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Photo of  Mohammad Azam, PhD

Mohammad Azam, PhD

Associate Professor-Affiliate

COM Pathology & Lab Medicine

Education/Credentials
  • Doctorate: JNU, New Delhi, India
  • Postdoctoral Fellow: Massachusetts Institute of Technology
  • Postdoctoral Fellow: Children’s Hospital of Boston
Contact Information
  • Cincinnati Childrens Hospital Medical Center
  • 3333 Burnet Avenue, ML 7013
  • Cincinnati, Ohio 45229
  • Office (513) 803-1413
  • Email mohammad.azam@cchmc.org

Peer Reviewed Publications

Dwivedi, Pankaj; Chutipongtanate, Somchai; Muench, David E; Azam, Mohammad; Grimes, Harry Leighton; Greis, Kenneth D 2020. SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling. Proteomics. Clinical applications, 14 5, e1900144

Dwivedi, Pankaj; Chutipongtanate, Somchai; Muench, David E; Azam, Mohammad; Grimes, Harry Leighton; Greis, Kenneth D 2020. SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling. Proteomics. Clinical applications, 14 5, e1900144

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D 2019. Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors. Scientific data, 6 1, 21

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D 2019. Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors. Leukemia, 33 1, 75-87

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D 2019. Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors. Leukemia, 33 1, 75-87

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D 2019. Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors. Scientific data, 6 1, 21

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad 2019. Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence. Journal of visualized experiments : JoVE, 143,

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad 2019. Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence. Journal of visualized experiments : JoVE, 143,

Lin, Peipei; Ren, Yanling; Yan, Xiaomei; Luo, Yingwan; Zhang, Hua; Kesarwani, Meenu; Bu, Jiachen; Zhan, Di; Zhou, Yile; Tang, Yuting; Zhu, Shuanghong; Xu, Weilai; Zhou, Xinping; Mei, Chen; Ma, Liya; Ye, Li; Hu, Chao; Azam, Mohammad; Ding, Wei; Jin, Jie; Huang, Gang; Tong, Hongyan 2019. The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes. Haematologica, 104 3, 485-496

Lin, Peipei; Ren, Yanling; Yan, Xiaomei; Luo, Yingwan; Zhang, Hua; Kesarwani, Meenu; Bu, Jiachen; Zhan, Di; Zhou, Yile; Tang, Yuting; Zhu, Shuanghong; Xu, Weilai; Zhou, Xinping; Mei, Chen; Ma, Liya; Ye, Li; Hu, Chao; Azam, Mohammad; Ding, Wei; Jin, Jie; Huang, Gang; Tong, Hongyan 2019. The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes. Haematologica, 104 3, 485-496

Ramkissoon, Annmarie; Chaney, Katherine E; Milewski, David; Williams, Kyle B; Williams, Rory L; Choi, Kwangmin; Miller, Adam; Kalin, Tanya V; Pressey, Joseph G; Szabo, Sara; Azam, Mohammad; Largaespada, David A; Ratner, Nancy 2019. Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clinical cancer research : an official journal of the American Association for Cancer Research, 25 13, 4117-4127

Ramkissoon, Annmarie; Chaney, Katherine E; Milewski, David; Williams, Kyle B; Williams, Rory L; Choi, Kwangmin; Miller, Adam; Kalin, Tanya V; Pressey, Joseph G; Szabo, Sara; Azam, Mohammad; Largaespada, David A; Ratner, Nancy 2019. Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clinical cancer research : an official journal of the American Association for Cancer Research, 25 13, 4117-4127

Azam, Mohammad; Al-Resayes, Saud I; Wabaidur, Saikh Mohammad; Altaf, Mohammad; Chaurasia, Bhaskar; Alam, Mahboob; Shukla, Satyendra Nath; Gaur, Pratiksha; Albaqami, Nader Talmas M; Islam, Mohammad Shahidul; Park, Soonheum 2018. Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand. Molecules (Basel, Switzerland), 23 4,

Sallam, Mowaffaq Awad; Sheikh, Kamaludin Ahmed; Baxendale, Ronald; Azam, Mohammad Nurul; Hossain, Anwar M; El-Setouhy, Maged 2018. The Physiological and Ergogenic Effects of Khat (Catha edulis Forsk) Extract. Substance use & misuse, 53 1, 94-100

Wang, Jieyu; Hayashi, Yoshihiro; Yokota, Asumi; Xu, Zefeng; Zhang, Yue; Huang, Rui; Yan, Xiaomei; Liu, Hongyun; Ma, Liping; Azam, Mohammad; Bridges, James P; Cancelas, Jose A; Kalfa, Theodosia A; An, Xiuli; Xiao, Zhijian; Huang, Gang 2018. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica, 103 1, 40-50

Wang, Jieyu; Hayashi, Yoshihiro; Yokota, Asumi; Xu, Zefeng; Zhang, Yue; Huang, Rui; Yan, Xiaomei; Liu, Hongyun; Ma, Liping; Azam, Mohammad; Bridges, James P; Cancelas, Jose A; Kalfa, Theodosia A; An, Xiuli; Xiao, Zhijian; Huang, Gang 2018. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica, 103 1, 40-50

Azam, Mohammad; Al-Resayes, Saud I; Soliman, Saied M; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Khan, Zahid 2017. A (salicylaldiminato)Pt(II) complex with dimethylpropylene linkage: Synthesis, structural characterization and antineoplastic activity. Journal of photochemistry and photobiology. B, Biology, 176 , 150-156

Azam, Mohammad; Al-Resayes, Saud I; Soliman, Saied M; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Khan, Zahid 2017. A (salicylaldiminato)Pt(II) complex with dimethylpropylene linkage: Synthesis, structural characterization and antineoplastic activity. Journal of photochemistry and photobiology. B, Biology, 176 , 150-156

Cui, Pei-Pei; Zhang, Xiu-Du; Wang, Peng; Zhao, Yue; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin 2017. Zinc(II) and Copper(II) Hybrid Frameworks via Metal-Ion Metathesis with Enhanced Gas Uptake and Photoluminescence Properties. Inorganic chemistry, 56 22, 14157-14163

kesarwani 2017. Nature medicine, ,

Kesarwani 2017. Fos and Dusp1 confer oncogene dependence in CML Nature Medcine, ,

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad 2017. MEK/ERK addiction in CNL/aCML. Oncotarget, 8 59, 99215-99216

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad 2017. MEK/ERK addiction in CNL/aCML. Oncotarget, 8 59, 99215-99216

Kesarwani, Meenu; Kincaid, Zachary; Gomaa, Ahmed; Huber, Erika; Rohrabaugh, Sara; Siddiqui, Zain; Bouso, Muhammad F; Latif, Tahir; Xu, Ming; Komurov, Kakajan; Mulloy, James C; Cancelas, Jose A; Grimes, H Leighton; Azam, Mohammad 2017. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nature medicine, 23 4, 472-482

Kesarwani, Meenu; Kincaid, Zachary; Gomaa, Ahmed; Huber, Erika; Rohrabaugh, Sara; Siddiqui, Zain; Bouso, Muhammad F; Latif, Tahir; Xu, Ming; Komurov, Kakajan; Mulloy, James C; Cancelas, Jose A; Grimes, H Leighton; Azam, Mohammad 2017. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nature medicine, 23 4, 472-482

Liu, Zhi-Qiang; Zhao, Yue; Wang, Peng; Kang, Yan-Shang; Azam, Mohammad; Al-Resayes, Saud I; Liu, Xiao-Hui; Lu, Qing-Yi; Sun, Wei-Yin 2017. Fluorescent sensing and selective adsorption properties of metal-organic frameworks with mixed tricarboxylate and 1H-imidazol-4-yl-containing ligands. Dalton transactions (Cambridge, England : 2003), 46 28, 9022-9029

Liu, Zhi-Qiang; Zhao, Yue; Wang, Peng; Kang, Yan-Shang; Azam, Mohammad; Al-Resayes, Saud I; Liu, Xiao-Hui; Lu, Qing-Yi; Sun, Wei-Yin 2017. Fluorescent sensing and selective adsorption properties of metal-organic frameworks with mixed tricarboxylate and 1H-imidazol-4-yl-containing ligands. Dalton transactions (Cambridge, England : 2003), 46 28, 9022-9029

Liu, Zhi-Qiang; Zhao, Yue; Zhang, Xiu-Du; Kang, Yan-Shang; Lu, Qing-Yi; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin 2017. Metal-organic frameworks with 1,4-di(1H-imidazol-4-yl)benzene and varied carboxylate ligands for selectively sensing Fe(iii) ions and ketone molecules. Dalton transactions (Cambridge, England : 2003), 46 40, 13943-13951

Liu, Zhi-Qiang; Zhao, Yue; Zhang, Xiu-Du; Kang, Yan-Shang; Lu, Qing-Yi; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin 2017. Metal-organic frameworks with 1,4-di(1H-imidazol-4-yl)benzene and varied carboxylate ligands for selectively sensing Fe(iii) ions and ketone molecules. Dalton transactions (Cambridge, England : 2003), 46 40, 13943-13951

Rohrabaugh, S; Kesarwani, M; Kincaid, Z; Huber, E; Leddonne, J; Siddiqui, Z; Khalifa, Y; Komurov, K; Grimes, H L; Azam, M 2017. Enhanced MAPK signaling is essential for CSF3R-induced leukemia. Leukemia, 31 8, 1770-1778

Wang, Peng; Chen, Kai; Liu, Qing; Wang, Huai-Wei; Azam, Mohammad; Al-Resayes, Saud I; Lu, Yi; Sun, Wei-Yin 2017. Fine tuning of catalytic and sorption properties of metal-organic frameworks via in situ ligand exchange. Dalton transactions (Cambridge, England : 2003), 46 34, 11425-11430

Wang, Peng; Chen, Kai; Liu, Qing; Wang, Huai-Wei; Azam, Mohammad; Al-Resayes, Saud I; Lu, Yi; Sun, Wei-Yin 2017. Fine tuning of catalytic and sorption properties of metal-organic frameworks via in situ ligand exchange. Dalton transactions (Cambridge, England : 2003), 46 34, 11425-11430

Azam, Mohammad Nurul; Shahjahan, Mohammad; Yeasmin, Mahbuba; Ahmed, Nasar U 2016. Prevalence of Smokeless Tobacco among Low Socioeconomic Populations: A Cross-Sectional Analysis. PloS one, 11 6, e0156887

Azam, Mohammad; Velmurugan, Gunasekaran; Wabaidur, Saikh Mohammad; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Al-Resayes, Saud I; Al-Othman, Zeid A; Venuvanalingam, Ponnambalam 2016. Structural elucidation and physicochemical properties of mononuclear Uranyl(VI) complexes incorporating dianionic units. Scientific reports, 6 , 32898

Azam, Mohammad; Velmurugan, Gunasekaran; Wabaidur, Saikh Mohammad; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Al-Resayes, Saud I; Al-Othman, Zeid A; Venuvanalingam, Ponnambalam 2016. Structural elucidation and physicochemical properties of mononuclear Uranyl(VI) complexes incorporating dianionic units. Scientific reports, 6 , 32898

Sallam, Mowaffaq Awad; Sheikh, Kamaludin Ahmed; Baxendale, Ronald; Azam, Mohammad Nurul; El-Setouhy, Maged 2016. The physiological and perceptual effects of plant extracts (Catha Edulis Forsk) during sustained exercise. Substance abuse treatment, prevention, and policy, 11 1, 18

Zhang, Xin; Jia, Deyong; Ao, Junping; Liu, Huijuan; Zang, Yi; Azam, Mohammad; Habib, Samy L; Li, Jia; Ruan, Xinsen; Jia, Hao; Wang, Xueying; Li, Baojie 2016. Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia. Oncotarget, 7 43, 69945-69960

Zhang, Xin; Jia, Deyong; Ao, Junping; Liu, Huijuan; Zang, Yi; Azam, Mohammad; Habib, Samy L; Li, Jia; Ruan, Xinsen; Jia, Hao; Wang, Xueying; Li, Baojie 2016. Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia. Oncotarget, 7 43, 69945-69960

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad 2015. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Scientific reports, 5 , 14538

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Azam, Mohammad 2014. A method for screening and validation of resistant mutations against kinase inhibitors. Journal of visualized experiments : JoVE, 94,

Kesarwani, M; Huber, E; Azam, M 2013. Overcoming AC220 resistance of FLT3-ITD by SAR302503. Blood cancer journal, 3 , e138

Azam, Mohammad 2012. An in vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents. Methods in molecular biology (Clifton, N.J.), 928 , 175-84

Kamthan, Ayushi; Kamthan, Mohan; Azam, Mohammad; Chakraborty, Niranjan; Chakraborty, Subhra; Datta, Asis 2012. Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality. Scientific reports, 2 , 951

Azam, Mohammad; Powers, John T; Einhorn, William; Huang, Wei-Sheng; Shakespeare, William C; Zhu, Xiaotian; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K; Daley, George Q 2010. AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance. Chemical biology & drug design, 75 2, 223-7

Zhang, Jianming; Adrián, Francisco J; Jahnke, Wolfgang; Cowan-Jacob, Sandra W; Li, Allen G; Iacob, Roxana E; Sim, Taebo; Powers, John; Dierks, Christine; Sun, Fangxian; Guo, Gui-Rong; Ding, Qiang; Okram, Barun; Choi, Yongmun; Wojciechowski, Amy; Deng, Xianming; Liu, Guoxun; Fendrich, Gabriele; Strauss, André; Vajpai, Navratna; Grzesiek, Stephan; Tuntland, Tove; Liu, Yi; Bursulaya, Badry; Azam, Mohammad; Manley, Paul W; Engen, John R; Daley, George Q; Warmuth, Markus; Gray, Nathanael S 2010. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature, 463 7280, 501-6

Huang, Wei-Sheng; Zhu, Xiaotian; Wang, Yihan; Azam, Mohammad; Wen, David; Sundaramoorthi, Raji; Thomas, R Mathew; Liu, Shuangying; Banda, Geetha; Lentini, Scott P; Das, Sasmita; Xu, Qihong; Keats, Jeff; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T; Broudy, Marc I; Russian, Karin; Daley, George Q; Iuliucci, John; Dalgarno, David C; Clackson, Tim; Sawyer, Tomi K; Shakespeare, William C 2009. 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation. Journal of medicinal chemistry, 52 15, 4743-56

Nardi, Valentina; Naveiras, Olaia; Azam, Mohammad; Daley, George Q 2009. ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines. Blood, 113 16, 3813-20

Viswanathan, Srinivas R; Powers, John T; Einhorn, William; Hoshida, Yujin; Ng, Tony L; Toffanin, Sara; O'Sullivan, Maureen; Lu, Jun; Phillips, Letha A; Lockhart, Victoria L; Shah, Samar P; Tanwar, Pradeep S; Mermel, Craig H; Beroukhim, Rameen; Azam, Mohammad; Teixeira, Jose; Meyerson, Matthew; Hughes, Timothy P; Llovet, Josep M; Radich, Jerald; Mullighan, Charles G; Golub, Todd R; Sorensen, Poul H; Daley, George Q 2009. Lin28 promotes transformation and is associated with advanced human malignancies. Nature genetics, 41 7, 843-8

Azam, Mohammad; Seeliger, Markus A; Gray, Nathanael S; Kuriyan, John; Daley, George Q 2008. Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nature structural & molecular biology, 15 10, 1109-18

Raz, Tal; Nardi, Valentina; Azam, Mohammad; Cortes, Jorge; Daley, George Q 2007. Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood, 110 6, 2102-9

Azam, Mohammad; Daley, George Q 2006. Anticipating clinical resistance to target-directed agents : the BCR-ABL paradigm. Molecular diagnosis & therapy, 10 2, 67-76

Azam, Mohammad; Nardi, Valentina; Shakespeare, William C; Metcalf, Chester A; Bohacek, Regine S; Wang, Yihan; Sundaramoorthi, Raji; Sliz, Piotr; Veach, Darren R; Bornmann, William G; Clarkson, Bayard; Dalgarno, David C; Sawyer, Tomi K; Daley, George Q 2006. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proceedings of the National Academy of Sciences of the United States of America, 103 24, 9244-9

Weisberg, Ellen; Manley, Paul W; Breitenstein, Werner; Brüggen, Josef; Cowan-Jacob, Sandra W; Ray, Arghya; Huntly, Brian; Fabbro, Doriano; Fendrich, Gabriele; Hall-Meyers, Elizabeth; Kung, Andrew L; Mestan, Jürgen; Daley, George Q; Callahan, Linda; Catley, Laurie; Cavazza, Cara; Azam, Mohammad; Mohammed, Azam; Neuberg, Donna; Wright, Renee D; Gilliland, D Gary; Griffin, James D 2005. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer cell, 7 2, 129-41

Nardi, Valentina; Azam, Mohammad; Daley, George Q 2004. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Current opinion in hematology, 11 1, 35-43

Azam, Mohammad; Latek, Robert R; Daley, George Q 2003. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell, 112 6, 831-43

Azam, Mohammad; Raz, Tal; Nardi, Valentina; Opitz, Sarah L.; Daley, George Q. 2003. A screen to identify drug resistant variants to target-directed anti-cancer agents. Biological procedures online, 5 , 204-210

Azam, Mohammad; Kesarwani, Meenu; Chakraborty, Subhra; Natarajan, Krishnamurthy; Datta, Asis 2002. Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes. The Biochemical journal, 367 Pt 1, 67-75

Khanna, Richie; Chang, Seon H; Andrabi, Shaida; Azam, Mohammad; Kim, Anthony; Rivera, Alicia; Brugnara, Carlo; Low, Philip S; Liu, Shih-Chun; Chishti, Athar H 2002. Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proceedings of the National Academy of Sciences of the United States of America, 99 10, 6637-42

Azam, M; Kesarwani, M; Natarajan, K; Datta, A 2001. A secretion signal is present in the Collybia velutipes oxalate decarboxylase gene. Biochemical and biophysical research communications, 289 4, 807-12

Kesarwani, M; Azam, M; Natarajan, K; Mehta, A; Datta, A 2000. Oxalate decarboxylase from Collybia velutipes. Molecular cloning and its overexpression to confer resistance to fungal infection in transgenic tobacco and tomato. The Journal of biological chemistry, 275 10, 7230-8

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