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Department of

Pharmacology & Systems Physiology 

Photo of Janusz Suszkiw

Janusz Suszkiw

Professor Emeritus

Education/Credentials
  • BS: George Washington Univ.
  • MS: George Washington Univ
  • PhD: George Washington Univ.

Contact Information

Peer Reviewed Publications

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Jankowska-Kulawy, Agnieszka; Gul-Hinc, Sylwia; Bielarczyk, Hanna; Suszkiw, Janusz B; Pawelczyk, Tadeusz; Dys, Aleksandra; Szutowicz, Andrzej 2008. Effects of lead on cholinergic SN56 neuroblastoma cells Acta neurobiologiae experimentalis, 68 4, 453-62

Suszkiw, Janusz B 2004. Presynaptic disruption of transmitter release by lead Neurotoxicology, 25 4, 599-604

Zhou, Mingfu; Suszkiw, Janusz B 2004. Nicotine attenuates spatial learning deficits induced in the rat by perinatal lead exposure Brain research, 999 1, 142-7

Tian, X; Sun, X; Suszkiw, J B 2000. Upregulation of tyrosine hydroxylase and downregulation of choline acetyltransferase in lead-exposed PC12 cells: the role of PKC activation Toxicology and applied pharmacology, 167 3, 246-52

Zhou, M; Tian, X; Suszkiw, J B 2000. Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum Brain research, 866 1-2, 268-73

Sun, X; Tian, X; Tomsig, J L; Suszkiw, J B 1999. Analysis of differential effects of Pb2+ on protein kinase C isozymes Toxicology and applied pharmacology, 156 1, 40-5

Narahashi, T; Treistman, S N; Suszkiw, J B; Miletic, V; Atchison, W D 1998. Symposium overview: chemical modulation of neuroreceptors and channels via intracellular components. Toxicological sciences : an official journal of the Society of Toxicology, 45 1, 9-25

Bourjeily, N; Suszkiw, J B 1997. Developmental cholinotoxicity of lead: loss of septal cholinergic neurons and long-term changes in cholinergic innervation of the hippocampus in perinatally lead-exposed rats. Brain research, 771 2, 319-28

Sun, X; Tian, X; Suszkiw, J B 1997. Reduction of vesicular acetylcholine transporter mRNA in the rat septum following lead exposure Neuroreport, 8 4, 891-4

Sun, X; Tian, X; Suszkiw, J B 1997. Reduction of choline acetyltransferase mRNA in the septum of developing rat exposed to inorganic lead Neurotoxicology, 18 1, 201-7

Bielarczyk, H; Tian, X; Suszkiw, J B 1996. Cholinergic denervation-like changes in rat hippocampus following developmental lead exposure Brain research, 708 1-2, 108-15

Tian, X; Sun, X; Suszkiw, J B 1996. Developmental age-dependent upregulation of choline acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor Neuroscience letters, 209 2, 134-6

Tomsig, J L; Suszkiw, J B 1996. Metal selectivity of exocytosis in alpha-toxin-permeabilized bovine chromaffin cells Journal of Neurochemistry, 66 2, 644-50

Sun, L R; Suszkiw, J B 1995. Extracellular inhibition and intracellular enhancement of Ca2+ currents by Pb2+ in bovine adrenal chromaffin cells. Journal of neurophysiology, 74 2, 574-81

Tian, X; Bourjeily, N; Bielarczyk, H; Suszkiw, J B 1995. Reduced densities of sodium-dependent [3H] hemicholinium-3 binding sites in hippocampus of developmental rats following perinatal low-level lead exposure. Brain research. Developmental brain research, 86 1-2, 268-74

Tomsig, J L; Suszkiw, J B 1995. Multisite interactions between Pb2+ and protein kinase C and its role in norepinephrine release from bovine adrenal chromaffin cells. Journal of neurochemistry, 64 6, 2667-73

Bielarczyk, H; Tomsig, J L; Suszkiw, J B 1994. Perinatal low-level lead exposure and the septo-hippocampal cholinergic system: selective reduction of muscarinic receptors and cholineacetyltransferase in the rat septum. Brain research, 643 1-2, 211-7

Sun, L R; Suszkiw, J B 1994. Pb2+ activates potassium currents in bovine adrenal chromaffin cells. Neuroscience letters, 182 1, 41-3

Tomsig, J L; Suszkiw, J B 1993. Intracellular mechanism of Pb(2+)-induced norepinephrine release from bovine chromaffin cells. The American journal of physiology, 265 6 Pt 1, C1630-6

Suszkiw, J B; Schaffner, A E; Barker, J L 1992. Electrophysiological properties of early postnatal rat septal neurons in short-term culture. Brain research, 588 2, 246-54

Shao, Z; Suszkiw, J B 1991. Ca2(+)-surrogate action of Pb2+ on acetylcholine release from rat brain synaptosomes. Journal of neurochemistry, 56 2, 568-74

Tomsig, J L; Suszkiw, J B 1991. Permeation of Pb2+ through calcium channels: fura-2 measurements of voltage- and dihydropyridine-sensitive Pb2+ entry in isolated bovine chromaffin cells. Biochimica et biophysica acta, 1069 2, 197-200

Lomneth, R; Suszkiw, J B; DasGupta, B R 1990. Response of the chick ciliary ganglion-iris neuromuscular preparation to botulinum neurotoxin. Neuroscience letters, 113 2, 211-6

Tomsig, J L; Suszkiw, J B 1990. Pb2(+)-induced secretion from bovine chromaffin cells: fura-2 as a probe for Pb2+. The American journal of physiology, 259 5 Pt 1, C762-8

Suszkiw, J B; Murawsky, M M; Shi, M 1989. Further characterization of phasic calcium influx in rat cerebrocortical synaptosomes: inferences regarding calcium channel type(s) in nerve endings. Journal of neurochemistry, 52 4, 1260-9

Suszkiw, J B; Murawsky, M M; Fortner, R C 1987. Heterogeneity of presynaptic calcium channels revealed by species differences in the sensitivity of synaptosomal 45Ca entry to omega-conotoxin. Biochemical and biophysical research communications, 145 3, 1283-6

Toth, G P; Cooper, G P; Suszkiw, J B 1987. Effects of divalent cations on acetylcholine release from digitonin-permeabilized rat cortical synaptosomes. Neurotoxicology, 8 4, 507-16

Suszkiw, J B; O'Leary, M E; Murawsky, M M; Wang, T 1986. Presynaptic calcium channels in rat cortical synaptosomes: fast-kinetics of phasic calcium influx, channel inactivation, and relationship to nitrendipine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 6 5, 1349-57

Suszkiw, J B; Toth, G 1986. Storage and release of acetylcholine in rat cortical synaptosomes: effects of D,L-2-(4-phenylpiperidino)cyclohexanol (AH5183). Brain research, 386 1-2, 371-8

Cooper, G P; Suszkiw, J B; Manalis, R S 1984. Heavy metals: effects on synaptic transmission. Neurotoxicology, 5 3, 247-66

O'Leary, M E; Suszkiw, J B 1983. Effect of colchicine on 45Ca and choline uptake, and acetylcholine release in rat brain synaptosomes. Journal of neurochemistry, 40 4, 1192-5

Suszkiw, J B; O'Leary, M E 1983. Temporal characteristics of potassium-stimulated acetylcholine release and inactivation of calcium influx in rat brain synaptosomes. Journal of neurochemistry, 41 3, 868-73

Suszkiw, J B; O'Leary, M E 1982. Differential labeling of depot and active acetylcholine pools in nondepolarized and potassium-depolarized rat brain synaptosomes. Journal of neurochemistry, 38 6, 1668-75

Suszkiw, J B 1980. Kinetics of acetylcholine recovery in Torpedo electromotor synapses depleted of synaptic vesicles. Neuroscience, 5 7, 1341-9

Tuttle, J B; Suszkiw, J B; Ard, M 1980. Long-term survival and development of dissociated parasympathetic neurons in culture. Brain research, 183 1, 161-80

Suszkiw, J B; Whittaker, V P 1979. Role of vesicle recycling in vesicular storage and release of acetylcholine in Torpedo electroplaque synapses. Progress in brain research, 49 , 153-62

Suszkiw, J B; Zimmermann, H; Whittaker, V P 1978. Vesicular storage and release of acetylcholine in Torpedo electroplaque synapses. Journal of neurochemistry, 30 6, 1269-80

Suszkiw, J B 1976. Acetylcholine translocation in synaptic vesicle ghosts in vitro. Journal of neurochemistry, 27 4, 853-7

Suszkiw, J B; Beach, R L; Pilar, G R 1976. Choline uptake by cholinergic neuron cell somas. Journal of neurochemistry, 26 6, 1123-31

Suszkiw, J B; Ichiki, M 1976. Fluorescein conjugated alpha-bungarotoxin: its properties and interaction with acetylcholine receptors. Analytical biochemistry, 73 1, 109-14

Suszkiw, J B; Pilar, G 1976. Selective localization of a high affinity choline uptake system and its role in ACh formation in cholinergic nerve terminals. Journal of neurochemistry, 26 6, 1133-8

Suszkiw, J B 1973. Concerning the rate limiting step in the hydrolysis of substituted phenyl acetates by acetylcholinesterase. Biochemical and biophysical research communications, 54 1, 417-25

Suszkiw, J B 1973. Quantitation of acetylcholinesterase and acetylcholine-binding sites in excitable membrane fragments from electric eel. Biochimica et biophysica acta, 318 1, 69-77

Suszkiw, J B 1973. Interaction of selected cholinergic effector molecules with acetylcholinesterase in physiological eel Ringer's solution. Molecular pharmacology, 9 4, 561-70

Suszkiw, J B 1971. Determination of normality of acetylcholinesterase. Analytical biochemistry, 44 1, 321-4

Suszkiw, J B; Brecher, A S 1971. A kinetic approach to the residues involved in brain aminoacyl arylamidase activity. Archives internationales de physiologie et de biochimie, 79 5, 967-79

Oliphant, B B; Suszkiw, J B; Brecher, A S 1970. The distribution of a particulate trypsin inhibitor in brain. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 135 3, 754-6

Suszkiw, J B; Brecher, A S 1970. Brain aminoacyl arylamidase. Further purification of the soluble bovine enzyme and studies on substrate specificity and possible active-site residues. Biochemistry, 9 20, 4008-17

Brecher, A S; Pugatch, R D; König, M; Wasilauskas, V P; Suszkiw, J B; Sobel, R E 1969. The hydrolytic activity in normal human and malignant tissue. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 131 3, 828-31

Brecher, A S; Suszkiw, J B 1969. Brain arylamidase. Purfication and characterization of the soluble bovine enzyme. The Biochemical journal, 112 3, 335-42

Healy, J K; Suszkiw, J B; Dennis, V W; Schreiner, G E 1966. Effect of aldosterone and salt intake on renal and pressor actions of angiotensin. Nephron, 3 6, 329-43

HEALY, J K; SUSZKIW, J B; SCHREINER, G E 1965. EFFECT OF ANGIOTENSIN 11 ON BLOOD GLUCOSE LEVEL IN THE DOG. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 119 , 734-6