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Department of

Pharmacology & Systems Physiology 

Photo of  Hong-Sheng Wang, PhD

Hong-Sheng Wang, PhD

Associate Professor

Education/Credentials
  • BS: University of Science and Technology of China
  • PhD: State University of New York

Research/Clinical Interests

Cardiovascular, Heart, Endocrine Disruptor, Environmental Health, Arrhythmias, Electrophysiology, Calcium Handling, Mechanism

Contact Information
  • Medical Sciences Building
  • Room 5151
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0575
  • Office 513-558-2379
  • Email wanghs@ucmail.uc.edu

Peer Reviewed Publications

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Koneva, L A; Vyas, A K; McEachin, R C; Puttabyatappa, M; Wang, H-S; Sartor, M A; Padmanabhan, V 2017. Developmental programming: Interaction between prenatal BPA and postnatal overfeeding on cardiac tissue gene expression in female sheep. Environmental and molecular mutagenesis, 58 1, 4-18

Ma, Jianyong; Hong, Kui; Wang, Hong-Sheng 2017. Progesterone Protects Against Bisphenol A-Induced Arrhythmias in Female Rat Cardiac Myocytes via Rapid Signaling. Endocrinology, 158 4, 778-790

Vairamani, Kanimozhi; Wang, Hong-Sheng; Medvedovic, Mario; Lorenz, John N; Shull, Gary E 2017. RNA SEQ Analysis Indicates that the AE3 Cl(-)/HCO3(-) Exchanger Contributes to Active Transport-Mediated CO2 Disposal in Heart. Scientific reports, 7 1, 7264

Gao, Xiaoqian; Ma, Jianyong; Chen, Yamei; Wang, Hong-Sheng 2015. Rapid Responses and Mechanism of Action for Low-Dose Bisphenol S on ex Vivo Rat Hearts and Isolated Myocytes: Evidence of Female-Specific Proarrhythmic Effects. Environmental health perspectives, ,

Haghighi, Kobra; Pritchard, Tracy J; Liu, Guan-Sheng; Singh, Vivek P; Bidwell, Philip; Lam, Chi Keung; Vafiadaki, Elizabeth; Das, Parthib; Ma, Jianyong; Kunduri, Swati; Sanoudou, Despina; Florea, Stela; Vanderbilt, Erica; Wang, Hong-Shang; Rubinstein, Jack; Hajjar, Roger J; Kranias, Evangelia G 2015. Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias. Journal of molecular and cellular cardiology, 89 Pt B, 349-59

Xiong, Qinmei; Liu, Xiao; Shen, Yang; Yu, Peng; Chen, Sisi; Hu, Jinzhu; Yu, Jianhua; Li, Juxiang; Wang, Hong-Sheng; Cheng, Xiaoshu; Hong, Kui 2015. Elevated serum Bisphenol A level in patients with dilated cardiomyopathy. International journal of environmental research and public health, 12 5, 5329-37

Gao, Xiaoqian; Wang, Hong-Sheng 2014. Impact of bisphenol a on the cardiovascular system - epidemiological and experimental evidence and molecular mechanisms. International journal of environmental research and public health, 11 8, 8399-413

Liang, Qian; Gao, Xiaoqian; Chen, Yamei; Hong, Kui; Wang, Hong-Sheng 2014. Cellular Mechanism of the Nonmonotonic Dose Response of Bisphenol A in Rat Cardiac Myocytes. Environmental health perspectives, ,

Wang, Hong-Sheng; Chen, Yamei; Vairamani, Kanimozhi; Shull, Gary E 2014. Critical role of bicarbonate and bicarbonate transporters in cardiac function. World journal of biological chemistry, 5 3, 334-45

Gao, Xiaoqian; Liang, Qian; Chen, Yamei; Wang, Hong-Sheng 2013. Molecular mechanisms underlying the rapid arrhythmogenic action of bisphenol A in female rat hearts. Endocrinology, 154 12, 4607-17

Singh, Vivek P; Rubinstein, Jack; Arvanitis, Demetrios A; Ren, Xiaoping; Gao, Xiaoqian; Haghighi, Kobra; Gilbert, Mark; Iyer, Venkat R; Kim, Do Han; Cho, Chunghee; Jones, Keith; Lorenz, John N; Armstrong, Clara F; Wang, Hong-Sheng; Gyorke, Sandor; Kranias, Evangelia G 2013. Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. Journal of the American Heart Association, 2 5, e000460

Belcher, Scott M; Chen, Yamei; Yan, Sujuan; Wang, Hong-Sheng 2012. Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17?-estradiol and the environmental endocrine disruptor bisphenol A. Endocrinology, 153 2, 712-20

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack 2012. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 1, 134-44

Dong, Min; Niklewski, Paul J; Wang, Hong-Sheng 2011. Ionic mechanisms of cellular electrical and mechanical abnormalities in Brugada syndrome. American journal of physiology. Heart and circulatory physiology, 300 1, H279-87

Qian, Jiang; Vafiadaki, Elizabeth; Florea, Stela M; Singh, Vivek P; Song, Weizhong; Lam, Chi Kung; Wang, Yigang; Yuan, Qunying; Pritchard, Tracy J; Cai, Wenfeng; Haghighi, Kobra; Rodriguez, Patricia; Wang, Hong-Sheng; Sanoudou, Despina; Fan, Guo-Chang; Kranias, Evangelia G 2011. Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circulation research, 108 12, 1429-38

Wang, Hong-Sheng; Arvanitis, Demetrios A; Dong, Min; Niklewski, Paul J; Zhao, Wen; Lam, Chi Keung; Kranias, Evangelia G; Sanoudou, Despina 2011. SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts. Physiological genomics, 43 7, 357-64

Yan, Sujuan; Chen, Yamei; Dong, Min; Song, Weizhong; Belcher, Scott M; Wang, Hong-Sheng 2011. Bisphenol A and 17?-estradiol promote arrhythmia in the female heart via alteration of calcium handling. PloS one, 6 9, e25455

Dong, Min; Yan, Sujuan; Chen, Yamei; Niklewski, Paul J; Sun, Xiaoyin; Chenault, Kathryn; Wang, Hong-Sheng 2010. Role of the transient outward current in regulating mechanical properties of canine ventricular myocytes. Journal of cardiovascular electrophysiology, 21 6, 697-703

Yuan, Qunying; Han, Peidong; Dong, Min; Ren, Xiaoping; Zhou, Xiaoyang; Chen, Shan; Jones, W Keith; Chu, Guoxiang; Wang, Hong-Sheng; Kranias, Evangelia G 2009. Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice. American journal of physiology. Heart and circulatory physiology, 296 5, H1484-90

Rosati B, Dong M, Cheng L, Liou S-R, Yan Q, Park JY, Shiang E, Sanguinetti M, Wang H-S & McKinnon D 2008. Evolution of ventricular myocyte electrophysiology Physiological Genomics, ,

Yuan QY, Fan GC, Dong M, Altschafl B, Diwan A, Ren XP, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW, Wang H-S, Valdivia HH, Chu GX & Kranias EG 2007. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity Circulation, 115 , 300-309

Yuan, Qunying; Fan, Guo-Chang; Dong, Min; Altschafl, Beth; Diwan, Abhinav; Ren, Xiaoping; Hahn, Harvey H; Zhao, Wen; Waggoner, Jason R; Jones, Larry R; Jones, W Keith; Bers, Donald M; Dorn, Gerald W; Wang, Hong-Sheng; Valdivia, Héctor H; Chu, Guoxiang; Kranias, Evangelia G 2007. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation, 115 3, 300-9

Dong M, Sun X, Prinz AA & Wang H-S 2006. Effect of simulated Ito on guinea pig and canine ventricular action potential morphology Am J Physiol Heart Circ Physiol, 291 , H631-H637

Dong, Min; Sun, Xiaoyin; Prinz, Astrid A; Wang, Hong-Sheng 2006. Effect of simulated I(to) on guinea pig and canine ventricular action potential morphology. American journal of physiology. Heart and circulatory physiology, 291 2, H631-7

Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, Wang H-S, Schultz JJ, Molkentin JD, Liggett SB, Dorn GW 2nd, Kranias EG 2006. Presence of Lys27 Instead of Asn27 in Human Phospholamban Promotes Sarcoplasmic Reticulum Ca2_-ATPase Superinhibition and Cardiac Remodeling Circulation, 113 , 995-1004

Zhao, Wen; Yuan, Qunying; Qian, Jiang; Waggoner, Jason R; Pathak, Anand; Chu, Guoxiang; Mitton, Bryan; Sun, Xiaoyin; Jin, Jay; Braz, Julian C; Hahn, Harvey S; Marreez, Yehia; Syed, Faisal; Pollesello, Piero; Annila, Arto; Wang, Hong-Sheng; Schultz, Jo El J; Molkentin, Jeffery D; Liggett, Stephen B; Dorn, Gerald W; Kranias, Evangelia G 2006. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation, 113 7, 995-1004

Sun X & Wang H-S 2005. Role of the transient outward current (Ito) in shaping canine ventricular action potential – a dynamic clamp study J Physiol, 564 , 411-419

Sun, Xiaoyin; Wang, Hong-Sheng 2005. Role of the transient outward current (Ito) in shaping canine ventricular action potential--a dynamic clamp study. The Journal of physiology, 564 Pt 2, 411-9

Zsarnovszky A, Le HH, Wang H-S, Belcher SM 2005. Ontogeny of rapid estrogen-mediated ERK1/2 signaling in the rat cerebellar cortex in vivo: potent non-genomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A Endocrinology, 146 , 5388-5396

Zsarnovszky, Attila; Le, Hoa H; Wang, Hong-Sheng; Belcher, Scott M 2005. Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the xenoestrogen bisphenol A. Endocrinology, 146 12, 5388-96

Wang H-S* & Cohen IS 2003. Calcium channel heterogeneity in canine left ventricular myocytes J Physiol, 547 , 825-833

Wang, Hong-Sheng; Cohen, Ira S 2003. Calcium channel heterogeneity in canine left ventricular myocytes. The Journal of physiology, 547 Pt 3, 825-33

Rosati B, Pan Z, Lypen S, Wang H-S, Cohen I, Dixon JE, McKinnon D 2001. Regulation of KChIP2 potassium channel  subunit gene expression underlies the gradient of transient outward current in canine and human ventricle J Physiol, 533 , 119-125

Yu H, Wu J, Potapova I, Wymore RT, Holmes B, Zuckerman J, Pan Z, Wang H-S, Shi W, Robinson RB, El-Maghrabi MR, Benjamin W, Dixon J, McKinnon D, Cohen IS, Wymore R 2001. MinK-related peptide 1: A  subunit for the HCN ion channel subunit family enhances expression and speeds activation Circ Res, 88 , e84-e87

Wang H-S*, Brown BS, McKinnon D, Cohen IS 2000. Molecular basis for differential sensitivity of KCNQ and IKs channels to the cognitive enhancer XE991 Mol Pharmacol, 57 , 1218-1223

Yu H, Gao J, Wang H-S, Wymore R, Steinberg S, Rosen MR, Cohen IS 2000. Effects of the renin-angiotensin system on the current Ito in epicardial and endocardial ventricular myocytes from the canine heart Circ Res, 86 , 1026-1068

Shi W, Wang H-S, Pan Z, Wymore RS, Cohen IS, McKinnon D, Dixon JE 1998. Cloning of a mammalian Elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia J Physiol, 511 , 675-682

Wang H-S, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D 1998. The KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel Science, 282 , 1890-1893

Shi W, Wymore RS, Wang H-S, Pan Z, Cohen IS, McKinnon D, Dixon JE 1997. Identification of two nervous system specific members of the erg potassium channel gene family J Neurosci, 17 , 9423-9432

Wang H-S, Dixon JE, McKinnon D 1997. Unexpected and differential effects of Cl- channel blockers on the Kv4.3 and Kv4.2 K+ channels: implications for the study of the Ito2 current Circ Res, 81 , 711-718

Davis BM, Wang H-S, Albers KM, Carlson SL, Goodness TP, McKinnon D 1996. Effects of NGF overexpression on anatomical and physiological properties of sympathetic postganglionic neurons Brain Res, 724 , 47-54

Dixon JE, Shi W, Wang H-S, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D 1996. Role of the Kv4.3 K+ channel in ventricular muscle: a molecular correlate for the transient outward current Circ Res, 79 , 659-668

Wang H-S 1996. Analysis of Potassium Channel Function Doctoral dissertation, SUNY at Stony Brook, Department of Neurobiology and Behavior, ,

Wang H-S & McKinnon D 1996. Modulation of inwardly rectifying currents in rat sympathetic neurons by muscarinic receptors J Physiol, 492 , 467-478

Wang H-S & McKinnon D 1995. Potassium currents in rat prevertebral and paravertebral sympathetic neurons: control of firing properties J Physiol, 485 , 319-335

Published Abstracts

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Dong M & Wang H-S 2006. Possible ionic mechanism of contractile dysfunction in Brugada syndrome Circulation, 114 18, 1699


Dong M, Sun X, Printz AA, Wang H-S 2006. Effect of simulated Ito on guinea pig and canine ventricular action potential morphology Biophysic J, 90 , 1980-pos


Dong M, Sun X, Wang H-S 2005. Role of the transient outward current in regulating ventricular action potential and contractility: a dynamic clamp study Circ Res, 97 , e13


Sun X & Wang H-S 2005. Role of Ito in shaping ventricular action potential – A dynamic clamp study Biophysic J, 88 , 2222-pos


Yuan QY, Altschafl B, Dong M, Fan GC, Jones LR, Wang H-S, Valdivia HH, Chu GX, Kranias EG 2005. Junctin deficiency is associated with arrhythmias in Junctin knockout mice Circulation, 112 , U268-U268


Pan Z, Wang H-S, Cohen IS 2004. Possible mechanism underlying transmural electrical heterogeneity in canine ventricle Biophysic J, 86 , 298a


Wang H-S 2004. Ionic and molecular basis of transmural electrical heterogeneity American Heart Association Symposium, New Orleans, LA, ,


Wang H-S & Cohen IS 2003. Heterogeneity in calcium channel properties in canine ventricular myocytes Biophysic J, 84 , 426a


B, Lypen S, Pan ZM, Wang H-S, Cohen IS, Dixon JE, McKinnon D 2001. Contribution of the KChIP2 accessory subunit to native Ito K+ channels in canine heart Biophysical J, 80 1, 638A


Wang H-S, Brown BS, McKinnon D, Cohen IS 2000. Molecular basis for differential sensitivity of KCNQ1 and IKs-channels to the cognitive enhancer XE991 Biophysical J, 78 1, 1200 pos


Wang H-S, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D 1999. The KQT2 and KQT3 potassium channel subunits: Molecular correlates of the M-channel Biophysical J, 76 , A330


Wang H-S, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D 1998. The KQT2 and KQT3 potassium channel subunits: Molecular correlates of the M-channel Soc Neurosci Abstr, 24 ,


Yu H, Wang H-S, Wymore R, et al 1998. Effects of chronic exposure to angiotensin on Ito and Kv4.3 Biophysical J, 74 2, A158


Shi W, Wymore RS, Pan Z, Wang H-S, Cohen IS, McKinnon D, Dixon JE 1997. Identification of two nervous system specific members of the ERG potassium channel gene family Soc Neurosci Abstr, 23 , 126.5


Wang H-S, Dixon JE, McKinnon D 1997. Unexpected and differential effects of Cl- channel blockers on the Kv4.3 and Kv4.2 K+ channels - Implications for the study of the Ito2 current Circulation, 96 , 2375


Wang H-S, Shi W, Wymore RS, Pan Z, Cohen IS, Dixon JE, McKinnon D 1997. Electrophysiological analysis of two ERG-related channels, ERG2 and ERG3 Soc Neurosci Abstr, 23 , 476.2


Yu H, Rosen MR, Danilo P, Steinberg S, Wymore RS, Wang H-S, McKinnon D, Cohen IS 1997. Angiotensin II alters Ito properties in cardiac myocytes Circulation, 96 , 1641


Dixon JE, Shi W, Wang H-S, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D 1996. Cloning and characterization of the Kv4.3 channel: a candidate for the transient outward current in dog and human heart Circulation, 95 , 0029


Wang H-S, Dixon JE, McKinnon D 1996. Muscarinic modulation of inward rectifier current Biophys J, 70 , Tu-PM-A2


Caton IB, McKinnon D, Wang H-S, Goodness TP, Davis FE, Alberts KM, Davis BM 1995. Overexpression of NGF in skin of transgenic mice increases trkA and p75 expression and size and number of sympathetic neurons Soc Neurosci Abstr, 21 , 606.6


Wang H-S, Dixon JE, McKinnon D 1995. Muscarinic modulation of inward rectifier current in rat sympathetic neurons Soc Neurosci Abstr, 21 , 524.13


Wang H-S and McKinnon D 1994. Potassium currents in prevertebral and paravertebral sympathetic neurons Soc Neurosci Abstr, 20 , 626.9