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Photo of  Samantha Brugmann, PhD

Samantha Brugmann, PhD

Assistant Professor of Pediatrics

  • Bachelor's Degree: Tulane University
  • Doctoral Degree: The George Washington University
  • Postdoctoral Research Fellowship: Stanford University

Contact Information
  • Division of Pediatric Plastic Surgery MLC 7007
  • Cincinnati Children's Hospital Medical Center
  • 3333 Burnet Avenue
  • Cincinnati, Ohio 45229
  • Office 513-636-7678
  • Email

Peer Reviewed Publications

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Chang, Ching-Fang; Chang, Ya-Ting; Millington, Grethel; Brugmann, Samantha A 2016. Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. PLoS genetics, 12 11, e1006351

Chang, Ya-Ting; Chaturvedi, Praneet; Schock, Elizabeth N; Brugmann, Samantha A 2016. Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid(2). Frontiers in physiology, 7 , 468

Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I 2016. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clinical cancer research : an official journal of the American Association for Cancer Research, 22 8, 2062-73

Schock, Elizabeth N; Chang, Ching-Fang; Youngworth, Ingrid A; Davey, Megan G; Delany, Mary E; Brugmann, Samantha A 2016. Utilizing the chicken as an animal model for human craniofacial ciliopathies. Developmental biology, 415 2, 326-37

Workman, Michael J; Mahe, Maxime M; Trisno, Stephen; Poling, Holly M; Watson, Carey L; Sundaram, Nambirajan; Chang, Ching-Fang; Schiesser, Jacqueline; Aubert, Philippe; Stanley, Edouard G; Elefanty, Andrew G; Miyaoka, Yuichiro; Mandegar, Mohammad A; Conklin, Bruce R; Neunlist, Michel; Brugmann, Samantha A; Helmrath, Michael A; Wells, James M 2016. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nature medicine, ,

Chang, Ching-Fang; Schock, Elizabeth N; Attia, Aria C; Stottmann, Rolf W; Brugmann, Samantha A 2015. The ciliary baton: orchestrating neural crest cell development. Current topics in developmental biology, 111 , 97-134

Saal, Howard M; Prows, Cynthia A; Guerreiro, Iris; Donlin, Milene; Knudson, Luke; Sund, Kristen L; Chang, Ching-Fang; Brugmann, Samantha A; Stottmann, Rolf W 2015. A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia. Human molecular genetics, 24 12, 3399-409

Schock, Elizabeth N; Chang, Ching-Fang; Struve, Jaime N; Chang, Ya-Ting; Chang, Julie; Delany, Mary E; Brugmann, Samantha A 2015. Using the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of oral-facial-digital syndrome. Disease models & mechanisms, 8 8, 855-66

Chang, Anne L S; Atzmon, Gil; Bergman, Aviv; Brugmann, Samantha; Atwood, Scott X; Chang, Howard Y; Barzilai, Nir 2014. Identification of genes promoting skin youthfulness by genome-wide association study. The Journal of investigative dermatology, 134 3, 651-7

Chang, Ching-Fang; Schock, Elizabeth N; O'Hare, Elizabeth A; Dodgson, Jerry; Cheng, Hans H; Muir, William M; Edelmann, Richard E; Delany, Mary E; Brugmann, Samantha A 2014. The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2. Development (Cambridge, England), 141 15, 3003-12

Brugmann, Samantha A; Wells, James M 2013. Building additional complexity to in vitro-derived intestinal tissues. Stem cell research & therapy, 4 Suppl 1 , S1

Liu, Han; Lan, Yu; Xu, Jingyue; Chang, Ching-Fang; Brugmann, Samantha A; Jiang, Rulang 2013. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proceedings of the National Academy of Sciences of the United States of America, 110 46, 18555-60

Powder, Kara E; Ku, Yuan-Chieh; Brugmann, Samantha A; Veile, Rose A; Renaud, Nicole A; Helms, Jill A; Lovett, Michael 2012. A cross-species analysis of microRNAs in the developing avian face. PloS one, 7 4, e35111

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Prescott, Sara; Brugmann, Samantha A; Swigut, Tomek; Wysocka, Joanna 2012. Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell stem cell, 11 5, 633-48

Cordero, Dwight R; Brugmann, Samantha; Chu, Yvonne; Bajpai, Ruchi; Jame, Maryam; Helms, Jill A 2011. Cranial neural crest cells on the move: their roles in craniofacial development. American journal of medical genetics. Part A, 155A 2, 270-9

Lenton, Kelly; James, Aaron W; Manu, Alina; Brugmann, Samantha A; Birker, Daniel; Nelson, Emily R; Leucht, Philipp; Helms, Jill A; Longaker, Michael T 2011. Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis (New York, N.Y. : 2000), 49 10, 784-96

Levi, Benjamin; James, Aaron W; Nelson, Emily R; Brugmann, Samantha A; Sorkin, Michael; Manu, Alina; Longaker, Michael T 2011. Role of Indian hedgehog signaling in palatal osteogenesis. Plastic and reconstructive surgery, 127 3, 1182-90

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Swigut, Tomek; Brugmann, Samantha A; Flynn, Ryan A; Wysocka, Joanna 2011. A unique chromatin signature uncovers early developmental enhancers in humans. Nature, 470 7333, 279-83

Zaghloul, Norann A; Brugmann, Samantha A 2011. The emerging face of primary cilia. Genesis (New York, N.Y. : 2000), 49 4, 231-46

Brugmann, Samantha A; Allen, Nancy C; James, Aaron W; Mekonnen, Zesemayat; Madan, Elena; Helms, Jill A 2010. A primary cilia-dependent etiology for midline facial disorders. Human molecular genetics, 19 8, 1577-92

Brugmann, Samantha A; Cordero, Dwight R; Helms, Jill A 2010. Craniofacial ciliopathies: A new classification for craniofacial disorders. American journal of medical genetics. Part A, 152A 12, 2995-3006

Levi, Benjamin; Brugmann, Samantha; Longaker, Michael T 2010. Discussion: Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells. The Journal of craniofacial surgery, 21 5, 1450-1

James, Aaron W; Theologis, Alexander A; Brugmann, Samantha A; Xu, Yue; Carre, Antoine L; Leucht, Philipp; Hamilton, Katherine; Korach, Kenneth S; Longaker, Michael T 2009. Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PloS one, 4 9, e7120

Anderson, Charles T; Castillo, Alesha B; Brugmann, Samantha A; Helms, Jill A; Jacobs, Christopher R; Stearns, Tim 2008. Primary cilia: cellular sensors for the skeleton. Anatomical record (Hoboken, N.J. : 2007), 291 9, 1074-8

Rinn, John L; Wang, Jordon K; Allen, Nancy; Brugmann, Samantha A; Mikels, Amanda J; Liu, Helen; Ridky, Todd W; Stadler, H Scott; Nusse, Roel; Helms, Jill A; Chang, Howard Y 2008. A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes & development, 22 3, 303-7

Schlosser, Gerhard; Awtry, Tammy; Brugmann, Samantha A; Jensen, Eric D; Neilson, Karen; Ruan, Gui; Stammler, Angelika; Voelker, Doris; Yan, Bo; Zhang, Chi; Klymkowsky, Michael W; Moody, Sally A 2008. Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. Developmental biology, 320 1, 199-214

ten Berge, Derk; Brugmann, Samantha A; Helms, Jill A; Nusse, Roel 2008. Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development (Cambridge, England), 135 19, 3247-57

Brugmann, Samantha A; Goodnough, L Henry; Gregorieff, Alex; Leucht, Philipp; ten Berge, Derk; Fuerer, Christophe; Clevers, Hans; Nusse, Roel; Helms, Jill A 2007. Wnt signaling mediates regional specification in the vertebrate face. Development (Cambridge, England), 134 18, 3283-95

Goodnough, L Henry; Brugmann, Samantha A; Hu, Diane; Helms, Jill A 2007. Stage-dependent craniofacial defects resulting from Sprouty2 overexpression. Developmental dynamics : an official publication of the American Association of Anatomists, 236 7, 1918-28

Rinn, John L; Kertesz, Michael; Wang, Jordon K; Squazzo, Sharon L; Xu, Xiao; Brugmann, Samantha A; Goodnough, L Henry; Helms, Jill A; Farnham, Peggy J; Segal, Eran; Chang, Howard Y 2007. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell, 129 7, 1311-23

Brugmann, Samantha A; Tapadia, Minal D; Helms, Jill A 2006. The molecular origins of species-specific facial pattern. Current topics in developmental biology, 73 , 1-42

Brugmann, Samantha A; Moody, Sally A 2005. Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. Biology of the cell, 97 5, 303-19

Brugmann, Samantha A; Pandur, Petra D; Kenyon, Kristy L; Pignoni, Francesca; Moody, Sally A 2004. Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development (Cambridge, England), 131 23, 5871-81