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Department of

Surgery

Photo of  Nikolai Timchenko, MD

Nikolai Timchenko, MD

Professor

Education/Credentials
  • Doctoral Degree: Institute of Experimental Medicine, St. Petersburg, Russia
  • Post-Doctoral Fellowship: Baylor College of Medicine

Contact Information
  • Cincinnati Children's Hospital Medical Center
  • Division of Pediatric Surgery
  • 3333 Burnet Avenue
  • Cincinnati, Ohio 45229
  • Office 513-636-0129
  • Email nikolai.timchenko@cchmc.org

Peer Reviewed Publications

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Lewis, Kyle; Valanejad, Leila; Cast, Ashley; Wright, Mary; Wei, Christina; Iakova, Polina; Stock, Lauren; Karns, Rebekah; Timchenko, Lubov; Timchenko, Nikolai 2017. RNA binding protein CUGBP1 inhibits liver cancer in a phosphorylation dependent manner. Molecular and cellular biology, ,

Valanejad, Leila; Lewis, Kyle; Wright, Mary; Jiang, Yanjun; D'Souza, Amber; Karns, Rebekah; Sheridan, Rachel; Gupta, Anita; Bove, Kevin; Witte, David; Geller, James; Tiao, Gregory; Nelson, David L; Timchenko, Lubov; Timchenko, Nikolai 2017. FXR-Gankyrin axis is involved in development of pediatric liver cancer. Carcinogenesis, ,

Jin, Jingling; Valanejad, Leila; Nguyen, Thuy Phuong; Lewis, Kyle; Wright, Mary; Cast, Ashley; Stock, Lauren; Timchenko, Lubov; Timchenko, Nikolai A 2016. Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease. Cell reports, 16 3, 744-56

Miller, Nicholas J; Schick, Kaitlyn; Timchenko, Nikolai; Harrison, Emmett; Roesler, William J 2016. The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBP?. Journal of cellular biochemistry, 117 3, 612-20

Tiao, Gregory; Geller, James; Timchenko, Nikolai A 2016. Generation of pediatric liver cancer patient-derived xenograft platforms for pediatric liver cancer: A critical stage in the development of anticancer treatments. Hepatology (Baltimore, Md.), 64 4, 1017-9

Valanejad, Leila; Timchenko, Nikolai 2016. Akt-FoxO1 axis controls liver regeneration. Hepatology (Baltimore, Md.), 63 5, 1424-6

Breaux, Meghan; Lewis, Kyle; Valanejad, Leila; Iakova, Polina; Chen, Fengju; Mo, Qianxing; Medrano, Estela; Timchenko, Lubov; Timchenko, Nikolai 2015. p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways. Molecular and cellular biology, 35 17, 3005-16

Fleet, Tiffany; Zhang, Bin; Lin, Fumin; Zhu, Bokai; Dasgupta, Subhamoy; Stashi, Erin; Tackett, Bryan; Thevananther, Sundararajah; Rajapakshe, Kimal I; Gonzales, Naomi; Dean, Adam; Mao, Jianqiang; Timchenko, Nikolai; Malovannaya, Anna; Qin, Jun; Coarfa, Cristian; DeMayo, Francesco; Dacso, Clifford C; Foulds, Charles E; O'Malley, Bert W; York, Brian 2015. SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 112 44, E6068-77

Jin, Jingling; Hong, Il-Hwa; Lewis, Kyle; Iakova, Polina; Breaux, Meghan; Jiang, Yanjun; Sullivan, Emily; Jawanmardi, Nicole; Timchenko, Lubov; Timchenko, Nikolai A 2015. Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration. Hepatology (Baltimore, Md.), 61 1, 315-25

Jones, Karlie; Wei, Christina; Schoser, Benedikt; Meola, Giovanni; Timchenko, Nikolai; Timchenko, Lubov 2015. Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5. Proceedings of the National Academy of Sciences of the United States of America, 112 26, 8041-5

Timchenko, Nikolai A 2015. Cell-type specific functions of epidermal growth factor receptor are involved in development of hepatocellular carcinoma. Hepatology (Baltimore, Md.), 62 1, 314-6

Hong, Il-Hwa; Lewis, Kyle; Iakova, Polina; Jin, Jingling; Sullivan, Emily; Jawanmardi, Nicole; Timchenko, Lubov; Timchenko, Nikolai 2014. Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments. The Journal of biological chemistry, 289 2, 1106-18

Jiang, Yanjun; Iakova, Polina; Jin, Jingling; Sullivan, Emily; Sharin, Vladislav; Hong, Il-Hwa; Anakk, Sayee; Mayor, Angela; Darlington, Gretchen; Finegold, Milton; Moore, David; Timchenko, Nikolai A 2013. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology (Baltimore, Md.), 57 3, 1098-106

Jiang, Yanjun; Jin, Jingling; Iakova, Polina; Hernandez, Julio Cesar; Jawanmardi, Nicole; Sullivan, Emily; Guo, Grace L; Timchenko, Nikolai A; Darlington, Gretchen J 2013. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mechanisms of ageing and development, 134 9, 407-15

Jin, Jingling; Iakova, Polina; Breaux, Meghan; Sullivan, Emily; Jawanmardi, Nicole; Chen, Dahu; Jiang, Yanjun; Medrano, Estela M; Timchenko, Nikolai A 2013. Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis. Cell reports, 3 3, 831-43

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Lewis, Kyle; Sullivan, Emily; Jawanmardi, Nicole; Donehower, Lawrence; Timchenko, Lubov; Timchenko, Nikolai A 2013. Transcriptional and translational regulation of C/EBP?-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1? proteins at the early and late stages of liver cancer. The Journal of biological chemistry, 288 20, 14451-62

Wei, Christina; Jones, Karlie; Timchenko, Nikolai A; Timchenko, Lubov 2013. GSK3? is a new therapeutic target for myotonic dystrophy type 1. Rare diseases (Austin, Tex.), 1 , e26555

Jones, Karlie; Timchenko, Lubov; Timchenko, Nikolai A 2012. The role of CUGBP1 in age-dependent changes of liver functions. Ageing research reviews, 11 4, 442-9

Jones, Karlie; Wei, Christina; Iakova, Polina; Bugiardini, Enrico; Schneider-Gold, Christiane; Meola, Giovanni; Woodgett, James; Killian, James; Timchenko, Nikolai A; Timchenko, Lubov T 2012. GSK3? mediates muscle pathology in myotonic dystrophy. The Journal of clinical investigation, 122 12, 4461-72

Haefliger, Simon; Klebig, Christiane; Schaubitzer, Kerstin; Schardt, Julian; Timchenko, Nikolai; Mueller, Beatrice U; Pabst, Thomas 2011. Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML. Blood, 117 22, 5931-40

Iakova, Polina; Timchenko, Lubov; Timchenko, Nikolai A 2011. Intracellular signaling and hepatocellular carcinoma. Seminars in cancer biology, 21 1, 28-34

Jin, Jingling; Iakova, Polina; Jiang, Yanjun; Medrano, Estela E; Timchenko, Nikolai A 2011. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology (Baltimore, Md.), 54 3, 989-98

Jones, Karlie; Jin, Bingwen; Iakova, Polina; Huichalaf, Claudia; Sarkar, Partha; Schneider-Gold, Christiane; Schoser, Benedikt; Meola, Giovanni; Shyu, Ann-Bin; Timchenko, Nikolai; Timchenko, Lubov 2011. RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2. The American journal of pathology, 179 5, 2475-89

Huichalaf, Claudia; Sakai, Keiko; Jin, Bingwen; Jones, Karlie; Wang, Guo-Li; Schoser, Benedikt; Schneider-Gold, Christiane; Sarkar, Partha; Pereira-Smith, Olivia M; Timchenko, Nikolai; Timchenko, Lubov 2010. Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 10, 3706-19

Jin, Jingling; Wang, Guo-Li; Iakova, Polina; Shi, Xiurong; Haefliger, Simon; Finegold, Milton; Timchenko, Nikolai A 2010. Epigenetic changes play critical role in age-associated dysfunctions of the liver. Aging cell, 9 5, 895-910

Lin, Qiushi; Chen, Dahu; Timchenko, Nikolai A; Medrano, Estela E 2010. SKI promotes Smad3 linker phosphorylations associated with the tumor-promoting trait of TGFbeta. Cell cycle (Georgetown, Tex.), 9 9, 1684-9

Orellana, Daniel; Liu, Xiaoying; Wang, Gou-Li; Jin, Jingling; Iakova, Polina; Timchenko, Nikolai A 2010. Calmodulin controls liver proliferation via interactions with C/EBPbeta-LAP and C/EBPbeta-LIP. The Journal of biological chemistry, 285 30, 23444-56

Schardt, Julian A; Eyholzer, Marianne; Timchenko, Nikolai A; Mueller, Beatrice U; Pabst, Thomas 2010. Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia. Journal of cellular and molecular medicine, 14 6B, 1509-19

Wang, Guo-Li; Shi, Xiurong; Haefliger, Simon; Jin, Jingling; Major, Angela; Iakova, Polina; Finegold, Milton; Timchenko, Nikolai A 2010. Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice. The Journal of clinical investigation, 120 7, 2549-62

Willis-Martinez, Danielle; Richards, Hunter W; Timchenko, Nikolai A; Medrano, Estela E 2010. Role of HDAC1 in senescence, aging, and cancer. Experimental gerontology, 45 4, 279-85

Chen, Dahu; Lin, Qiushi; Box, Neil; Roop, Dennis; Ishii, Shunsuke; Matsuzaki, Koichi; Fan, Tao; Hornyak, Thomas J; Reed, Jon A; Stavnezer, Ed; Timchenko, Nikolai A; Medrano, Estela E 2009. SKI knockdown inhibits human melanoma tumor growth in vivo. Pigment cell & melanoma research, 22 6, 761-72

Jin, Jingling; Wang, Guo-Li; Salisbury, Elizabeth; Timchenko, Lubov; Timchenko, Nikolai A 2009. GSK3beta-cyclin D3-CUGBP1-eIF2 pathway in aging and in myotonic dystrophy. Cell cycle (Georgetown, Tex.), 8 15, 2356-9

Jin, Jingling; Wang, Guo-Li; Shi, Xiurong; Darlington, Gretchen J; Timchenko, Nikolai A 2009. The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Molecular and cellular biology, 29 14, 3867-80

Jin, Jingling; Wang, Guo-Li; Timchenko, Lubov; Timchenko, Nikolai A 2009. GSK3beta and aging liver. Aging, 1 6, 582-5

Salisbury, Elizabeth; Schoser, Benedikt; Schneider-Gold, Christiane; Wang, Guo-Li; Huichalaf, Claudia; Jin, Bingwen; Sirito, Mario; Sarkar, Partha; Krahe, Ralf; Timchenko, Nikolai A; Timchenko, Lubov T 2009. Expression of RNA CCUG repeats dysregulates translation and degradation of proteins in myotonic dystrophy 2 patients. The American journal of pathology, 175 2, 748-62

Timchenko, Nikolai A 2009. Aging and liver regeneration. Trends in endocrinology and metabolism: TEM, 20 4, 171-6

Wang, Guo-Li; Salisbury, Elizabeth; Shi, Xiurong; Timchenko, Lubov; Medrano, Estela E; Timchenko, Nikolai A 2008. HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice. The Journal of biological chemistry, 283 38, 26169-78

Wang, Guo-Li; Salisbury, Elizabeth; Shi, Xiurong; Timchenko, Lubov; Medrano, Estela E; Timchenko, Nikolai A 2008. HDAC1 promotes liver proliferation in young mice via interactions with C/EBPbeta. The Journal of biological chemistry, 283 38, 26179-87

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Timchenko, Nikolai A 2008. Regulation of apoptotic and growth inhibitory activities of C/EBPalpha in different cell lines. Experimental cell research, 314 7, 1626-39

Bandyopadhyay, Debdutta; Curry, Jonathan L; Lin, Qiushi; Richards, Hunter W; Chen, Dahu; Hornsby, Peter J; Timchenko, Nikolai A; Medrano, Estela E 2007. Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging cell, 6 4, 577-91

Choi, William T; Folsom, Matthew R; Azim, Mohammed F; Meyer, Claus; Kowarz, Eric; Marschalek, Rolf; Timchenko, Nikolai A; Naeem, Rizwan C; Lee, Dean A 2007. C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL. Cancer genetics and cytogenetics, 177 2, 108-14

Harrison-Findik, Duygu Dee; Klein, Elizabeth; Crist, Callie; Evans, John; Timchenko, Nikolai; Gollan, John 2007. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology (Baltimore, Md.), 46 6, 1979-85

Huichalaf, Claudia H; Sakai, Keiko; Wang, Guo-Li; Timchenko, Nikolai A; Timchenko, Lubov 2007. Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis. Gene, 396 2, 391-402

Smith, Roy G; Sun, Yuxiang; Jiang, Hong; Albarran-Zeckler, Rosie; Timchenko, Nikolai 2007. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Annals of the New York Academy of Sciences, 1119 , 147-64

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Sun, Yuxiang; Albrecht, Jeffrey H; Smith, Roy G; Timchenko, Nikolai A 2007. Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex. The Journal of biological chemistry, 282 2, 1468-78

Harrison-Findik, Duygu Dee; Schafer, Denise; Klein, Elizabeth; Timchenko, Nikolai A; Kulaksiz, Hasan; Clemens, Dahn; Fein, Evelyn; Andriopoulos, Billy; Pantopoulos, Kostas; Gollan, John 2006. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. The Journal of biological chemistry, 281 32, 22974-82

Karagiannides, Iordanes; Thomou, Thomas; Tchkonia, Tamara; Pirtskhalava, Tamar; Kypreos, Kyriakos E; Cartwright, Andrew; Dalagiorgou, Georgia; Lash, Timothy L; Farmer, Stephen R; Timchenko, Nikolai A; Kirkland, James L 2006. Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. The Journal of biological chemistry, 281 32, 23025-33

Lee, Young-Jin; Jones, Letetia C; Timchenko, Nikolai A; Perrotti, Danilo; Tenen, Daniel G; Kogan, Scott C 2006. CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities. Blood, 108 7, 2416-9

Timchenko, Lubov T; Salisbury, Elizabeth; Wang, Guo-Li; Nguyen, Heather; Albrecht, Jeffrey H; Hershey, John W B; Timchenko, Nikolai A 2006. Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. The Journal of biological chemistry, 281 43, 32806-19

Wang, Guo-Li; Shi, Xiurong; Salisbury, Elizabeth; Sun, Yuxiang; Albrecht, Jeffrey H; Smith, Roy G; Timchenko, Nikolai A 2006. Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes. Molecular and cellular biology, 26 7, 2570-82

Bales, Elise; Mills, Lisa; Milam, Nancy; McGahren-Murray, Mollianne; Bandyopadhyay, Debdutta; Chen, Dahu; Reed, Jon A; Timchenko, Nikolai; van den Oord, Joost J; Bar-Eli, Menashe; Keyomarsi, Khandan; Medrano, Estela E 2005. The low molecular weight cyclin E isoforms augment angiogenesis and metastasis of human melanoma cells in vivo. Cancer research, 65 3, 692-7

Helbling, Daniel; Mueller, Beatrice U; Timchenko, Nikolai A; Schardt, Julian; Eyer, Myriam; Betts, David R; Jotterand, Martine; Meyer-Monard, Sandrine; Fey, Martin F; Pabst, Thomas 2005. CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Blood, 106 4, 1369-75

Schwahn, Denise J; Timchenko, Nikolai A; Shibahara, Shigeki; Medrano, Estela E 2005. Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 18 3, 203-13

Timchenko, Nikolai A; Wang, Gou-Li; Timchenko, Lubov T 2005. RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2. The Journal of biological chemistry, 280 21, 20549-57

Wang, Guo-Li; Timchenko, Nikolai A 2005. Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein. Molecular and cellular biology, 25 4, 1325-38

Baldwin, Brenda R; Timchenko, Nikolai A; Zahnow, Cynthia A 2004. Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells. Molecular and cellular biology, 24 9, 3682-91

Helbling, Daniel; Mueller, Beatrice U; Timchenko, Nikolai A; Hagemeijer, Anne; Jotterand, Martine; Meyer-Monard, Sandrine; Lister, Andrew; Rowley, Janet D; Huegli, Barbara; Fey, Martin F; Pabst, Thomas 2004. The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin. Proceedings of the National Academy of Sciences of the United States of America, 101 36, 13312-7

Iakova, Polina; Wang, Guo-Li; Timchenko, Lubov; Michalak, Marek; Pereira-Smith, Olivia M; Smith, James R; Timchenko, Nikolai A 2004. Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. The EMBO journal, 23 2, 406-17

Timchenko, Nikolai A; Patel, Roma; Iakova, Polina; Cai, Zong-Jin; Quan, Ling; Timchenko, Lubov T 2004. Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis. The Journal of biological chemistry, 279 13, 13129-39

Wang, Guo-Li; Iakova, Polina; Wilde, Margie; Awad, Samir; Timchenko, Nikolai A 2004. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes & development, 18 8, 912-25

Yan, Yan; Phan, Leuyen; Yang, Fan; Talpaz, Moshe; Yang, Yu; Xiong, Zeyu; Ng, Bernard; Timchenko, Nikolai A; Wu, Catherine J; Ritz, Jerome; Wang, Hong; Yang, Xiao-Feng 2004. A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. Journal of immunology (Baltimore, Md. : 1950), 172 1, 651-60

Iakova, Polina; Awad, Samir S; Timchenko, Nikolai A 2003. Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell, 113 4, 495-506

Rickheim, David G; Nelsen, Christopher J; Fassett, John T; Timchenko, Nikolai A; Hansen, Linda K; Albrecht, Jeffrey H 2002. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology (Baltimore, Md.), 36 1, 30-8

Timchenko, Lubov T; Iakova, Polina; Welm, Alana L; Cai, Z-J; Timchenko, Nikolai A 2002. Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins. Molecular and cellular biology, 22 20, 7242-57

Wang, Hongmei; Goode, Triona; Iakova, Polina; Albrecht, Jeffrey H; Timchenko, Nikolai A 2002. C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest. The EMBO journal, 21 5, 930-41

Welm, Alana L; Timchenko, Nikolai A; Ono, Yasuko; Sorimachi, Hiroyuki; Radomska, Hannah S; Tenen, Daniel G; Lekstrom-Himes, Julie; Darlington, Gretchen J 2002. C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells. The Journal of biological chemistry, 277 37, 33848-56

Timchenko, Nikolai A . Old livers--C/EBPalpha meets new partners. Cell cycle (Georgetown, Tex.), 2 5, 445-6