Today is Tuesday, Dec. 10, 2019

Department of

Radiation Oncology

Department of Radiation Oncology

Recent Publications

Peer Reviewed Publications

  1. Medek S, De B, Pater L, Breneman J, Mahajan A, Wolden S, Vatner RE. Practice patterns among radiation oncologists treating pediatric patients with proton craniospinal irradiation. Pract Raciat Oncol. 2019 Nov;9(6):441-447.
  2. Guo M, Chee G, O'Connell D, Dhou S, Fu J, Singhrao K, Ionascu D, Ruan D, Lee P, Low DA, Zhao J, Lewis JH. Reconstruction of a high-quality volumetric image and a respiratory motion model from patient CBCT projections. Med Phys. 2019 Aug;46(8):3627-3639.
  3. Breneman J, Laack NNI, MacDonald S, Ermoian R, Baldini E. Pediatric Radiation Therapy- When Too Much Is Not Enough. Int J Radiat Oncolo Biol Phys. 2019 Aug 1:104(5):963-966.
  4. Fakhry C, Zhang Q, Gillison ML, Nguyen-Tan PF, Rosenthal DI, Weber RS, Lambert L, Trotti AM 3rd, Barrett WL, Thorstad WL, Yom SS, Wong SJ, Ridge JA, Rao SSD, Spencer S, Fortin A, Raben D, Harris J, Le QT. Validation of NRG oncology/RTOG-0129 risk groups for HPV-positive and HPV-negative oropharyngeal squamous cell cancer: Implications for risk-based therapeutic intensity trials. Cancer. 2019 Jun 15:125(12):2027-2038.
  5. Tang AL, Miller A, Hauff S, Myer CM 3rd, Takiar V, Howell RJ, Mark JR. Maternity and paternity leave in otolaryngology residency training in the United States. Laryngoscope. 2019 May;129(5):1093-1099.
  6. Kharofa J, Mierzwa M, Olowokure O, Sussman J, Latif T, Gupta A, Xie C, Patel S, Esslinger H, Mcgill B, Wolf E, Ahmad SA. Pattern of marginal local failure in a phase II trial of neoadjuvant chemotherapy and stereotactic body radiation therapy for resectable and borderline resectable pancreas cancer. Am J Clin Oncol. 2019 Mar;42(3):247-252.
  7. Daugherty M, Daugherty E, Jacob J, Shapiro O, Mollapour M, Bratslavsky G. Renal cell carcinoma and brain metastasis: Questioning the dogma of role for cytoreductive nephrectomy. Urol Oncol. 2019 Mar;37(3):182.e9-182.e15.
  8. Turpin B, Pressey JG, Nagarajan R, Weiss BD, Trout AT, Gelfand MJ, Pater L, Vatner RE, Breneman JC, Dasgupta R. Sentinel lymph node biopsy in head and neck rhabdomyosarcoma. Pediatr Blood Cancer. 2019 Mar;66(3):e27532.
  9. Agresta L, Salloum R, Hummel TR, Ratner N, Mangano FT, Fuller C, McMasters RL, Pater L, Jones BV, Szabo S, Pressey JG. Malignant peripheral nerve sheath tumor: Transformation in a patient with neurofibromatosis type 2. Pediatr Blood Cancer. 2019 Feb;66(2):e27520
  10. Ermoian R, MacDonald S, Laack NNI, Baldini E, Breneman J. Reirradiation in pediatric patients with recurrent brain tumors: A last hope, but one with greatly feared consequences. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):1-4.
  11. Walterhouse DO, Barkauskas DA, Hall D, Ferrari A, De Salvo GL, Koscielniak E, Stevens MCG, Martelli H, Seitz G, Rodeberg DA, Shnorhavorian M, Dasgupta R, Breneman JC, Anderson JR, Bergeron C, Bisogno G, Meyer WH, Hawkins DS, Minard-Colin V. Demographic and treatment variables influencing outcome for localized paratesticular rhabdomyosarcoma: Results from a pooled analysis of North American and European cooperative groups. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):19-27.
  12. Daugherty EC, Lawrence G. In regard to Tyler et al. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):284-285.
  13. Davis HW, Vallabhapurapu SD, Chu Z, Vallabhapurapu SL, Franco RS, Mierzwa M, Kassing W, Barrett WL, Qi X. Enhanced phosphatidylserine-selective cancer therapy with irradiation and SapC-DOPS nanovesicles. Oncotarget. 2019 Jan 25;10(8):856-868.
  14. Haque S, Karivedu V, Riaz MK, Choi D, Roof L, Hassan SZ, Zhu Z, Jandarov R, Takiar V, Tang A, Wise-Draper T. High-risk pathological features at the time of salvage surgery predict poor survival after definitive therapy in patients with head and neck squamous cell carcinoma. Oral Oncol. 2019 Jan;88:9-15.
  15. Prasad RN, Breneman JC, Struve T, Warnick RE, Pater LE. Linac-based fractionated stereotactic radiosurgery for high-risk meningioma. J Radiosurg SBRT. 2018;5(4):269-276.
  16. Prasad RN, Elson J, Kharofa J. The effect of dose escalation for large squamous cell carcinomas of the anal canal. Clinical & Translational Oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018.
  17. Forster N, Warnick R, Takiar V, Pater L, Breneman J. Debulking surgery of pituitary adenoma as a strategy to facilitate definitive stereotactic radiosurgery. Journal of Neuro-oncology 2018;138:335-340.
  18. Weber DC, Habrand JL, Hoppe BS, Hill Kayser C, Laack NN, Langendijk JA, MacDonald SM, McGovern SL, Pater L, Perentesis JP, Thariat J, Timmerman B, Yock TI, Mahajan A. Proton therapy for pediatric malignancies: Fact, figures and costs. A joint consensus statement from the pediatric subcommittee of PTCOG, PROS and EPTN. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology 2018.
  19. Zhou YM, Freese C, Meier T, Go D, Khullar K, Sudhoff M, Lamba M, Kharofa J. The absolute volume of pet-defined, active bone marrow spared predicts for high grade hematologic toxicity in cervical cancer patients undergoing chemoradiation. Clinical & Translational Oncology: official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018;20:713-718.
  20. Raghubar KP, Lamba M, Cecil KM, Yeates KO, Mahone EM, Limke C, Grosshans D, Beckwith TJ, Ris MD. Dose-volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study. Pediatric Blood & Cancer 2018:e27245.
  21. Freese C, Sudhoff M, Lewis L, Lamba M, Kharofa J. The volume of pet-defined, active bone marrow spared predicts acute hematologic toxicities in anal cancer patients receiving concurrent chemoradiotherapy. Acta Oncologica (Stockholm, Sweden) 2018;57:683-686.
  22. Frankart AJ, Meier T, Minges TL, Kharofa J. Comparison of spinal and general anesthesia approaches for MRI-guided brachytherapy for cervical cancer. Brachytherapy 2018.
  23. Hess CB, Indelicato DJ, Paulino AC, Hartsell WF, Hill-Kayser CE, Perkins SM, Mahajan A, Laack NN, Ermoian RP, Chang AL, Wolden SL, Mangona VS, Kwok Y, Breneman JC, Perentesis JP, Gallotto SL, Weyman EA, Bajaj BVM, Lawell MP, Yeap BY, Yock TI. An update from the pediatric proton consortium registry. Frontiers in Oncology 2018;8:165.
  24. Minniti G, Soltys SG, Halasz LM, Breneman JC, Chan M, Laack NN, Kirkpatrick JP. Stereotactic radiosurgery for resected brain metastases: New evidence supports a practice shift, but questions remain. Int J Radiat Oncol Biol, Physics 2018;100:535-538.
  25. Wise-Draper T, Sendilnathan A, Palackdharry S, Pease N, Qualtieri J, Butler R, Sadraei NH, Morris JC, Patil Y, Wilson K, Mark J, Casper K, Takiar V, Lane A, Privette Vinnedge L. Decreased plasma DEK oncogene levels correlate with p16-negative disease and advanced tumor stage in a case-control study of patients with head and neck squamous cell carcinoma. Translational Oncology 2018;11:168-174.
  26. Qin A, Ionascu D, Liang J, Han X, O’Connell N, Yan D. The evaluation of a hybrid biomechanical deformable registration method on a multistage physical phantom with reproducible deformation. Radiat Oncol. 2018 Dec 4;13(1):240.
  27. Tao R, Ager B, Lloyd S, Torgeson A, Denney M, Gaffney D, Kharofa J, Lin SH, Koong AC, Anzai Y, Hoffman JM. Hypoxia imaging in upper gastrointestinal tumors and application to radiation therapy. J Gastrointest Oncol. 2018 Dec;9(6):1044-1053.
  28. Elson JK, Kachnic LA, Kharofa JR. Intensity-modulated radiotherapy improves survival and reduces treatment time in squamous cell carcinoma of the anus: A National Cancer Data Base study. Cancer. 2018 Nov 15;124(22):4383-4392.
  29. Fakhry C, Nguyen-Tân PF, Lambert L, Rosenthal DI, Weber RS, Gillison ML, Trotti AM 3rd, Barrett WL, Thorstad WL, Jones CU, Yom SS, Wong SJ, Ridge JA, Rao SSD, Bonner JA, Vigneault E, Raben D, Kudrimoti MR, Harris J, Le QT. In regard to Bossi et al. Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):669-670.
  30. Vatner RE, Niemierko A, Misra M, Weyman EA, Goebel CP, Ebb DH, Jones RM, Huang MS, Mahajan A, Grosshans DR, Paulino AC, Stanley T, MacDonald SM, Tarbell NJ, Yock TI. Endocrine deficiency as a function of radiation dose to the hypothalamus and pituitary in pediatric and young adult patients with brain tumors. J Clin Oncol. 2018 Oct 1;36(28):2854-2862.
  31. Raghubar KP, Lamba M, Cecil KM, Yeates KO, Mahone EM, Limke C, Grosshans D, Beckwith TJ, Ris MD. Dose-volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study. Pediatr Blood Cancer. 2018 Sep;65(9):e27245.
  32. Weber DC, Habrand JL, Hoppe BS, Hill Kayser C, Laack NN, Langendijk JA, MacDonald SM, McGovern SL, Pater L, Perentesis JP, Thariat J, Timmerman B, Yock TI, Mahajan A. Proton therapy for pediatric malignancies: Fact, figures and costs. A joint consensus statement from the pediatric subcommittee of PTCOG, PROS, and EPTN. Radiother Oncol. 2018 Jul;128(1):44-55.
  33. Breneman JC, Donaldson SS, Constine L, Merchant T, Marcus K, Paulino AC, Followill D, Mahajan A, Laack N, Esiashvili N, Haas-Kogan D, Laurie F, Olch A, Ulin K, Hodgson D, Yock TI, Terezakis S, Krasin M, Panoff J, Chuba P, Hua CH, Hess CB, Houghton PJ, Wolden S, Buchsbaum J, Fitzgerald TJ, Kalapurakal JA. The Children’s Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer. Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):860-874.
  34. Sandwall PA, Bastow BP, Spitz HB, Elson HR, Lamba M, Connick WB, Fenichel H. Radio-fluorogenic gel dosimetry with Coumarin. Bioengineering (Basel). 2018 Jul 10;5(3).
  35. Sandwall PA, Feng Y, Platt M, Lamba M, Mahalingam S. Evolution of brachytherapy treatment planning to deterministic radiation transport for calculation of cardiac dose. Med Dosim. 2018 Summer;43(2):150-158
  36. Kim Y, Stahl CC, Makramalla A, Olowokure OO, Ristagno RL, Dhar VK, Schoech MR, Chadalavada S, Latif T, Kharofa J, Bari K, Shah SA. Downstaging therapy followed by liver transplantation for hepatocellular carcinoma beyond milan criteria. Surgery 2017;162:1250-1258.
  37. Pater L, Turpin B, Mascia A. Pencil beam scanning proton therapy for rhabdomyosarcoma of the biliary tract. Cureus 2017;9:e1747.
  38. Meier T, Hazenfield JM, Girnius S, Hagen M, Warnick RE, Kharofa J. A rare case of central nervous system amyloidoma treated with fractionated radiotherapy. Journal of Neurosurgery 2017;127:338-341.
  39. Vatner RE, Janssen EM. STING, DCs and the link between innate and adaptive tumor immunity. Mol Immunol. 2017 Dec 20. pii: S0161-5890(17)30594-1
  40. Halasz LM, Soltys SG, Breneman JC, Chan MD, Laack NN, Minniti G, Kirkpatrick JP. Treatment of Gliomas: A Changing Landscape. Int J Radiat Oncol Biol Phys. 2017 Jun 1;98(2):255-258
  41. Walterhouse DO, Pappo AS, Meza JL, Breneman JC, Hayes-Jordan A, Parham DM, Cripe TP, Anderson JR, Meyer WH, Hawkins DS. Reduction of cyclophosphamide dose for patients with subset 2 low-risk rhabdomyosarcoma is associated with an increased risk of recurrence: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. Cancer. 2017 Jun 15;123(12):2368-2375.
  42. Ermoian RP, Breneman J, Walterhouse DO, Chi YY, Meza J, Anderson J, Hawkins DS, Hayes-Jordan AA, Parham DM, Yock TI, Donaldson SS, Wolden SL. 45 Gy is not sufficient radiotherapy dose for Group III orbital embryonal rhabdomyosarcoma after less than complete response to 12 weeks of ARST0331 chemotherapy: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. Pediatr Blood Cancer. 2017 May 26.
  43. Xia BT, Fu B, Wang J, Kim Y, Ahmad SA, Dhar VK, Levinsky NC, Hanseman DJ, Habib DA, Wilson GC, Smith M, Olowokure OO, Kharofa J, Al Humaidi AH, Choe KA, Abbott DE, Ahmad SA. Does radiologic response correlate to pathologic response in patients undergoing neoadjuvant therapy for borderline resectable pancreatic malignancy? J Surg Oncol. 2017 Mar;115(4):376-383.
  44. Tuttle TR, Takiar V, Kumar B, Kumar P, Ben-Jonathan N. Soluble Guanylate Cyclase Stimulators Increase Sensitivity to Cisplatin in Head and Neck Squamous Cell Carcinoma Cells. Cancer Letters. 2017 Mar 28;389:33-40.
  45. Freese C, Takiar V, Fouladi M, DeWire M, Breneman J, Pater L. Institutional Outcomes in the Treatment of Primary and Recurrent Diffuse Intrinsic Pontine Gliomas. Practical Radiation Oncology. 2017 Mar-Apr;7(2):86-92.
  46. Freese C, Takiar V, Fouladi M, DeWire M, Breneman J, Pater L. Radiation and subsequent reirradiation outcomes in the treatment of diffuse intrinsic pontine glioma and a systematic review of the reirradiation literature. Practical Radiation Oncology. Mar-Apr 2017;Vol. 7, Issue 2, p86-92.
  47. Sadraei NH, Huth BJ. Try to Avoid Tri-Modality Treatment. Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):3.
  48. Costello MS, Golub JS, Barrord JV, Pater L, Pensak ML, Samy RN. Cochlear implantation after radiation therapy for acoustic neuroma. Journal of Radiosurgery and SBRT 2016;4:69-74.
  49. Zhang Y., Rana S., Gao S., Zhang L., Court L., Yang J. Intensity-based Deformable Image Registration with Anatomical Constraints for Image-guided Radiation Therapy. Recent Patent on Medical Imaging, 5(2), 2016.
  50. Brahimaj B, Lamba M, Breneman J, Warnick R, Kemper M. Iodine-125 Seed Migration within Brain Parenchyma after Brachytherapy for Brain Metastasis: Case Report. J. of Neurosurgery, pp1-4, Nov 2016.
  51. Takiar V, Ip CKM, Gao M, Mills, GB, Huang LWT. Neomorphic Mutations Create Therapeutic Challenges in Cancer. Oncogene. Nov, 2016.
  52. Kirkpatrick JP, Laack NN, Soltys SG, Halasz LM, Breneman JC, Shih HA. Brain Metastases From Melanoma: Therapy at the Crossroads. Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):713-716.
  53. Takiar V, Phan J. In Reply to Mansha. (Commentary) Int J Radiat Oncol Biol Phys. 2016 Nov 1; 96(3):709.
  54. Khullar K, Sudhoff M, Elson JK, Herzog T, Jackson A, Billingsley C, Lamba M, Kharofa JR. A Comparison of Dosimetric Parameters in PET-Based Active Bone Marrow Vlume and Total Bone Volume in Prediction of Hematologic Toxicity in Cervical Cancer Patients Treated with Chemoradiation. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2): E307-E308.
  55. Phan J, Sio TT, Nguyen TP, Takiar V, Gunn GB, Garden AS, Rosenthal DI, Fuller CD, Morrison WH, Beadle BM, Ma D, Kupferman ME, William WN, Frank SJ. Re-Irradiation of Head and Neck Cancers with Proton Therapy: Outcomes and Analyses. Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):30-41.
  56. Qi Z, Lemen L, Lamba M, Chen H, Samaratunga R, Mahoney M, Hendrick R. Radiation Dose to the Breast by 64-slice CT: Effects of Scanner Model and Study Protocol. Academic Radiology. 23(8) 987-993, Aug 2016.
  57. Damast S, Takiar V, McCarthy S, Higgins SA. Treatment of Early Stage Vaginal Cancer with EBRT and MRI-Based Intracavitary Brachytherapy: A Retrospective Case Review. Gynecologic Oncology Reports. 2016 Aug 4;17:89-92.
  58. Takiar V, Garden AS, Ma D, Morrison WH, Edson MA, Zafareo M, Gunn GB, Fuller CD, Beadle BM, Frank SJ, William WN, Kies M, El-Naggar AK, Weber RS, Rosenthal DI, Phan J. Reirradiation of Head and Neck Cancers with IMRT: Updated Outcomes and Analysis. Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1117-31.
  59. Lee E, Juergen Meyer, George Sandison. Collimator Design for Spatially-Fractionated Proton Beams for Radiobiology Research. Phys. Med. Biol. 61, 5378-89, July 2016.
  60. Mitra S, Federico L, Zhao W, Dennison J, Sarkar TR, Zhang F, Takiar V, Cheng KW, Mani S, Lee JS, Mills GB. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget. 2016 Jun 28;7(26):40252-40265
  61. Wang H, Wang C, Tung S, Dimmitt AW, Wong PF, Edson MA, Garden AS, Rosenthal DI, Fuller CD, Gunn GB, Takiar V, Wang XA, Luo D, Yang JN, Wong J, Phan J. Improved setup and positioning accuracy using a three-point customized cushion/mask/bite-block immobilization system for stereotactic reirradiation of head and neck cancer.J Appl Clin Med Phys. 2016 May 8;17(3):180-189
  62. Meier T, Kharofa J. Magnetic resonance imaging-guided high-dose rate brachytherapy for cervical cancer. Semin Roentgenol. 2016 Apr;51(2):106-11
  63. Takiar V, Ma D, Garden AS, Li J, Rosenthal DI, Beadle BM, Frank SJ, Fuller CGunn GB, Morrison WH, Hutcheson K, El-Naggar AK, Gold KA, Kupferman ME, Phan J. Disease control and toxicity outcomes for T4 carcinoma of the nasopharynx treated with intensity-modulated radiotherapy. Head Neck. 2016 Apr;38 Suppl 1:E925-33
  64. Tao R, Ma D, Takiar V, Frank SJ, Fuller CD, Gunn GB, Beadle BM, Morrison WH, Rosenthal DI, Edson MA, Esmaeli B, Kupferman ME, Hanna EY, Garden AS, Phan J. Orbital carcinomas treated with adjuvant intensity-modulated radiation therapy. Head Neck. 2016 Apr;38 Suppl 1:E580-7
  65. Nabavizadeh N, Burt LM, Mancini BR, Morris ZS, Walker AJ, Miller SM, Bhavsar S, Mohindra P, Kim MB, Kharofa J; ARRO Executive Committee. Results of the 2013-2015 Association of Residents in Radiation Oncology Survey of Chief Residents in the United States. Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):228-34
  66. Yu ZH, Kudchadker R, Dong L, Zhang Y, Court LE, Mourtada F, Yock A, Tucker SL, Yang J. Learning anatomy changes from patient populations to create artificial CT images for voxel-level validation of deformable image registration. J Appl Clin Med Phys. 2016 Jan 8;17(1):246-258
  67. Edson MA, Garden AS, Takiar V, Glisson BS, Fuller CD, Gunn GB, Beadle BM, Morrison WH, Frank SJ, Shah SJ, Tao R, William WN, Weber RS, Rosenthal DI, Phan J. Outcomes for hypopharyngeal carcinoma treated with organ-preservation therapy. Head & Neck 2016;38 Suppl 1:E2091-2099.
  68. Sandwall, PA, Spitz, HB, Elson, HR, Lamba MAS, Connick WB,Fenichel H. Measuring the photon depth dose distribution produced by a medical linear accelerator in a water-equivalent radio-fluorogenic gel. J Radioanal Nucl Chem 2016;307:2505-2508.