Education/CredentialsPostdoctoral Research Fellowship : University of North Carolina at Chapel Hill (Rheumatology and Immunology )Postdoctoral Research Fellowship : National Jewish Hospital & Research Center (Department of Pediatrics )Doctoral Degree: University of Alabama Medical Center (Microbiology)Master's Degree: University of Alabama (Cell and Molecular Biology)Bachelor's Degree: Emory University Contact Information Email newmansl@ucmail.uc.edu Research InterestsThe Role of Human Neutrophils, Monocyte/Macrophages and Dendritic Cells in Host Defense Against Medically Important Fungal Pathogens, Including Histoplasma Capsulatum, Candida Albicans, Blastomyces Dermatitidis and Cryptococcus Neoformans, Define the Role of Extracellular Matrix Proteins and Cytokines in Activating Macrophage Anti-Histoplasma Cctivity, Define the Interactions Between Dendritic Cells and Fungi as to Their Phagocytic Capacity and Ability to Present Fungal Antigens to T cells, and the R... Peer Reviewed Publications Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S 2011. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS pathogens, 7 10, e1002330Hilty, Jeremy; George Smulian, A; Newman, Simon L 2011. Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages. Medical mycology : official publication of the International Society for Human and Animal Mycology, , Newman, Simon L; Lemen, Wendy; Smulian, Alan G 2011. Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts. Medical mycology : official publication of the International Society for Human and Animal Mycology, 49 4, 356-64Gomez, Francisco J; Pilcher-Roberts, Robyn; Alborzi, Arash; Newman, Simon L 2008. Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5. Journal of immunology (Baltimore, Md. : 1950), 181 10, 7106-14Hilty, Jeremy; Smulian, A George; Newman, Simon L 2008. The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis. Molecular microbiology, 70 1, 127-39Newman, Simon L; Gootee, Lisa; Hilty, Jeremy; Morris, Randall E 2006. Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 176 3, 1806-13Gildea, Lucy A; Ciraolo, Georgianne M; Morris, Randal E; Newman, Simon L 2005. Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion. Infection and immunity, 73 10, 6803-11Newman, Simon L 2005. Interaction of Histoplasma capsulatum with human macrophages, dendritic cells, and neutrophils. Methods in molecular medicine, 118 , 181-91Newman, Simon L; Bhugra, Bindu; Holly, Angela; Morris, Randal E 2005. Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion. Infection and immunity, 73 2, 770-7Long, Kristin H; Gomez, Francisco J; Morris, Randall E; Newman, Simon L 2003. Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. Journal of immunology (Baltimore, Md. : 1950), 170 1, 487-94
Research InterestsThe Role of Human Neutrophils, Monocyte/Macrophages and Dendritic Cells in Host Defense Against Medically Important Fungal Pathogens, Including Histoplasma Capsulatum, Candida Albicans, Blastomyces Dermatitidis and Cryptococcus Neoformans, Define the Role of Extracellular Matrix Proteins and Cytokines in Activating Macrophage Anti-Histoplasma Cctivity, Define the Interactions Between Dendritic Cells and Fungi as to Their Phagocytic Capacity and Ability to Present Fungal Antigens to T cells, and the R...
Peer Reviewed Publications Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S 2011. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS pathogens, 7 10, e1002330Hilty, Jeremy; George Smulian, A; Newman, Simon L 2011. Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages. Medical mycology : official publication of the International Society for Human and Animal Mycology, , Newman, Simon L; Lemen, Wendy; Smulian, Alan G 2011. Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts. Medical mycology : official publication of the International Society for Human and Animal Mycology, 49 4, 356-64Gomez, Francisco J; Pilcher-Roberts, Robyn; Alborzi, Arash; Newman, Simon L 2008. Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5. Journal of immunology (Baltimore, Md. : 1950), 181 10, 7106-14Hilty, Jeremy; Smulian, A George; Newman, Simon L 2008. The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis. Molecular microbiology, 70 1, 127-39Newman, Simon L; Gootee, Lisa; Hilty, Jeremy; Morris, Randall E 2006. Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 176 3, 1806-13Gildea, Lucy A; Ciraolo, Georgianne M; Morris, Randal E; Newman, Simon L 2005. Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion. Infection and immunity, 73 10, 6803-11Newman, Simon L 2005. Interaction of Histoplasma capsulatum with human macrophages, dendritic cells, and neutrophils. Methods in molecular medicine, 118 , 181-91Newman, Simon L; Bhugra, Bindu; Holly, Angela; Morris, Randal E 2005. Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion. Infection and immunity, 73 2, 770-7Long, Kristin H; Gomez, Francisco J; Morris, Randall E; Newman, Simon L 2003. Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. Journal of immunology (Baltimore, Md. : 1950), 170 1, 487-94
Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S 2011. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS pathogens, 7 10, e1002330Hilty, Jeremy; George Smulian, A; Newman, Simon L 2011. Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages. Medical mycology : official publication of the International Society for Human and Animal Mycology, , Newman, Simon L; Lemen, Wendy; Smulian, Alan G 2011. Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts. Medical mycology : official publication of the International Society for Human and Animal Mycology, 49 4, 356-64Gomez, Francisco J; Pilcher-Roberts, Robyn; Alborzi, Arash; Newman, Simon L 2008. Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5. Journal of immunology (Baltimore, Md. : 1950), 181 10, 7106-14Hilty, Jeremy; Smulian, A George; Newman, Simon L 2008. The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis. Molecular microbiology, 70 1, 127-39Newman, Simon L; Gootee, Lisa; Hilty, Jeremy; Morris, Randall E 2006. Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 176 3, 1806-13Gildea, Lucy A; Ciraolo, Georgianne M; Morris, Randal E; Newman, Simon L 2005. Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion. Infection and immunity, 73 10, 6803-11Newman, Simon L 2005. Interaction of Histoplasma capsulatum with human macrophages, dendritic cells, and neutrophils. Methods in molecular medicine, 118 , 181-91Newman, Simon L; Bhugra, Bindu; Holly, Angela; Morris, Randal E 2005. Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion. Infection and immunity, 73 2, 770-7Long, Kristin H; Gomez, Francisco J; Morris, Randall E; Newman, Simon L 2003. Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. Journal of immunology (Baltimore, Md. : 1950), 170 1, 487-94