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Pharmacology & Systems Physiology 

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Roger Worrell

Assistant Professor–Educator

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Shawki, Ali; Engevik, Melinda A; Kim, Robert S; Knight, Patrick B; Baik, Rusty A; Anthony, Sarah R; Worrell, Roger T; Shull, Gary E; Mackenzie, Bryan 2016. Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse. American journal of physiology. Gastrointestinal and liver physiology, 311 3, G423-30

Engevik, Melinda A; Engevik, Kristen A; Yacyshyn, Mary Beth; Wang, Jiang; Hassett, Daniel J; Darien, Benjamin; Yacyshyn, Bruce R; Worrell, Roger T 2015. Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile. American journal of physiology. Gastrointestinal and liver physiology, 308 6, G497-509

Engevik, Melinda A; Yacyshyn, Mary Beth; Engevik, Kristen A; Wang, Jiang; Darien, Benjamin; Hassett, Daniel J; Yacyshyn, Bruce R; Worrell, Roger T 2015. Human Clostridium difficile infection: altered mucus production and composition. American journal of physiology. Gastrointestinal and liver physiology, 308 6, G510-24

Schumacher, Michael A; Aihara, Eitaro; Feng, Rui; Engevik, Amy; Shroyer, Noah F; Ottemann, Karen M; Worrell, Roger T; Montrose, Marshall H; Shivdasani, Ramesh A; Zavros, Yana 2015. The use of murine-derived fundic organoids in studies of gastric physiology. The Journal of physiology, 593 8, 1809-27

Shawki, Ali; Anthony, Sarah R; Nose, Yasuhiro; Engevik, Melinda A; Niespodzany, Eric J; Barrientos, Tomasa; Öhrvik, Helena; Worrell, Roger T; Thiele, Dennis J; Mackenzie, Bryan 2015. Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. American journal of physiology. Gastrointestinal and liver physiology, 309 8, G635-47

Donnelly, Jessica M; Engevik, Amy C; Engevik, Melinda; Schumacher, Michael A; Xiao, Chang; Yang, Li; Worrell, Roger T; Zavros, Yana 2014. Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell. Digestive diseases and sciences, 59 3, 569-82

Engevik, Melinda A; Aihara, Eitaro; Montrose, Marshall H; Shull, Gary E; Hassett, Daniel J; Worrell, Roger T 2013. Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth. American journal of physiology. Gastrointestinal and liver physiology, 305 10, G697-711

Engevik, Melinda A; Faletti, Carla J; Paulmichl, Markus; Worrell, Roger T 2013. Prebiotic properties of galursan HF 7K on mouse gut microbiota. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 32 7, 96-110

Engevik, Melinda A; Hickerson, Annelies; Shull, Gary E; Worrell, Roger T 2013. Acidic conditions in the NHE2(-/-) mouse intestine result in an altered mucosa-associated bacterial population with changes in mucus oligosaccharides. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 32 7, 111-28

Mykoniatis, Andreas; Shen, Le; Fedor-Chaiken, Mary; Tang, Jun; Tang, Xu; Worrell, Roger T; Delpire, Eric; Turner, Jerrold R; Matlin, Karl S; Bouyer, Patrice; Matthews, Jeffrey B 2010. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. American journal of physiology. Cell physiology, 298 1, C85-97

Guan, Yanfang; Worrell, Roger T; Pritts, Timothy A; Montrose, Marshall H 2009. Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo. American journal of physiology. Gastrointestinal and liver physiology, 297 1, G187-96

Worrell, Roger T; Merk, Lisa; Matthews, Jeffrey B 2008. Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1. American journal of physiology. Gastrointestinal and liver physiology, 294 2, G429-40

Ishiguro, Hiroshi; Namkung, Wan; Yamamoto, Akiko; Wang, Zhaohui; Worrell, Roger T; Xu, Jie; Lee, Min Goo; Soleimani, Manoocher 2007. Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct. American journal of physiology. Gastrointestinal and liver physiology, 292 1, G447-55

Schweinfest, Clifford W; Spyropoulos, Demetri D; Henderson, Kelly W; Kim, Jae-Ho; Chapman, Jeannie M; Barone, Sharon; Worrell, Roger T; Wang, Zhaohui; Soleimani, Manoocher 2006. slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. The Journal of biological chemistry, 281 49, 37962-71

Xu, Jie; Worrell, Roger T; Li, Hong C; Barone, Sharon L; Petrovic, Snezana; Amlal, Hassane; Soleimani, Manoocher 2006. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. Journal of the American Society of Nephrology : JASN, 17 4, 956-67

Li, Hong C; Szigligeti, Peter; Worrell, Roger T; Matthews, Jeffrey B; Conforti, Laura; Soleimani, Manoocher 2005. Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis. American journal of physiology. Renal physiology, 289 1, F61-71

Mammen, Joshua M V; Song, J Cecilia; Yoo, James; Kim, Peter S; Davis, Harold W; Calvo, M Isabel; Worrell, Roger T; Matlin, Karl S; Matthews, Jeffrey B 2005. Differential subcellular targeting of PKC-epsilon in response to pharmacological or ischemic stimuli in intestinal epithelia. American journal of physiology. Gastrointestinal and liver physiology, 288 1, G135-42

Worrell, Roger T; Best, Alison; Crawford, Oscar R; Xu, Jie; Soleimani, Manoocher; Matthews, Jeffrey B 2005. Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent. American journal of physiology. Gastrointestinal and liver physiology, 289 4, G768-78

Li, Hong C; Worrell, Roger T; Matthews, Jeffrey B; Husseinzadeh, Holleh; Neumeier, Lisa; Petrovic, Snezana; Conforti, Laura; Soleimani, Manoocher 2004. Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane. The Journal of biological chemistry, 279 41, 43190-7

Tong, Qiusheng; Booth, Rachell E; Worrell, Roger T; Stockand, James D 2004. Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades. American journal of physiology. Renal physiology, 286 6, F1232-8

Worrell, Roger T; Matthews, Jeffrey B 2004. Effects of ammonium on ion channels and transporters in colonic secretory cells. Advances in experimental medicine and biology, 559 , 131-9

Worrell, Roger T; Oghene, Jennifer; Matthews, Jeffrey B 2004. Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior. American journal of physiology. Gastrointestinal and liver physiology, 286 1, G14-22

Yoo, James; Nichols, Anthony; Mammen, Joshua; Calvo, Isabel; Song, Jaekyung C; Worrell, Roger T; Matlin, Karl; Matthews, Jeffrey B 2003. Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins. American journal of physiology. Cell physiology, 285 2, C300-9

Yoo, James; Nichols, Anthony; Song, Jaekyung C; Mammen, Joshua; Calvo, Isabel; Worrell, Roger T; Cuppoletti, John; Matlin, Karl; Matthews, Jeffrey B 2003. Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes. American journal of physiology. Gastrointestinal and liver physiology, 284 4, G703-12

Fink, Aaron S; Wang, Yuanhong; Mendez, Tatiana; Worrell, Roger T; Eaton, Douglas; Nguyen, Toan D; Lee, Sum P 2002. Angiotensin II evokes calcium-mediated signaling events in isolated dog pancreatic epithelial cells. Pancreas, 25 3, 290-5

Denson, D D; Wang, X; Worrell, R T; AlKhalili, O; Eaton, D C 2001. Cytosolic phospholipase A2 is required for optimal ATP activation of BK channels in GH(3) cells. The Journal of biological chemistry, 276 10, 7136-42

Stockand, J D; Zeltwanger, S; Bao, H F; Becchetti, A; Worrell, R T; Eaton, D C 2001. S-adenosyl-L-homocysteine hydrolase is necessary for aldosterone-induced activity of epithelial Na(+) channels. American journal of physiology. Cell physiology, 281 3, C773-85

Worrell, R T; Bao, H F; Denson, D D; Eaton, D C 2001. Contrasting effects of cPLA2 on epithelial Na+ transport. American journal of physiology. Cell physiology, 281 1, C147-56

Denson, D D; Wang, X; Worrell, R T; Eaton, D C 2000. Effects of fatty acids on BK channels in GH(3) cells. American journal of physiology. Cell physiology, 279 4, C1211-9

Denson, D D; Worrell, R T; Middleton, P; Eaton, D C 1999. Ca2+ sensitivity of BK channels in GH3 cells involves cytosolic phospholipase A2. The American journal of physiology, 276 1 Pt 1, C201-9

Stockand, J D; Al-Baldawi, N F; Al-Khalili, O K; Worrell, R T; Eaton, D C 1999. S-adenosyl-L-homocysteine hydrolase regulates aldosterone-induced Na+ transport. The Journal of biological chemistry, 274 6, 3842-50

Stockand, J D; Spier, B J; Worrell, R T; Yue, G; Al-Baldawi, N; Eaton, D C 1999. Regulation of Na(+) reabsorption by the aldosterone-induced small G protein K-Ras2A. The Journal of biological chemistry, 274 50, 35449-54

Ling, B N; Zuckerman, J B; Lin, C; Harte, B J; McNulty, K A; Smith, P R; Gomez, L M; Worrell, R T; Eaton, D C; Kleyman, T R 1997. Expression of the cystic fibrosis phenotype in a renal amphibian epithelial cell line. The Journal of biological chemistry, 272 1, 594-600

Denson, D D; Worrell, R T; Eaton, D C 1996. A possible role for phospholipase A2 in the action of general anesthetics. The American journal of physiology, 270 2 Pt 1, C636-44

Cunningham, S A; Worrell, R T; Benos, D J; Frizzell, R A 1992. cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA. The American journal of physiology, 262 3 Pt 1, C783-8

Cliff, W H; Worrell, R T; Morris, A P; Frizzell, R A 1991. Conductance pathways involved in chloride secretion and their regulation. Advances in experimental medicine and biology, 290 , 197-206; discussion

Drumm, M L; Wilkinson, D J; Smit, L S; Worrell, R T; Strong, T V; Frizzell, R A; Dawson, D C; Collins, F S 1991. Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes. Science (New York, N.Y.), 254 5039, 1797-9

Shoemaker, R L; Worrell, R T 1991. Ca2(+)-sensitive K+ channel in aortic smooth muscle of rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 196 3, 325-32

Worrell, R T; Frizzell, R A 1991. CaMKII mediates stimulation of chloride conductance by calcium in T84 cells. The American journal of physiology, 260 4 Pt 1, C877-82

Bridges, R J; Worrell, R T; Frizzell, R A; Benos, D J 1989. Stilbene disulfonate blockade of colonic secretory Cl- channels in planar lipid bilayers. The American journal of physiology, 256 4 Pt 1, C902-12

Worrell, R T; Butt, A G; Cliff, W H; Frizzell, R A 1989. A volume-sensitive chloride conductance in human colonic cell line T84. The American journal of physiology, 256 6 Pt 1, C1111-9