Today is Thursday, Dec. 12, 2019

Department of

Biomedical Informatics

Data Services - Cincinnati Children's

Research Data Warehouse & Honest Broker Service 

BMI supports an Honest Broker service, which allows the creation of an integrated patient record using data from CCHMC’s clinical information systems as well as select research systems.  

This information is de-identified and access is made available through the Research Data Warehouse, which consists of a suite of software applications as well as a core data repository that is intended to support translational research.  

The warehouse contains much of the data that are stored in CCHMC’s electronic health record, including demographics, diagnoses, procedures, laboratory results, medication orders, vital signs and allergies.  The warehouse is also linked to the institutional biorepository, which allows investigators to include sample-related metadata in their search queries.     

The warehouse is primarily used for cohort identification, allowing users to perform an enterprise-wide search on a limited data repository to determine the existence of a set of patients meeting certain inclusion or exclusion criteria. 

Once a cohort has been identified, investigators at Cincinnati Children’s are able to work with the Honest Broker service to obtain the data needed to complete their research as specified in their Institutional Review Board (IRB) protocol.  Investigators can also work with the Honest Broker service directly to obtain the data they need to complete their research study.  

The research data warehouse is also used to support Cincinnati Children’s participation in several distributed data sharing networks. Data from the warehouse is transformed into the appropriate data model and terminology standards and then exposed in a way that preserves privacy and allows queries for aggregate counts or summary statistics to be broadcast from approved investigators to all network participants. 

The queries are executed against the data and then the results are sent back to the originating investigator, rapidly lowering the time needed to identify cohorts or validate hypotheses among large, diverse patient populations spread among multiple care centers.


Clinical, Translational, and Health Services Research Support

Through our core services and faculty labs, BMI supports the data collection, transformation, reporting and visualization needs of research projects, including multi-center clinical research studies, research data registries and project-specific datamarts, and learning networks. We support studies using REDCap and a number of custom-developed solutions tailored to the specific needs of the investigator and their research team. 

Due to high demand, data service provision is prioritized especially for academic collaboration, supported and sustainable projects, and strategic initiatives.