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Photo of  Soma Sengupta, MD,PhD,FRCP

Soma Sengupta, MD,PhD,FRCP

Harold C. Schott Endowed Brain Tumor Molecular Therapeutics Chair

Education/Credentials
  • Medical Degree: University of Cambridge
  • Doctoral Degree: University of Cambridge (Biochemistry)
  • Bachelor's Degree: University of Wales (Biochemistry)
Board Certifications & Licenses

United Council for Neurologic Subspecialties (Certification Date: 2015-08-31)
American Board of Psychiatry and Neurology (Neurology) (Certification Date: 2011-09-22) - (Recertification Date: 2022-01-15)

Contact Information

Clinical Interests

Neurology

Brain Tumor

Meningioma

Peer Reviewed Publications

Bachir, Suha; Shah, Sanjit; Shapiro, Scott; Koehler, Abigail; Mahammedi, Abdelkader; Samy, Ravi N; Zuccarello, Mario; Schorry, Elizabeth; Sengupta, Soma 2021. Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis. International journal of molecular sciences, 22 2,

Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R; Qi, Xiaoyang; Read, Renee D; Sasaki, Atsuo T; Gawali, Vaibhavkumar S; Toukam, Donatien K; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A; Sengupta, Soma 2021. Reuse of Molecules for Glioblastoma Therapy. Pharmaceuticals (Basel, Switzerland), 14 2,

Pomeranz Krummel, Daniel A; Nasti, Tahseen H; Kaluzova, Milota; Kallay, Laura; Bhattacharya, Debanjan; Melms, Johannes C; Izar, Benjamin; Xu, Maxwell; Burnham, Andre; Ahmed, Taukir; Li, Guanguan; Lawson, David; Kowalski, Jeanne; Cao, Yichun; Switchenko, Jeffrey M; Ionascu, Dan; Cook, James M; Medvedovic, Mario; Jenkins, Andrew; Khan, Mohammad K; Sengupta, Soma 2021. Melanoma Cell Intrinsic GABAA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity. International journal of radiation oncology, biology, physics, 109 4, 1040-1053

Worrell, Stacey L; Kirschner, Michelle L; Shatz, Rhonna S; Sengupta, Soma; Erickson, Melissa G 2021. Interdisciplinary Approaches to Survivorship with a Focus on the Low-grade and Benign Brain Tumor Populations. Current oncology reports, 23 2, 19

Bhattacharya, Debanjan; Pomeroy, Scott L; Pomeranz Krummel, Daniel A; Sengupta, Soma 2020. Epigenetics and survivorship in pediatric brain tumor patients. Journal of neuro-oncology, 150 1, 77-83

Chakraborty, Samrat; Dlie, Zewdu Yilma; Mukherjee, Biswajit; Besra, Shila Elizabeth; Sengupta, Soma; Sen, Ramkrishna; Mukherjee, Alankar 2020. A Comparative Investigation of the Ability of Various Aptamer-Functionalized Drug Nanocarriers to Induce Selective Apoptosis in Neoplastic Hepatocytes: In Vitro and In Vivo Outcome. AAPS PharmSciTech, 21 3, 89

Mahammedi, Abdelkader; Saba, Luca; Vagal, Achala; Leali, Michela; Rossi, Andrea; Gaskill, Mary; Sengupta, Soma; Zhang, Bin; Carriero, Alessandro; Bachir, Suha; Crivelli, Paola; Paschè, Alessio; Premi, Enrico; Padovani, Alessandro; Gasparotti, Roberto 2020. Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study. Radiology, 297 2, E270-E273

Pomeranz Krummel, Daniel A; Nasti, Tahseen H; Izar, Benjamin; Press, Robert H; Xu, Maxwell; Lowder, Lindsey; Kallay, Laura; Rupji, Manali; Rosen, Havi; Su, Jing; Curran, Walter; Olson, Jeffrey; Weinberg, Brent; Schniederjan, Matthew; Neill, Stewart; Lawson, David; Kowalski, Jeanne; Khan, Mohammad K; Sengupta, Soma 2020. Impact of Sequencing Radiation Therapy and Immune Checkpoint Inhibitors in the Treatment of Melanoma Brain Metastases. International journal of radiation oncology, biology, physics, ,

Press, Robert H; Shafer, Sarah L; Jiang, Renjian; Buchwald, Zachary S; Abugideiri, Mustafa; Tian, Sibo; Morgan, Tiffany M; Behera, Madhusmita; Sengupta, Soma; Voloschin, Alfredo D; Olson, Jeffrey J; Hasan, Shaakir; Blumenthal, Deborah T; Curran, Walter J; Eaton, Bree R; Shu, Hui-Kuo G; Zhong, Jim 2020. Optimal timing of chemoradiotherapy after surgical resection of glioblastoma: Stratification by validated prognostic classification. Cancer, ,

Cicka, Danielle; Ford, Charles Lester; Templin, Erica; Pitts, Zachary; Gurbani, Saumya; Eaton, Bree; Lowder, Lindsey; Olson, Jeffrey; Weinberg, Brent D; Shim, Hyunsuk; Sengupta, Soma 2019. Presentation of treatment effect in glioblastoma after dose-escalation radiation therapy. Oxford medical case reports, 2019 9, omz085

Kallay, Laura; Keskin, Havva; Ross, Alexandra; Rupji, Manali; Moody, Olivia A; Wang, Xin; Li, Guanguan; Ahmed, Taukir; Rashid, Farjana; Stephen, Michael Rajesh; Cottrill, Kirsten A; Nuckols, T Austin; Xu, Maxwell; Martinson, Deborah E; Tranghese, Frank; Pei, Yanxin; Cook, James M; Kowalski, Jeanne; Taylor, Michael D; Jenkins, Andrew; Pomeranz Krummel, Daniel A; Sengupta, Soma 2019. Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death. Journal of neuro-oncology, 142 3, 411-422

Karschnia, Philipp; Sengupta, Soma; Dietrich, Jorg 2019. MRI findings in trigeminal neuropathy: bilateral Meckel's cave lesions. Acta neurologica Belgica, ,

Lowder, Lindsey; Hauenstein, Jennifer; Woods, Ashley; Chen, Hsiao-Rong; Rupji, Manali; Kowalski, Jeanne; Olson, Jeffrey J; Saxe, Debra; Schniederjan, Matthew; Neill, Stewart; Weinberg, Brent; Sengupta, Soma 2019. Gliosarcoma: distinct molecular pathways and genomic alterations identified by DNA copy number/SNP microarray analysis. Journal of neuro-oncology, 143 3, 381-392

Sadigh, Gelareh; Gallagher, Kathleen; Obenchain, Jennifer; Benson, Al; Mitchell, Edith; Sengupta, Soma; Carlos, Ruth C 2019. Pilot Feasibility Study of an Oncology Financial Navigation Program in Brain Cancer Patients. Journal of the American College of Radiology : JACR, 16 10, 1420-1424

Archer, Tenley C; Sengupta, Soma; Pomeroy, Scott L 2018. Brain cancer genomics and epigenomics. Handbook of clinical neurology, 148 , 785-797

Clark, Amanda R; Calligaris, David; Regan, Michael S; Pomeranz Krummel, Daniel; Agar, Jeffrey N; Kallay, Laura; MacDonald, Tobey; Schniederjan, Matthew; Santagata, Sandro; Pomeroy, Scott L; Agar, Nathalie Y R; Sengupta, Soma 2018. Rapid discrimination of pediatric brain tumors by mass spectrometry imaging. Journal of neuro-oncology, 140 2, 269-279

Doyle, Sean P; Gurbani, Saumya S; Ross, Alexandra S; Rosen, Havi; Barrett, Charlice Dunn; Olson, Jeffrey J; Shim, Hyunsuk; Shu, Hui-Kuo; Sengupta, Soma 2018. The role of erlotinib and the Optune device in a patient with an epidermal growth factor receptor viii amplified glioblastoma. Oxford medical case reports, 2018 12, omy095

Melms, Johannes C; Ho, Ka-Wai; Thummalapalli, Rohit; Tyler, Janice; Brinker, Titus Josef; Singh, Veena; Sengupta, Soma; Mier, James; Izar, Benjamin 2018. Implementation of cell-free tumor DNA sequencing from the cerebrospinal fluid to guide treatment in a patient with primary leptomeningeal melanoma: A case report. Molecular and clinical oncology, 9 1, 58-61

Sengupta, Soma; Pomeranz Krummel, Daniel; Pomeroy, Scott 2017. The evolution of medulloblastoma therapy to personalized medicine. F1000Research, 6 , 490

Jonas, Oliver; Calligaris, David; Methuku, Kashi Reddy; Poe, Michael M; Francois, Jessica Pierre; Tranghese, Frank; Changelian, Armen; Sieghart, Werner; Ernst, Margot; Krummel, Daniel A Pomeranz; Cook, James M; Pomeroy, Scott L; Cima, Michael; Agar, Nathalie Y R; Langer, Robert; Sengupta, Soma 2016. First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. Journal of biomedical nanotechnology, 12 6, 1297-302

Sengupta, Soma; Voloschin, Alfredo 2016. Redefining Management of Adult Low-Grade Gliomas. Journal of oncology practice, 12 12, 1244-1245

Ippen, Franziska M; Mahadevan, Anand; Wong, Eric T; Uhlmann, Erik J; Sengupta, Soma; Kasper, Ekkehard M 2015. Stereotactic Radiosurgery for Renal Cancer Brain Metastasis: Prognostic Factors and the Role of Whole-Brain Radiation and Surgical Resection. Journal of oncology, 2015 , 636918

Mahadevan, Anand; Sampson, Carrie; LaRosa, Salvatore; Floyd, Scott R; Wong, Eric T; Uhlmann, Erik J; Sengupta, Soma; Kasper, Ekkehard M 2015. Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy. Radiation oncology (London, England), 10 , 245

Christman, Mitalee P; Turbett, Sarah E; Sengupta, Soma; Bakhadirov, Khamidulla U; Williamson, Craig A; Nayak, Lakshmi; Milligan, Tracey; Katz, Joel T 2014. Recurrence of herpes simplex encephalitis associated with temozolomide chemoradiation for malignant glioma: a case report and review of the literature. Oxford medical case reports, 2014 1, 1-4

Sengupta, Soma; Benkers, Tara; Blitstein, Marisa; Palmer, Edwin; Plotkin, Scott R; Abramson, Jeremy S 2014. Posterior reversible encephalopathy syndrome (PRES) complicating newly-diagnosed diffuse large B-cell lymphoma. Clinical lymphoma, myeloma & leukemia, 14 4, e111-3

Sengupta, Soma; Weeraratne, Shyamal D; Cho, Yoon-Jae; Pomeroy, Scott L 2014. Could ?5-GABA-A receptor activation be used as a target for managing medulloblastomas? CNS oncology, 3 4, 245-7

Sengupta, Soma; Weeraratne, Shyamal Dilhan; Sun, Hongyu; Phallen, Jillian; Rallapalli, Sundari K; Teider, Natalia; Kosaras, Bela; Amani, Vladimir; Pierre-Francois, Jessica; Tang, Yujie; Nguyen, Brian; Yu, Furong; Schubert, Simone; Balansay, Brianna; Mathios, Dimitris; Lechpammer, Mirna; Archer, Tenley C; Tran, Phuoc; Reimer, Richard J; Cook, James M; Lim, Michael; Jensen, Frances E; Pomeroy, Scott L; Cho, Yoon-Jae 2014. ?5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Acta neuropathologica, 127 4, 593-603

Sengupta, Soma; Tarsy, Daniel; Joyce, Robin; Jeyapalan, Suriya 2013. Novel use of dual immunomodulation for treating stiff-person syndrome, cerebellar variant. Movement disorders : official journal of the Movement Disorder Society, 28 13, 1905-6

Pugh, Trevor J; Weeraratne, Shyamal Dilhan; Archer, Tenley C; Pomeranz Krummel, Daniel A; Auclair, Daniel; Bochicchio, James; Carneiro, Mauricio O; Carter, Scott L; Cibulskis, Kristian; Erlich, Rachel L; Greulich, Heidi; Lawrence, Michael S; Lennon, Niall J; McKenna, Aaron; Meldrim, James; Ramos, Alex H; Ross, Michael G; Russ, Carsten; Shefler, Erica; Sivachenko, Andrey; Sogoloff, Brian; Stojanov, Petar; Tamayo, Pablo; Mesirov, Jill P; Amani, Vladimir; Teider, Natalia; Sengupta, Soma; Francois, Jessica Pierre; Northcott, Paul A; Taylor, Michael D; Yu, Furong; Crabtree, Gerald R; Kautzman, Amanda G; Gabriel, Stacey B; Getz, Gad; Jäger, Natalie; Jones, David T W; Lichter, Peter; Pfister, Stefan M; Roberts, Thomas M; Meyerson, Matthew; Pomeroy, Scott L; Cho, Yoon-Jae 2012. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature, 488 7409, 106-10

Weeraratne, Shyamal Dilhan; Amani, Vladimir; Teider, Natalia; Pierre-Francois, Jessica; Winter, Dominic; Kye, Min Jeong; Sengupta, Soma; Archer, Tenley; Remke, Marc; Bai, Alfa H C; Warren, Peter; Pfister, Stefan M; Steen, Judith A J; Pomeroy, Scott L; Cho, Yoon-Jae 2012. Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma. Acta neuropathologica, 123 4, 539-52

Maski, Kiran P; Sengupta, Soma; Silvera, Michelle; Rivkin, Michael J 2011. Intracranial artery dissection in an adolescent with Marfan syndrome. Pediatric neurology, 45 1, 39-41

Sengupta, Soma; Pedersen, Nigel P; Davis, James E; Rojas, Rafael; Reddy, Hasini; Kasper, Ekkehard; Greenstein, Patricia; Wong, Eric T 2011. Illusion of stroke: intravascular lymphomatosis. Reviews in neurological diseases, 8 3-4, e107-13

Nathan, James A; Sengupta, Soma; Wood, Stephen A; Admon, Arie; Markson, Gabriel; Sanderson, Chris; Lehner, Paul J 2008. The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic (Copenhagen, Denmark), 9 7, 1130-45

Hewitt, E W; Gupta, S S; Lehner, P J 2001. The human cytomegalovirus gene product US6 inhibits ATP binding by TAP. The EMBO journal, 20 3, 387-96

Karttunen, J T; Lehner, P J; Gupta, S S; Hewitt, E W; Cresswell, P 2001. Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP). Proceedings of the National Academy of Sciences of the United States of America, 98 13, 7431-6

dos Santos, C F; DeWitt, N D; Gupta, S S; Allen, K E; Slayman, C W 2000. Epitope-tagged constructs of the yeast plasma-membrane H(+)-ATPase. IUBMB life, 49 2, 153-9

Gupta, S S; Canessa, C M 2000. Heterologous expression of a mammalian epithelial sodium channel in yeast. FEBS letters, 481 1, 77-80

Gupta, S S; DeWitt, N D; Allen, K E; Slayman, C W 1998. Evidence for a salt bridge between transmembrane segments 5 and 6 of the yeast plasma-membrane H+-ATPase. The Journal of biological chemistry, 273 51, 34328-34

Sen Gupta, S; Kerridge, D; Chevallier, M R 1995. A purine permease in Candida glabrata. FEMS microbiology letters, 126 1, 93-6

Vanden Bossche, H; Warnock, D W; Dupont, B; Kerridge, D; Sen Gupta, S; Improvisi, L; Marichal, P; Odds, F C; Provost, F; Ronin, O 1994. Mechanisms and clinical impact of antifungal drug resistance. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 32 Suppl 1 , 189-202

Gallia, Gary L; Holdhoff, Matthias; Brem, Henry; Joshi, Avadhut D; Hann, Christine L; Bai, Ren-Yuan; Staedtke, Verena; Blakeley, Jaishri O; Sengupta, Soma; Jarrell, T Che; Wollett, Jessica; Szajna, Kelly; Helie, Nicole; Mattox, Austin K; Ye, Xiaobu; Rudek, Michelle A; Riggins, Gregory J . Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial. Neuro-oncology advances, 3 1, vdaa154