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Photo of  William Hurford, MD

William Hurford, MD

Professor of Anesthesiology

Clinical Interest

Anesthesiology
Critical Care Medicine

Research Interests

Anesthesiology,Thoracic Anesthesia, Critical Care Medicine, Acute Respiratory Distress Syndrome, Nitric oxide

Specialties

Anesthesiology
Critical Care Medicine

Education/Credentials
  • Bachelor's Degree: Dartmouth College
  • Medical Degree: University of Pennsylvania
  • Residency: Massachusetts General Hospital
  • Fellowship: Massachusetts General Hospital
Contact Information
  • Medical Sciences Building
  • Room 3555
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0531
  • Office 513-558-2402
  • Fax 513-558-0995
  • Email william.hurford@uc.edu

Peer Reviewed Publications

Hurford, William E 2020. Neuromuscular Blockade Applicability in Early Acute Respiratory Distress Syndrome. Anesthesiology, 132 6, 1577-1584

Bennett, Suzanne; Grawe, Erin; Jones, Courtney; Josephs, Sean A; Mechlin, Maggie; Hurford, William E 2018. Role of the anesthesiologist-intensivist outside the ICU: opportunity to add value for the hospital or an unnecessary distraction? Current opinion in anaesthesiology, 31 2, 165-171

Josephs, Sean A; Lemmink, Gretchen A; Strong, Judith A; Barry, Cassandra L; Hurford, William E 2018. Improving Adherence to Intraoperative Lung-Protective Ventilation Strategies at a University Medical Center. Anesthesia and analgesia, 126 1, 150-160

Josephs, Sean A; Lemmink, Gretchen A; Strong, Judith A; Hurford, William E 2018. In Response. Anesthesia and analgesia, 127 2, e30

Trester, Joshua T; Grawe, Erin S; Hurford, William E 2018. Percutaneous Tracheostomy On Veno-Venous Extracorporeal Membrane Oxygenation: Balancing the Risk of Bleeding With Thrombosis. Journal of cardiothoracic and vascular anesthesia, 32 3, 1167-1168

Grawe, Erin S; Bennett, Suzanne; Hurford, William E 2016. Early Paralysis for the Management of ARDS. Respiratory care, 61 6, 830-8

Marini, John J; Hurford, William E 2016. Should Early Prone Positioning Be a Standard of Care in ARDS With Refractory Hypoxemia? Wrong Question-Reply. Respiratory care, 61 11, 1564-1565

Marini, John J; Josephs, Sean A; Mechlin, Maggie; Hurford, William E 2016. Should Early Prone Positioning Be a Standard of Care in ARDS With Refractory Hypoxemia? Respiratory care, 61 6, 818-29

Grawe, Erin; Wojciechowski, Paul J; Hurford, William E 2015. Balancing early extubation and rates of reintubation in cardiac surgical patients: where does the fulcrum lie? Journal of cardiothoracic and vascular anesthesia, 29 3, 549-50

Mechlin, Maggie W; Hurford, William E 2014. Emergency tracheal intubation: techniques and outcomes. Respiratory care, 59 6, 881-92; discussion 8

Dodge, Heather S; Ekhator, Nosakhare N; Jefferson-Wilson, Lena; Fischer, Mark; Jansen, Ian; Horn, Paul S; Hurford, William E; Geracioti, Thomas D 2013. Cigarette smokers have reduced risk for post-dural puncture headache. Pain physician, 16 1, E25-30

Hurford, William E 2013. Controversies and considerations in formulating a hospital policy for procedural sedation. International anesthesiology clinics, 51 2, 23-32

Hurford, William E; Staubach, Katherine C 2013. Preface: procedural sedation. International anesthesiology clinics, 51 2, xi-xii

Hurford, William E; Staubach, Katherine C 2013. A hospital policy for procedural sedation in the nonintubated patient. International anesthesiology clinics, 51 2, 1-22

Hurford, William E 2012. Preface--Updates in head-to-toe applications of regional anesthesia for ambulatory surgery. International anesthesiology clinics, 50 1, x-xi

Bennett, Suzanne; Hurford, William E 2011. When should sedation or neuromuscular blockade be used during mechanical ventilation? Respiratory care, 56 2, 168-76; discussion 1

Hurford, William E 2011. Some comments on the cuff. Respiratory care, 56 10, 1625-6

Hurford, William E 2010. The video revolution: a new view of laryngoscopy. Respiratory care, 55 8, 1036-45

Utrup, Theresa R; Mueller, Eric W; Healy, Daniel P; Callcut, Rachael A; Peterson, John D; Hurford, William E 2010. High-dose ciprofloxacin for serious gram-negative infection in an obese, critically ill patient receiving continuous venovenous hemodiafiltration. The Annals of pharmacotherapy, 44 10, 1660-4

Benedetto, William J; Hess, Dean R; Gettings, Elise; Bigatello, Luca M; Toon, Hannah; Hurford, William E; Schmidt, Ulrich 2007. Urgent tracheal intubation in general hospital units: an observational study. Journal of clinical anesthesia, 19 1, 20-4

Deem, Steven; Hurford, William E 2007. Respiratory controversies in the critical care setting. Should all patients be treated with hypothermia following cardiac arrest? Respiratory care, 52 4, 443-50; discussion 4

Hurford, William E; Cheifetz, Ira M 2007. Respiratory controversies in the critical care setting. Should heliox be used for mechanically ventilated patients? Respiratory care, 52 5, 582-91; discussion 5

Gettings, Elise M; Brush, Kathryn A; Van Cott, Elizabeth M; Hurford, William E 2006. Outcome of postoperative critically ill patients with heparin-induced thrombocytopenia: an observational retrospective case-control study. Critical care (London, England), 10 6, R161

Gordon, James A; Shaffer, David W; Raemer, Daniel B; Pawlowski, John; Hurford, William E; Cooper, Jeffrey B 2006. A randomized controlled trial of simulation-based teaching versus traditional instruction in medicine: a pilot study among clinical medical students. Advances in health sciences education : theory and practice, 11 1, 33-9

Fitzsimons, Michael G; Peralta, Ruben; Hurford, William 2005. Cricoid fracture after physical assault. The Journal of trauma, 59 5, 1237-8

Hurford, William E 2005. Nitric oxide as a bactericidal agent: is the cure worse than the disease? Respiratory care, 50 11, 1428-9

Fitzsimons, Michael G; Gaudette, Ronald R; Hurford, William E 2004. Critical rebound methemoglobinemia after methylene blue treatment: case report. Pharmacotherapy, 24 4, 538-40

Hurford, William E; Kratz, Alexander 2004. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23-2004. A 50-year-old woman with low oxygen saturation. The New England journal of medicine, 351 4, 380-7

Shaw, Cheryl I; Kacmarek, Robert M; Hampton, Rickey L; Riggi, Vincent; El Masry, Ashraf; Cooper, Jeffrey B; Hurford, William E 2004. Cellular phone interference with the operation of mechanical ventilators. Critical care medicine, 32 4, 928-31

Bigatello, Luca M; George, Edward; Hurford, William E 2003. Ethical considerations for research in critically ill patients. Critical care medicine, 31 3 Suppl, S178-81

Koh, Younsuck; Hurford, William E 2003. Inhaled nitric oxide in acute respiratory distress syndrome: from bench to bedside. International anesthesiology clinics, 41 1, 91-102

Bigatello, Luca M; George, Ed; Hurford, William E 2002. The alveolus and the capillary. Critical care medicine, 30 6, 1394-5

Hurford, William E 2002. Inhaled nitric oxide. Respiratory care clinics of North America, 8 2, 261-79

Hurford, William E 2002. Sedation and paralysis during mechanical ventilation. Respiratory care, 47 3, 334-46; discussion 3

Hurford, William E; Bigatello, Luca M 2002. NO-body's perfect. Anesthesiology, 96 6, 1285-7

Cist, A F; Truog, R D; Brackett, S E; Hurford, W E 2001. Practical guidelines on the withdrawal of life-sustaining therapies. International anesthesiology clinics, 39 3, 87-102

Truog, R D; Cist, A F; Brackett, S E; Burns, J P; Curley, M A; Danis, M; DeVita, M A; Rosenbaum, S H; Rothenberg, D M; Sprung, C L; Webb, S A; Wlody, G S; Hurford, W E 2001. Recommendations for end-of-life care in the intensive care unit: The Ethics Committee of the Society of Critical Care Medicine. Critical care medicine, 29 12, 2332-48

Adrie, C; Holzmann, A; Hirani, W M; Zapol, W M; Hurford, W E 2000. Effects of intravenous Zaprinast and inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of acute respiratory distress syndrome. Anesthesiology, 93 2, 422-30

Bigatello, L M; Hess, D; Dennehy, K C; Medoff, B D; Hurford, W E 2000. Sildenafil can increase the response to inhaled nitric oxide. Anesthesiology, 92 6, 1827-9

Ceccarelli, P; Bigatello, L M; Hess, D; Kwo, J; Melendez, L; Hurford, W E 2000. Inhaled nitric oxide delivery by anesthesia machines. Anesthesia and analgesia, 90 2, 482-8

Hurford, W E 2000. Techniques for endotracheal intubation. International anesthesiology clinics, 38 3, 1-28

Hurford, W E 2000. The bronchospastic patient. International anesthesiology clinics, 38 1, 77-90

Peralta, R; Hurford, W E 2000. Airway trauma. International anesthesiology clinics, 38 3, 111-27

Bigatello, L M; Hurford, W E 1999. Inhaled nitric oxide and pulmonary vascular resistance. Critical care medicine, 27 9, 2060-1

Bigatello, L M; Hurford, W E; Pesenti, A 1999. Ventilatory management of severe acute respiratory failure for Y2K. Anesthesiology, 91 6, 1567-70

Hurford, W E 1999. Sedation in the intensive care unit. International anesthesiology clinics, 37 4, 113-22

Hurford, W E 1999. Cardiopulmonary interactions during mechanical ventilation. International anesthesiology clinics, 37 3, 35-46

Steudel, W; Hurford, W E; Zapol, W M 1999. Inhaled nitric oxide: basic biology and clinical applications. Anesthesiology, 91 4, 1090-121

Adrie, C; Hirani, W M; Holzmann, A; Keefer, L; Zapol, W M; Hurford, W E 1998. Selective pulmonary vasodilation by intravenous infusion of an ultrashort half-life nucleophile/nitric oxide adduct. Anesthesiology, 88 1, 190-5

Adrie, C; Ichinose, F; Holzmann, A; Keefer, L; Hurford, W E; Zapol, W M 1998. Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension. Journal of applied physiology (Bethesda, Md. : 1985), 84 2, 435-41

Ichinose, F; Adrie, C; Hurford, W E; Bloch, K D; Zapol, W M 1998. Selective pulmonary vasodilation induced by aerosolized zaprinast. Anesthesiology, 88 2, 410-6

Kirmse, M; Hess, D; Fujino, Y; Kacmarek, R M; Hurford, W E 1998. Delivery of inhaled nitric oxide using the Ohmeda INOvent Delivery System. Chest, 113 6, 1650-7

Mathisen, D J; Kuo, E Y; Hahn, C; Moncure, A C; Wain, J C; Grillo, H C; Hurford, W E; Wright, C D 1998. Inhaled nitric oxide for adult respiratory distress syndrome after pulmonary resection. The Annals of thoracic surgery, 66 6, 1894-902

Bigatello, L M; Hurford, W E; Hess, D 1997. Use of inhaled nitric oxide for ARDS. Respiratory care clinics of North America, 3 3, 437-58

Hess, D; Bigatello, L; Hurford, W E 1997. Toxicity and complications of inhaled nitric oxide. Respiratory care clinics of North America, 3 4, 487-503

Hurford, W E 1997. The biologic basis for inhaled nitric oxide. Respiratory care clinics of North America, 3 3, 357-69

Imanaka, H; Hess, D; al-Himyary, A; Bigatello, L M; Ritz, R; Kacmarek, R M; Hurford, W E 1997. Assessment of errors when expiratory condensate PCO2 is used as a proxy for mixed expired PCO2 during mechanical ventilation. Journal of clinical monitoring, 13 4, 215-22

Imanaka, H; Hess, D; Kirmse, M; Bigatello, L M; Kacmarek, R M; Steudel, W; Hurford, W E 1997. Inaccuracies of nitric oxide delivery systems during adult mechanical ventilation. Anesthesiology, 86 3, 676-88

Manktelow, C; Bigatello, L M; Hess, D; Hurford, W E 1997. Physiologic determinants of the response to inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology, 87 2, 297-307

Sheridan, R L; Hurford, W E; Kacmarek, R M; Ritz, R H; Yin, L M; Ryan, C M; Tompkins, R G 1997. Inhaled nitric oxide in burn patients with respiratory failure. The Journal of trauma, 42 4, 629-34

Steudel, W; Ichinose, F; Huang, P L; Hurford, W E; Jones, R C; Bevan, J A; Fishman, M C; Zapol, W M 1997. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circulation research, 81 1, 34-41

Adrie, C; Bloch, K D; Moreno, P R; Hurford, W E; Guerrero, J L; Holt, R; Zapol, W M; Gold, H K; Semigran, M J 1996. Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation, 94 8, 1919-26

Hurford, W E; Hochachka, P W; Schneider, R C; Guyton, G P; Stanek, K S; Zapol, D G; Liggins, G C; Zapol, W M 1996. Splenic contraction, catecholamine release, and blood volume redistribution during diving in the Weddell seal. Journal of applied physiology (Bethesda, Md. : 1985), 80 1, 298-306

Saavedra, J E; Southan, G J; Davies, K M; Lundell, A; Markou, C; Hanson, S R; Adrie, C; Hurford, W E; Zapol, W M; Keefer, L K 1996. Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor. Journal of medicinal chemistry, 39 22, 4361-5

Body, S C; Hartigan, P M; Shernan, S K; Formanek, V; Hurford, W E 1995. Nitric oxide: delivery, measurement, and clinical application. Journal of cardiothoracic and vascular anesthesia, 9 6, 748-63

Guyton, G P; Stanek, K S; Schneider, R C; Hochachka, P W; Hurford, W E; Zapol, D G; Liggins, G C; Zapol, W M 1995. Myoglobin saturation in free-diving Weddell seals. Journal of applied physiology (Bethesda, Md. : 1985), 79 4, 1148-55

Hochachka, P W; Liggins, G C; Guyton, G P; Schneider, R C; Stanek, K S; Hurford, W E; Creasy, R K; Zapol, D G; Zapol, W M 1995. Hormonal regulatory adjustments during voluntary diving in Weddell seals. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 112 2, 361-75

Hurford, W E 1995. Current status of nitric oxide inhalation. Nihon Ky?bu Shikkan Gakkai zasshi, 33 Suppl , 199-204

Hurford, W E; Favorito, F 1995. Association of myocardial ischemia with failure to wean from mechanical ventilation. Critical care medicine, 23 9, 1475-80

Ichinose, F; Adrie, C; Hurford, W E; Zapol, W M 1995. Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs. Journal of applied physiology (Bethesda, Md. : 1985), 78 4, 1288-95

Nishimura, M; Hess, D; Kacmarek, R M; Ritz, R; Hurford, W E 1995. Nitrogen dioxide production during mechanical ventilation with nitric oxide in adults. Effects of ventilator internal volume, air versus nitrogen dilution, minute ventilation, and inspired oxygen fraction. Anesthesiology, 82 5, 1246-54

Bigatello, L M; Hurford, W E; Kacmarek, R M; Roberts, J D; Zapol, W M 1994. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology, 80 4, 761-70

Sapirstein, A; Hurford, W E 1994. Neuromuscular blocking agents in the management of respiratory failure. Indications and treatment guidelines. Critical care clinics, 10 4, 831-43

Zapol, W M; Falke, K J; Hurford, W E; Roberts, J D 1994. Inhaling nitric oxide: a selective pulmonary vasodilator and bronchodilator. Chest, 105 3 Suppl, 87S-91S

Zapol, W M; Hurford, W E 1994. Inhaled nitric oxide in adult respiratory distress syndrome and other lung diseases. Advances in pharmacology (San Diego, Calif.), 31 , 513-30

Hurford, W E; Alfille, P H 1993. A quality improvement study of the placement and complications of double-lumen endobronchial tubes. Journal of cardiothoracic and vascular anesthesia, 7 5, 517-20

Hurford, W E; Dutton, R P; Alfille, P H; Clement, D; Wilson, R S 1993. Comparison of thoracic and lumbar epidural infusions of bupivacaine and fentanyl for post-thoracotomy analgesia. Journal of cardiothoracic and vascular anesthesia, 7 5, 521-5

Qvist, J; Hurford, W E; Park, Y S; Radermacher, P; Falke, K J; Ahn, D W; Guyton, G P; Stanek, K S; Hong, S K; Weber, R E 1993. Arterial blood gas tensions during breath-hold diving in the Korean ama. Journal of applied physiology (Bethesda, Md. : 1985), 75 1, 285-93

Stanek, K S; Guyton, G P; Hurford, W E; Park, Y S; Ahn, D W; Qvist, J; Falke, K J; Hong, S K; Kobayashi, K; Kobayashi, H 1993. Continuous pulse oximetry in the breath-hold diving women of Korea and Japan. Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 20 4, 297-307

Szabo, M D; Crosby, G; Hurford, W E; Strauss, H W 1993. Myocardial perfusion following acute subarachnoid hemorrhage in patients with an abnormal electrocardiogram. Anesthesia and analgesia, 76 2, 253-8

Zapol, W M; Hurford, W E 1993. Inhaled nitric oxide in the adult respiratory distress syndrome and other lung diseases. New horizons (Baltimore, Md.), 1 4, 638-50

Simon, B A; Hurford, W E; Alfille, P H; Haspel, K; Behringer, E C 1992. An aid in the diagnosis of malpositioned double-lumen tubes. Anesthesiology, 76 5, 862-3

Hurford, W E; Lynch, K E; Strauss, H W; Lowenstein, E; Zapol, W M 1991. Myocardial perfusion as assessed by thallium-201 scintigraphy during the discontinuation of mechanical ventilation in ventilator-dependent patients. Anesthesiology, 74 6, 1007-16

Hurford, W E 1990. Thermodilution right ventricular ejection fraction. Remaining questions. Chest, 98 5, 1054-5

Hurford, W E; Crosby, G; Strauss, H W; Jones, R; Lowenstein, E 1990. Ventricular performance and glucose uptake in rats during chronic hypobaric hypoxia. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31 8, 1344-51

Hurford, W E; Hong, S K; Park, Y S; Ahn, D W; Shiraki, K; Mohri, M; Zapol, W M 1990. Splenic contraction during breath-hold diving in the Korean ama. Journal of applied physiology (Bethesda, Md. : 1985), 69 3, 932-6

Hurford, W E; Crosby, G 1989. Regional brain glucose utilization in the conscious rat exposed to prolonged hypobaric hypoxia. Journal of neurosurgical anesthesiology, 1 3, 249-55

Hurford, W E; Lowenstein, E; Strauss, W 1989. Are all myocardial infarctions alike? Anesthesiology, 71 6, 815-7

Hurford, W E; Zapol, W M 1988. The right ventricle and critical illness: a review of anatomy, physiology, and clinical evaluation of its function. Intensive care medicine, 14 Suppl 2 , 448-57

Hurford, W E; Kolker, A C; Strauss, H W 1987. The use of ventilation/perfusion lung scans to predict oxygenation during one-lung anesthesia. Anesthesiology, 67 5, 841-4

Stoller, J K; Herbst, T J; Hurford, W; Rie, M A 1986. Spuriously high cardiac output from injecting thermal indicator through an ensheathed port. Critical care medicine, 14 12, 1064-5

Silverman, D G; Hurford, W E; Cooper, H S; Robinson, M; Brousseau, D A 1983. Quantification of fluorescein distribution to strangulated rat ileum. The Journal of surgical research, 34 2, 179-86

Weisman, R A; Blumberg, A L; Brousseau, D A; Hurford, W E; Silverman, D G 1983. Fluorometric assessment of skin flap viability in the rat: effect of radiation therapy. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 91 2, 151-5

Silverman, D G; Cedrone, F A; Hurford, W E; Bering, T G; LaRossa, D D 1981. Monitoring tissue elimination of fluorescein with the perfusion fluorometer: a new method to assess capillary blood flow. Surgery, 90 2, 409-17

Alfille, P H; Hurford, W E . Upper airway injuries. Journal of clinical anesthesia, 3 2, 88-90

Cohen, L G; DiBiasio, A; Lisco, S J; Hurford, W E . Fluconazole serum concentrations and pharmacokinetics in an obese patient. Pharmacotherapy, 17 5, 1023-6

Datta, Sukdeb; Hurford, William . Transverse myelitis associated with Acinetobacter baumanii intrathecal pump catheter-related infection. Where was the source of the infection? Regional anesthesia and pain medicine, 29 5, 503-4; author reply

Goto, T; Hurford, W E . Postoperative acute respiratory failure following thoracotomy in a patient with Charcot-Marie-Tooth disease. Journal of clinical anesthesia, 6 5, 434-6

Hong, S K; Henderson, J; Olszowka, A; Hurford, W E; Falke, K J; Qvist, J; Radermacher, P; Shiraki, K; Mohri, M; Takeuchi, H . Daily diving pattern of Korean and Japanese breath-hold divers (ama). Undersea biomedical research, 18 5-6, 433-43

Whalen, R L; Hurford, W E; Skoskiewicz, M; Wonders, T R; Zapol, W M . A new right ventricular assist device. The extracorporeal pulsatile assist device (EPAD). ASAIO transactions / American Society for Artificial Internal Organs, 33 3, 222-6

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Department of Anesthesiology

Medical Sciences Building
Room 3502
231 Albert Sabin Way
PO Box 670531
Cincinnati, OH 45267-0531

Mail Location: 0531
Phone: 513-558-2402
Fax: 513-558-0995
Email: mcclanpa@ucmail.uc.edu