Led by Kelly Brunst, Ph.D. and Jack Rubinstein, MD, the Integrative Health Sciences Facilities Core (IHSFC), now known as the Translational Research Support Core (TRSC), facilitates investigations that enhance bidirectional translation of research on environmental factors in disease causation. Core aims are accomplished through expert consultative services in medicine, epidemiology, statistics, exposure assessment, and informatics tools, as well as clinical research conferences that highlight opportunities for translational research in environmental health. Our goal is to accelerate the transfer of basic biomedical knowledge from the laboratory to applications in prevention, early detection, and treatment, including public policy changes toward improved environmental and human health. We provide consultations on environmental epidemiology, data management & sharing (see, e.g., below), and both traditional and cutting-edge statistical approaches, including analysis of microarray and deep sequencing data, in conjunction with the CEG Bioinformatics Core.

Methods to Better Clarify Your DNA Methylation Data
We are pleased to share here some of the information shared by Dr. Corina Lesseur, Assistant Professor, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mt. Sinai, and by Dr. Liang Niu, Associate Professor, CEG Bioinformatics Core, during our February 2024 DNA Methylation Workshop.  Dr. Lesseur discussed Post EWAS platforms for interrogating results. Dr. Niu explored ipDMR: Identification of differentially methylated regions with interval P-values.

Click here to view Post EWAS Platforms

Click here to view Niu slides: ipDMR

Data Management and Sharing (DMS) | Biospecimen Sharing | Training and Resources

• Data Management & Sharing Plan Hints (Hint sheet, PDF)
• Data Management & Sharing Plan Hints (Slides, PDF)
• NIH Policy for Data Management and Sharing (PDF)
• NIH Policy for Data Management and Sharing Webinar (PPT)
• Data and Biospecimen Sharing Workshop, 2015 Oct 15 (Videos)
• The many benefits of sharing (Video: Susan Pinney, PhD)
• (Setting the stage for sharing (PPT) and Setting the stage for sharing (PDF) Susan Pinney, PhD)
• Sample sharing policy: Procedures to access FCC database & biosamples (PDF)
• Public repositories for deposition and sharing of "omics" data (Video: Scott Langevin, PhD)
• Public repositories for deposition and sharing of "omics" data (PPT: Scott Langevin, PhD)  
• NIH Genomic Data Sharing Policy (PDF)
• Genomic Data Sharing: Supplemental Information (PDF)
• The HOME Study (PPT: Kimberly Yolton, PhD)

Further Resources 

• TRSC Pannel of Experts Expert consultations on study design, human subjects, et al.
  
• Fernald Community Cohort
• Human Biomonitoring Resources
• MEB-Labs Database
  

Human Subjects Studies and Human Clinical Trials Research

Navigating ASSIST (MP4): Application Submission System & Interface for Submission Tracking (ASSIST) used by NIH (including NIEHS) and other Public Health Service agencies. Required human subjects enrollment reporting, etc., online workshop with NIEHS specialist Martha Barnes, MS.