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Photo of  Ambikaipakan Balasubramaniam, PhD

Ambikaipakan Balasubramaniam, PhD

Professor-Emeritus

COM Surgery Research

Education/Credentials
  • Bachelor's Degree: University of Sri Lanka
  • Doctoral Degree: University of Exeter
  • Postdoctoral Research: University of Iowa
  • Postdoctoral Research: University of Illinois
  • Postdoctoral Research: University of Cincinnati
Research Interests

Pharmacology of Neurogastrointestinal Hormones

Contact Information
  • Medical Sciences Building
  • Department of Surgery
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-3819
  • Email ambi.bala@uc.edu

Peer Reviewed Publications

Balasubramaniam, Ambikaipakan; Sheriff, Sulaiman; Friend, Lou Ann; James, J Howard 2018. Phosphodiesterase (PDE) 4B Knock-out Prevents Skeletal Muscle Atrophy in Rats with Burn Injury. American journal of physiology. Regulatory, integrative and comparative physiology, ,

Parker, Michael S; Balasubramaniam, Ambikaipakan; Parker, Steven L 2018. The Expansion Segments of Human 28S rRNA Match MicroRNAs Much Above 18S rRNA or Core Segments. MicroRNA (Shariqah, United Arab Emirates), 7 2, 128-137

Parker, Michael S; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Parker, Steven L 2018. The Expansion Segments of 28S Ribosomal RNA Extensively Match Human Messenger RNAs. Frontiers in genetics, 9 , 66

Parker, Michael S; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Parker, Steven L 2017. Canonical microRNA matching differs greatly across groups of G-protein coupled receptor mRNAs. MicroRNA (Shariqah, United Arab Emirates), ,

Portelli, Jeanelle; Meurs, Alfred; Bihel, Frederic; Hammoud, Hassan; Schmitt, Martine; De Kock, Joery; Utard, Valerie; Humbert, Jean-Paul; Bertin, Isabelle; Buffel, Ine; Coppens, Jessica; Tourwe, Dirk; Maes, Veronique; De Prins, An; Vanhaecke, Tamara; Massie, Ann; Balasubramaniam, Ambikaipakan; Boon, Paul; Bourguignon, Jean-Jacques; Simonin, Frederic; Smolders, Ilse 2015. Neuropeptide FF receptors as novel targets for limbic seizure attenuation. Neuropharmacology, 95 , 415-23

Joshi, Rashika; Kadeer, Nijiati; Sheriff, Sulaiman; Friend, Lou Ann; James, J Howard; Balasubramaniam, Ambikaipakan 2014. Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Molecular and cellular endocrinology, 393 1-2, 152-63

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Park, Edwards A; Sallee, Floyd R; Parker, Steven L 2014. Dimers of G-protein coupled receptors as versatile storage and response units. International journal of molecular sciences, 15 3, 4856-77

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Park, Edwards A; Parker, Steven L 2014. On the expansion of ribosomal proteins and RNAs in eukaryotes. Amino acids, 46 7, 1589-604

Sheriff, Sulaiman; Kadeer, Nijiati; Friend, Lou Ann; James, J Howard; Alexander, J Wesley; Balasubramaniam, Ambikaipakan 2014. Des-acyl-ghrelin (DAG) normalizes hyperlactacidemia and improves survival in a lethal rat model of burn trauma. Peptides, 60 , 1-7

Meurs, Alfred; Portelli, Jeanelle; Clinckers, Ralph; Balasubramaniam, Ambikaipakan; Michotte, Yvette; Smolders, Ilse 2012. Neuropeptide Y increases in vivo hippocampal extracellular glutamate levels through Y1 receptor activation. Neuroscience letters, 510 2, 143-7

Parker, Michael S; Balasubramaniam, Ambikaipakan; Parker, Steven L 2012. On the segregation of protein ionic residues by charge type. Amino acids, 43 6, 2231-47

Sheriff, Sulaiman; Kadeer, Nijiati; Joshi, Rashika; Friend, Lou Ann; James, J Howard; Balasubramaniam, Ambikaipakan 2012. Des-acyl ghrelin exhibits pro-anabolic and anti-catabolic effects on C2C12 myotubes exposed to cytokines and reduces burn-induced muscle proteolysis in rats. Molecular and cellular endocrinology, 351 2, 286-95

Watanabe, Miki; Sheriff, Sulaiman; Lewis, Kenneth B; Cho, Junho; Tinch, Stuart L; Balasubramaniam, Ambikaipakan; Kennedy, Michael A 2012. Metabolic Profiling Comparison of Human Pancreatic Ductal Epithelial Cells and Three Pancreatic Cancer Cell Lines using NMR Based Metabonomics. Journal of molecular biomarkers & diagnosis, 3 2,

Watanabe, Miki; Sheriff, Sulaiman; Lewis, Kenneth B; Tinch, Stuart L; Cho, Junho; Balasubramaniam, Ambikaipakan; Kennedy, Michael A 2012. HMGA-targeted phosphorothioate DNA aptamers increase sensitivity to gemcitabine chemotherapy in human pancreatic cancer cell lines. Cancer letters, 315 1, 18-27

Estes, Anne-Marie; McAllen, Kathleen; Parker, Michael S; Sah, Renu; Sweatman, Trevor; Park, Edwards A; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Walker, Mary W; Parker, Steven L 2011. Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers. Amino acids, 40 2, 371-80

Li, Jiang-Bo; Asakawa, Akihiro; Terashi, Mutsumi; Cheng, KaiChun; Chaolu, Huhe; Zoshiki, Takahiro; Ushikai, Miharu; Sheriff, Sulaiman; Balasubramaniam, Ambikaipakan; Inui, Akio 2010. Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake. Peptides, 31 9, 1706-10

Sheriff, Sulaiman; Ali, Marwan; Yahya, Ayesha; Haider, Khawaja H; Balasubramaniam, Ambikaipakan; Amlal, Hassane 2010. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. Molecular cancer research : MCR, 8 4, 604-14

Wang, Yigang; Zhang, Dongsheng; Ashraf, Muhammad; Zhao, Tiemin; Huang, Wei; Ashraf, Atif; Balasubramaniam, Ambikaipakan 2010. Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction. American journal of physiology. Heart and circulatory physiology, 298 1, H275-86

Balasubramaniam, Ambikaipakan; Joshi, Rashika; Friend, Lou Ann; James, J Howard 2009. GHRP-2 attenuates burn-induced dysfunctions in rodents. Advances in experimental medicine and biology, 611 , 571-2

Balasubramaniam, Ambikaipakan; Joshi, Rashika; Su, Chunhua; Friend, Lou Ann; Sheriff, Sulaiman; Kagan, Richard J; James, J Howard 2009. Ghrelin inhibits skeletal muscle protein breakdown in rats with thermal injury through normalizing elevated expression of E3 ubiquitin ligases MuRF1 and MAFbx. American journal of physiology. Regulatory, integrative and comparative physiology, 296 4, R893-901

Sheriff, Sulaiman; Joshi, Rashika; Friend, Lou Ann; James, J Howard; Balasubramaniam, Ambikaipakan 2009. Ghrelin receptor agonist, GHRP-2, attenuates burn injury-induced MuRF-1 and MAFbx expression and muscle proteolysis in rats. Peptides, 30 10, 1909-13

Parker, Steven L; Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2008. Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells. European journal of pharmacology, 579 1-3, 13-25

Parker, Steven L; Parker, Michael S; Wong, Ying Y; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd 2008. Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor. European journal of pharmacology, 594 1-3, 26-31

Balasubramaniam, Ambikaipakan; Joshi, Rashika; Su, Chunhua; Friend, Lou Ann; James, J Howard 2007. Neuropeptide Y (NPY) Y2 receptor-selective agonist inhibits food intake and promotes fat metabolism in mice: combined anorectic effects of Y2 and Y4 receptor-selective agonists. Peptides, 28 2, 235-40

Sah, Renu; Parker, Steven L; Sheriff, Sulaiman; Eaton, Katherine; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2007. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides, 28 2, 302-9

Amlal, Hassane; Faroqui, Somia; Balasubramaniam, Ambikaipakan; Sheriff, Sulaiman 2006. Estrogen up-regulates neuropeptide Y Y1 receptor expression in a human breast cancer cell line. Cancer research, 66 7, 3706-14

Balasubramaniam, Ambikaipakan; Mullins, Deborra E; Lin, Shu; Zhai, Wexiu; Tao, Zhiyong; Dhawan, Vikas C; Guzzi, Mario; Knittel, James J; Slack, Katy; Herzog, Herbert; Parker, Eric M 2006. Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity. Journal of medicinal chemistry, 49 8, 2661-5

Balasubramaniam, Ambikaipakan; Wood, Steve; Joshi, Rashika; Su, Chunhua; Friend, Lou Ann; Sheriff, Sulaiman; James, J Howard 2006. Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: synthesis of ghrelin. Peptides, 27 7, 1624-31

Chance, William T; Sheriff, Sulaiman; Dayal, Ramesh; Friend, Lou Ann; Thomas, Ingrid; Balasubramaniam, Ambikaipakan 2006. The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia. Peptides, 27 4, 883-92

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Steven L 2005. Lithium inhibits internalization and endosomal processing of both neuropeptide Y (NPY) Y1 and transferrin receptors. Neuroscience letters, 374 1, 43-6

Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Michael S; Sallee, Floyd; Parker, Steven L 2005. Neuropeptide Y as a partial agonist of the Y1 receptor. European journal of pharmacology, 525 1-3, 60-8

Balasubramaniam, Ambikaipakan 2003. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Current pharmaceutical design, 9 15, 1165-75

Chance, William T; Sheriff, Sulaiman; Dayal, Rameshewar; Balasubramaniam, Ambikaipakan 2003. Refractory hypothalamic alpha-mSH satiety and AGRP feeding systems in rats bearing MCA sarcomas. Peptides, 24 12, 1909-19

Jois, Seetharama D S; Balasubramaniam, Ambikaipakan 2003. Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides, 24 7, 1035-43

Parker, Steven L; Parker, Michael S; Buschauer, Armin; Balasubramaniam, Ambikaipakan 2003. Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European journal of pharmacology, 474 1, 31-42

Balasubramaniam, Ambikaipakan 2002. Clinical potentials of neuropeptide Y family of hormones. American journal of surgery, 183 4, 430-4

Balasubramaniam, Ambikaipakan; Sheriff, Sulaiman; Zhai, Weixu; Chance, William T 2002. Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)]: a neuropeptide Y (NPY) Y(5) receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides, 23 8, 1485-90

Bell, David; Allen, Adrian R; Kelso, Elizabeth J; Balasubramaniam, Ambikaipakan; McDermott, Barbara J 2002. Induction of hypertrophic responsiveness of cardiomyocytes to neuropeptide Y in response to pressure overload. The Journal of pharmacology and experimental therapeutics, 303 2, 581-91

Sheriff, Sulaiman; F Qureshy, Asbah; T Chance, William; Kasckow, John W; Balasubramaniam, Ambikaipakan 2002. Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]. Peptides, 23 1, 87-96

Balasubramaniam,A.; Rigel,D.F.; Chance,W.T.; Stein,M.; Fischer,J.E.; King,D.; Plisetskaya,E.M. 1990. Salmon pancreatic polypeptide exhibits neuropeptide y-like activities in rats Peptides, 11 4, 673

Balasubramaniam,A.; Sheriff,S. 1990. Neuropeptide y(18-36) is a competitive antagonist of neuropeptide y in rat cardiac ventricular membranes Journal of Biological Chemistry, 265 25, 14724

Balasubramaniam,A.; Sheriff,S.; Ferguson,D.G.; Stein,M.; Rigel,D.F. 1990. N-α-biotinylated-neuropeptide y analogs: syntheses, cardiovascular properties, and application to cardiac npy receptor visualization Peptides, 11 6, 1151

Balasubramaniam,A.; Sheriff,S.; Renugopalakrishnan,V.; Huang,S.G.; Prabhakaran,M.; Chance,W.T.; Fischer,J.E. 1990. Cardiac properties and conformational studies of neuropeptide y (npy) and npy(17-36) Annals of the New York Academy of Sciences, 611 , 355

Balasubramaniam,A.; Sheriff,S.; Rigel,D.F.; Fischer,J.E. 1990. Characterization of neuropeptide y binding sites in rat cardiac ventricular membranes Peptides, 11 3, 545

Ramo,O.J.; Balasubramaniam,A.; Sheriff,S.; Rogers,D.H.; McCullough,P.J.; Bell Jr.,R.H. 1990. Neuropeptide y and peptide yy stimulate the growth of exocrine pancreatic carcinoma cells Neuropeptides, 15 2, 101

Rudnicki,M.; McFadden,D.W.; Liwnicz,B.H.; Balasubramaniam,A.; Nussbaum,M.S.; Dayal,R.; Fischer,J.E. 1990. Endogenous peptide yy is dependent on jejunal exposure to gastrointestinal contents Journal of Surgical Research, 48 5, 485

Sheriff,S.; Rigel,D.F.; Fischer,J.E.; Balasubramaniam,A. 1990. Interaction of 125i-neuropeptide y with rat cardiac membranes Neuropeptides, 15 3, 157

Chance,W.T.; Sheriff,S.; Foley-Nelson,T.; Fischer,J.E.; Balasubramaniam,A. 1989. Pertussis toxin inhibits neuropeptide y-induced feeding in rats Peptides, 10 6, 1283

Parker S.;Balasubramaniam A. 12-25-2008. Neuropeptide Y Y2 receptor in health and disease (British Journal of Pharmacology (2007) 153, (420-4 British Journal of Pharmacology, 155 8, 1307

Balasubramaniam A.;Zhai W.;Tao Z.;Huang Y.;Fischer J.;Eden P.;Taylor J.;Kar L.;Samarasinghe S.;Johnson M. 12-24-1996. Synthesis, structure, and antagonistic properties of Des-Asn<sup>29</sup>[D-Trp-<sup& Peptides, 17 7, 1113-1118

Parker M.;Sah R.;Sheriff S.;Balasubramaniam A.;Parker S. 12-15-2005. Internalization of cloned pancreatic polypeptide receptors is accelerated by all types of Y4 agonist Regulatory Peptides, 132 1-3, 91-101

Porter J.;Balasubramaniam A.;Abel P.;Conlon J. 12-15-1994. Differential actions of lamprey peptide methionine-tyrosine at Y<inf>1</inf> and Y<in Regulatory Peptides, 54 2-3, 489-493

Goumain M.;Voisin T.;Lorinet A.;Balasubramaniam A.;Laburthe M. 12-04-1998. Pharmacological profile of the rat intestinal crypt peptide YY receptor vs. the recombinant rat Y5 r European Journal of Pharmacology, 362 2-3, 245-249

Parker M.;Sah R.;Balasubramaniam A.;Sallee F.;Crowley W.;Parker S. 12-01-2013. Neuropeptide y in feeding: Specific and protean actions Neuropeptide Y: Molecular Structure, Role in Food Intake and Direct/Indirect Effects, , 107-167

Watanabe M.;Sheriff S.;Ramelot T.;Kadeer N.;Cho J.;Lewis K.;Balasubramaniam A.;Kennedy M. 12-01-2011. NMR based metabonomics study of DAG treatment in a C2C12 mouse skeletal muscle cell line myotube mod International Journal of Peptide Research and Therapeutics, 17 4, 281-299

Parker S.;Parker M.;Sallee F.;Balasubramaniam A. 12-01-2007. Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis to Regulatory Peptides, 144 1-3, 72-81

Samarasinghe S.;Karl L.;Balasubramaniam A.;Johnson M. 12-01-1997. Sequence-specific <sup>1</sup>H NMR assignments and secondary structure of neuropeptide Protein and Peptide Letters, 4 4, 251-258

Millar B.;McDermott B.;Piper H.;Balasubramaniam A.;Weis T. 12-01-1991. NPY-(18-36) and pertussis toxin distinguish between the negative and positive contractile effects of Advances in Experimental Medicine and Biology, 311 , 325-326

Millar B.C.;Weis T.;Piper H.M.;Weber M.;Borchard U.;McDermott B.J.;Balasubramaniam A. 12-01-1991. Positive and negative contractile effects of neuropeptide Y on ventricular cardiomyocytes American Journal of Physiology - Heart and Circulatory Physiology, 261 6 30-6,

McFadden D.;Rudnicki M.;Nussbaum M.;Balasubramaniam A.;Dayal R.;Fischer J. 12-01-1989. Atropine inhibits the postprandial circulating release of neuropeptide Y in conscious dogs Surgical Forum, 40 , 182-184

Murphy R.;Balasubramaniam A.;Mei-Huei Chen;Cardin A.;Rayford P.;Jackson R.;Joffe S. 11-16-1984. Specificity of cholecystokinin antibody may influence choice of tracer for radioimmunoassay Journal of Immunological Methods, 74 1, 199-203

Chance W.T.;Foley-Nelson T.;Thomas I.;Balasubramaniam A. 10-13-1997. Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2 American Journal of Physiology - Gastrointestinal and Liver Physiology, 273 2 36-2,

Estes A.M.;Wong Y.Y.;Parker M.S.;Sallee F.R.;Balasubramaniam A.;Parker S.L. 10-09-2008. Neuropeptide Y (NPY) Y2 receptors of rabbit kidney cortex are largely dimeric Regulatory Peptides, 150 1-3, 88-94

Chance W.T.;Balasubramaniam A.;Thomas I.;Fischer J.E. 10-09-1992. Amylin increases transport of tyrosine and tryptophan into the brain Brain Research, 593 1, 20-24

McDermott B.;Millar B.;Dolan F.;Bell D.;Balasubramaniam A. 10-08-1997. Evidence for Y<inf>1</inf> and Y<inf>2</inf> subtypes of neuropeptide Y rece European Journal of Pharmacology, 336 2-3, 257-265

Wang B.;Sheriff S.;Balasubramaniam A.;Kennedy M. 10-07-2015. NMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuro Metabolomics, 11 5, 1243-1252

McLean L.;Best S.;Balasubramaniam A.;Jackson R. 10-03-1986. Fatty acyl chain specificity of phosphatidylcholine hydrolysis catalyzed by lipoprotein lipase. Effe Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 878 3, 446-449

Watanabe M.;Sheriff S.;Kadeer N.;Cho J.;Lewis K.;Balasubramaniam A.;Kennedy M. 10-01-2012. NMR based metabonomics study of NPY Y5 receptor activation in BT-549, a human breast carcinoma cell Metabolomics, 8 5, 854-868

Shahab M.;Balasubramaniam A.;Sahu A.;Plant T. 10-01-2003. Central nervous system receptors involved in mediating the inhibitory action of neuropeptide Y on lu Journal of Neuroendocrinology, 15 10, 965-970

Balasubramaniam A.;Sheriff S. 09-28-1990. Neuropeptide Y(18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membr Journal of Biological Chemistry, 265 25, 14724-14727

Chance W.;Sheriff S.;Kasckow J.;Regmi A.;Balasubramaniam A. 09-25-1998. NPY messenger RNA is increased in medial hypothalamus of anorectic tumor-bearing rats Regulatory Peptides, 75-76 , 347-353

Sheriff S.;Dayal R.;Kasckow J.;Regmi A.;Chance W.;Fischer J.;Balasubramaniam A. 09-25-1998. NPY upregulates genes containing cyclic AMP response element in human neuroblastoma cell lines beari Regulatory Peptides, 75-76 , 309-318

Chance W.;Balasubramaniam A.;Borchers M.;Fischer J. 09-11-1995. Refractory hypothalamic adenylate cyclase in anorectic tumor-bearing rats: implications for NPY-indu Brain Research, 691 1-2, 180-184

Balasubramaniam A.;Tao Z.;Zhai W.;Stein M.;Sheriff S.;Chance W.;Fischer J.;Eden P.;Taylor J.;Liu C.;McFadden D.;Voisin T.;Roze C.;Laburthe M. 09-07-2000. Structure-activity studies including a ?(CH<inf>2</inf>-NH) scan of peptide YY (PYY) act Journal of Medicinal Chemistry, 43 18, 3420-3427

Parker M.;Sah R.;Balasubramaniam A.;Sallee F.;Sweatman T.;Park E.;Parker S. 09-01-2008. Dimers of the neuropeptide Y (NPY) Y2 receptor show asymmetry in agonist affinity and association wi Journal of Receptors and Signal Transduction, 28 5, 437-451

Balasubramaniam A. 09-01-2007. Editorial Current Topics in Medicinal Chemistry, 7 17, 1644

Diccianni M.B.;Lilly-Stauderman M.;Harmony J.A.K.;McLean L.R.;Balasubramaniam A. 09-01-1991. Heparin Prevents the Binding of Phospholipase A<inf>2</inf> to Phospholipid Micelles: Im Biochemistry, 30 37, 9090-9097

Balasubramaniam A.;Renugopalakrishnan V.;Rigel D.;Nussbaum M.;Rapaka R.;Dobbs J.;Carreira L.;Fischer J. 08-31-1989. Synthesis and biological properties of 4-norleucine-neuropeptide Y; secondary structure of neuropept Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 997 3, 176-181

Chance W.;Sheriff S.;Moore J.;Peng F.;Balasubramaniam A. 08-24-1998. Reciprocal changes in hypothalamic receptor binding and circulating leptin in anorectic tumor-bearin Brain Research, 803 1-2, 27-33

Chance W.;Tao Z.;Sheriff S.;Balasubramaniam A. 08-24-1998. Wryamide, a NPY-based tripeptide that antagonizes feeding in rats Brain Research, 803 1-2, 39-43

McLean L.;Balasubramaniam A. 08-21-1992. Promotion of ?-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidy Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 1122 3, 317-320

Sheriff S.;Fischer J.;Balasubramaniam A. 08-12-1992. Amylin inhibits insulin-stimulated glucose uptake in C<inf>2</inf>C<inf>12</inf BBA - Molecular Cell Research, 1136 2, 219-222

Sheriff S.;Qureshy A.;Chance W.;Kasckow J.;Balasubramaniam A. 07-30-2002. Erratum: Predominant role by CaM kinase in NPY Y<inf>1</inf> receptor signaling: Involve Peptides, 23 6, 1195

Amoscato A.;Balasubramaniam A.;Wesley Alexander J.;Bebcock G. 07-20-1988. Degradation of thymopentin by human lymphocytes: evidence for aminopeptidase activity Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 955 2, 164-174

Parker S.L.;Parker M.S.;Lundell I.;Balasubramaniam A.;Buschauer A.;Kane J.K.;Yalcin A.;Berglund M.M. 07-15-2002. Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells sh Regulatory Peptides, 107 1-3, 49-62

James J.H.;Wagner K.R.;King J.K.;Leffler R.E.;Upputuri R.K.;Balasubramaniam A.;Friend L.A.;Shelly D.A.;Paul R.J.;Fischer J.E. 07-01-1999. Stimulation of both aerobic glycolysis and Na<sup>+</sup>-K<sup>+</sup>-ATPa American Journal of Physiology - Endocrinology and Metabolism, 277 1 40-1,

Balasubramaniam A.;Rechtin A.;McLean L.;Jackson R.;Demel R. 06-30-1986. Activation of lipoprotein lipase by N-?-palmitoyl (56-79) fragment of apolipoprotein C-II Biochemical and Biophysical Research Communications, 137 3, 1041-1048

Balasubramaniam A. 06-09-1997. Neuropeptide Y family of hormones: Receptor subtypes and antagonists Peptides, 18 3, 445-457

Chance W.;Balasubramaniam A.;Sheriff S. 06-04-2003. Neuropeptide Y and cancer anorexia Current Medicinal Chemistry - Central Nervous System Agents, 3 2, 127-139

Chance W.;Zhang X.;Zuo L.;Balasubramaniam A. 06-01-1998. Reduction of gut hypoplasia and cachexia in tumor-bearing rats maintained on total parenteral nutrit Nutrition, 14 6, 502-507

Parker E.;Babij C.;Balasubramaniam A.;Burrier R.;Guzzi M.;Hamud F.;Gitali Mukhopadhyay;Rudinski M.;Tao Z.;Tice M.;Xia L.;Mullins D.;Salisbury B. 05-15-1998. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y European Journal of Pharmacology, 349 1, 97-105

Balasubramaniam A.;Dhawan V.;Mullins D.;Chance W.;Sheriff S.;Guzzi M.;Prabhakaran M.;Parker E. 05-10-2001. Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro<sup>30& Journal of Medicinal Chemistry, 44 10, 1479-1482

Parker S.L.;Parker M.S.;Estes A.M.;Wong Y.Y.;Sah R.;Sweatman T.;Park E.A.;Balasubramaniam A.;Sallee F.R. 05-01-2008. The neuropeptide Y (NPY) Y2 receptors are largely dimeric in the kidney, but monomeric in the forebr Journal of Receptors and Signal Transduction, 28 3, 245-263

Conlon J.M.;Balasubramaniam A.;Hazon N. 05-01-1991. Structural characterization and biological activity of a neuropeptide Y-related peptide from the dog Endocrinology, 128 5, 2273-2279

Chance W.;Zhang X.;Balasubramaniam A.;Fischer J. 04-19-1996. Preservation of intestine protein by peptide YY during total parenteral nutrition Life Sciences, 58 21, 1785-1794

Chance W.;Balasubramaniam A.;Stallion A.;Fischer J. 04-02-1993. Anorexia following the systemic injection of amylin Brain Research, 607 1-2, 185-188

Jois S.;Nagarajarao L.;Prabhakaran M.;Balasubramaniam A. 04-01-2006. Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist anal Journal of Biomolecular Structure and Dynamics, 23 5, 497-508

Balasubramaniam A.;Zhai W.;Sheriff S.;Tao Z.;Chance W.;Fischer J.;Eden P.;Taylor J. 03-08-1996. Bis(31/31'){[Cys<sup>31</sup>,Trp<sup>32</sup>,Nva<sup>34</sup>] Journal of Medicinal Chemistry, 39 4, 811-813

Parker M.;Balasubramaniam A.;Sallee F.;Parker S. 03-07-2018. The expansion segments of 28S Ribosomal RNA extensively match human messenger RNAs Frontiers in Genetics, 9 MAR,

Parker S.;Parker M.;Sah R.;Sallee F.;Balasubramaniam A. 03-01-2007. Parallel inactivation of Y<inf>2</inf> receptor and G-proteins in CHO cells by pertussis Regulatory Peptides, 139 1-3, 128-135

Parker E.;Balasubramaniam A.;Guzzi M.;Mullins D.;Salisbury B.;Sheriff S.;Witten M.;Hwa J. 03-01-2000. [D-Trp<sup>34</sup>] neuropeptide Y is a potent and selective neuropeptide Y Y<inf> Peptides, 21 3, 393-399

Balasubramaniam A.;Ujhelyi M.;Borchers M.;Huang Y.;Zhai W.;Zhou Y.;Johnson M.;Sheriff S.;Fischer J.E. 03-01-1996. Antagonistic properties of centrally truncated analogs of [D-Trp<sup>32</sup>]NPY Journal of Medicinal Chemistry, 39 5, 1142-1147

Balasubramaniam A.;Sheriff S.;Johnson E.;Prabhakaran M.;Huang Y.;Fischer J.;Chance W. 03-01-1994. [d-TRP<sup>32</sup>]Neuropeptide Y: A Competitive Antagonist of NPY in Rat Hypothalamus Journal of Medicinal Chemistry, 37 6, 811-815

Michael Conlon J.;Balasubramaniam A.;Sower S. 02-24-1994. Purification of a neuropeptide Y-related peptide from the brain of the sea lamprey and its effect on Regulatory Peptides, 50 2, 167-175

Jackson R.;Balasubramaniam A.;Murphy R.;Demel R. 02-12-1986. Interaction of synthetic peptides of apolipoprotein C-II and lipoprotein lipase at monomolecular lip Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 875 2, 203-210

Parker M.;Sah R.;Balasubramaniam A.;Sallee F.;Zerbe O.;Parker S. 02-01-2011. Non-specific binding and general cross-reactivity of y receptor agonists are correlated and should i Peptides, 32 2, 258-265

Parker S.;Parker M.;Sah R.;Balasubramaniam A.;Sallee F. 02-01-2007. Self-regulation of agonist activity at the Y receptors Peptides, 28 2, 203-213

Sheriff S.;Chance W.T.;Iqbal S.;Rizvi T.A.;Xiao C.;Kasckow J.W.;Balasubramaniam A. 02-01-2003. Hypothalamic administration of cAMP agonist/PKA activator inhibits both schedule feeding and NPY-ind Peptides, 24 2, 245-254

Chance W.T.;Balasubramaniam A.;Zhang F.S.;Wimalawansa S.J.;Fischer J.E. 01-25-1991. Anorexia following the intrahypothalamic administration of amylin Brain Research, 539 2, 352-354

Gangadhar B.P.;Jois S.D.S.;Balasubramaniam A. 01-05-2004. Convenient high yield and stereoselective synthesis of O-glycopeptides using N-?-Fmoc-Tyr/Ser[?-D-Gl Tetrahedron Letters, 45 2, 355-358

Parker M.;Sah R.;Park E.;Sweatman T.;Balasubramaniam A.;Sallee F.;Parker S. 01-01-2009. Oligomerization of the heptahelical G protein coupling receptors: A case for association using trans Mini-Reviews in Medicinal Chemistry, 9 3, 329-339

Parker S.;Balasubramaniam A. 01-01-2008. Neuropeptide Y Y2 receptor in health and disease British Journal of Pharmacology, 153 3, 420-431

Jois S.;Nagarajarao L.;Prabhakaran M.;Balasubramaniam A. 01-01-2004. Modeling of neuropeptide receptors y1, y4, y5, and docking studies with neuropeptide antagonist anal Journal of Biomolecular Structure and Dynamics, 22 1, 497-508

Goumain M.;Voisin T.;Lorinet A.;Ducroc R.;Tsocas A.;Rozé C.;Rouet-Benzineb P.;Herzog H.;Balasubramaniam A.;Laburthe M. 01-01-2001. The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a periphera Molecular Pharmacology, 60 1, 124-134

Sheriff S.;Dautzenberg F.;Mulchahey J.;Pisarska M.;Hauger R.;Chance W.;Balasubramaniam A.;Kasckow J. 01-01-2001. Interaction of neuropeptide Y and corticotropin-releasing factor signaling pathways in AR-5 amygdala Peptides, 22 12, 2083-2089

Chance W.;Sheriff S.;Peng F.;Balasubramaniam A. 01-01-2000. Antagonism of NPY-induced feeding by pretreatrnent with cyclic AMP response element binding protein Neuropeptides, 34 3-4, 167-172

Chance W.T.;Sheriff S.;Foley-Nelson T.;Thomas I.;Balasubramaniam A. 01-01-2000. Maintaining gut integrity during parenteral nutrition of tumor-bearing rats: Effects of glucagon-lik Nutrition and Cancer, 37 2, 215-222

Sheriff S.;Chance W.T.;Balasubramaniam A. 01-01-2000. Antisense oligonucleotide approach to study NPY-mediated feeding signal transduction. Methods in molecular biology (Clifton, N.J.), 153 , 103-114

Litvak D.;Iseki H.;Evers B.;Greeley G.;Hellmich M.;Iwase K.;Balasubramaniam A.;Townsend C. 01-01-1999. Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C Digestive Diseases and Sciences, 44 3, 643-648

Mulchahey J.;Regmi A.;Sheriff S.;Balasubramaniam A.;Kasckow J. 01-01-1999. Coordinate and divergent regulation of corticotropin-releasing factor (CRF) and CRF-binding protein Endocrinology, 140 1, 251-259

Samarasinghe S.;Balasubramaniam A.;Johnson M. 01-01-1997. Proton nuclear magnetic resonance studies of the structure of neuropeptide Y and its analogs Current Medicinal Chemistry, 4 2, 151-158

Sheriff S.;Chance W.;Fischer J.;Balasubramaniam A. 01-01-1997. Neuropeptide Y treatment and food deprivation increase cyclic AMP response element-binding in rat hy Molecular Pharmacology, 51 4, 597-604

Souli A.;Chariot J.;Voisin T.;Presset O.;Tsocas A.;Balasubramaniam A.;Laburthe M.;Rozé C. 01-01-1997. Several receptors mediate the antisecretory effect of peptide YY, neuropeptide Y, and pancreatic pol Peptides, 18 4, 551-557

Chance W.;Balasubramaniam A.;Thompson H.;Mohapatra B.;Ramo J.;Fischer J. 01-01-1996. Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuro Peptides, 17 5, 797-801

Huang Y.;Fischer J.E.;Balasubramaniam A. 01-01-1996. Amylin mobilizes [Ca<sup>2+</sup>]<inf>i</inf> and stimulates the release of Peptides, 17 3, 497-502

Liu C.;Rongione A.;Garvey L.;Balasubramaniam A.;McFadden D. 01-01-1996. Adjuvant hormonal treatment with peptide YY or its analog decreases human pancreatic carcinoma growt American Journal of Surgery, 171 1, 192-196

Chance W.;Balasubramaniam A.;Fischer J. 01-01-1995. Neuropeptide Y and the development of cancer anorexia Annals of Surgery, 221 5, 579-589

Clay M.;Anantharamaiah M.;Mistry M.;Balasubramaniam A.;Harmony J. 01-01-1995. Localization of a Domain in Apolipoprotein E with both Cytostatic and Cytotoxic Activity Biochemistry, 34 35, 11142-11151

Eto B.;Boisset M.;Eden P.;Balasubramaniam A.;Desjeux J. 01-01-1995. Effects of peptide YY and its analogues on chloride ion secretion in fed and fasted rat jejunum Peptides, 16 8, 1403-1409

Liu C.;Balasubramaniam A.;Saxton R.;Paiva M.;McFadden D. 01-01-1995. Human pancreatic cancer growth is inhibited by peptide YY and BIM-43004-1 Journal of Surgical Research, 58 6, 707-712

Liu C.;Slice L.;Balasubramaniam A.;Walsh J.;Newton T.;Saxton R.;McFadden D. 01-01-1995. Y2 receptors decrease human pancreatic cancer growth and intracellular cyclic adenosine monophosphat Surgery, 118 2, 229-236

Lui C.;Hines O.;Whang E.;Balasubramaniam A.;Newton T.;Zinner M.;Ashley S.;McFadden D. 01-01-1995. A novel synthetic analog of peptide YY, BIM-43004, given intraluminally, is proabsorptive Journal of Surgical Research, 59 1, 80-84

Chance W.;Balasubramaniam A.;Dayal R.;Brown J.;Fischer J. 01-01-1994. Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorecti Life Sciences, 54 24, 1869-1874

Chance W.T.;Balasubramaniam A.;Sheriff S.;Fischer J.E. 01-01-1994. Possible role of neuropeptide Y in experimental cancer anorexia Advances in Experimental Medicine and Biology, 354 , 185-201

Balasubramaniam A.;Cox H.;Voisin T.;Laburthe M.;Stein M.;Fischer J. 01-01-1993. Structure-activity studies of peptide YY(22-36): N-?-Ac-[Phe<sup>27</sup>]PYY(22-36), a Peptides, 14 5, 1011-1016

Bjenning C.;Hazon N.;Balasubramaniam A.;Holmgren S.;Conlon J.M. 01-01-1993. Distribution and activity of dogfish NPY and peptide YY in the cardiovascular system of the common d American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 264 6 33-6,

Lilly-Stauderman M.;Brown T.;Balasubramaniam A.;Harmony J. 01-01-1993. Heparin releases newly synthesized cell surface-associated apolipoprotein E from HepG2 cells Journal of Lipid Research, 34 2, 190-200

Wadhwa S.;Jotwani G.;Balasubramaniam A. 01-01-1993. Development of neuropeptide Y-like immunoreactivity in the rat heart Acta Histochemica et Cytochemica, 26 3, 227-232

Balasubramaniam A.;Rigel D.;Chance W.;Fischer J. 01-01-1992. Central and peripheral effects of sculpin pancreatic polypeptide and anglerfish peptide Y in rats. Peptide research, 5 2, 106-109

Chance W.;Balasubramaniam A.;Chen X.;Fischer J. 01-01-1992. Tests of adipsia and conditioned taste aversion following the intrahypothalamic injection of amylin Peptides, 13 5, 961-964

Inui A.;Okita M.;Miura M.;Hirosue Y.;Nakajima M.;Shii K.;Baba S.;Balasubramaniam A.;Kasuga M. 01-01-1992. Solubilization of high affinity peptide-YY receptors from porcine brain Endocrinology, 130 4, 2120-2128

Sheriff S.;Balasubramaniam A. 01-01-1992. Inhibitory and stimulatory effects of neuropeptide Y(17-36) on rat cardiac adenylate cyclase activit Journal of Biological Chemistry, 267 7, 4680-4685

Sheriff S.;Fischer J.;Balasubramaniam A. 01-01-1992. Characterization of amylin binding sites in a human hepatoblastoma cell line Peptides, 13 6, 1193-1199

Balasubramaniam A.;Renugopalakrishnan V.;Stein M.;Fischer J.;Chance W. 01-01-1991. Syntheses, structures and anorectic effects of human and rat amylin Peptides, 12 5, 919-924

Mcfadden D.;Rudnicki M.;Balasubramaniam A.;Fischer J. 01-01-1991. Intraluminal Heal Recovery of Pancreatic Polypeptide Archives of Surgery, 126 8, 1032-1035

Balasubramaniam A.;Rigel D.F.;Chance W.T.;Stein M.;Fischer J.E.;King D.;Plisetskaya E.M. 01-01-1990. Salmon pancreatic polypeptide exhibits neuropeptide Y-like activities in rats Peptides, 11 4, 673-677

Balasubramaniam A.;Sheriff S.;Ferguson D.G.;Stein M.;Rigel D.F. 01-01-1990. N-?-biotinylated-neuropeptide Y analogs: Syntheses, cardiovascular properties, and application to ca Peptides, 11 6, 1151-1156

BALASUBRAMANIAM A.;SHERIFF S.;RENUGOPALAKRISHNAN V.;HUANG S.;PRABHAKARAN M.;CHANCE W.;FISCHER J. 01-01-1990. Cardiac Properties and Conformational Studies of Neuropeptide Y (NPY) and NPY(17–36) Annals of the New York Academy of Sciences, 611 1, 355-358

Balasubramaniam A.;Sheriff S.;Rigel D.F.;Fischer J.E. 01-01-1990. Characterization of neuropeptide Y binding sites in rat cardiac ventricular membranes Peptides, 11 3, 545-550

CHANCE W.T.;RAMO J.;SHERIFF S.;ZHANG F.;FISCHER J.E.;BALASUBRAMANIAM A. 01-01-1990. Reduction of Neuropeptide Y?Induced Feeding in Tumor?Bearing Rats Annals of the New York Academy of Sciences, 611 1, 497-499

Rämö O.;Balasubramaniam A.;Sheriff S.;Rogers D.;McCullough P.;Bell R. 01-01-1990. Neuropeptide Y and peptide YY stimulate the growth of exocrine pancreatic carcinoma cells Neuropeptides, 15 2, 101-106

Rudnicki M.;McFadden D.;Balasubramaniam A.;Nussbaum M.;Fischer J. 01-01-1990. The postprandial circulatory and lleal intraluminal release of neuropeptide Y in conscious dogs Journal of Surgical Research, 49 6, 514-518

RUDNICKI M.;McFADDEN D.;BALASUBRAMANIAM A.;NUSSBAUM M.;FISCHER J. 01-01-1990. Neuropeptide Y and Anglerfish Peptide Amide Inhibit Secretin?Stimulated Pancreatic Exocrine Secretio Annals of the New York Academy of Sciences, 611 1, 423-425

Rudnicki M.;McFadden D.;Liwnicz B.;Balasubramaniam A.;Nussbaum M.;Dayal R.;Fischer J. 01-01-1990. Endogenous peptide YY is dependent on jejunal exposure to gastrointestinal contents Journal of Surgical Research, 48 5, 485-490

Rudnicki M.;Patel D.G.;McFadden D.W.;Balasubramaniam A.;Nussbaum M.S.;Fischer J.E. 01-01-1990. Proximal jejunal and biliary effects on the enteroinsular axis Surgery, 107 4, 455-460

Sheriff S.;Rigel D.;Fischer J.;Balasubramaniam A. 01-01-1990. Interaction of <sup>125</sup>I-Neuropeptide Y with rat cardiac membranes Neuropeptides, 15 3, 157-160

Balasubramaniam A.;Andrews P.C.;Renugopalakrishnan V.;Rigel D.F. 01-01-1989. Glycine-extended anglerfish peptide YG (aPY) a neuropeptide Y (NPY) homologue may be a precursor of Peptides, 10 3, 581-585

BALASUBRAMANIAM A.;KNITTEL J.J.;GILL C.;ANDREWS P.C. 01-01-1989. Detection of conformational isomers of anglerfish peptide YG (aPY) by reversed phase chromatography International Journal of Peptide and Protein Research, 34 2, 158-160

Balasubramaniam A.;McFadden D.;Rudnicki M.;Nussbaum M.;Dayal R.;Srivastava L.;Fischer J. 01-01-1989. Radioimmunoassay to determine postprandial changes in plasma Neuropeptide Y levels in awake dogs Neuropeptides, 14 3, 209-212

Chance W.T.;Sheriff S.;Foley-Nelson T.;Fischer J.E.;Balasubramaniam A. 01-01-1989. Pertussis toxin inhibits neuropeptide Y-induced feeding in rats Peptides, 10 6, 1283-1286

McFadden D.;Rudnicki M.;Nussbaum M.;Balasubramaniam A.;Fischer J. 01-01-1989. Independent release of peptide YY (PYY) into the circulation and ileal lumen of the awake dog Journal of Surgical Research, 46 4, 380-385

Milgram S.;Balasubramaniam A.;Andrews P.;McDonald J.;Noe B. 01-01-1989. Characterization of aPY-like peptides in anglerfish brain using a novel radioimmunoassay for aPY-Gly Peptides, 10 5, 1013-1017

Noe B.;Milgram S.;Balasubramaniam A.;Andrews P.;Calka J.;McDonald J. 01-01-1989. Localization and characterization of neuropeptide Y-like peptides in the brain and islet organ of th Cell and Tissue Research, 257 2, 303-311

Renugopalakrishnan V.;Prabhakaran M.;Huang S.;Balasubramaniam A.;Strawich E.;Glimcher M. 01-01-1989. Secondary structure and limited three-dimensional structure of bovine amelogenin Connective Tissue Research, 22 1-4, 757-764

Rigel D.;Grupp I.;Balasubramaniam A.;Grupp G. 01-01-1989. Contractile effects of cardiac neuropeptides in isolated canine atrial and ventricular muscles American Journal of Physiology - Heart and Circulatory Physiology, 257 4,

Servin A.L.;Rouyer-Fessard C.;Balasubramaniam A.;Pierre S.S.;Laburthe M. 01-01-1989. Peptide-yy and neuropeptide-y inhibit vasoactive intestinal peptide-stimulated adenosine 3', 5'-mono Endocrinology, 124 2, 692-700

Balasubramaniam A.;Grupp I.;Matlib M.;Benza R.;Jackson R.;Fischer J.;Grupp G. 01-01-1988. Comparison of the effects of neuropeptide Y (NPY) and 4-norleucine-NPY on isolated perfused rat hear Regulatory Peptides, 21 3-4, 289-299

Balasubramaniam A.;Servin A.L.;Rigel D.F.;Rouyer-Fessard C.R.;Laburthe M. 01-01-1988. Syntheses and receptor affinities of partial sequences of peptide YY (PYY). Peptide research, 1 1, 32-35

McFadden D.;Nussbaum M.;Rudnicki M.;Balasubramaniam A.;Fischer J. 01-01-1988. Postprandial neuropeptide Y release in the conscious dog Surgical Forum, 39 , 143-145

Balasubramaniam A.;Chopra Y.;Yates M.;Jackson R. 01-01-1987. Total synthesis of human plasma apolipoprotein C-II Bioorganic Chemistry, 15 2, 141-151

BALASUBRAMANIAM A.;GRUPP I.;SRIVASTAVA L.;TATEMOTO K.;MURPHY R.F.;JOFFE S.N.;FISCHER J.E. 01-01-1987. Synthesis of neuropeptide Y International Journal of Peptide and Protein Research, 29 1, 78-83

Clark J.;Sahu A.;Kalra P.;Balasubramaniam A.;Kalra S. 01-01-1987. Neuropeptide Y (NPY)-induced feeding behavior in female rats: comparison with human NPY ([Met<sup Regulatory Peptides, 17 1, 31-39

Sahu A.;Crowley W.;Tatemoto K.;Balasubramaniam A.;Kalra S. 01-01-1987. Effects of neuropeptide Y, NPY analog (norleucine<sup>4</sup>-NPY), galanin and neuropep Peptides, 8 5, 921-926

Balasubramaniam A.;Demel R.;Murphy R.;Sparrow J.;Jackson R. 01-01-1986. Substitution of SER<inf>61</inf> ? GLY<inf>61</inf> in human apolipoprotein Chemistry and Physics of Lipids, 39 4, 341-346

BALASUBRAMANIAM A.;MURPHY R.;BLUMENTHAL K. 01-01-1986. Synthesis of sequences 1–16 and 63–95 of Cerebratulus lacteus toxin AIII: Hemolytic activity in a to International Journal of Peptide and Protein Research, 27 5, 508-513