Education/CredentialsFellowship: Mt. Sinai School of Medicine (Renal Diseases ) Residency: New York Infirmary (Internal Medicine )Residency: University of Lausanne Medical Center (Pathophysiology )Medical Degree: University of Lausanne School of MedicineBachelor's Degree: University of Basel School of Medicine (Pre-Med) Board Certifications & LicensesAmerican Board of Internal Medicine (Certification Date: 1978-09-13)American Board of Internal Medicine (Nephrology) (Certification Date: 1982-11-09) SpecialtiesInternal MedicineNephrology Contact Information Email reifmc@ucmail.uc.edu Research InterestsThe Genetic Background of Salt Metabolism and Its Relationship to Hypertension, Cardiovascular Risk Reduction, Hypertension, Metabolic Syndrome, Hyperlipidemia and Heart Failure. Clinical Interests Nephrology Peer Reviewed Publications Bakris G, Gradman A, Reif M, Wofford M, Munger M, Harris S, Vendetti J, Michelson E, Wang R and the CLAIM study investigators 2001. Antihypertensive efficacy of candesartan in comparison to losartan. The CLAIM study J Clin Hypertens, 3 , 16Kishore BK, Krane CM, Reif MC, Menon AG 2001. Urinary concentration defect in the elderly population: Insights from recent advances in physiology and pathophysiology of renal aquaporins Int Urol and Nephrol, 33 , 235Papademetriou V, Reif M, Henry D, Neutel JM, Levine JH, Hardison JD, Flanagan T, Michelson EL 2000. Combination therapy with candesartan cilexetil and hydrochlorothiazide in patients with systemic hypertension J Clin Hypertens, 1 , 2Reif MC 2000. New hope for protecting the kidneys from hypertension Drug Benefit Trades, 12(supplement E) , 17Reif MC 2000. The pharmaceutical industry - to whom is it accountable? N Engl J Med, 343 , 1415Bindels RJM, Schafer JA, Reif MC 1998. Stimulation of sodium transport by aldosterone and arginine vasotocin in A6 cells Biochim Biophys Acta, 972 , 320Onions K, Hunt SC, Rutkowski MP, Klanke CA, Su YR, Reif MC, Menon AG 1998. Genetic markers at the leptin locus are not linked to hypertension in African Americans Hypertension, 31 , 1230Reif MC, White W, Fagan T, Oparil S, Flanagan TL, Edwards DR, Cushing DJ, Michelson EL 1998. Effects if candesartan cilexitil in patients with systemic hypertension Am J Cardiol, 82 , 961Cui Y, Su YR, Rutkowski M, Reif M, Menon AG, Pun RYK 1997. Loss of protein kinase C (PKC) inhibition in the beta T594M variant of the amiloride-sensitive sodium channel Pro Natl Acad Sci, 94 , 9962Oparil S, Kobril I, Abernethy DR, Levine BS, Reif MS, Shepherd AM 1997. Dose-response characteristics of mibefradil, a novel calcium channel antagonist, in the treatment of essential hypertension AM J Hypertens, 10 , 735-742Hebert LA, Agarwal G, Ladson-Wofford SE, Reif MC, Hiremath L, Carlton SG, Nahman NS, Falkenhain ME, Agarwal A 1996. Nocturnal blood pressure in treated hypertensive African-Americans compared to treated hypertensive European Americans. J Am Soc Neph, 7 , 2130Reif MC, Hanto DW, Moulton JS, Alspaugh JP, Bejarano P 1996. Primary hepatic pheochromocytoma AM J Hypertens, 9 , 1040Su YR, Rutkowski MP, Klanke CA, Wu X, Pun RYK, Carter V, Gartside PS, Reif MC, Menon A 1996. A novel variant of the amiloride-sensitive sodium channel beta-subunit in African Americans is associated with enhanced cAMP responsiveness J Am Soc Neph, 7 , 2543Reif MC, Carter V 1994. The retail cost of antihypertensive therapy. Physician and patient as educated consumers AM J Hypertens, 7 , 571Chen L, Reif MC, Schafer JA 1991. Clonidine and PGE2 have different effets on Na+ and water transport in the rat and rabbit CCT Am J Physiol, 261 , F126Reif MC, Troutman SL, Schafer JA 1986. Sodium transport by rat cortical collecting tubule. Effects of vasopressin and desoxycorticosterone J Clin Invest, 77 4, 1291Wall B, Keller FS, Spalding MD, Reif MC 1986. Massive hemorrhage from a lumbar artery following percutaneous renal biopsy Am J Kidney Dis, 7 3, 250Reif MC, Troutman SL, Schafer JA 1984. Sustained response to vasopressin in isolated rat cortical collecting tubule Kidney Int, 26 5, 725Abramson RG, King VF, Reif MC, Leal-Pinto E, Baruch SB 1982. Urate uptake in membrane vesicles of rat renal cortex: Effect of copper Am J Physiol, 242 , F158Reif MC, Constantiner A, Levitt MF 1981. Chronic gouty nephropathy: A vanishing syndrome? N Engl J Med, 304 , 535 Abstract Publications Chen L, Parris M, Willilams SK, Reif MC, Schafer JA 1989. Different effects of clonidine and prostaglandin E2 on vasopressin response of rat and rabbit cortical collecting duct. Nephrol, 178A , Bindels RJM, Schafer JA, Reif MC 1987. Stiumulation of Na+ transport by novobiocin in cultured kidney A6 cells. Am Soc Nephrol, 269A , Reif MC, Bindels RJM, Schafer JA 1987. Regulation of Na+ transport by aldosterone and arginine vasotocin (AVT) in cultured kidney A6 cells. Am Soc Nephrol, 136A , Reif MC, Schafer JA 1985. Prostaglandin E2 does not inhibit vasopressin action in the isolated perfused rat cortical collecting tubule. Kidney Int, 27 1, 332Reif MC, Schafer JA 1984. Arginine vasopressin (ADH) induces a stable increase in rat Na+ absoprtion by rat cortical collecting tubule. Fed Proc, 43 108, Reif MC, Troutman SL, Schafer JA 1984. Water permeability response of rat collecting tubules to ADH. Kidney Int, 25 1, 314Abramson RG, Baruch SB, Reif MC, Leal-Pinto E, King VF 1980. Apparent dependence of urate transport on chloride permeability in membrane vesicles from rat renal cortex. Renal Physiol, 2(3) 20, 150Abramson RG, Reif MC, King VF, Leal-Pinto E, Baruch, SB 1980. Effect of copper on urate transport on chloride permeability in membrane vesicles from rat renal cortex. Renal Physiol, Fed Proc 39 2436, Abramson RG, Reif M, King VF, Leal-Pinto E, Baruch SB 1979. Role of copper in urate transport and oxidation by membrane vesicles of rat renal cortex. Am Soc Nephrol, 12 32A,
Research InterestsThe Genetic Background of Salt Metabolism and Its Relationship to Hypertension, Cardiovascular Risk Reduction, Hypertension, Metabolic Syndrome, Hyperlipidemia and Heart Failure.
Peer Reviewed Publications Bakris G, Gradman A, Reif M, Wofford M, Munger M, Harris S, Vendetti J, Michelson E, Wang R and the CLAIM study investigators 2001. Antihypertensive efficacy of candesartan in comparison to losartan. The CLAIM study J Clin Hypertens, 3 , 16Kishore BK, Krane CM, Reif MC, Menon AG 2001. Urinary concentration defect in the elderly population: Insights from recent advances in physiology and pathophysiology of renal aquaporins Int Urol and Nephrol, 33 , 235Papademetriou V, Reif M, Henry D, Neutel JM, Levine JH, Hardison JD, Flanagan T, Michelson EL 2000. Combination therapy with candesartan cilexetil and hydrochlorothiazide in patients with systemic hypertension J Clin Hypertens, 1 , 2Reif MC 2000. New hope for protecting the kidneys from hypertension Drug Benefit Trades, 12(supplement E) , 17Reif MC 2000. The pharmaceutical industry - to whom is it accountable? N Engl J Med, 343 , 1415Bindels RJM, Schafer JA, Reif MC 1998. Stimulation of sodium transport by aldosterone and arginine vasotocin in A6 cells Biochim Biophys Acta, 972 , 320Onions K, Hunt SC, Rutkowski MP, Klanke CA, Su YR, Reif MC, Menon AG 1998. Genetic markers at the leptin locus are not linked to hypertension in African Americans Hypertension, 31 , 1230Reif MC, White W, Fagan T, Oparil S, Flanagan TL, Edwards DR, Cushing DJ, Michelson EL 1998. Effects if candesartan cilexitil in patients with systemic hypertension Am J Cardiol, 82 , 961Cui Y, Su YR, Rutkowski M, Reif M, Menon AG, Pun RYK 1997. Loss of protein kinase C (PKC) inhibition in the beta T594M variant of the amiloride-sensitive sodium channel Pro Natl Acad Sci, 94 , 9962Oparil S, Kobril I, Abernethy DR, Levine BS, Reif MS, Shepherd AM 1997. Dose-response characteristics of mibefradil, a novel calcium channel antagonist, in the treatment of essential hypertension AM J Hypertens, 10 , 735-742Hebert LA, Agarwal G, Ladson-Wofford SE, Reif MC, Hiremath L, Carlton SG, Nahman NS, Falkenhain ME, Agarwal A 1996. Nocturnal blood pressure in treated hypertensive African-Americans compared to treated hypertensive European Americans. J Am Soc Neph, 7 , 2130Reif MC, Hanto DW, Moulton JS, Alspaugh JP, Bejarano P 1996. Primary hepatic pheochromocytoma AM J Hypertens, 9 , 1040Su YR, Rutkowski MP, Klanke CA, Wu X, Pun RYK, Carter V, Gartside PS, Reif MC, Menon A 1996. A novel variant of the amiloride-sensitive sodium channel beta-subunit in African Americans is associated with enhanced cAMP responsiveness J Am Soc Neph, 7 , 2543Reif MC, Carter V 1994. The retail cost of antihypertensive therapy. Physician and patient as educated consumers AM J Hypertens, 7 , 571Chen L, Reif MC, Schafer JA 1991. Clonidine and PGE2 have different effets on Na+ and water transport in the rat and rabbit CCT Am J Physiol, 261 , F126Reif MC, Troutman SL, Schafer JA 1986. Sodium transport by rat cortical collecting tubule. Effects of vasopressin and desoxycorticosterone J Clin Invest, 77 4, 1291Wall B, Keller FS, Spalding MD, Reif MC 1986. Massive hemorrhage from a lumbar artery following percutaneous renal biopsy Am J Kidney Dis, 7 3, 250Reif MC, Troutman SL, Schafer JA 1984. Sustained response to vasopressin in isolated rat cortical collecting tubule Kidney Int, 26 5, 725Abramson RG, King VF, Reif MC, Leal-Pinto E, Baruch SB 1982. Urate uptake in membrane vesicles of rat renal cortex: Effect of copper Am J Physiol, 242 , F158Reif MC, Constantiner A, Levitt MF 1981. Chronic gouty nephropathy: A vanishing syndrome? N Engl J Med, 304 , 535
Bakris G, Gradman A, Reif M, Wofford M, Munger M, Harris S, Vendetti J, Michelson E, Wang R and the CLAIM study investigators 2001. Antihypertensive efficacy of candesartan in comparison to losartan. The CLAIM study J Clin Hypertens, 3 , 16Kishore BK, Krane CM, Reif MC, Menon AG 2001. Urinary concentration defect in the elderly population: Insights from recent advances in physiology and pathophysiology of renal aquaporins Int Urol and Nephrol, 33 , 235Papademetriou V, Reif M, Henry D, Neutel JM, Levine JH, Hardison JD, Flanagan T, Michelson EL 2000. Combination therapy with candesartan cilexetil and hydrochlorothiazide in patients with systemic hypertension J Clin Hypertens, 1 , 2Reif MC 2000. New hope for protecting the kidneys from hypertension Drug Benefit Trades, 12(supplement E) , 17Reif MC 2000. The pharmaceutical industry - to whom is it accountable? N Engl J Med, 343 , 1415Bindels RJM, Schafer JA, Reif MC 1998. Stimulation of sodium transport by aldosterone and arginine vasotocin in A6 cells Biochim Biophys Acta, 972 , 320Onions K, Hunt SC, Rutkowski MP, Klanke CA, Su YR, Reif MC, Menon AG 1998. Genetic markers at the leptin locus are not linked to hypertension in African Americans Hypertension, 31 , 1230Reif MC, White W, Fagan T, Oparil S, Flanagan TL, Edwards DR, Cushing DJ, Michelson EL 1998. Effects if candesartan cilexitil in patients with systemic hypertension Am J Cardiol, 82 , 961Cui Y, Su YR, Rutkowski M, Reif M, Menon AG, Pun RYK 1997. Loss of protein kinase C (PKC) inhibition in the beta T594M variant of the amiloride-sensitive sodium channel Pro Natl Acad Sci, 94 , 9962Oparil S, Kobril I, Abernethy DR, Levine BS, Reif MS, Shepherd AM 1997. Dose-response characteristics of mibefradil, a novel calcium channel antagonist, in the treatment of essential hypertension AM J Hypertens, 10 , 735-742Hebert LA, Agarwal G, Ladson-Wofford SE, Reif MC, Hiremath L, Carlton SG, Nahman NS, Falkenhain ME, Agarwal A 1996. Nocturnal blood pressure in treated hypertensive African-Americans compared to treated hypertensive European Americans. J Am Soc Neph, 7 , 2130Reif MC, Hanto DW, Moulton JS, Alspaugh JP, Bejarano P 1996. Primary hepatic pheochromocytoma AM J Hypertens, 9 , 1040Su YR, Rutkowski MP, Klanke CA, Wu X, Pun RYK, Carter V, Gartside PS, Reif MC, Menon A 1996. A novel variant of the amiloride-sensitive sodium channel beta-subunit in African Americans is associated with enhanced cAMP responsiveness J Am Soc Neph, 7 , 2543Reif MC, Carter V 1994. The retail cost of antihypertensive therapy. Physician and patient as educated consumers AM J Hypertens, 7 , 571Chen L, Reif MC, Schafer JA 1991. Clonidine and PGE2 have different effets on Na+ and water transport in the rat and rabbit CCT Am J Physiol, 261 , F126Reif MC, Troutman SL, Schafer JA 1986. Sodium transport by rat cortical collecting tubule. Effects of vasopressin and desoxycorticosterone J Clin Invest, 77 4, 1291Wall B, Keller FS, Spalding MD, Reif MC 1986. Massive hemorrhage from a lumbar artery following percutaneous renal biopsy Am J Kidney Dis, 7 3, 250Reif MC, Troutman SL, Schafer JA 1984. Sustained response to vasopressin in isolated rat cortical collecting tubule Kidney Int, 26 5, 725Abramson RG, King VF, Reif MC, Leal-Pinto E, Baruch SB 1982. Urate uptake in membrane vesicles of rat renal cortex: Effect of copper Am J Physiol, 242 , F158Reif MC, Constantiner A, Levitt MF 1981. Chronic gouty nephropathy: A vanishing syndrome? N Engl J Med, 304 , 535
Abstract Publications Chen L, Parris M, Willilams SK, Reif MC, Schafer JA 1989. Different effects of clonidine and prostaglandin E2 on vasopressin response of rat and rabbit cortical collecting duct. Nephrol, 178A , Bindels RJM, Schafer JA, Reif MC 1987. Stiumulation of Na+ transport by novobiocin in cultured kidney A6 cells. Am Soc Nephrol, 269A , Reif MC, Bindels RJM, Schafer JA 1987. Regulation of Na+ transport by aldosterone and arginine vasotocin (AVT) in cultured kidney A6 cells. Am Soc Nephrol, 136A , Reif MC, Schafer JA 1985. Prostaglandin E2 does not inhibit vasopressin action in the isolated perfused rat cortical collecting tubule. Kidney Int, 27 1, 332Reif MC, Schafer JA 1984. Arginine vasopressin (ADH) induces a stable increase in rat Na+ absoprtion by rat cortical collecting tubule. Fed Proc, 43 108, Reif MC, Troutman SL, Schafer JA 1984. Water permeability response of rat collecting tubules to ADH. Kidney Int, 25 1, 314Abramson RG, Baruch SB, Reif MC, Leal-Pinto E, King VF 1980. Apparent dependence of urate transport on chloride permeability in membrane vesicles from rat renal cortex. Renal Physiol, 2(3) 20, 150Abramson RG, Reif MC, King VF, Leal-Pinto E, Baruch, SB 1980. Effect of copper on urate transport on chloride permeability in membrane vesicles from rat renal cortex. Renal Physiol, Fed Proc 39 2436, Abramson RG, Reif M, King VF, Leal-Pinto E, Baruch SB 1979. Role of copper in urate transport and oxidation by membrane vesicles of rat renal cortex. Am Soc Nephrol, 12 32A,
Chen L, Parris M, Willilams SK, Reif MC, Schafer JA 1989. Different effects of clonidine and prostaglandin E2 on vasopressin response of rat and rabbit cortical collecting duct. Nephrol, 178A , Bindels RJM, Schafer JA, Reif MC 1987. Stiumulation of Na+ transport by novobiocin in cultured kidney A6 cells. Am Soc Nephrol, 269A , Reif MC, Bindels RJM, Schafer JA 1987. Regulation of Na+ transport by aldosterone and arginine vasotocin (AVT) in cultured kidney A6 cells. Am Soc Nephrol, 136A , Reif MC, Schafer JA 1985. Prostaglandin E2 does not inhibit vasopressin action in the isolated perfused rat cortical collecting tubule. Kidney Int, 27 1, 332Reif MC, Schafer JA 1984. Arginine vasopressin (ADH) induces a stable increase in rat Na+ absoprtion by rat cortical collecting tubule. Fed Proc, 43 108, Reif MC, Troutman SL, Schafer JA 1984. Water permeability response of rat collecting tubules to ADH. Kidney Int, 25 1, 314Abramson RG, Baruch SB, Reif MC, Leal-Pinto E, King VF 1980. Apparent dependence of urate transport on chloride permeability in membrane vesicles from rat renal cortex. Renal Physiol, 2(3) 20, 150Abramson RG, Reif MC, King VF, Leal-Pinto E, Baruch, SB 1980. Effect of copper on urate transport on chloride permeability in membrane vesicles from rat renal cortex. Renal Physiol, Fed Proc 39 2436, Abramson RG, Reif M, King VF, Leal-Pinto E, Baruch SB 1979. Role of copper in urate transport and oxidation by membrane vesicles of rat renal cortex. Am Soc Nephrol, 12 32A,