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Department of


Collaborative Research on Acute Neurological Injuries

News and Events

CRANI Hosts Special Guests in Biomedical Engineering - September 26, 2019

CRANI hosted Martyn Boutelle, PhD., and Fred Bowman, PhD., CEO, Hermedex Inc., at their September 26th science conference. 

Dr. Boutelle is professor of Engineering in the Department of Biomedical engineering at the Imperial College London and works with clinicians at King’s College in the development and use of on-line microdialysis systems to detect tissue ischemia, the development of combined multimodal biosensors, and in recording cortical electrophysiology. He is one of the founding members of COSBID, alongside our own Jed Hartings. Dr. Boutelle’s talk was entitled 'Measuring dynamic neurochemical changes in the injured brain using continuous on-line microdialysis' - which was of interest to our biomedical engineers, translational scientists, and clinicians, since we’ve deployed intermittent microdialysis into our clinical management of patients with traumatic brain injuries. 

Dr. Bowman is the founder and CEO of Hemedex Inc, which makes the Bowman Perfusion Monitor that is currently used to record rCBF in our clinical multimodality monitoring platform in the NSICU. Dr. Bowman is a biomedical engineer by training and former faculty with the Harvard-MIT Division of Health Sciences and Technology.

Neurotrauma Symposium 2019 Presentations

Overview of Spreading Depolarization Monitoring (pre-symposium workshop)

- Jed Hartings, PhD, Associate Professor of Neurosurgery

Neurotrauma in the Southern Ohio Region (includes opening and closing remarks)

- Laura Ngwenya MD, PhD, Director of Neurotrauma, Assistant Professor of Neurosurgery

Military Advances in TBI Research

- Michael Goodman, MD, Associate Professor of Trauma and Critical Care

Vision Therapy for Concussion Rehabilitation

- Joseph Clark, PhD, Professor of Neurology and Rehabilitation Medicine

Maxillofacial Trauma and its Implications in Neurological Surgery

- Deepak Krishnan, DDS, FACS, Associate Professor of Oral and Maxillofacial Surgery

Identifying & Treating PTSD in TBI Patients

- Kathleen Chard, PhD, Professor of Psychiatry, UC Health Stress Center

Brain Death in the Era of Therapeutic Hypothermia - Uncharted & Frozen Waters

- Jordan Bonomo, MD, FCCM, FNCS, Associate Professor of Emergency Med. and Neurology

5th Annual Kentucky Spinal Cord and Head Injury Research Trust Symposium (KSCHIRT)

Louisville hosted the 25th annual KSCHIRT on May 15-16, with general assembly topics including "Big Data Approaches to Big Questions," "Novel Approaches for Investigating Bladder and Bowel Dysfunction," and "Emerging Topics in Neuroscience." More speaker/session details.

Concussions and Neural-Visual Training with Dr. Joe Clark

Podcast features Joseph Clark, PhD, professor in the Department of Neurology and Rehabilitation Medicine. "On this program, we have the great honor of hosting Dr. Joe Clark, professor of neurology at the University of Cincinnati. Dr. Clark currently serves as a professor at Cincinnati in the Department of Neurology and Rehabilitation Medicine where part of his responsibilities have to do with concussion research." - Mind For Life, November 2, 2018

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CLOVERS examines ways of increasing blood pressure in sepsis patients

Sepsis occurs when the body has a severe reaction to infection, that can become a life-threatening condition, and one of the major dangers for sepsis patients is low blood pressure. Researchers at the University of Cincinnati (UC) are involved in a national study comparing two methods of increasing blood pressure in those patients.

Over 1.5 million people in the United States and 19 million worldwide get sepsis every year, according to Kristin Hudock, MD, assistant professor in the Division of Pulmonary, Critical Care and Sleep Medicine in the Department of Internal Medicine at the UC College of Medicine, and the UC site principal investigator on the study.

"We’re looking specifically at septic shock which is a more extreme version of sepsis,” says Hudock. "Depending on the source of the information, there is anywhere from 25 percent to 40 percent mortality in that patient population. Approximately 50 hospitals, including Johns Hopkins, Harvard, Vanderbilt and the Cleveland Clinic are centers for this study.

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UC Awarded $1.5M to Study Blood Clotting in Traumatic Brain Injury

Congratulations to Michael Goodman, MD, assistant professor in the Department of Surgery at the UC College of Medicine, and colleagues for the award of a $1.5 million, five-year NIH grant to develop therapies to better prevent and treat post-injury blood clots.

"My hope is that this results in a multimodal approach to stop bleeding and prevent blood clots that happen in traumatic brain injury patients, and by extension other patients,” said Dr. Goodman. "We want to zero in on when an injury causes a transition from bleeding to clotting to figure out how to prevent these clots during recovery.”

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UC's 'Top Notch' Neurotrauma Care Team highlighted in LEAD Cincinnati article

"It Takes a Team: Thankful to Be Alive" features Laura Ngwenya, MD, PhD, assistant professor in the Department of Neurosurgery at the UC College of Medicine, and UC Gardner Neuroscience Institute's neurotrauma care team as key to grateful Kourtney Hurst's survivor success story.

"When Kourtney arrived, the trauma bay was notified immediately,” Dr. Ngwenya recalls. “On her imaging we saw she had a bleed on her brain,” indicating she must be taken at once to the operating room. She also required emergency surgery for multiple other brain and orthopaedic injuries. “It took a big team effort to get Kourtney back to health.”

Dying Brain: WVXU

Jed Hartings, PhD, research associate professor in the Department of Neurosurgery at the UC College of Medicine, is senior author of a new study that, for the first time, monitored dying patients to confirm the energy release known as "spreading depolarization," or "brain tsunamis."

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Dying Brain: Science Daily

A new study provides insight into the neurobiology of dying. For the study, investigators performed continuous patient monitoring following Do Not Resuscitate - Comfort Care orders in patients with devastating brain injury to investigate the mechanisms and timing of events in the brain and the circulation during the dying process.

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Life Foundation Grant Award

Dr. Ngwenya is an Assistant Professor in the Departments of Neurosurgery and Neurology & Rehabilitation Medicine at University of Cincinnati. She is also the Director of the Neurotrauma Center at the University of Cincinnati Gardner Neuroscience Institute. Traumatic brain injury (TBI) affects 2.8 million people in the United States annually,1 many of whom have untreated impaired cognitive recovery. Understanding how genetic risk impacts TBI recovery will lead to identification of novel substrate targets for development of patient-centered therapeutics.

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Moberg Multimodality Webinar

Interpreting and Reporting Multimodal Neuromonitoring Data: A Medical Record for the Brain

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Work on Concussions by Joe Clark

Joe Clark, PhD, professor in the Department of Neurology and Rehabilitation Medicine at the UC College of Medicine has discovered colored glasses effectively calm the brain down after a concussion and provide relief for the patient.

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A slide of a brain injury, colored green and blue

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