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Photo of Marlena Wosiski-Kuhn, MD, PhD

Marlena Wosiski-Kuhn, MD, PhD

Clinical Instructor

Emergency Medicine | College of Medicine

Education/Credentials
  • Bachelors Degree: Johns Hopkins University
  • Graduate Degree: Wake Forest University
  • Medical Degree: Wake Forest University
Contact Information

Peer Reviewed Publications

Milligan, Carol; Atassi, Nazem; Babu, Suma; Barohn, Richard J; Caress, James B; Cudkowicz, Merit E; Evora, Armineuza; Hawkins, Gregory A; Wosiski-Kuhn, Marlena; Macklin, Eric A; Shefner, Jeremy M; Simmons, Zachary; Bowser, Robert P; Ladha, Shafeeq S 2021. Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients. Muscle & nerve, ,

Wosiski-Kuhn, Marlena; Caress, James B; Cartwright, Michael S; Hawkins, Gregory A; Milligan, Carol 2021. Interleukin 6 (IL6) level is a biomarker for functional disease progression within IL6R358Ala variant groups in amyotrophic lateral sclerosis patients. Amyotrophic lateral sclerosis & frontotemporal degeneration, 22 3-4, 248-259

Lyon, Miles S; Wosiski-Kuhn, Marlena; Gillespie, Rachel; Caress, James; Milligan, Carol 2019. Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology. Muscle & nerve, 59 1, 10-22

Pathak, Sapna; Caress, James B; Wosiski-Kuhn, Marlena; Milligan, Carol; Williams, Delaney; Cartwright, Michael S 2019. A pilot study of neuromuscular ultrasound as a biomarker for amyotrophic lateral sclerosis. Muscle & nerve, 59 2, 181-186

Wosiski-Kuhn, Marlena; Lyon, Miles S; Caress, James; Milligan, Carol 2019. Inflammation, immunity, and amyotrophic lateral sclerosis: II. immune-modulating therapies. Muscle & nerve, 59 1, 23-33

Wosiski-Kuhn, Marlena; Robinson, Mac; Strupe, Jane; Arounleut, Phonepasong; Martin, Matthew; Caress, James; Cartwright, Michael; Bowser, Robert; Cudkowicz, Merit; Langefeld, Carl; Hawkins, Gregory A; Milligan, Carol 2019. IL6 receptor358Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis. Neurology(R) neuroimmunology & neuroinflammation, 6 6, e631

Wosiski-Kuhn, Marlena; Bota, Mihail; Snider, Christina A; Wilson, Steven P; Venkataraju, Kannan U; Osten, Pavel; Stranahan, Alexis M 2018. Hippocampal brain-derived neurotrophic factor determines recruitment of anatomically connected networks after stress in diabetic mice. Hippocampus, 28 12, 900-912

Dey, Aditi; Hao, Shuai; Wosiski-Kuhn, Marlena; Stranahan, Alexis M 2017. Glucocorticoid-mediated activation of GSK3? promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiology of aging, 57 , 75-83

McGee-Lawrence, Meghan E; Wenger, Karl H; Misra, Sudipta; Davis, Catherine L; Pollock, Norman K; Elsalanty, Mohammed; Ding, Kehong; Isales, Carlos M; Hamrick, Mark W; Wosiski-Kuhn, Marlena; Arounleut, Phonepasong; Mattson, Mark P; Cutler, Roy G; Yu, Jack C; Stranahan, Alexis M 2017. Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice. Endocrinology, 158 5, 1160-1171

Dey, Aditi; Hao, Shuai; Erion, Joanna R; Wosiski-Kuhn, Marlena; Stranahan, Alexis M 2014. Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes. Journal of neuroimmunology, 269 1-2, 20-27

Erion, Joanna R; Wosiski-Kuhn, Marlena; Dey, Aditi; Hao, Shuai; Davis, Catherine L; Pollock, Norman K; Stranahan, Alexis M 2014. Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 7, 2618-31

Wosiski-Kuhn, Marlena; Erion, Joanna R; Gomez-Sanchez, Elise P; Gomez-Sanchez, Celso E; Stranahan, Alexis M 2014. Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice. Psychoneuroendocrinology, 42 , 165-77

Stranahan, Alexis M; Erion, Joanna R; Wosiski-Kuhn, Marlena 2013. Reelin signaling in development, maintenance, and plasticity of neural networks. Ageing research reviews, 12 3, 815-22

Wosiski-Kuhn, Marlena; Stranahan, Alexis M 2013. From pattern separation to mood regulation: multiple roles for developmental signals in the adult dentate gyrus. Frontiers in cellular neuroscience, 7 , 96

Sherwood, Andrew; Wosiski-Kuhn, Marlena; Nguyen, Truc; Holland, Peter C; Lakaye, Bernard; Adamantidis, Antoine; Johnson, Alexander W 2012. The role of melanin-concentrating hormone in conditioned reward learning. The European journal of neuroscience, 36 8, 3126-33

Wosiski-Kuhn, Marlena; Stranahan, Alexis M 2012. Opposing effects of positive and negative stress on hippocampal plasticity over the lifespan. Ageing research reviews, 11 3, 399-403

Wosiski-Kuhn, Marlena; Stranahan, Alexis M 2012. Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiation. Synapse (New York, N.Y.), 66 7, 661-4

Johnson, A W; Sherwood, A; Smith, D R; Wosiski-Kuhn, M; Gallagher, M; Holland, P C 2010. An analysis of licking microstructure in three strains of mice. Appetite, 54 2, 320-30