Education/CredentialsResearch Pharmacologist: Veterans Affairs Medical CenterPostdoctoral: Stanford University (Pharmacology )Postdoctoral: University of Virginia (Pharmacology )Doctoral Degree: University of California Los Angeles (Pharmacology)Bachelor's Degree: University of California (Biological Sciences ) Contact Information Email rapoporm@ucmail.uc.edu Research InterestsNitric Oxide and Endothelin-1 in Peripheral and Cerebral Vascular Pathophysiologies Peer Reviewed Publications Rapoport, Robert M 2014. Acute nitric oxide synthase inhibition and endothelin-1-dependent arterial pressure elevation. Frontiers in pharmacology, 5 , 57Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Sensory nerves and transient receptor potential vanilloid 1 channels in CO2 regulation of cerebrovascular tone. Respiratory physiology & neurobiology, , Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Cocaine Constriction of Rat Basilar Artery in situ: Roles of Nitric Oxide and Endothelin-1. Pharmacology, 93 3-4, 151-154Rapoport, Robert M; Zuccarello, Mario 2012. EndothelinA-EndothelinB Receptor Cross Talk in Endothelin-1-Induced Contraction of Smooth Muscle. Journal of cardiovascular pharmacology, 60 5, 483-94Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2012. pCO(2) and pH regulation of cerebral blood flow. Frontiers in physiology, 3 , 365Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2012. EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn-Schmiedeberg's archives of pharmacology, 385 4, 437-41Rapoport, Robert M; Zuccarello, Mario 2011. Endothelin(A)-endothelin(B) receptor cross-talk and endothelin receptor binding. The Journal of pharmacy and pharmacology, 63 11, 1373-7Fandino, Javier; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2003. Cocaine-induced endothelin-1-dependent spasm in rabbit basilar artery in vivo. Journal of cardiovascular pharmacology, 41 2, 158-61Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway. Neurological research, 25 3, 268-70Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Repeated constriction to respiration-induced hypocapnia is not mimicked by isocapnic alkaline solution in rabbit basilar artery in situ. Vascular pharmacology, 40 1, 7-11Yoon, Seonghun; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2002. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway. Neurological research, 24 4, 392-4Rapoport, R M; Campbell, A K; Chang, K C 2000. Differential regulation of norepinephrine- and prostaglandin F2alpha-induced contraction by extracellular Na+ in rat aorta. Journal of cardiovascular pharmacology, 36 3, 288-96Rapoport, R M; Williams, S P; Campbell, A K 2000. Phorbol ester-induced phosphoinositide hydrolysis in rat aorta: role of cyclooxygenase products. Life sciences, 67 15, 1815-24Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces endothelin-dependent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 333-40Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 325-32Zuccarello, M; Boccaletti, R; Rapoport, R M 2000. Role of NO in endothelium-dependent relaxation of rabbit basilar artery in situ. Neurological research, 22 2, 204-8Zuccarello, M; Lee, B H; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by N(G)-monomethyl-L-arginine monoacetate and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 401 2, 213-9Zuccarello, M; Lee, B H; Rapoport, R M 2000. Reduced verapamil inhibition of endothelin-1-constricted rabbit basilar artery due to enhanced non L-type Ca(2+)-channel-dependent constriction. General pharmacology, 35 1, 11-5Zuccarello, M; Lee, B H; Rapoport, R M 2000. Endothelin-1 mediates hypocapnic constriction of the rabbit basilar artery in-vitro. The Journal of pharmacy and pharmacology, 52 2, 225-6Zuccarello, M; Lee, B; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by serotonin and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 407 1-2, 191-5Zuccarello, M; Boccaletti, R; Rapoport, R M 1999. Does blockade of endothelinB1-receptor activation increase endothelinB2/endothelinA receptor-mediated constriction in the rabbit basilar artery? Journal of cardiovascular pharmacology, 33 5, 679-84Tosun, M; Paul, R J; Rapoport, R M 1998. Coupling of store-operated Ca++ entry to contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 285 2, 759-66Tosun, M; Paul, R J; Rapoport, R M 1998. Role of extracellular Ca++ influx via L-type and non-L-type Ca++ channels in thromboxane A2 receptor-mediated contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 284 3, 921-8Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B1) receptor-mediated relaxation of rabbit basilar artery. European journal of pharmacology, 357 1, 67-71Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B) receptor-mediated constriction in the rabbit basilar artery. European journal of pharmacology, 350 1, R7-9Zuccarello, M; Boccaletti, R; Romano, A; Rapoport, R M 1998. Endothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm. Stroke; a journal of cerebral circulation, 29 9, 1924-9Chuprun, J K; Rapoport, R M 1997. Protein kinase C regulation of ATP-induced phosphoinositide hydrolysis in bovine aorta endothelial cells. Journal of receptor and signal transduction research, 17 6, 787-814Tosun, M; Paul, R J; Rapoport, R M 1997. Intracellular Ca2+ elevation and contraction due to prostaglandin F2alpha in rat aorta. European journal of pharmacology, 340 2-3, 203-8Bazan, E; Rapoport, R M 1996. Methodological considerations for the measurement of protein kinase C translocation in intact smooth muscle. Journal of pharmacological and toxicological methods, 36 2, 87-95Rapoport, R M; Williams, S P 1996. Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension, 28 1, 64-75Zuccarello, M; Boccaletti, R; Tosun, M; Rapoport, R M 1996. Role of extracellular Ca2+ in subarachnoid hemorrhage-induced spasm of the rabbit basilar artery. Stroke; a journal of cerebral circulation, 27 10, 1896-902Zuccarello, M; Bonasso, C L; Lewis, A I; Sperelakis, N; Rapoport, R M 1996. Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim. Stroke; a journal of cerebral circulation, 27 2, 311-6Zuccarello, M; Soattin, G B; Lewis, A I; Breu, V; Hallak, H; Rapoport, R M 1996. Prevention of subarachnoid hemorrhage-induced cerebral vasospasm by oral administration of endothelin receptor antagonists. Journal of neurosurgery, 84 3, 503-7Bazan, E; Campbell, A K; Rapoport, R M 1995. Time course of phorbol ester-induced contraction and protein kinase C activation in rat aorta. European journal of pharmacology, 290 3, 253-7Rapoport, R M; Campbell, A K; Bazan, E 1995. Effects of PKC downregulation on norepinephrine- and prostaglandin F2 alpha-induced contraction in rat aorta. The American journal of physiology, 269 2 Pt 2, H590-8Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Decreased endothelium-dependent relaxation in subarachnoid hemorrhage-induced vasospasm: role of ET-1. The American journal of physiology, 269 3 Pt 2, H1009-15Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Endothelin-1-induced endothelin-1 release causes cerebral vasospasm in-vivo. The Journal of pharmacy and pharmacology, 47 8, 702Baik, Y H; French, J F; Schwartz, A; Rapoport, R M 1994. Dihydropyridine Ca2+ channel agonists and antagonists potentiate ultraviolet light-induced relaxation through cyclic GMP formation in porcine coronary artery. Journal of cardiovascular pharmacology, 23 5, 785-91Bazan, E; Campbell, A K; Rapoport, R M 1994. Effects of phorbol esters on contraction and protein kinase C activation in rabbit aorta. Life sciences, 54 2, PL29-33Williams, S P; Campbell, A K; Roszell, N; Myatt, L; Leikauf, G D; Rapoport, R M 1994. Modulation of phorbol ester-induced contraction by endogenously released cyclooxygenase products in rat aorta. The American journal of physiology, 267 5 Pt 2, H1654-62Williams, S P; Dorn, G W; Rapoport, R M 1994. Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle. The American journal of physiology, 267 2 Pt 2, H796-803Zuccarello, M; Lewis, A I; Rapoport, R M 1994. Endothelin ETA and ETB receptors in subarachnoid hemorrhage-induced cerebral vasospasm. European journal of pharmacology, 259 1, R1-2Bazan, E; Campbell, A K; Rapoport, R M 1993. Effects of protein kinase C activation on norepinephrine-induced phosphatidylinositide hydrolysis in intact rat aorta. European journal of pharmacology, 245 2, 173-7Rapoport, R M 1993. Potentiation of norepinephrine-induced contraction by primary prostaglandin receptor activation in rat aorta. European journal of pharmacology, 243 2, 207-10Rapoport, R M 1993. Regulation of vascular smooth muscle contraction by extracellular Na+. General pharmacology, 24 3, 531-7Bazan, E; Campbell, A K; Rapoport, R M 1992. Protein kinase C activity in blood vessels from normotensive and spontaneously hypertensive rats. European journal of pharmacology, 227 3, 343-8Chuprun, J K; Bazan, E; Chang, K C; Campbell, A K; Rapoport, R M 1991. Inhibition of phorbol ester-induced contraction by calmodulin antagonists in rat aorta. The American journal of physiology, 261 4 Pt 1, C675-84Rapoport, R M 1991. Inhibitory effects of cyclic AMP-elevating agents on norepinephrine-induced phosphatidylinositide hydrolysis and contraction in rat aorta. General pharmacology, 22 3, 449-58Rapoport, R M; Campbell, A K 1991. Norepinephrine-induced phosphatidylcholine hydrolysis in intact rat aorta. European journal of pharmacology, 208 1, 89-92Rapoport, R M; Stauderman, K A; Highsmith, R F 1990. Effects of EDCF and endothelin on phosphatidylinositol hydrolysis and contraction in rat aorta. The American journal of physiology, 258 1 Pt 1, C122-31Rapoport, R M; Van Gorp, C; Chang, K C 1990. Inositol uptake in rat aorta. Life sciences, 46 23, 1715-25French, J F; Rapoport, R M; Matlib, M A 1989. Possible mechanism of benzodiazepine-induced relaxation of vascular smooth muscle. Journal of cardiovascular pharmacology, 14 3, 405-11Highsmith, R F; Pang, D C; Rapoport, R M 1989. Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. Journal of cardiovascular pharmacology, 13 Suppl 5 , S36-44; discussion SRapoport, R M; Ashraf, M; Murad, F 1989. Effects of melittin on endothelium-dependent relaxation and cyclic GMP levels in rat aorta. Circulation research, 64 3, 463-73Waldman, S A; Rapoport, R M; Fiscus, R R; Leitman, D C; Chang, L Y; Murad, F 1989. Regulation of particulate guanylate cyclase by atriopeptins: relation between peptide structure, receptor binding, and enzyme kinetics. Biochimica et biophysica acta, 999 2, 157-62Rapoport, R M; Murad, F 1988. Effects of ethacrynic acid and cystamine on sodium nitroprusside-induced relaxation, cyclic GMP levels and guanylate cyclase activity in rat aorta. General pharmacology, 19 1, 61-5Chuprun, J K; Rapoport, R M 1987. Nitroglycerin-induced desensitization of vascular smooth muscle may be mediated through cyclic GMP-disinhibition of phosphatidylinositol hydrolysis. Experientia, 43 3, 316-8Molina, C R; Andresen, J W; Rapoport, R M; Waldman, S; Murad, F 1987. Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. Journal of cardiovascular pharmacology, 10 4, 371-8Rapoport, R M 1987. Effects of norepinephrine on contraction and hydrolysis of phosphatidylinositols in rat aorta. The Journal of pharmacology and experimental therapeutics, 242 1, 188-94Rapoport, R M; Waldman, S A; Ginsburg, R; Molina, C R; Murad, F 1987. Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery. Journal of cardiovascular pharmacology, 10 1, 82-9Draznin, M B; Rapoport, R M; Murad, F 1986. Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta. The International journal of biochemistry, 18 10, 917-28Murad, F; Waldman, S A; Fiscus, R R; Rapoport, R M 1986. Regulation of cyclic GMP synthesis and the interactions with calcium. Journal of cardiovascular pharmacology, 8 Suppl 8 , S57-60Rapoport, R M 1986. Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta. Circulation research, 58 3, 407-10Rapoport, R M; Ginsburg, R; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro. European journal of pharmacology, 124 1-2, 193-6Rapoport, R M; Winquist, R J; Baskin, E P; Faison, E P; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas. European journal of pharmacology, 120 1, 123-6Waldman, S A; Rapoport, R M; Ginsburg, R; Murad, F 1986. Desensitization to nitroglycerin in vascular smooth muscle from rat and human. Biochemical pharmacology, 35 20, 3525-31Fiscus, R R; Rapoport, R M; Waldman, S A; Murad, F 1985. Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. Biochimica et biophysica acta, 846 1, 179-84Leitman, D C; Waldman, S A; Rapoport, R M; Murad, F 1985. Specific atrial natriuretic factor receptors mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and smooth muscle cells. Transactions of the Association of American Physicians, 98 , 243-52Murad, F; Rapoport, R M; Fiscus, R 1985. Role of cyclic-GMP in relaxations of vascular smooth muscle. Journal of cardiovascular pharmacology, 7 Suppl 3 , S111-8Rapoport, R M; Schwartz, K; Murad, F 1985. Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circulation research, 57 1, 164-70Rapoport, R M; Schwartz, K; Murad, F 1985. Effects of Na+,K+-pump inhibitors and membrane depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP accumulation in rat aorta. European journal of pharmacology, 110 2, 203-9Rapoport, R M; Waldman, S A; Schwartz, K; Winquist, R J; Murad, F 1985. Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. European journal of pharmacology, 115 2-3, 219-29Waldman, S A; Rapoport, R M; Fiscus, R R; Murad, F 1985. Effects of atriopeptin on particulate guanylate cyclase from rat adrenal. Biochimica et biophysica acta, 845 2, 298-303Rapoport, R M; Draznin, M B; Murad, F 1984. Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circulation research, 55 4, 468-79Rapoport, R M; Murad, F 1984. Effect of cyanide on nitrovasodilator-induced relaxation, cyclic GMP accumulation and guanylate cyclase activation in rat aorta. European journal of pharmacology, 104 1-2, 61-70Waldman, S A; Rapoport, R M; Murad, F 1984. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. The Journal of biological chemistry, 259 23, 14332-4Winquist, R J; Faison, E P; Waldman, S A; Schwartz, K; Murad, F; Rapoport, R M 1984. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proceedings of the National Academy of Sciences of the United States of America, 81 23, 7661-4Rapoport, R M; Bevan, J A 1983. Effect of contraction on the subsequent responsiveness and maximum contractility of the rabbit ear artery and saphenous vein in vitro. Blood vessels, 20 1, 44-55Rapoport, R M; Draznin, M B; Murad, F 1983. Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Transactions of the Association of American Physicians, 96 , 19-30Rapoport, R M; Murad, F 1983. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circulation research, 52 3, 352-7Rapoport, R M; Murad, F 1983. Effect of ouabain and alterations in potassium concentration on relaxation induced by sodium nitroprusside. Blood vessels, 20 5, 255-64Rapoport, R M; Murad, F 1983. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. Journal of cyclic nucleotide and protein phosphorylation research, 9 4-5, 281-96Rapoport, R M; Bevan, J A 1982. Increased contractility induced in rabbit ear artery by prior exposure to serotonin masks concomitant desensitization to norepinephrine. The Journal of pharmacology and experimental therapeutics, 222 2, 338-43Rapoport, R M; Draznin, M B; Murad, F 1982. Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proceedings of the National Academy of Sciences of the United States of America, 79 21, 6470-4Rapoport, R M; Bevan, J A 1981. Mechanism of electrical stimulation-induced subsensitivity of vascular smooth muscle. The Journal of pharmacology and experimental therapeutics, 218 2, 382-9Rapoport, R M; Bevan, J A 1981. Vascular smooth muscle contraction induced by direct electrical stimulation and its subsequent effect of reactivity to agonists. The Journal of pharmacology and experimental therapeutics, 218 2, 375-81Rapoport, R M; Takimoto, G S; Cho, A K 1981. Compartmental analysis of tyramine-induced norepinephrine depletion. Pharmacology, 22 4, 235-42Rapoport, R M 1978. [Hygienic evaluation of the working conditions at a pilot factory for spindleless spinning]. Gigiena truda i professional'nye zabolevaniia, 4, 51-2Brusova, L A; Iuzhelevski?, Iu A; Rapoport, R M; Poiurovskaia, I Ia; Panikarovski?, V V; Antipova, Z P; Shitsel', L A; Tuzanova, L I . [A new siloxane material for eliminating defects of the soft facial tissues by an injection method. I. The laboratory and experimental research]. Stomatologii?a, 4, 13-5Fiscus, R R; Rapoport, R M; Murad, F . Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta. Journal of cyclic nucleotide and protein phosphorylation research, 9 6, 415-25Motz, Gregory T; Zuccarello, Mario; Rapoport, Robert M . Alkaline pH-induced extracellular regulated protein kinase activation in brain microvascular endothelial cells: differential effects of Tris and lowered CO2. Endothelium : journal of endothelial cell research, 13 5, 313-6Poiurovskaia, I Ia; Rapoport, R M; Nechaenko, N A; Tagiev, A I . [Comparative laboratory evaluation of silicone impression materials used in preparing metalloceramic dentures]. Stomatologii?a, 67 3, 56-8Rapoport, R M; Draznin, M B; Murad, F . Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature, 306 5939, 174-6Yoon, Seong Hun; Zuccarello, Mario; Rapoport, Robert M . Acute cocaine induces endothelin-1-dependent constriction of rabbit basilar artery. Endothelium : journal of endothelial cell research, 14 3, 137-9 Abstract Publications Yoon SH, Zuccarello M, Rapoport RM 2003. Respiratory induced hypocapnic constriction of rat basilar artery: dependence on endothelin-1 FASEB, , Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Cerebral Vasospasm: Advances in Research and Treatment, , 75-78Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Congress Neurological Surgeons, , Fandino, J., Sherman, D., Zuccarello, M., and Rapoport, R.M. 2000. Endothelin-1 mediates cocaine-induced cerebrovasospasm 7th International Conference on Cerebral Vasospasm, , 6Sherman, J.D., Fandino, J., Zuccarello, M., and Rapoport, R.M. 2000. Cocaine-induced cerebral vasospasm in vivo: mediated by endothelin-1 Stroke, , Zuccarello, M., Sherman, J., and Rapoport, R.M. 2000. Subarachnoid hemorrhage-induced vasospasm: role of calcium sensitization 6th Internet World Congress for Biomedical Sciences, , Sherman, J.D., Zuccarello, M., and Rapoport, R.M. 1999. Role of calcium sensitization in cerebral vasospasm Congress Neurological Surgeons, , Sherman, J.D., Rapoport, R.M., and Zuccarello, M. 1998. The role of endothelin-1 in subarachnoid hemorrhage-induced vasospasm INABIS ’98 - 5th Internet World Congress on Biomedical Sciences at McMater University, Canada, , Tosun, M., Paul, R.J., and Rapoport, R.M. 1998. Coupling of store-operated Ca2+ entry to contraction in rat aorta FASEB J., , Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelium-derived nitric oxide regulates endothelin A versus endothelin B receptor-mediated constriction in rabbit basilar artery in situ Stroke, 29 , 323Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelin B receptor antagonists prevent subarachnoid hemorrhage-induced spasm in rabbit basilar artery in vivo Congress Neurological Surgeons, Seattle, WA, , Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1997. Endothelin B1 receptor-mediated endothelin-1 release maintains subarachnoid hemorrhage-induced spasm of rabbit basilar 18th Int. Symp. Cerebral Blood Flow and Metabolism, 17 , S471Zuccarello, M. Boccaletti, R., and Rapoport, R.M. 1995. Ca2+ Influx Through Non-L-Type Ca2+ Channels Mediates Subarachnoid Hemorrhage-Induced Vasospasm: Role of Endothelin-1 (ET-1) Stroke, , Zuccarello, M., Soattin, G.B., Lewis, A.I., and Rapoport, R.M. 1995. Oral Bosentan, an endothelin (ET)A and ETB receptor antagonist, prevents subarachnoid hemorrhage (SAH)-induced cerebral vasospasm The Fourth International Workshop on Cerebrovascular Surgery (INCVS), Chicago, Illinois, , Zuccarello, M., Rapoport, R.M., and Romano, A. 1994. Subarachnoid hemorrhage (SAH)-induced vasospasm may be due to endothelin (ET) release and not decreased endothelium-dependent relaxation (EDR) Stroke, 25 , 136Zuccarello, M. and Rapoport, R.M. 1993. Role of K+ channels in vasospasm after subarachnoid hemorrhage Stroke, 24 , 168Zuccarello, M., Bonasso, C., Rapoport, R.M., and Sperelakis, N. 1993. Role of membrane potential in vasospasm after subarachnoid hemorrhage (SAH) Vth Int. Symp. Cerebral Vasospasm, Edmonton, , Williams, S.P., Dorn, G.W., II, Campbell, A.K., Leikauf, G.O., Myatt, L., and Rapoport, R.M. 1992. Prostaglandin I2 (PGI2) may mediate phorbol ester induced increased inositol phosphate levels FASEB, , Chuprun, J.K. and Rapoport, R.M. 1991. Protein kinase C attenuates agonist and G protein stimulated phospholipase C activity in endothelial cell membranes FASEB J., 5 , A1598Rapoport, R.M., Bazan, E., and Campbell, A.K. 1991. Relationship between protein kinase C (PKC) activation, phosphoinositide hydrolysis and contraction in rat aorta J. Mol. Cell. Cardiol, 23 , S12Williams, S.P., Dorn, G.W. II, Campbell, A.K., Leikauf, G.D., Myatt, L. and Rapoport, R.M. 1991. Phorbol ester induced phosphatidylinositide hydrolysis in rat aorta: potential role of prostacyclin (PGI2) J. Molec. Cell. Cardiol., 23 , S65Chuprun, J.K., and Rapoport, R.M. 1990. Regulation of endothelial cell membrane phospholipase C activity by protein kinase C 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, , Williams, S.P., Campbell, A.K., Leikauf, G.D., and Rapoport, R.M. 1990. Phorbol esters induce phosphatidylinositide hydrolysis and arachidonic acid metabolism in rat aorta 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, , Highsmith, R.F., Pang, D., Schmidt, D., and Rapoport, R. 1989. Mechanisms of action of endothelial cell derived constricting factors J. Vascular Medicine Biology, 1 , 92Highsmith, R.F., Koth, D.M., Westrich, L.A., and Rapoport, R.M. 1987. Vasoconstriction induced by endothelium derived constricting factor (EDCF) may be mediated through phosphatidylinositol (PI) turnover Circulation, 15 , Chuprun, J.K. and Rapoport, R.M. 1986. Nitroglycerin induced desensitization of vascular smooth muscle may be mediated through cyclic GMP disinhibition of phosphatidylinositol hydrolysis 27th National Student Research Forum, , 17Rapoport, R.M. 1986. Effects of norepinephrine on contraction and hydrolysis of phospha-tidylinositides in rat aorta Veterans Administration National Research and Development Conference, Las Vegas, Nevada, , Baik, Y.H., Dube, G., Vaghy, P., Rapoport, R., and Schwartz, A. 1985. Modification of effects of the enantiomers of a 1,4 dihydropyridine (202 791) by endothelium and light in pig coronary artery Pharmacology, , Fiscus, R.R., Robles, B.T., Rapoport, R.M., Waldman, S.A., and Murad, F. 1985. Atrial natriuretic factor elevates cyclic GMP and activates cyclic GMP dependent protein kinase in rat aorta: potential mechanism of vasodilation Fed. Proc., 44 , 698Molina, C.R., Andresen, J.W., Rapoport, R., Waldman, S., and Murad, F. 1985. The effect of in vivo nitroglycerin therapy on endothelium dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta Clin. Res., , Murad, F., Rapoport, R.M., Waldman, S.A., Fiscus, R.R., and Leitman, D.C. 1985. The role of cyclic GMP in endothelium dependent, nitrovasodilator and atriopeptin mediated vascular relaxation , , Fiscus, R.R., Rapoport, R.M., and Murad, F. 1984. Activation of cyclic GMP dependent protein kinase in rat aorta by sodium nitroprusside and endothelium dependent vasodilators Clin. Res., 32 , 5ADraznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Effects of norepi-nephrine, sodium nitroprusside, calcium free buffer and a calmodulin inhibitor on protein phosphorylation related to contraction and relaxation in intact rat aorta Clin. Res., 31 , 6ADraznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Myosin light chain dephosphorylation in intact rat thoracic aorta treated with sodium nitroprusside: role of cyclic GMP Clin. Res., 31 , 466ARapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Effect of endothelium dependent vasodilators on relaxation, cyclic GMP levels and protein phosphorylation in rat thoracic aorta Clin. Res., 3l , 16ARapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Endothelium dependent vascular relaxation may be mediated through cyclic GMP dependent protein phosphorylation Clin. Res., 31 , 526ADraznin, M.B., Rapoport, R.M., and Murad, F. 1982. Vascular smooth muscle protein phosphorylation following sodium nitroprusside treatment: possible role in smooth muscle relaxation Clin. Res., 30 , 6ARapoport, R.M. and Murad, F. 1982. Ouabain inhibits relaxation by nitroprusside and 8 bromo cyclic GMP in rat aorta Clin. Res., 30 , 18ARapoport, R.M., Draznin, M.B., and Murad, F. 1982. Sodium nitroprusside induced protein phosphorylation in intact rat aorta is mimicked by 8 bromo cyclic GMP Clin. Res., 30 , 484ARapoport, R.M., Brandwein, H.J., and Murad, F. 1981. Cystamine inhibits relaxation, increases in cyclic GMP accumulation, and guanylate cyclase activation induced by nitroprusside in rat aorta Fed. Proc., 40 , 690Rapoport, R.M., Lewicki, J.A., and Murad, F. 1981. Cyanide inhibits relaxation, increases in cyclic GMP accumulation and guanylate cyclase activation induced by nitroprusside in rat aorta Circulation, 64 , 70Duckles, S.P. and Rapoport, R. 1980. Lack of effect of clonidine on norepinephrine (NE) release from a rabbit cerebral artery Fed. Proc., 38 , 367Rapoport, R.M. and Bevan, J.A. 1980. Sympathetic nerve activity desensitizes vascular smooth muscle in vitro Fed. Proc., 38 , 367Rapoport, R.M. and Bevan, J.A. 1980. Electrical stimulation of vascular smooth muscle induces subsensitivity in vitro Fed. Proc., 39 , 1071Bevan, J.A., Bevan, R.D., Pascual, R., and Rapoport, R. 1978. Some anatomical and functional factors influencing vascular smooth muscle sensitivity to norepinephrine 7th International Congress on Pharmacology, , 36Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Release of norepinephrine (NE) from cerebral blood vessels: correlation of two techniques 7th International Congress on Pharmacology, , 36Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Nerve stimulation of cerebral arteries releases endogenous norepinephrine (NE): confirmation by radioenzymatic assay of adrenergic nerve function 3rd International Symposium on Vascular Neuroeffector Mechanisms, , 28-29Molina, C.R., Andresen, J.W., Rapoport, R.M., and Murad, F. . The effect of nitroglycerin tolerance on endothelium dependent vascular relaxation Circulation, 74 , 287
Research InterestsNitric Oxide and Endothelin-1 in Peripheral and Cerebral Vascular Pathophysiologies
Peer Reviewed Publications Rapoport, Robert M 2014. Acute nitric oxide synthase inhibition and endothelin-1-dependent arterial pressure elevation. Frontiers in pharmacology, 5 , 57Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Sensory nerves and transient receptor potential vanilloid 1 channels in CO2 regulation of cerebrovascular tone. Respiratory physiology & neurobiology, , Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Cocaine Constriction of Rat Basilar Artery in situ: Roles of Nitric Oxide and Endothelin-1. Pharmacology, 93 3-4, 151-154Rapoport, Robert M; Zuccarello, Mario 2012. EndothelinA-EndothelinB Receptor Cross Talk in Endothelin-1-Induced Contraction of Smooth Muscle. Journal of cardiovascular pharmacology, 60 5, 483-94Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2012. pCO(2) and pH regulation of cerebral blood flow. Frontiers in physiology, 3 , 365Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2012. EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn-Schmiedeberg's archives of pharmacology, 385 4, 437-41Rapoport, Robert M; Zuccarello, Mario 2011. Endothelin(A)-endothelin(B) receptor cross-talk and endothelin receptor binding. The Journal of pharmacy and pharmacology, 63 11, 1373-7Fandino, Javier; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2003. Cocaine-induced endothelin-1-dependent spasm in rabbit basilar artery in vivo. Journal of cardiovascular pharmacology, 41 2, 158-61Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway. Neurological research, 25 3, 268-70Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Repeated constriction to respiration-induced hypocapnia is not mimicked by isocapnic alkaline solution in rabbit basilar artery in situ. Vascular pharmacology, 40 1, 7-11Yoon, Seonghun; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2002. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway. Neurological research, 24 4, 392-4Rapoport, R M; Campbell, A K; Chang, K C 2000. Differential regulation of norepinephrine- and prostaglandin F2alpha-induced contraction by extracellular Na+ in rat aorta. Journal of cardiovascular pharmacology, 36 3, 288-96Rapoport, R M; Williams, S P; Campbell, A K 2000. Phorbol ester-induced phosphoinositide hydrolysis in rat aorta: role of cyclooxygenase products. Life sciences, 67 15, 1815-24Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces endothelin-dependent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 333-40Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 325-32Zuccarello, M; Boccaletti, R; Rapoport, R M 2000. Role of NO in endothelium-dependent relaxation of rabbit basilar artery in situ. Neurological research, 22 2, 204-8Zuccarello, M; Lee, B H; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by N(G)-monomethyl-L-arginine monoacetate and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 401 2, 213-9Zuccarello, M; Lee, B H; Rapoport, R M 2000. Reduced verapamil inhibition of endothelin-1-constricted rabbit basilar artery due to enhanced non L-type Ca(2+)-channel-dependent constriction. General pharmacology, 35 1, 11-5Zuccarello, M; Lee, B H; Rapoport, R M 2000. Endothelin-1 mediates hypocapnic constriction of the rabbit basilar artery in-vitro. The Journal of pharmacy and pharmacology, 52 2, 225-6Zuccarello, M; Lee, B; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by serotonin and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 407 1-2, 191-5Zuccarello, M; Boccaletti, R; Rapoport, R M 1999. Does blockade of endothelinB1-receptor activation increase endothelinB2/endothelinA receptor-mediated constriction in the rabbit basilar artery? Journal of cardiovascular pharmacology, 33 5, 679-84Tosun, M; Paul, R J; Rapoport, R M 1998. Coupling of store-operated Ca++ entry to contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 285 2, 759-66Tosun, M; Paul, R J; Rapoport, R M 1998. Role of extracellular Ca++ influx via L-type and non-L-type Ca++ channels in thromboxane A2 receptor-mediated contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 284 3, 921-8Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B1) receptor-mediated relaxation of rabbit basilar artery. European journal of pharmacology, 357 1, 67-71Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B) receptor-mediated constriction in the rabbit basilar artery. European journal of pharmacology, 350 1, R7-9Zuccarello, M; Boccaletti, R; Romano, A; Rapoport, R M 1998. Endothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm. Stroke; a journal of cerebral circulation, 29 9, 1924-9Chuprun, J K; Rapoport, R M 1997. Protein kinase C regulation of ATP-induced phosphoinositide hydrolysis in bovine aorta endothelial cells. Journal of receptor and signal transduction research, 17 6, 787-814Tosun, M; Paul, R J; Rapoport, R M 1997. Intracellular Ca2+ elevation and contraction due to prostaglandin F2alpha in rat aorta. European journal of pharmacology, 340 2-3, 203-8Bazan, E; Rapoport, R M 1996. Methodological considerations for the measurement of protein kinase C translocation in intact smooth muscle. Journal of pharmacological and toxicological methods, 36 2, 87-95Rapoport, R M; Williams, S P 1996. Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension, 28 1, 64-75Zuccarello, M; Boccaletti, R; Tosun, M; Rapoport, R M 1996. Role of extracellular Ca2+ in subarachnoid hemorrhage-induced spasm of the rabbit basilar artery. Stroke; a journal of cerebral circulation, 27 10, 1896-902Zuccarello, M; Bonasso, C L; Lewis, A I; Sperelakis, N; Rapoport, R M 1996. Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim. Stroke; a journal of cerebral circulation, 27 2, 311-6Zuccarello, M; Soattin, G B; Lewis, A I; Breu, V; Hallak, H; Rapoport, R M 1996. Prevention of subarachnoid hemorrhage-induced cerebral vasospasm by oral administration of endothelin receptor antagonists. Journal of neurosurgery, 84 3, 503-7Bazan, E; Campbell, A K; Rapoport, R M 1995. Time course of phorbol ester-induced contraction and protein kinase C activation in rat aorta. European journal of pharmacology, 290 3, 253-7Rapoport, R M; Campbell, A K; Bazan, E 1995. Effects of PKC downregulation on norepinephrine- and prostaglandin F2 alpha-induced contraction in rat aorta. The American journal of physiology, 269 2 Pt 2, H590-8Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Decreased endothelium-dependent relaxation in subarachnoid hemorrhage-induced vasospasm: role of ET-1. The American journal of physiology, 269 3 Pt 2, H1009-15Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Endothelin-1-induced endothelin-1 release causes cerebral vasospasm in-vivo. The Journal of pharmacy and pharmacology, 47 8, 702Baik, Y H; French, J F; Schwartz, A; Rapoport, R M 1994. Dihydropyridine Ca2+ channel agonists and antagonists potentiate ultraviolet light-induced relaxation through cyclic GMP formation in porcine coronary artery. Journal of cardiovascular pharmacology, 23 5, 785-91Bazan, E; Campbell, A K; Rapoport, R M 1994. Effects of phorbol esters on contraction and protein kinase C activation in rabbit aorta. Life sciences, 54 2, PL29-33Williams, S P; Campbell, A K; Roszell, N; Myatt, L; Leikauf, G D; Rapoport, R M 1994. Modulation of phorbol ester-induced contraction by endogenously released cyclooxygenase products in rat aorta. The American journal of physiology, 267 5 Pt 2, H1654-62Williams, S P; Dorn, G W; Rapoport, R M 1994. Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle. The American journal of physiology, 267 2 Pt 2, H796-803Zuccarello, M; Lewis, A I; Rapoport, R M 1994. Endothelin ETA and ETB receptors in subarachnoid hemorrhage-induced cerebral vasospasm. European journal of pharmacology, 259 1, R1-2Bazan, E; Campbell, A K; Rapoport, R M 1993. Effects of protein kinase C activation on norepinephrine-induced phosphatidylinositide hydrolysis in intact rat aorta. European journal of pharmacology, 245 2, 173-7Rapoport, R M 1993. Potentiation of norepinephrine-induced contraction by primary prostaglandin receptor activation in rat aorta. European journal of pharmacology, 243 2, 207-10Rapoport, R M 1993. Regulation of vascular smooth muscle contraction by extracellular Na+. General pharmacology, 24 3, 531-7Bazan, E; Campbell, A K; Rapoport, R M 1992. Protein kinase C activity in blood vessels from normotensive and spontaneously hypertensive rats. European journal of pharmacology, 227 3, 343-8Chuprun, J K; Bazan, E; Chang, K C; Campbell, A K; Rapoport, R M 1991. Inhibition of phorbol ester-induced contraction by calmodulin antagonists in rat aorta. The American journal of physiology, 261 4 Pt 1, C675-84Rapoport, R M 1991. Inhibitory effects of cyclic AMP-elevating agents on norepinephrine-induced phosphatidylinositide hydrolysis and contraction in rat aorta. General pharmacology, 22 3, 449-58Rapoport, R M; Campbell, A K 1991. Norepinephrine-induced phosphatidylcholine hydrolysis in intact rat aorta. European journal of pharmacology, 208 1, 89-92Rapoport, R M; Stauderman, K A; Highsmith, R F 1990. Effects of EDCF and endothelin on phosphatidylinositol hydrolysis and contraction in rat aorta. The American journal of physiology, 258 1 Pt 1, C122-31Rapoport, R M; Van Gorp, C; Chang, K C 1990. Inositol uptake in rat aorta. Life sciences, 46 23, 1715-25French, J F; Rapoport, R M; Matlib, M A 1989. Possible mechanism of benzodiazepine-induced relaxation of vascular smooth muscle. Journal of cardiovascular pharmacology, 14 3, 405-11Highsmith, R F; Pang, D C; Rapoport, R M 1989. Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. Journal of cardiovascular pharmacology, 13 Suppl 5 , S36-44; discussion SRapoport, R M; Ashraf, M; Murad, F 1989. Effects of melittin on endothelium-dependent relaxation and cyclic GMP levels in rat aorta. Circulation research, 64 3, 463-73Waldman, S A; Rapoport, R M; Fiscus, R R; Leitman, D C; Chang, L Y; Murad, F 1989. Regulation of particulate guanylate cyclase by atriopeptins: relation between peptide structure, receptor binding, and enzyme kinetics. Biochimica et biophysica acta, 999 2, 157-62Rapoport, R M; Murad, F 1988. Effects of ethacrynic acid and cystamine on sodium nitroprusside-induced relaxation, cyclic GMP levels and guanylate cyclase activity in rat aorta. General pharmacology, 19 1, 61-5Chuprun, J K; Rapoport, R M 1987. Nitroglycerin-induced desensitization of vascular smooth muscle may be mediated through cyclic GMP-disinhibition of phosphatidylinositol hydrolysis. Experientia, 43 3, 316-8Molina, C R; Andresen, J W; Rapoport, R M; Waldman, S; Murad, F 1987. Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. Journal of cardiovascular pharmacology, 10 4, 371-8Rapoport, R M 1987. Effects of norepinephrine on contraction and hydrolysis of phosphatidylinositols in rat aorta. The Journal of pharmacology and experimental therapeutics, 242 1, 188-94Rapoport, R M; Waldman, S A; Ginsburg, R; Molina, C R; Murad, F 1987. Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery. Journal of cardiovascular pharmacology, 10 1, 82-9Draznin, M B; Rapoport, R M; Murad, F 1986. Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta. The International journal of biochemistry, 18 10, 917-28Murad, F; Waldman, S A; Fiscus, R R; Rapoport, R M 1986. Regulation of cyclic GMP synthesis and the interactions with calcium. Journal of cardiovascular pharmacology, 8 Suppl 8 , S57-60Rapoport, R M 1986. Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta. Circulation research, 58 3, 407-10Rapoport, R M; Ginsburg, R; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro. European journal of pharmacology, 124 1-2, 193-6Rapoport, R M; Winquist, R J; Baskin, E P; Faison, E P; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas. European journal of pharmacology, 120 1, 123-6Waldman, S A; Rapoport, R M; Ginsburg, R; Murad, F 1986. Desensitization to nitroglycerin in vascular smooth muscle from rat and human. Biochemical pharmacology, 35 20, 3525-31Fiscus, R R; Rapoport, R M; Waldman, S A; Murad, F 1985. Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. Biochimica et biophysica acta, 846 1, 179-84Leitman, D C; Waldman, S A; Rapoport, R M; Murad, F 1985. Specific atrial natriuretic factor receptors mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and smooth muscle cells. Transactions of the Association of American Physicians, 98 , 243-52Murad, F; Rapoport, R M; Fiscus, R 1985. Role of cyclic-GMP in relaxations of vascular smooth muscle. Journal of cardiovascular pharmacology, 7 Suppl 3 , S111-8Rapoport, R M; Schwartz, K; Murad, F 1985. Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circulation research, 57 1, 164-70Rapoport, R M; Schwartz, K; Murad, F 1985. Effects of Na+,K+-pump inhibitors and membrane depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP accumulation in rat aorta. European journal of pharmacology, 110 2, 203-9Rapoport, R M; Waldman, S A; Schwartz, K; Winquist, R J; Murad, F 1985. Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. European journal of pharmacology, 115 2-3, 219-29Waldman, S A; Rapoport, R M; Fiscus, R R; Murad, F 1985. Effects of atriopeptin on particulate guanylate cyclase from rat adrenal. Biochimica et biophysica acta, 845 2, 298-303Rapoport, R M; Draznin, M B; Murad, F 1984. Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circulation research, 55 4, 468-79Rapoport, R M; Murad, F 1984. Effect of cyanide on nitrovasodilator-induced relaxation, cyclic GMP accumulation and guanylate cyclase activation in rat aorta. European journal of pharmacology, 104 1-2, 61-70Waldman, S A; Rapoport, R M; Murad, F 1984. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. The Journal of biological chemistry, 259 23, 14332-4Winquist, R J; Faison, E P; Waldman, S A; Schwartz, K; Murad, F; Rapoport, R M 1984. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proceedings of the National Academy of Sciences of the United States of America, 81 23, 7661-4Rapoport, R M; Bevan, J A 1983. Effect of contraction on the subsequent responsiveness and maximum contractility of the rabbit ear artery and saphenous vein in vitro. Blood vessels, 20 1, 44-55Rapoport, R M; Draznin, M B; Murad, F 1983. Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Transactions of the Association of American Physicians, 96 , 19-30Rapoport, R M; Murad, F 1983. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circulation research, 52 3, 352-7Rapoport, R M; Murad, F 1983. Effect of ouabain and alterations in potassium concentration on relaxation induced by sodium nitroprusside. Blood vessels, 20 5, 255-64Rapoport, R M; Murad, F 1983. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. Journal of cyclic nucleotide and protein phosphorylation research, 9 4-5, 281-96Rapoport, R M; Bevan, J A 1982. Increased contractility induced in rabbit ear artery by prior exposure to serotonin masks concomitant desensitization to norepinephrine. The Journal of pharmacology and experimental therapeutics, 222 2, 338-43Rapoport, R M; Draznin, M B; Murad, F 1982. Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proceedings of the National Academy of Sciences of the United States of America, 79 21, 6470-4Rapoport, R M; Bevan, J A 1981. Mechanism of electrical stimulation-induced subsensitivity of vascular smooth muscle. The Journal of pharmacology and experimental therapeutics, 218 2, 382-9Rapoport, R M; Bevan, J A 1981. Vascular smooth muscle contraction induced by direct electrical stimulation and its subsequent effect of reactivity to agonists. The Journal of pharmacology and experimental therapeutics, 218 2, 375-81Rapoport, R M; Takimoto, G S; Cho, A K 1981. Compartmental analysis of tyramine-induced norepinephrine depletion. Pharmacology, 22 4, 235-42Rapoport, R M 1978. [Hygienic evaluation of the working conditions at a pilot factory for spindleless spinning]. Gigiena truda i professional'nye zabolevaniia, 4, 51-2Brusova, L A; Iuzhelevski?, Iu A; Rapoport, R M; Poiurovskaia, I Ia; Panikarovski?, V V; Antipova, Z P; Shitsel', L A; Tuzanova, L I . [A new siloxane material for eliminating defects of the soft facial tissues by an injection method. I. The laboratory and experimental research]. Stomatologii?a, 4, 13-5Fiscus, R R; Rapoport, R M; Murad, F . Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta. Journal of cyclic nucleotide and protein phosphorylation research, 9 6, 415-25Motz, Gregory T; Zuccarello, Mario; Rapoport, Robert M . Alkaline pH-induced extracellular regulated protein kinase activation in brain microvascular endothelial cells: differential effects of Tris and lowered CO2. Endothelium : journal of endothelial cell research, 13 5, 313-6Poiurovskaia, I Ia; Rapoport, R M; Nechaenko, N A; Tagiev, A I . [Comparative laboratory evaluation of silicone impression materials used in preparing metalloceramic dentures]. Stomatologii?a, 67 3, 56-8Rapoport, R M; Draznin, M B; Murad, F . Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature, 306 5939, 174-6Yoon, Seong Hun; Zuccarello, Mario; Rapoport, Robert M . Acute cocaine induces endothelin-1-dependent constriction of rabbit basilar artery. Endothelium : journal of endothelial cell research, 14 3, 137-9
Rapoport, Robert M 2014. Acute nitric oxide synthase inhibition and endothelin-1-dependent arterial pressure elevation. Frontiers in pharmacology, 5 , 57Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Sensory nerves and transient receptor potential vanilloid 1 channels in CO2 regulation of cerebrovascular tone. Respiratory physiology & neurobiology, , Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Cocaine Constriction of Rat Basilar Artery in situ: Roles of Nitric Oxide and Endothelin-1. Pharmacology, 93 3-4, 151-154Rapoport, Robert M; Zuccarello, Mario 2012. EndothelinA-EndothelinB Receptor Cross Talk in Endothelin-1-Induced Contraction of Smooth Muscle. Journal of cardiovascular pharmacology, 60 5, 483-94Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2012. pCO(2) and pH regulation of cerebral blood flow. Frontiers in physiology, 3 , 365Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2012. EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn-Schmiedeberg's archives of pharmacology, 385 4, 437-41Rapoport, Robert M; Zuccarello, Mario 2011. Endothelin(A)-endothelin(B) receptor cross-talk and endothelin receptor binding. The Journal of pharmacy and pharmacology, 63 11, 1373-7Fandino, Javier; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2003. Cocaine-induced endothelin-1-dependent spasm in rabbit basilar artery in vivo. Journal of cardiovascular pharmacology, 41 2, 158-61Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway. Neurological research, 25 3, 268-70Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Repeated constriction to respiration-induced hypocapnia is not mimicked by isocapnic alkaline solution in rabbit basilar artery in situ. Vascular pharmacology, 40 1, 7-11Yoon, Seonghun; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2002. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway. Neurological research, 24 4, 392-4Rapoport, R M; Campbell, A K; Chang, K C 2000. Differential regulation of norepinephrine- and prostaglandin F2alpha-induced contraction by extracellular Na+ in rat aorta. Journal of cardiovascular pharmacology, 36 3, 288-96Rapoport, R M; Williams, S P; Campbell, A K 2000. Phorbol ester-induced phosphoinositide hydrolysis in rat aorta: role of cyclooxygenase products. Life sciences, 67 15, 1815-24Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces endothelin-dependent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 333-40Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 325-32Zuccarello, M; Boccaletti, R; Rapoport, R M 2000. Role of NO in endothelium-dependent relaxation of rabbit basilar artery in situ. Neurological research, 22 2, 204-8Zuccarello, M; Lee, B H; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by N(G)-monomethyl-L-arginine monoacetate and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 401 2, 213-9Zuccarello, M; Lee, B H; Rapoport, R M 2000. Reduced verapamil inhibition of endothelin-1-constricted rabbit basilar artery due to enhanced non L-type Ca(2+)-channel-dependent constriction. General pharmacology, 35 1, 11-5Zuccarello, M; Lee, B H; Rapoport, R M 2000. Endothelin-1 mediates hypocapnic constriction of the rabbit basilar artery in-vitro. The Journal of pharmacy and pharmacology, 52 2, 225-6Zuccarello, M; Lee, B; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by serotonin and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 407 1-2, 191-5Zuccarello, M; Boccaletti, R; Rapoport, R M 1999. Does blockade of endothelinB1-receptor activation increase endothelinB2/endothelinA receptor-mediated constriction in the rabbit basilar artery? Journal of cardiovascular pharmacology, 33 5, 679-84Tosun, M; Paul, R J; Rapoport, R M 1998. Coupling of store-operated Ca++ entry to contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 285 2, 759-66Tosun, M; Paul, R J; Rapoport, R M 1998. Role of extracellular Ca++ influx via L-type and non-L-type Ca++ channels in thromboxane A2 receptor-mediated contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 284 3, 921-8Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B1) receptor-mediated relaxation of rabbit basilar artery. European journal of pharmacology, 357 1, 67-71Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B) receptor-mediated constriction in the rabbit basilar artery. European journal of pharmacology, 350 1, R7-9Zuccarello, M; Boccaletti, R; Romano, A; Rapoport, R M 1998. Endothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm. Stroke; a journal of cerebral circulation, 29 9, 1924-9Chuprun, J K; Rapoport, R M 1997. Protein kinase C regulation of ATP-induced phosphoinositide hydrolysis in bovine aorta endothelial cells. Journal of receptor and signal transduction research, 17 6, 787-814Tosun, M; Paul, R J; Rapoport, R M 1997. Intracellular Ca2+ elevation and contraction due to prostaglandin F2alpha in rat aorta. European journal of pharmacology, 340 2-3, 203-8Bazan, E; Rapoport, R M 1996. Methodological considerations for the measurement of protein kinase C translocation in intact smooth muscle. Journal of pharmacological and toxicological methods, 36 2, 87-95Rapoport, R M; Williams, S P 1996. Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension, 28 1, 64-75Zuccarello, M; Boccaletti, R; Tosun, M; Rapoport, R M 1996. Role of extracellular Ca2+ in subarachnoid hemorrhage-induced spasm of the rabbit basilar artery. Stroke; a journal of cerebral circulation, 27 10, 1896-902Zuccarello, M; Bonasso, C L; Lewis, A I; Sperelakis, N; Rapoport, R M 1996. Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim. Stroke; a journal of cerebral circulation, 27 2, 311-6Zuccarello, M; Soattin, G B; Lewis, A I; Breu, V; Hallak, H; Rapoport, R M 1996. Prevention of subarachnoid hemorrhage-induced cerebral vasospasm by oral administration of endothelin receptor antagonists. Journal of neurosurgery, 84 3, 503-7Bazan, E; Campbell, A K; Rapoport, R M 1995. Time course of phorbol ester-induced contraction and protein kinase C activation in rat aorta. European journal of pharmacology, 290 3, 253-7Rapoport, R M; Campbell, A K; Bazan, E 1995. Effects of PKC downregulation on norepinephrine- and prostaglandin F2 alpha-induced contraction in rat aorta. The American journal of physiology, 269 2 Pt 2, H590-8Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Decreased endothelium-dependent relaxation in subarachnoid hemorrhage-induced vasospasm: role of ET-1. The American journal of physiology, 269 3 Pt 2, H1009-15Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Endothelin-1-induced endothelin-1 release causes cerebral vasospasm in-vivo. The Journal of pharmacy and pharmacology, 47 8, 702Baik, Y H; French, J F; Schwartz, A; Rapoport, R M 1994. Dihydropyridine Ca2+ channel agonists and antagonists potentiate ultraviolet light-induced relaxation through cyclic GMP formation in porcine coronary artery. Journal of cardiovascular pharmacology, 23 5, 785-91Bazan, E; Campbell, A K; Rapoport, R M 1994. Effects of phorbol esters on contraction and protein kinase C activation in rabbit aorta. Life sciences, 54 2, PL29-33Williams, S P; Campbell, A K; Roszell, N; Myatt, L; Leikauf, G D; Rapoport, R M 1994. Modulation of phorbol ester-induced contraction by endogenously released cyclooxygenase products in rat aorta. The American journal of physiology, 267 5 Pt 2, H1654-62Williams, S P; Dorn, G W; Rapoport, R M 1994. Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle. The American journal of physiology, 267 2 Pt 2, H796-803Zuccarello, M; Lewis, A I; Rapoport, R M 1994. Endothelin ETA and ETB receptors in subarachnoid hemorrhage-induced cerebral vasospasm. European journal of pharmacology, 259 1, R1-2Bazan, E; Campbell, A K; Rapoport, R M 1993. Effects of protein kinase C activation on norepinephrine-induced phosphatidylinositide hydrolysis in intact rat aorta. European journal of pharmacology, 245 2, 173-7Rapoport, R M 1993. Potentiation of norepinephrine-induced contraction by primary prostaglandin receptor activation in rat aorta. European journal of pharmacology, 243 2, 207-10Rapoport, R M 1993. Regulation of vascular smooth muscle contraction by extracellular Na+. General pharmacology, 24 3, 531-7Bazan, E; Campbell, A K; Rapoport, R M 1992. Protein kinase C activity in blood vessels from normotensive and spontaneously hypertensive rats. European journal of pharmacology, 227 3, 343-8Chuprun, J K; Bazan, E; Chang, K C; Campbell, A K; Rapoport, R M 1991. Inhibition of phorbol ester-induced contraction by calmodulin antagonists in rat aorta. The American journal of physiology, 261 4 Pt 1, C675-84Rapoport, R M 1991. Inhibitory effects of cyclic AMP-elevating agents on norepinephrine-induced phosphatidylinositide hydrolysis and contraction in rat aorta. General pharmacology, 22 3, 449-58Rapoport, R M; Campbell, A K 1991. Norepinephrine-induced phosphatidylcholine hydrolysis in intact rat aorta. European journal of pharmacology, 208 1, 89-92Rapoport, R M; Stauderman, K A; Highsmith, R F 1990. Effects of EDCF and endothelin on phosphatidylinositol hydrolysis and contraction in rat aorta. The American journal of physiology, 258 1 Pt 1, C122-31Rapoport, R M; Van Gorp, C; Chang, K C 1990. Inositol uptake in rat aorta. Life sciences, 46 23, 1715-25French, J F; Rapoport, R M; Matlib, M A 1989. Possible mechanism of benzodiazepine-induced relaxation of vascular smooth muscle. Journal of cardiovascular pharmacology, 14 3, 405-11Highsmith, R F; Pang, D C; Rapoport, R M 1989. Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. Journal of cardiovascular pharmacology, 13 Suppl 5 , S36-44; discussion SRapoport, R M; Ashraf, M; Murad, F 1989. Effects of melittin on endothelium-dependent relaxation and cyclic GMP levels in rat aorta. Circulation research, 64 3, 463-73Waldman, S A; Rapoport, R M; Fiscus, R R; Leitman, D C; Chang, L Y; Murad, F 1989. Regulation of particulate guanylate cyclase by atriopeptins: relation between peptide structure, receptor binding, and enzyme kinetics. Biochimica et biophysica acta, 999 2, 157-62Rapoport, R M; Murad, F 1988. Effects of ethacrynic acid and cystamine on sodium nitroprusside-induced relaxation, cyclic GMP levels and guanylate cyclase activity in rat aorta. General pharmacology, 19 1, 61-5Chuprun, J K; Rapoport, R M 1987. Nitroglycerin-induced desensitization of vascular smooth muscle may be mediated through cyclic GMP-disinhibition of phosphatidylinositol hydrolysis. Experientia, 43 3, 316-8Molina, C R; Andresen, J W; Rapoport, R M; Waldman, S; Murad, F 1987. Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. Journal of cardiovascular pharmacology, 10 4, 371-8Rapoport, R M 1987. Effects of norepinephrine on contraction and hydrolysis of phosphatidylinositols in rat aorta. The Journal of pharmacology and experimental therapeutics, 242 1, 188-94Rapoport, R M; Waldman, S A; Ginsburg, R; Molina, C R; Murad, F 1987. Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery. Journal of cardiovascular pharmacology, 10 1, 82-9Draznin, M B; Rapoport, R M; Murad, F 1986. Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta. The International journal of biochemistry, 18 10, 917-28Murad, F; Waldman, S A; Fiscus, R R; Rapoport, R M 1986. Regulation of cyclic GMP synthesis and the interactions with calcium. Journal of cardiovascular pharmacology, 8 Suppl 8 , S57-60Rapoport, R M 1986. Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta. Circulation research, 58 3, 407-10Rapoport, R M; Ginsburg, R; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro. European journal of pharmacology, 124 1-2, 193-6Rapoport, R M; Winquist, R J; Baskin, E P; Faison, E P; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas. European journal of pharmacology, 120 1, 123-6Waldman, S A; Rapoport, R M; Ginsburg, R; Murad, F 1986. Desensitization to nitroglycerin in vascular smooth muscle from rat and human. Biochemical pharmacology, 35 20, 3525-31Fiscus, R R; Rapoport, R M; Waldman, S A; Murad, F 1985. Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. Biochimica et biophysica acta, 846 1, 179-84Leitman, D C; Waldman, S A; Rapoport, R M; Murad, F 1985. Specific atrial natriuretic factor receptors mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and smooth muscle cells. Transactions of the Association of American Physicians, 98 , 243-52Murad, F; Rapoport, R M; Fiscus, R 1985. Role of cyclic-GMP in relaxations of vascular smooth muscle. Journal of cardiovascular pharmacology, 7 Suppl 3 , S111-8Rapoport, R M; Schwartz, K; Murad, F 1985. Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circulation research, 57 1, 164-70Rapoport, R M; Schwartz, K; Murad, F 1985. Effects of Na+,K+-pump inhibitors and membrane depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP accumulation in rat aorta. European journal of pharmacology, 110 2, 203-9Rapoport, R M; Waldman, S A; Schwartz, K; Winquist, R J; Murad, F 1985. Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. European journal of pharmacology, 115 2-3, 219-29Waldman, S A; Rapoport, R M; Fiscus, R R; Murad, F 1985. Effects of atriopeptin on particulate guanylate cyclase from rat adrenal. Biochimica et biophysica acta, 845 2, 298-303Rapoport, R M; Draznin, M B; Murad, F 1984. Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circulation research, 55 4, 468-79Rapoport, R M; Murad, F 1984. Effect of cyanide on nitrovasodilator-induced relaxation, cyclic GMP accumulation and guanylate cyclase activation in rat aorta. European journal of pharmacology, 104 1-2, 61-70Waldman, S A; Rapoport, R M; Murad, F 1984. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. The Journal of biological chemistry, 259 23, 14332-4Winquist, R J; Faison, E P; Waldman, S A; Schwartz, K; Murad, F; Rapoport, R M 1984. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proceedings of the National Academy of Sciences of the United States of America, 81 23, 7661-4Rapoport, R M; Bevan, J A 1983. Effect of contraction on the subsequent responsiveness and maximum contractility of the rabbit ear artery and saphenous vein in vitro. Blood vessels, 20 1, 44-55Rapoport, R M; Draznin, M B; Murad, F 1983. Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Transactions of the Association of American Physicians, 96 , 19-30Rapoport, R M; Murad, F 1983. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circulation research, 52 3, 352-7Rapoport, R M; Murad, F 1983. Effect of ouabain and alterations in potassium concentration on relaxation induced by sodium nitroprusside. Blood vessels, 20 5, 255-64Rapoport, R M; Murad, F 1983. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. Journal of cyclic nucleotide and protein phosphorylation research, 9 4-5, 281-96Rapoport, R M; Bevan, J A 1982. Increased contractility induced in rabbit ear artery by prior exposure to serotonin masks concomitant desensitization to norepinephrine. The Journal of pharmacology and experimental therapeutics, 222 2, 338-43Rapoport, R M; Draznin, M B; Murad, F 1982. Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proceedings of the National Academy of Sciences of the United States of America, 79 21, 6470-4Rapoport, R M; Bevan, J A 1981. Mechanism of electrical stimulation-induced subsensitivity of vascular smooth muscle. The Journal of pharmacology and experimental therapeutics, 218 2, 382-9Rapoport, R M; Bevan, J A 1981. Vascular smooth muscle contraction induced by direct electrical stimulation and its subsequent effect of reactivity to agonists. The Journal of pharmacology and experimental therapeutics, 218 2, 375-81Rapoport, R M; Takimoto, G S; Cho, A K 1981. Compartmental analysis of tyramine-induced norepinephrine depletion. Pharmacology, 22 4, 235-42Rapoport, R M 1978. [Hygienic evaluation of the working conditions at a pilot factory for spindleless spinning]. Gigiena truda i professional'nye zabolevaniia, 4, 51-2Brusova, L A; Iuzhelevski?, Iu A; Rapoport, R M; Poiurovskaia, I Ia; Panikarovski?, V V; Antipova, Z P; Shitsel', L A; Tuzanova, L I . [A new siloxane material for eliminating defects of the soft facial tissues by an injection method. I. The laboratory and experimental research]. Stomatologii?a, 4, 13-5Fiscus, R R; Rapoport, R M; Murad, F . Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta. Journal of cyclic nucleotide and protein phosphorylation research, 9 6, 415-25Motz, Gregory T; Zuccarello, Mario; Rapoport, Robert M . Alkaline pH-induced extracellular regulated protein kinase activation in brain microvascular endothelial cells: differential effects of Tris and lowered CO2. Endothelium : journal of endothelial cell research, 13 5, 313-6Poiurovskaia, I Ia; Rapoport, R M; Nechaenko, N A; Tagiev, A I . [Comparative laboratory evaluation of silicone impression materials used in preparing metalloceramic dentures]. Stomatologii?a, 67 3, 56-8Rapoport, R M; Draznin, M B; Murad, F . Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature, 306 5939, 174-6Yoon, Seong Hun; Zuccarello, Mario; Rapoport, Robert M . Acute cocaine induces endothelin-1-dependent constriction of rabbit basilar artery. Endothelium : journal of endothelial cell research, 14 3, 137-9
Abstract Publications Yoon SH, Zuccarello M, Rapoport RM 2003. Respiratory induced hypocapnic constriction of rat basilar artery: dependence on endothelin-1 FASEB, , Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Cerebral Vasospasm: Advances in Research and Treatment, , 75-78Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Congress Neurological Surgeons, , Fandino, J., Sherman, D., Zuccarello, M., and Rapoport, R.M. 2000. Endothelin-1 mediates cocaine-induced cerebrovasospasm 7th International Conference on Cerebral Vasospasm, , 6Sherman, J.D., Fandino, J., Zuccarello, M., and Rapoport, R.M. 2000. Cocaine-induced cerebral vasospasm in vivo: mediated by endothelin-1 Stroke, , Zuccarello, M., Sherman, J., and Rapoport, R.M. 2000. Subarachnoid hemorrhage-induced vasospasm: role of calcium sensitization 6th Internet World Congress for Biomedical Sciences, , Sherman, J.D., Zuccarello, M., and Rapoport, R.M. 1999. Role of calcium sensitization in cerebral vasospasm Congress Neurological Surgeons, , Sherman, J.D., Rapoport, R.M., and Zuccarello, M. 1998. The role of endothelin-1 in subarachnoid hemorrhage-induced vasospasm INABIS ’98 - 5th Internet World Congress on Biomedical Sciences at McMater University, Canada, , Tosun, M., Paul, R.J., and Rapoport, R.M. 1998. Coupling of store-operated Ca2+ entry to contraction in rat aorta FASEB J., , Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelium-derived nitric oxide regulates endothelin A versus endothelin B receptor-mediated constriction in rabbit basilar artery in situ Stroke, 29 , 323Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelin B receptor antagonists prevent subarachnoid hemorrhage-induced spasm in rabbit basilar artery in vivo Congress Neurological Surgeons, Seattle, WA, , Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1997. Endothelin B1 receptor-mediated endothelin-1 release maintains subarachnoid hemorrhage-induced spasm of rabbit basilar 18th Int. Symp. Cerebral Blood Flow and Metabolism, 17 , S471Zuccarello, M. Boccaletti, R., and Rapoport, R.M. 1995. Ca2+ Influx Through Non-L-Type Ca2+ Channels Mediates Subarachnoid Hemorrhage-Induced Vasospasm: Role of Endothelin-1 (ET-1) Stroke, , Zuccarello, M., Soattin, G.B., Lewis, A.I., and Rapoport, R.M. 1995. Oral Bosentan, an endothelin (ET)A and ETB receptor antagonist, prevents subarachnoid hemorrhage (SAH)-induced cerebral vasospasm The Fourth International Workshop on Cerebrovascular Surgery (INCVS), Chicago, Illinois, , Zuccarello, M., Rapoport, R.M., and Romano, A. 1994. Subarachnoid hemorrhage (SAH)-induced vasospasm may be due to endothelin (ET) release and not decreased endothelium-dependent relaxation (EDR) Stroke, 25 , 136Zuccarello, M. and Rapoport, R.M. 1993. Role of K+ channels in vasospasm after subarachnoid hemorrhage Stroke, 24 , 168Zuccarello, M., Bonasso, C., Rapoport, R.M., and Sperelakis, N. 1993. Role of membrane potential in vasospasm after subarachnoid hemorrhage (SAH) Vth Int. Symp. Cerebral Vasospasm, Edmonton, , Williams, S.P., Dorn, G.W., II, Campbell, A.K., Leikauf, G.O., Myatt, L., and Rapoport, R.M. 1992. Prostaglandin I2 (PGI2) may mediate phorbol ester induced increased inositol phosphate levels FASEB, , Chuprun, J.K. and Rapoport, R.M. 1991. Protein kinase C attenuates agonist and G protein stimulated phospholipase C activity in endothelial cell membranes FASEB J., 5 , A1598Rapoport, R.M., Bazan, E., and Campbell, A.K. 1991. Relationship between protein kinase C (PKC) activation, phosphoinositide hydrolysis and contraction in rat aorta J. Mol. Cell. Cardiol, 23 , S12Williams, S.P., Dorn, G.W. II, Campbell, A.K., Leikauf, G.D., Myatt, L. and Rapoport, R.M. 1991. Phorbol ester induced phosphatidylinositide hydrolysis in rat aorta: potential role of prostacyclin (PGI2) J. Molec. Cell. Cardiol., 23 , S65Chuprun, J.K., and Rapoport, R.M. 1990. Regulation of endothelial cell membrane phospholipase C activity by protein kinase C 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, , Williams, S.P., Campbell, A.K., Leikauf, G.D., and Rapoport, R.M. 1990. Phorbol esters induce phosphatidylinositide hydrolysis and arachidonic acid metabolism in rat aorta 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, , Highsmith, R.F., Pang, D., Schmidt, D., and Rapoport, R. 1989. Mechanisms of action of endothelial cell derived constricting factors J. Vascular Medicine Biology, 1 , 92Highsmith, R.F., Koth, D.M., Westrich, L.A., and Rapoport, R.M. 1987. Vasoconstriction induced by endothelium derived constricting factor (EDCF) may be mediated through phosphatidylinositol (PI) turnover Circulation, 15 , Chuprun, J.K. and Rapoport, R.M. 1986. Nitroglycerin induced desensitization of vascular smooth muscle may be mediated through cyclic GMP disinhibition of phosphatidylinositol hydrolysis 27th National Student Research Forum, , 17Rapoport, R.M. 1986. Effects of norepinephrine on contraction and hydrolysis of phospha-tidylinositides in rat aorta Veterans Administration National Research and Development Conference, Las Vegas, Nevada, , Baik, Y.H., Dube, G., Vaghy, P., Rapoport, R., and Schwartz, A. 1985. Modification of effects of the enantiomers of a 1,4 dihydropyridine (202 791) by endothelium and light in pig coronary artery Pharmacology, , Fiscus, R.R., Robles, B.T., Rapoport, R.M., Waldman, S.A., and Murad, F. 1985. Atrial natriuretic factor elevates cyclic GMP and activates cyclic GMP dependent protein kinase in rat aorta: potential mechanism of vasodilation Fed. Proc., 44 , 698Molina, C.R., Andresen, J.W., Rapoport, R., Waldman, S., and Murad, F. 1985. The effect of in vivo nitroglycerin therapy on endothelium dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta Clin. Res., , Murad, F., Rapoport, R.M., Waldman, S.A., Fiscus, R.R., and Leitman, D.C. 1985. The role of cyclic GMP in endothelium dependent, nitrovasodilator and atriopeptin mediated vascular relaxation , , Fiscus, R.R., Rapoport, R.M., and Murad, F. 1984. Activation of cyclic GMP dependent protein kinase in rat aorta by sodium nitroprusside and endothelium dependent vasodilators Clin. Res., 32 , 5ADraznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Effects of norepi-nephrine, sodium nitroprusside, calcium free buffer and a calmodulin inhibitor on protein phosphorylation related to contraction and relaxation in intact rat aorta Clin. Res., 31 , 6ADraznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Myosin light chain dephosphorylation in intact rat thoracic aorta treated with sodium nitroprusside: role of cyclic GMP Clin. Res., 31 , 466ARapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Effect of endothelium dependent vasodilators on relaxation, cyclic GMP levels and protein phosphorylation in rat thoracic aorta Clin. Res., 3l , 16ARapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Endothelium dependent vascular relaxation may be mediated through cyclic GMP dependent protein phosphorylation Clin. Res., 31 , 526ADraznin, M.B., Rapoport, R.M., and Murad, F. 1982. Vascular smooth muscle protein phosphorylation following sodium nitroprusside treatment: possible role in smooth muscle relaxation Clin. Res., 30 , 6ARapoport, R.M. and Murad, F. 1982. Ouabain inhibits relaxation by nitroprusside and 8 bromo cyclic GMP in rat aorta Clin. Res., 30 , 18ARapoport, R.M., Draznin, M.B., and Murad, F. 1982. Sodium nitroprusside induced protein phosphorylation in intact rat aorta is mimicked by 8 bromo cyclic GMP Clin. Res., 30 , 484ARapoport, R.M., Brandwein, H.J., and Murad, F. 1981. Cystamine inhibits relaxation, increases in cyclic GMP accumulation, and guanylate cyclase activation induced by nitroprusside in rat aorta Fed. Proc., 40 , 690Rapoport, R.M., Lewicki, J.A., and Murad, F. 1981. Cyanide inhibits relaxation, increases in cyclic GMP accumulation and guanylate cyclase activation induced by nitroprusside in rat aorta Circulation, 64 , 70Duckles, S.P. and Rapoport, R. 1980. Lack of effect of clonidine on norepinephrine (NE) release from a rabbit cerebral artery Fed. Proc., 38 , 367Rapoport, R.M. and Bevan, J.A. 1980. Sympathetic nerve activity desensitizes vascular smooth muscle in vitro Fed. Proc., 38 , 367Rapoport, R.M. and Bevan, J.A. 1980. Electrical stimulation of vascular smooth muscle induces subsensitivity in vitro Fed. Proc., 39 , 1071Bevan, J.A., Bevan, R.D., Pascual, R., and Rapoport, R. 1978. Some anatomical and functional factors influencing vascular smooth muscle sensitivity to norepinephrine 7th International Congress on Pharmacology, , 36Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Release of norepinephrine (NE) from cerebral blood vessels: correlation of two techniques 7th International Congress on Pharmacology, , 36Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Nerve stimulation of cerebral arteries releases endogenous norepinephrine (NE): confirmation by radioenzymatic assay of adrenergic nerve function 3rd International Symposium on Vascular Neuroeffector Mechanisms, , 28-29Molina, C.R., Andresen, J.W., Rapoport, R.M., and Murad, F. . The effect of nitroglycerin tolerance on endothelium dependent vascular relaxation Circulation, 74 , 287
Yoon SH, Zuccarello M, Rapoport RM 2003. Respiratory induced hypocapnic constriction of rat basilar artery: dependence on endothelin-1 FASEB, , Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Cerebral Vasospasm: Advances in Research and Treatment, , 75-78Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Congress Neurological Surgeons, , Fandino, J., Sherman, D., Zuccarello, M., and Rapoport, R.M. 2000. Endothelin-1 mediates cocaine-induced cerebrovasospasm 7th International Conference on Cerebral Vasospasm, , 6Sherman, J.D., Fandino, J., Zuccarello, M., and Rapoport, R.M. 2000. Cocaine-induced cerebral vasospasm in vivo: mediated by endothelin-1 Stroke, , Zuccarello, M., Sherman, J., and Rapoport, R.M. 2000. Subarachnoid hemorrhage-induced vasospasm: role of calcium sensitization 6th Internet World Congress for Biomedical Sciences, , Sherman, J.D., Zuccarello, M., and Rapoport, R.M. 1999. Role of calcium sensitization in cerebral vasospasm Congress Neurological Surgeons, , Sherman, J.D., Rapoport, R.M., and Zuccarello, M. 1998. The role of endothelin-1 in subarachnoid hemorrhage-induced vasospasm INABIS ’98 - 5th Internet World Congress on Biomedical Sciences at McMater University, Canada, , Tosun, M., Paul, R.J., and Rapoport, R.M. 1998. Coupling of store-operated Ca2+ entry to contraction in rat aorta FASEB J., , Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelium-derived nitric oxide regulates endothelin A versus endothelin B receptor-mediated constriction in rabbit basilar artery in situ Stroke, 29 , 323Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelin B receptor antagonists prevent subarachnoid hemorrhage-induced spasm in rabbit basilar artery in vivo Congress Neurological Surgeons, Seattle, WA, , Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1997. Endothelin B1 receptor-mediated endothelin-1 release maintains subarachnoid hemorrhage-induced spasm of rabbit basilar 18th Int. Symp. Cerebral Blood Flow and Metabolism, 17 , S471Zuccarello, M. Boccaletti, R., and Rapoport, R.M. 1995. Ca2+ Influx Through Non-L-Type Ca2+ Channels Mediates Subarachnoid Hemorrhage-Induced Vasospasm: Role of Endothelin-1 (ET-1) Stroke, , Zuccarello, M., Soattin, G.B., Lewis, A.I., and Rapoport, R.M. 1995. Oral Bosentan, an endothelin (ET)A and ETB receptor antagonist, prevents subarachnoid hemorrhage (SAH)-induced cerebral vasospasm The Fourth International Workshop on Cerebrovascular Surgery (INCVS), Chicago, Illinois, , Zuccarello, M., Rapoport, R.M., and Romano, A. 1994. Subarachnoid hemorrhage (SAH)-induced vasospasm may be due to endothelin (ET) release and not decreased endothelium-dependent relaxation (EDR) Stroke, 25 , 136Zuccarello, M. and Rapoport, R.M. 1993. Role of K+ channels in vasospasm after subarachnoid hemorrhage Stroke, 24 , 168Zuccarello, M., Bonasso, C., Rapoport, R.M., and Sperelakis, N. 1993. Role of membrane potential in vasospasm after subarachnoid hemorrhage (SAH) Vth Int. Symp. Cerebral Vasospasm, Edmonton, , Williams, S.P., Dorn, G.W., II, Campbell, A.K., Leikauf, G.O., Myatt, L., and Rapoport, R.M. 1992. Prostaglandin I2 (PGI2) may mediate phorbol ester induced increased inositol phosphate levels FASEB, , Chuprun, J.K. and Rapoport, R.M. 1991. Protein kinase C attenuates agonist and G protein stimulated phospholipase C activity in endothelial cell membranes FASEB J., 5 , A1598Rapoport, R.M., Bazan, E., and Campbell, A.K. 1991. Relationship between protein kinase C (PKC) activation, phosphoinositide hydrolysis and contraction in rat aorta J. Mol. Cell. Cardiol, 23 , S12Williams, S.P., Dorn, G.W. II, Campbell, A.K., Leikauf, G.D., Myatt, L. and Rapoport, R.M. 1991. Phorbol ester induced phosphatidylinositide hydrolysis in rat aorta: potential role of prostacyclin (PGI2) J. Molec. Cell. Cardiol., 23 , S65Chuprun, J.K., and Rapoport, R.M. 1990. Regulation of endothelial cell membrane phospholipase C activity by protein kinase C 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, , Williams, S.P., Campbell, A.K., Leikauf, G.D., and Rapoport, R.M. 1990. Phorbol esters induce phosphatidylinositide hydrolysis and arachidonic acid metabolism in rat aorta 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, , Highsmith, R.F., Pang, D., Schmidt, D., and Rapoport, R. 1989. Mechanisms of action of endothelial cell derived constricting factors J. Vascular Medicine Biology, 1 , 92Highsmith, R.F., Koth, D.M., Westrich, L.A., and Rapoport, R.M. 1987. Vasoconstriction induced by endothelium derived constricting factor (EDCF) may be mediated through phosphatidylinositol (PI) turnover Circulation, 15 , Chuprun, J.K. and Rapoport, R.M. 1986. Nitroglycerin induced desensitization of vascular smooth muscle may be mediated through cyclic GMP disinhibition of phosphatidylinositol hydrolysis 27th National Student Research Forum, , 17Rapoport, R.M. 1986. Effects of norepinephrine on contraction and hydrolysis of phospha-tidylinositides in rat aorta Veterans Administration National Research and Development Conference, Las Vegas, Nevada, , Baik, Y.H., Dube, G., Vaghy, P., Rapoport, R., and Schwartz, A. 1985. Modification of effects of the enantiomers of a 1,4 dihydropyridine (202 791) by endothelium and light in pig coronary artery Pharmacology, , Fiscus, R.R., Robles, B.T., Rapoport, R.M., Waldman, S.A., and Murad, F. 1985. Atrial natriuretic factor elevates cyclic GMP and activates cyclic GMP dependent protein kinase in rat aorta: potential mechanism of vasodilation Fed. Proc., 44 , 698Molina, C.R., Andresen, J.W., Rapoport, R., Waldman, S., and Murad, F. 1985. The effect of in vivo nitroglycerin therapy on endothelium dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta Clin. Res., , Murad, F., Rapoport, R.M., Waldman, S.A., Fiscus, R.R., and Leitman, D.C. 1985. The role of cyclic GMP in endothelium dependent, nitrovasodilator and atriopeptin mediated vascular relaxation , , Fiscus, R.R., Rapoport, R.M., and Murad, F. 1984. Activation of cyclic GMP dependent protein kinase in rat aorta by sodium nitroprusside and endothelium dependent vasodilators Clin. Res., 32 , 5ADraznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Effects of norepi-nephrine, sodium nitroprusside, calcium free buffer and a calmodulin inhibitor on protein phosphorylation related to contraction and relaxation in intact rat aorta Clin. Res., 31 , 6ADraznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Myosin light chain dephosphorylation in intact rat thoracic aorta treated with sodium nitroprusside: role of cyclic GMP Clin. Res., 31 , 466ARapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Effect of endothelium dependent vasodilators on relaxation, cyclic GMP levels and protein phosphorylation in rat thoracic aorta Clin. Res., 3l , 16ARapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Endothelium dependent vascular relaxation may be mediated through cyclic GMP dependent protein phosphorylation Clin. Res., 31 , 526ADraznin, M.B., Rapoport, R.M., and Murad, F. 1982. Vascular smooth muscle protein phosphorylation following sodium nitroprusside treatment: possible role in smooth muscle relaxation Clin. Res., 30 , 6ARapoport, R.M. and Murad, F. 1982. Ouabain inhibits relaxation by nitroprusside and 8 bromo cyclic GMP in rat aorta Clin. Res., 30 , 18ARapoport, R.M., Draznin, M.B., and Murad, F. 1982. Sodium nitroprusside induced protein phosphorylation in intact rat aorta is mimicked by 8 bromo cyclic GMP Clin. Res., 30 , 484ARapoport, R.M., Brandwein, H.J., and Murad, F. 1981. Cystamine inhibits relaxation, increases in cyclic GMP accumulation, and guanylate cyclase activation induced by nitroprusside in rat aorta Fed. Proc., 40 , 690Rapoport, R.M., Lewicki, J.A., and Murad, F. 1981. Cyanide inhibits relaxation, increases in cyclic GMP accumulation and guanylate cyclase activation induced by nitroprusside in rat aorta Circulation, 64 , 70Duckles, S.P. and Rapoport, R. 1980. Lack of effect of clonidine on norepinephrine (NE) release from a rabbit cerebral artery Fed. Proc., 38 , 367Rapoport, R.M. and Bevan, J.A. 1980. Sympathetic nerve activity desensitizes vascular smooth muscle in vitro Fed. Proc., 38 , 367Rapoport, R.M. and Bevan, J.A. 1980. Electrical stimulation of vascular smooth muscle induces subsensitivity in vitro Fed. Proc., 39 , 1071Bevan, J.A., Bevan, R.D., Pascual, R., and Rapoport, R. 1978. Some anatomical and functional factors influencing vascular smooth muscle sensitivity to norepinephrine 7th International Congress on Pharmacology, , 36Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Release of norepinephrine (NE) from cerebral blood vessels: correlation of two techniques 7th International Congress on Pharmacology, , 36Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Nerve stimulation of cerebral arteries releases endogenous norepinephrine (NE): confirmation by radioenzymatic assay of adrenergic nerve function 3rd International Symposium on Vascular Neuroeffector Mechanisms, , 28-29Molina, C.R., Andresen, J.W., Rapoport, R.M., and Murad, F. . The effect of nitroglycerin tolerance on endothelium dependent vascular relaxation Circulation, 74 , 287