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Pharmacology & Systems Physiology 

Photo of Yana Zavros, PhD

Yana Zavros, PhD

Professor of Physiology; Co-Director UC WISE-REWU Program

Research/Clinical Interests

Correa described the multi-step model for gastric cancer over 30 years ago beginning with an active chronic inflammatory phase now known to be typically caused by Helicobacter pylori infection. The subsequent phases are dominated by alterations of the epithelial cell cycle, progressing to atrophy, intestinal metaplasia, dysplasia and the eventual development of gastric cancer. During the progression of the inflamed stomach to gastric cancer, the acid-producing parietal cells fail to secrete acid and are replaced by metaplastic mucus-secreting cells, a process called atrophy. My past research interests have revolved around understanding the Correa model with a particular focus on the role of inflammation as a trigger for parietal-cell atrophy. To investigate the role of inflammation as a trigger for atrophy, the gastrin-deficient (GÐ/Ð) mouse model (developed by Linda C. Samuelson, University of Michigan) was used. Interestingly, we found that in the hypochlorhydric GÐ/Ð mouse stomach the chronic gastritis, atrophy, metaplasia, dysplasia paradigm typically observed in the human was recapitulated in these mice. Therefore, the GÐ/Ð mouse became an excellent model for us to study the development of gastric cancer from chronic atrophic gastritis. Parietal cells within the stomach not only secrete acid, but are also the major source of factors that are responsible for regulating the differentiation of the gastric epithelium. Thus, it is not surprising that loss of the parietal cells triggers a cascade that develops into neoplasia. Amongst the proteins synthesized and secreted from the parietal cells is the morphogen sonic hedgehog (Shh). Remarkably, Shh is involved not only in the development of the gastrointestinal tract, but also sustains the gastric phenotype of the adult stomach. However, little is known of the interaction between Shh expression, parietal cell function and the development of gastric cancer. Gastrin, a known trophic factor for the gastric epithelium, is the principal stimulant of acid production and sustains the differentiated state of the parietal cell. We have shown that GÐ/Ð mice develop parietal cell atrophy that eventually results in gastric cancer [Zavros et al, 2005]. Since loss of Shh induces a metaplastic phenotype reminiscent of the atrophy that emerges with chronic inflammation, we tested the hypothesis that gastrin regulates Shh. Indeed we found that GÐ/Ð mice had reduced levels of gastric Shh expression while gastrin infusion induced Shh expression at both the mRNA and protein level. Since most Shh is in an inactive precursor form, our observation that gastrin increased the conversion of the 45-kDa Shh precursor to the 19-kDa biologically active and secreted protein was highly significant. Furthermore, the activation was associated with increased conversion of pepsinogen A (PgA) to pepsin A [Fig 1]. There is compelling evidence that gastric atrophy initiates the development of gastric cancer. Shh, produced by the parietal cell, is believed to be a key regulator of gastric differentiation. Therefore, our focus is to study the molecular mechanisms underlying the relationship between Shh processing, inflammation, parietal cell function and cancer development. Moreover, our research will extend the knowledge of the role of pepsinogen A in the stomach. Pepsin A protease function is highly significant, given that protease activity is absent in the stomachs of patients with gastric cancer that coincides with loss of Shh protein processing and bioactivity.

Contact Information
  • Office 4255 Medical Sciences Building
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0576
  • Office (513)558-2421
  • Fax (513)558-5738
  • Email yana.zavros@uc.edu

Peer Reviewed Publications

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Chakrabarti, Jayati; Holokai, Loryn; Syu, LiJyun; Steele, Nina; Chang, Julie; Dlugosz, Andrzej; Zavros, Yana 2018. Mouse-Derived Gastric Organoid and Immune Cell Co-culture for the Study of the Tumor Microenvironment. Methods in molecular biology (Clifton, N.J.), 1817 , 157-168

Teal, Emma; Bertaux-Skeirik, Nina; Chakrabarti, Jayati; Holokai, Loryn; Zavros, Yana 2018. Establishment of Human- and Mouse-Derived Gastric Primary Epithelial Cell Monolayers from Organoids. Methods in molecular biology (Clifton, N.J.), 1817 , 145-155

Teal, Emma; Steele, Nina G; Chakrabarti, Jayati; Holokai, Loryn; Zavros, Yana 2018. Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration. Journal of visualized experiments : JoVE, 135,

Zavros, Yana 2018. The Novel Role of Lgr5 as a Regulator of Cell Homeostasis and Disease of the Gastric Oxyntic Mucosa. Cellular and molecular gastroenterology and hepatology, 5 4, 645-646

Bertaux-Skeirik, Nina; Wunderlich, Mark; Teal, Emma; Chakrabarti, Jayati; Biesiada, Jacek; Mahe, Maxime; Sundaram, Nambirajan; Gabre, Joel; Hawkins, Jennifer; Jian, Gao; Engevik, Amy C; Yang, Li; Wang, Jiang; Goldenring, James R; Qualls, Joseph E; Medvedovic, Mario; Helmrath, Michael A; Diwan, Tayyab; Mulloy, James C; Zavros, Yana 2017. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. The Journal of pathology, 242 4, 463-475

Braune, Julia; Weyer, Ulrike; Matz-Soja, Madlen; Hobusch, Constance; Kern, Matthias; Kunath, Anne; Klöting, Nora; Kralisch, Susann; Blüher, Matthias; Gebhardt, Rolf; Zavros, Yana; Bechmann, Ingo; Gericke, Martin 2017. Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism. Diabetologia, 60 5, 889-899

Zavros, Yana 2017. Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells. Cellular and molecular gastroenterology and hepatology, 4 1, 55-63

Bertaux-Skeirik, Nina; Centeno, Jomaris; Feng, Rui; Schumacher, Michael A; Shivdasani, Ramesh A; Zavros, Yana 2016. Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods in molecular biology (Clifton, N.J.), 1422 , 23-31

Bertaux-Skeirik, Nina; Centeno, Jomaris; Gao, Jian; Gabre, Joel; Zavros, Yana 2016. Oncogenic Transformation of Human-Derived Gastric Organoids. Methods in molecular biology (Clifton, N.J.), ,

Dedhia, Priya H; Bertaux-Skeirik, Nina; Zavros, Yana; Spence, Jason R 2016. Organoid Models of Human Gastrointestinal Development and Disease. Gastroenterology, 150 5, 1098-1112

Engevik, Amy C; Feng, Rui; Choi, Eunyoung; White, Shana; Bertaux-Skeirik, Nina; Li, Jing; Mahe, Maxime M; Aihara, Eitaro; Yang, Li; DiPasquale, Betsy; Oh, Sunghee; Engevik, Kristen A; Giraud, Andrew S; Montrose, Marshall H; Medvedovic, Mario; Helmrath, Michael A; Goldenring, James R; Zavros, Yana 2016. The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach. Cellular and molecular gastroenterology and hepatology, 2 5, 605-624

Keilberg, Daniela; Zavros, Yana; Shepherd, Benjamin; Salama, Nina R; Ottemann, Karen M 2016. Spatial and Temporal Shifts in Bacterial Biogeography and Gland Occupation during the Development of a Chronic Infection. mBio, 7 5,

Konstantinou, Daniel; Bertaux-Skeirik, Nina; Zavros, Yana 2016. Hedgehog signaling in the stomach. Current opinion in pharmacology, 31 , 76-82

Aihara, Eitaro; Mahe, Maxime M; Schumacher, Michael A; Matthis, Andrea L; Feng, Rui; Ren, Wenwen; Noah, Taeko K; Matsu-ura, Toru; Moore, Sean R; Hong, Christian I; Zavros, Yana; Herness, Scott; Shroyer, Noah F; Iwatsuki, Ken; Jiang, Peihua; Helmrath, Michael A; Montrose, Marshall H 2015. Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid. Scientific reports, 5 , 17185

Bertaux-Skeirik, Nina; Feng, Rui; Schumacher, Michael A; Li, Jing; Mahe, Maxime M; Engevik, Amy C; Javier, Jose E; Peek, Richard M; Ottemann, Karen; Orian-Rousseau, Veronique; Boivin, Gregory P; Helmrath, Michael A; Zavros, Yana 2015. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS pathogens, 11 2, e1004663

Schumacher, Michael A; Aihara, Eitaro; Feng, Rui; Engevik, Amy; Shroyer, Noah F; Ottemann, Karen M; Worrell, Roger T; Montrose, Marshall H; Shivdasani, Ramesh A; Zavros, Yana 2015. The use of murine-derived fundic organoids in studies of gastric physiology. The Journal of physiology, 593 8, 1809-27

Schumacher, Michael A; Feng, Rui; Aihara, Eitaro; Engevik, Amy C; Montrose, Marshall H; Ottemann, Karen M; Zavros, Yana 2015. Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NF?B pathway activation: the use of a novel in vitro model to study epithelial response to infection. Helicobacter, 20 1, 19-28

Wroblewski, Lydia E; Piazuelo, M Blanca; Chaturvedi, Rupesh; Schumacher, Michael; Aihara, Eitaro; Feng, Rui; Noto, Jennifer M; Delgado, Alberto; Israel, Dawn A; Zavros, Yana; Montrose, Marshall H; Shroyer, Noah; Correa, Pelayo; Wilson, Keith T; Peek, Richard M 2015. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut, 64 5, 720-30

Aihara, Eitaro; Closson, Chet; Matthis, Andrea L; Schumacher, Michael A; Engevik, Amy C; Zavros, Yana; Ottemann, Karen M; Montrose, Marshall H 2014. Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori. PLoS pathogens, 10 7, e1004275

Donnelly, Jessica M; Engevik, Amy C; Engevik, Melinda; Schumacher, Michael A; Xiao, Chang; Yang, Li; Worrell, Roger T; Zavros, Yana 2014. Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell. Digestive diseases and sciences, 59 3, 569-82

Donnelly, Jessica M; Engevik, Amy; Feng, Rui; Xiao, Chang; Boivin, Gregory P; Li, Jing; Houghton, JeanMarie; Zavros, Yana 2014. Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach. American journal of physiology. Gastrointestinal and liver physiology, 306 12, G1075-88

Feng, Rui; Aihara, Eitaro; Kenny, Susan; Yang, Li; Li, Jing; Varro, Andrea; Montrose, Marshall H; Shroyer, Noah F; Wang, Timothy C; Shivdasani, Ramesh A; Zavros, Yana 2014. Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology, 147 3, 655-666.e9

Marwaha, Shruti; Schumacher, Michael A; Zavros, Yana; Eghbalnia, Hamid R 2014. Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model. PloS one, 9 11, e111338

McCracken, Kyle W; Catá, Emily M; Crawford, Calyn M; Sinagoga, Katie L; Schumacher, Michael; Rockich, Briana E; Tsai, Yu-Hwai; Mayhew, Christopher N; Spence, Jason R; Zavros, Yana; Wells, James M 2014. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature, 516 7531, 400-4

Donnelly, Jessica M; Chawla, Ambreesh; Houghton, Jeanmarie; Zavros, Yana 2013. Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. PloS one, 8 9, e75225

Engevik, Amy C; Feng, Rui; Yang, Li; Zavros, Yana 2013. The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology, 154 12, 4627-39

Mahé, Maxime M; Aihara, Eitaro; Schumacher, Michael A; Zavros, Yana; Montrose, Marshall H; Helmrath, Michael A; Sato, Toshiro; Shroyer, Noah F 2013. Establishment of gastrointestinal epithelial organoids. Current protocols in mouse biology, 3 , 217-240

Xiao, Chang; Feng, Rui; Engevik, Amy C; Martin, Jason R; Tritschler, Julie A; Schumacher, Michael; Koncar, Robert; Roland, Joseph; Nam, Ki Taek; Goldenring, James R; Zavros, Yana 2013. Sonic Hedgehog contributes to gastric mucosal restitution after injury. Laboratory investigation; a journal of technical methods and pathology, 93 1, 96-111

Craig, Michael; Schumacher, Michael; Zavros, Yana 2012. Techniques for following labeled cells in vivo: use of X/Y FISH, techniques to optimize fluorescent detection, and beta-galactosidase detection. Methods in molecular biology (Clifton, N.J.), 921 , 227-38

Feng, Rui; Xiao, Chang; Zavros, Yana 2012. The role of Sonic Hedgehog as a regulator of gastric function and differentiation. Vitamins and hormones, 88 , 473-89

Schumacher, Michael A; Donnelly, Jessica M; Engevik, Amy C; Xiao, Chang; Yang, Li; Kenny, Susan; Varro, Andrea; Hollande, Frédéric; Samuelson, Linda C; Zavros, Yana 2012. Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology, 142 5, 1150-1159.e6

Zavros, Yana; Rogler, Gerhard 2012. Variants in autophagy genes affect susceptibility to both Crohn's disease and Helicobacter pylori infection. Gastroenterology, 142 5, 1060-3

Sherman, Alexander E; Zavros, Yana 2011. Role of Sonic Hedgehog signaling during progression from inflammation to cancer in the stomach. World journal of gastrointestinal pathophysiology, 2 6, 103-8

El-Zaatari, Mohamad; Zavros, Yana; Tessier, Art; Waghray, Meghna; Lentz, Steve; Gumucio, Deborah; Todisco, Andrea; Merchant, Juanita L 2010. Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology, 139 6, 2061-2071.e2

Martin, Jason; Donnelly, Jessica M; Houghton, JeanMarie; Zavros, Yana 2010. The role of Sonic Hedgehog reemergence during gastric cancer. Digestive diseases and sciences, 55 6, 1516-24

Miller, Marian L; Andringa, Anastasia; Zavros, Yana; Bradford, Emily M; Shull, Gary E 2010. Volume density, distribution, and ultrastructure of secretory and basolateral membranes and mitochondria predict parietal cell secretory (dys)function. Journal of biomedicine & biotechnology, 2010 , 394198

Tokhunts, Robert; Singh, Samer; Chu, Tehyen; D'Angelo, Gisela; Baubet, Valerie; Goetz, John A; Huang, Zhen; Yuan, Ziqiang; Ascano, Manuel; Zavros, Yana; Thérond, Pascal P; Kunes, Sam; Dahmane, Nadia; Robbins, David J 2010. The full-length unprocessed hedgehog protein is an active signaling molecule. The Journal of biological chemistry, 285 4, 2562-8

Waghray, Meghna; Zavros, Yana; Saqui-Salces, Milena; El-Zaatari, Mohamad; Alamelumangapuram, C Bharath; Todisco, Andrea; Eaton, Kathryn A; Merchant, Juanita L 2010. Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology, 138 2, 562-72, 572.e1-2

Xiao, Chang; Ogle, Sally A; Schumacher, Michael A; Orr-Asman, Melissa A; Miller, Marian L; Lertkowit, Nantaporn; Varro, Andrea; Hollande, Frederic; Zavros, Yana 2010. Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology, 138 2, 550-61, 561.e1-8

Xiao, Chang; Ogle, Sally A; Schumacher, Michael A; Schilling, Neal; Tokhunts, Robert A; Orr-Asman, Melissa A; Miller, Marian L; Robbins, David J; Hollande, Frederic; Zavros, Yana 2010. Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. American journal of physiology. Gastrointestinal and liver physiology, 299 6, G1252-65

Zavros, Yana; Mesiwala, Nisreen; Waghray, Meghna; Todisco, Andrea; Shulkes, Arthur; Merchant, Juanita L 2010. Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis. World journal of gastrointestinal pathophysiology, 1 5, 154-65

Donnelly J and Zavros Y. 2009. Sonic Hedgehog signaling modulates the recruitment of T cells to the gastric mucosa during Helicobacter-induced inflammation. Infection and Immunity, ,

Donnelly JM, Chawla A, Xiao C, Orr MA, Houghton J and Zavros Y 2009. Hedgehog Signaling Mediates IFN-gamma-Induced Mesenchymal Stem Cell Recruitment during Gastric Infection. Cancer Research, ,

M El-Zaatari, Y Zavros, A Tessier, M Waghray, A Todisco, and J.L. Merchant. 2009. Acid regulation of Shh gene expression is MCB, ,

Xiao C, Ogle S, Orr-Asman M, Hollande F and Zavros Y. 2009. Hedgehog Signaling Regulates the Distribution of ZO-1 and Barrier Function of the Gastric Epithelium. BBRC, ,

Kang, Weiqun; Saqui-Salces, Milena; Zavros, Yana; Merchant, Juanita L 2008. Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochemical and biophysical research communications, 376 3, 573-7

Mensah-Osman, Edith; Labut, Ed; Zavros, Yana; El-Zaatari, Mohamad; Law, David J; Merchant, Juanita L 2008. Regulated expression of the human gastrin gene in mice. Regulatory peptides, 151 1-3, 115-22

Mensah-Osman, Edith; Zavros, Yana; Merchant, Juanita L 2008. Somatostatin stimulates menin gene expression by inhibiting protein kinase A. American journal of physiology. Gastrointestinal and liver physiology, 295 4, G843-54

Zavros, Yana 2008. The adventures of sonic hedgehog in development and repair. IV. Sonic hedgehog processing, secretion, and function in the stomach. American journal of physiology. Gastrointestinal and liver physiology, 294 5, G1105-8

Zavros, Yana; Orr, Melissa A; Xiao, Chang; Malinowska, Danuta H 2008. Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. American journal of physiology. Gastrointestinal and liver physiology, 295 1, G99-G111

Zavros, Yana; Waghray, Meghna; Tessier, Arthur; Bai, Longchuan; Todisco, Andrea; L Gumucio, Deborah; Samuelson, Linda C; Dlugosz, Andrzej; Merchant, Juanita L 2007. Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. The Journal of biological chemistry, 282 46, 33265-74

Kao, John Y; Pierzchala, Anna; Rathinavelu, Sivaprakash; Zavros, Yana; Tessier, Arthur; Merchant, Juanita L 2006. Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori. Regulatory peptides, 134 1, 23-9

Kao, John Y; Rathinavelu, Sivaprakash; Eaton, Kathryn A; Bai, Longchuan; Zavros, Yana; Takami, Mimi; Pierzchala, Anna; Merchant, Juanita L 2006. Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense. American journal of physiology. Gastrointestinal and liver physiology, 291 1, G73-81

Lopez-Diaz, Lymari; Hinkle, Karen L; Jain, Renu N; Zavros, Yana; Brunkan, Cynthia S; Keeley, Theresa; Eaton, Kathryn A; Merchant, Juanita L; Chew, Catherine S; Samuelson, Linda C 2006. Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice. American journal of physiology. Gastrointestinal and liver physiology, 290 5, G970-9

Rathinavelu, Sivaprakash; Kao, John Y; Zavros, Yana; Merchant, Juanita L 2005. Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function. Helicobacter, 10 5, 424-32

Stepan, Vinzenz; Ramamoorthy, Saravanan; Nitsche, Hildegard; Zavros, Yana; Merchant, Juanita L; Todisco, Andrea 2005. Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. The Journal of biological chemistry, 280 16, 15700-8

Zavros, Yana; Eaton, Kathryn A; Kang, Weiqun; Rathinavelu, Sivaprakash; Katukuri, Vinay; Kao, John Y; Samuelson, Linda C; Merchant, Juanita L 2005. Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene, 24 14, 2354-66

Zavros, Yana; Merchant, Juanita L 2005. Modulating the cytokine response to treat Helicobacter gastritis. Biochemical pharmacology, 69 3, 365-71

Zavros, Yana; Kao, John Y; Merchant, Juanita L 2004. Inflammation and cancer III. Somatostatin and the innate immune system. American journal of physiology. Gastrointestinal and liver physiology, 286 5, G698-701

Joseph, Ian M P; Zavros, Yana; Merchant, Juanita L; Kirschner, Denise 2003. A model for integrative study of human gastric acid secretion. Journal of applied physiology (Bethesda, Md. : 1985), 94 4, 1602-18

Rathinavelu, Sivaprakash; Zavros, Yana; Merchant, Juanita L 2003. Acinetobacter lwoffii infection and gastritis. Microbes and infection / Institut Pasteur, 5 7, 651-7

Zavros, Yana; Rathinavelu, Sivaprakash; Kao, John Y; Todisco, Andrea; Del Valle, John; Weinstock, Joel V; Low, Malcolm J; Merchant, Juanita L 2003. Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Proceedings of the National Academy of Sciences of the United States of America, 100 22, 12944-9

Zavros, Y; Rieder, G; Ferguson, Amy; Merchant, J L 2002. Gastritis and hypergastrinemia due to Acinetobacter lwoffii in mice. Infection and immunity, 70 5, 2630-9

Zavros, Yana; Rieder, Gabriele; Ferguson, Amy; Samuelson, Linda C; Merchant, Juanita L 2002. Hypergastrinemia in response to gastric inflammation suppresses somatostatin. American journal of physiology. Gastrointestinal and liver physiology, 282 1, G175-83

Zavros, Yana; Rieder, Gabriele; Ferguson, Amy; Samuelson, Linda C; Merchant, Juanita L 2002. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology, 122 1, 119-33

Ofori-Darko, E; Zavros, Y; Rieder, G; Tarlé, S A; Van Antwerp, M; Merchant, J L 2000. An OmpA-like protein from Acinetobacter spp. stimulates gastrin and interleukin-8 promoters. Infection and immunity, 68 6, 3657-66

Zavros, Y; Paterson, A; Lambert, J; Shulkes, A 2000. Expression of progastrin-derived peptides and somatostatin in fundus and antrum of nonulcer dyspepsia subjects with and without Helicobacter pylori infection. Digestive diseases and sciences, 45 10, 2058-64

Zavros, Y; Van Antwerp, M; Merchant, J L 2000. Use of flow cytometry to quantify mouse gastric epithelial cell populations. Digestive diseases and sciences, 45 6, 1192-9

Grabau, B J; Zavros, Y; Hardy, K J; Shulkes, A 1999. Developmental regulation of gastric somatostatin secretion in the sheep. Endocrinology, 140 2, 603-8

Zavros, Y; Fleming, W R; Shulkes, A 1999. Concurrent elevation of fundic somatostatin prevents gastrin stimulation by GRP. The American journal of physiology, 276 1 Pt 1, G21-7

Zavros, Y; Fleming, W R; Hardy, K J; Shulkes, A 1998. Regulation of fundic and antral somatostatin secretion by CCK and gastrin. The American journal of physiology, 274 4 Pt 1, G742-50

Zavros, Y; Shulkes, A 1997. Cholecystokinin (CCK) regulates somatostatin secretion through both the CCK-A and CCK-B/gastrin receptors in sheep. The Journal of physiology, 505 ( Pt 3) , 811-21

Published Abstracts

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Donnelly JM, Chawla A, Xiao C, Orr MA, Houghton J and Zavros Y. 2009. Hedgehog Signaling Mediates IFN-gamma-Induced Mesenchymal Stem Cell Recruitment during Gastric Infection. , ,


J Martin and Y. Zavros. 2009. Hedgehog signaling and the development of gastric cancer. Digestive Diseases and Sciences, ,


M El-Zaatari, Y Zavros, A Tessier, M Waghray, A Todisco, and J.L. Merchant. 2009. Acid regulation of Shh gene expression is mediated by intracellular calcium release. MCB, ,


Miller ML, Andringa A, Spicer Z, Schultheis PJ, Zavros Y, Bradford EM and Shull GE. 2009. Parietal secretory cell volume density, distribution and ultrastructure of secretory membranes and mitochondria predict (dys)function. Journal of Biomedicine and Biotechnology - Epithelium Molecular Landscaping for an Interactive Barrier, ,


Robert Tokhunts, Samer Singh, Tehyen Chu, Gisela D’Angelo, Valerie Baubet, John A Goetz, Zhen Huang, Ziqiang Yuan, Manuel Ascano, Yana Zavros, Pascal P. Thérond, Sam Kunes, Nadia Dahmane, and David J. Robbins. 2009. The Unprocessed Full-Length HEDGEHOG Protein Has Activity as a Short Range Signaling Molecule. PNAS, ,


Waghray M, Zavros Y, Saqui-Salces M, Todisco A, Eaton KA, Merchant JL. 2009. Interleukin-1 Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog. Gastroenterology, ,


Xiao C, Ogle S, Orr MA, Miller ML, Varro A, Hollande F and Zavros Y. 2009. Parietal Cell-Expressed Sonic Hedgehog Is Required for Maintenance of a Functional and Differentiated Gastric Epithelium. Gastroenterology, ,


Xiao C, Ogle S, Orr-Asman M, Hollande F and Zavros Y. 2009. Hedgehog Signaling Regulates the Distribution of ZO-1 and Barrier Function of the Gastric Epithelium. BBRC, ,


Kang W, Saqui-Salces M, Zavros Y, Merchant JL 2008. Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochem Biophys Res Commun, 376(3), 573-577


Mensah-Osman E, Labut E, Zavros Y, El-Zaatari M, Law DJ, Merchant JL. 2008. Regulated expression of the human gastrin gene in mice. Regul Pept., 151(1-3), 115-122


Mensah-Osman E, Zavros Y, Merchant JL. 2008. Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol., 295(4), G843-854


Zavros Y, Orr MA, Xiao, C and Malinowska DH. 2008. Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. Am J Phyisol. , 295, G99-G111


Donnelly J and Zavros Y. . Sonic Hedgehog signaling modulates the recruitment of T cells to the gastric mucosa during Helicobacter-induced inflammation. , ,