-7

Patel, Nick C; DelBello, Melissa P; Cecil, Kim M; Stanford, Kevin E; Adler, Caleb M; Strakowski, Stephen M 2008. Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium. Journal of child and adolescent psychopharmacology, 18 2, 132-9

Walz, Nicolay Chertkoff; Cecil, Kim M; Wade, Shari L; Michaud, Linda J 2008. Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes. Journal of neurotrauma, 25 2, 94-103

Cecil, Kim M 2006. MR spectroscopy of metabolic disorders. Neuroimaging clinics of North America, 16 1, 87-116, viii

Cecil, Kim M; Kos, Radmila Savcic 2006. Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disorders. Topics in magnetic resonance imaging : TMRI, 17 4, 275-93

DelBello, Melissa P; Cecil, Kim M; Adler, Caleb M; Daniels, John P; Strakowski, Stephen M 2006. Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 31 6, 1264-73

Patel, Nick C; DelBello, Melissa P; Cecil, Kim M; Adler, Caleb M; Bryan, Holly S; Stanford, Kevin E; Strakowski, Stephen M 2006. Lithium treatment effects on Myo-inositol in adolescents with bipolar depression. Biological psychiatry, 60 9, 998-1004

Yuan, Weihong; Holland, Scott K; Cecil, Kim M; Dietrich, Kim N; Wessel, Stephanie D; Altaye, Mekibib; Hornung, Richard W; Ris, M Douglas; Egelhoff, John C; Lanphear, Bruce P 2006. The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function. Pediatrics, 118 3, 971-7

Dinopoulos, A; Cecil, K M; Schapiro, M B; Papadimitriou, A; Hadjigeorgiou, G M; Wong, B; deGrauw, T; Egelhoff, J C 2005. Brain MRI and proton MRS findings in infants and children with respiratory chain defects. Neuropediatrics, 36 5, 290-301

Makoroff, Kathi L; Cecil, Kim M; Care, Marguerite; Ball, William S 2005. Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. Pediatric radiology, 35 7, 668-76

Newmeyer, Amy; Cecil, Kim M; Schapiro, Mark; Clark, Joseph F; Degrauw, Ton J 2005. Incidence of brain creatine transporter deficiency in males with developmental delay referred for brain magnetic resonance imaging. Journal of developmental and behavioral pediatrics : JDBP, 26 4, 276-82

Ris, M Douglas; Ryan, Patricia McDonough; Lamba, Michael; Brenemen, John; Cecil, Kim; Succop, Paul; Ball, William 2005. An improved methodology for modeling neurobehavioral late-effects of radiotherapy in pediatric brain tumors. Pediatric blood & cancer, 44 5, 487-93

Pyne-Geithman, Gail J; deGrauw, Ton J; Cecil, Kim M; Chuck, Gail; Lyons, Melissa A; Ishida, Yukisato; Clark, Joseph F 2004. Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case study. Molecular and cellular biochemistry, 262 1-2, 35-9

Schapiro, Mark; Cecil, Kim M; Doescher, Jason; Kiefer, Alaina M; Jones, Blaise V 2004. MR imaging and spectroscopy in juvenile Huntington disease. Pediatric radiology, 34 8, 640-3

Cecil, Kim M; DelBello, Melissa P; Sellars, Michele C; Strakowski, Stephen M 2003. Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. Journal of child and adolescent psychopharmacology, 13 4, 545-55

deGrauw, Ton J; Cecil, Kim M; Byars, Anna W; Salomons, Gajja S; Ball, William S; Jakobs, Cornelis 2003. The clinical syndrome of creatine transporter deficiency. Molecular and cellular biochemistry, 244 1-2, 45-8

Salomons, G S; van Dooren, S J M; Verhoeven, N M; Marsden, D; Schwartz, C; Cecil, K M; DeGrauw, T J; Jakobs, C 2003. X-linked creatine transporter defect: an overview. Journal of inherited metabolic disease, 26 2-3, 309-18

Cecil, Kim M; DelBello, Melissa P; Morey, Rachel; Strakowski, Stephen M 2002. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar disorders, 4 6, 357-65

deGrauw, T J; Salomons, G S; Cecil, K M; Chuck, G; Newmeyer, A; Schapiro, M B; Jakobs, C 2002. Congenital creatine transporter deficiency. Neuropediatrics, 33 5, 232-8

Cecil, K M; Jones, B V 2001. Magnetic resonance spectroscopy of the pediatric brain. Topics in magnetic resonance imaging : TMRI, 12 6, 435-52

Cecil, K M; Salomons, G S; Ball, W S; Wong, B; Chuck, G; Verhoeven, N M; Jakobs, C; DeGrauw, T J 2001. Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect? Annals of neurology, 49 3, 401-4

Cecil, K M; Schnall, M D; Siegelman, E S; Lenkinski, R E 2001. The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy. Breast cancer research and treatment, 68 1, 45-54

Salomons, G S; van Dooren, S J; Verhoeven, N M; Cecil, K M; Ball, W S; Degrauw, T J; Jakobs, C 2001. X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome. American journal of human genetics, 68 6, 1497-500

Sinson, G; Bagley, L J; Cecil, K M; Torchia, M; McGowan, J C; Lenkinski, R E; McIntosh, T K; Grossman, R I 2001. Magnetization transfer imaging and proton MR spectroscopy in the evaluation of axonal injury: correlation with clinical outcome after traumatic brain injury. AJNR. American journal of neuroradiology, 22 1, 143-51

Trope, I; Lopez-Villegas, D; Cecil, K M; Lenkinski, R E 2001. Exposure to lead appears to selectively alter metabolism of cortical gray matter. Pediatrics, 107 6, 1437-42

Bagley, L J; Cecil, K M 2000. MR and PET assist in workup of patients with epilepsy. Diagnostic imaging, 22 1, 55-9

Cecil, K M; Jones, B V; Williams, S; Hedlund, G L 2000. CT, MRI and MRS of Epstein-Barr virus infection: case report. Neuroradiology, 42 8, 619-22

McGowan, J C; Yang, J H; Plotkin, R C; Grossman, R I; Umile, E M; Cecil, K M; Bagley, L J 2000. Magnetization transfer imaging in the detection of injury associated with mild head trauma. AJNR. American journal of neuroradiology, 21 5, 875-80

Cecil, K M; Lenkinski, R E; Gur, R E; Gur, R C 1999. Proton magnetic resonance spectroscopy in the frontal and temporal lobes of neuroleptic naive patients with schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 20 2, 131-40

McGowan, J C; McCormack, T M; Grossman, R I; Mendonça, R; Chen, X H; Berlin, J A; Meaney, D F; Xu, B N; Cecil, K M; McIntosh, T K; Smith, D H 1999. Diffuse axonal pathology detected with magnetization transfer imaging following brain injury in the pig. Magnetic resonance in medicine, 41 4, 727-33

Quan, D; Hackney, D B; Pruitt, A A; Lenkinski, R E; Cecil, K M 1999. Transient MRI enhancement in a patient with seizures and previously resected glioma: use of MRS. Neurology, 53 1, 211-3

Cecil, K M; Hills, E C; Sandel, M E; Smith, D H; McIntosh, T K; Mannon, L J; Sinson, G P; Bagley, L J; Grossman, R I; Lenkinski, R E 1998. Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients. Journal of neurosurgery, 88 5, 795-801

Cecil, K M; Lenkinski, R E 1998. Proton MR spectroscopy in inflammatory and infectious brain disorders. Neuroimaging clinics of North America, 8 4, 863-80

Cecil, K M; Lenkinski, R E; Meaney, D F; McIntosh, T K; Smith, D H 1998. High-field proton magnetic resonance spectroscopy of a swine model for axonal injury. Journal of neurochemistry, 70 5, 2038-44

Roebuck, J R; Cecil, K M; Schnall, M D; Lenkinski, R E 1998. Human breast lesions: characterization with proton MR spectroscopy. Radiology, 209 1, 269-75

Smith, D H; Cecil, K M; Meaney, D F; Chen, X H; McIntosh, T K; Gennarelli, T A; Lenkinski, R E 1998. Magnetic resonance spectroscopy of diffuse brain trauma in the pig. Journal of neurotrauma, 15 9, 665-74

Rubin, Y; Cecil, K; Wehrli, S; McIntosh, T K; Lenkinski, R E; Smith, D H 1997. High-resolution 1H NMR spectroscopy following experimental brain trauma. Journal of neurotrauma, 14 7, 441-9

Cecil, Kim M; DeGrauw, Ton J; Salomons, Gajja S; Jakobs, Cornelis; Egelhoff, John C; Clark, Joseph F . Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiency. Journal of computer assisted tomography, 27 1, 44-7

Cecil, Kim M; Halsted, Mark J; Schapiro, Mark; Dinopoulos, Argirios; Jones, Blaise V . Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy. Journal of computer assisted tomography, 26 6, 948-51

Cecil, Kim M; Lin, Alexander; Ross, Brian D; Egelhoff, John C . Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation Journal of Computer Assisted Tomography, 26 5, 818-20

Dinopoulos, A; Gorospe, J R; Egelhoff, J C; Cecil, K M; Nicolaidou, P; Morehart, P; DeGrauw, T . Discrepancy between neuroimaging findings and clinical phenotype in Alexander disease. AJNR. American journal of neuroradiology, 27 10, 2088-92

Miles, Lili; DeGrauw, Ton J; Dinopoulos, Argirios; Cecil, Kim M; van der Knaap, Marjo S; Bove, Kevin E . Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 12 3, 180-6

Molenda, J J; Jones, M M; Cecil, K M; Basinger, M A . Structure/activity relationships affecting the ability of monoanionic 3-hydroxyprid-4-ones to mobilize iron. Chemical research in toxicology, 7 6, 815-22

Yuan, W; Holland, S K; Schmithorst, V J; Walz, N C; Cecil, K M; Jones, B V; Karunanayaka, P; Michaud, L; Wade, S L . Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR. American journal of neuroradiology, 28 10, 1919-25