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Department of

Pharmacology & Systems Physiology 

Photo of  Renu Sah, PhD

Renu Sah, PhD

Associate Professor of Department of Pharmacology & Systems Physiology

Education/Credentials
  • Doctoral Degree: Lucknow University
  • Post-Doctoral Training: University of Wisconsin and Duke University

Research/Clinical Interests

The focus of my research program is to understand mechanisms underlying fear and anxiety behaviors and how they manifest into disorders such as Panic Disorder (PD) and Posttraumatic Stress disorder (PTSD).

Contact Information
  • Reading Campus
  • 2120 East Galbraith Road
  • A-133
  • Cincinnati, Ohio 45237
  • Office 513-558-5129
  • Fax 513-297-0966
  • Email renu.sah@uc.edu

Peer Reviewed Publications

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McMurray, Katherine M J; Strawn, Jeffrey R; Sah, Renu 2019. Fluoxetine Modulates Spontaneous and Conditioned Behaviors to Carbon Dioxide (CO2) Inhalation and Alters Forebrain-Midbrain Neuronal Activation. Neuroscience, 396 , 108-118

Schubert, Inga; Ahlbrand, Rebecca; Winter, Andrew; Vollmer, Lauren; Lewkowich, Ian; Sah, Renu 2018. Enhanced fear and altered neuronal activation in forebrain limbic regions of CX3CR1-deficient mice. Brain, behavior, and immunity, 68 , 34-43

Strawn, Jeffrey R; Vollmer, Lauren L; McMurray, Katherine M J; Mills, Jeffrey A; Mossman, Sarah A; Varney, Sara T; Schroeder, Heidi K; Sah, Renu 2018. Acid-sensing T cell death associated gene-8 receptor expression in panic disorder. Brain, behavior, and immunity, 67 , 36-41

Winter, Andrew; Ahlbrand, Rebecca; Naik, Devanshi; Sah, Renu 2017. Differential behavioral sensitivity to carbon dioxide (CO2) inhalation in rats. Neuroscience, 346 , 423-433

Schmeltzer, Sarah N; Herman, James P; Sah, Renu 2016. Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update. Experimental neurology, 284 Pt B, 196-210

Smith, Brittany L; Schmeltzer, Sarah N; Packard, Benjamin A; Sah, Renu; Herman, James P 2016. Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection. Brain, behavior, and immunity, 57 , 263-70

Sun, Xuming; Tommasi, Ellen; Molina, Doris; Sah, Renu; Brosnihan, K Bridget; Diz, Debra; Petrovic, Snezana 2016. Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO. American journal of physiology. Renal physiology, 311 6, F1260-F1266

Vollmer, Lauren L; Schmeltzer, Sarah; Schurdak, Jennifer; Ahlbrand, Rebecca; Rush, Jennifer; Dolgas, Charles M; Baccei, Mark L; Sah, Renu 2016. Neuropeptide Y Impairs Retrieval of Extinguished Fear and Modulates Excitability of Neurons in the Infralimbic Prefrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 4, 1306-15

Vollmer, Lauren Larke; Ghosal, Sriparna; McGuire, Jennifer L; Ahlbrand, Rebecca L; Li, Ke-Yong; Santin, Joseph M; Ratliff-Rang, Christine A; Patrone, Luis G A; Rush, Jennifer; Lewkowich, Ian P; Herman, James P; Putnam, Robert W; Sah, Renu 2016. Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear. Biological psychiatry, 80 7, 541-51

Sah, Renu; Ulrich-Lai, Yvonne M 2015. Introduction to the 2014 Neurobiology of Stress Special Issue. Physiology & behavior, 150 , 1

Schmeltzer, Sarah N; Vollmer, Lauren L; Rush, Jennifer E; Weinert, Mychal; Dolgas, Charles M; Sah, Renu 2015. History of chronic stress modifies acute stress-evoked fear memory and acoustic startle in male rats. Stress (Amsterdam, Netherlands), 18 2, 244-53

Vollmer, L L; Strawn, J R; Sah, R 2015. Acid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update. Translational psychiatry, 5 , e572

Vollmer, Lauren Larke; Schmeltzer, Sarah N; Ahlbrand, Rebecca; Sah, Renu 2015. A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior. Physiology & behavior, 150 , 78-82

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Park, Edwards A; Sallee, Floyd R; Parker, Steven L 2014. Dimers of G-protein coupled receptors as versatile storage and response units. International journal of molecular sciences, 15 3, 4856-77

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Park, Edwards A; Parker, Steven L 2014. On the expansion of ribosomal proteins and RNAs in eukaryotes. Amino acids, 46 7, 1589-604

Sah, Renu; Ekhator, Nosakhare N; Jefferson-Wilson, Lena; Horn, Paul S; Geracioti, Thomas D 2014. Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology, 40 , 277-83

E Vollmer, L; Ghosal, S; A Rush, J; R Sallee, F; P Herman, J; Weinert, M; Sah, R 2013. Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice. Genes, brain, and behavior, 12 2, 241-9

Müller, Timo D; Müller, Anne; Yi, Chun-Xia; Habegger, Kirk M; Meyer, Carola W; Gaylinn, Bruce D; Finan, Brian; Heppner, Kristy; Trivedi, Chitrang; Bielohuby, Maximilian; Abplanalp, William; Meyer, Franziska; Piechowski, Carolin L; Pratzka, Juliane; Stemmer, Kerstin; Holland, Jenna; Hembree, Jazzmin; Bhardwaj, Nakul; Raver, Christine; Ottaway, Nickki; Krishna, Radha; Sah, Renu; Sallee, Floyd R; Woods, Stephen C; Perez-Tilve, Diego; Bidlingmaier, Martin; Thorner, Michael O; Krude, Heiko; Smiley, David; DiMarchi, Richard; Hofmann, Susanna; Pfluger, Paul T; Kleinau, Gunnar; Biebermann, Heike; Tschöp, Matthias H 2013. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature communications, 4 , 1968

Sah R and Geracioti TD 2013. Neuropeptide Y and posttraumatic stress disorder. Molecular Psychiatry, ,

Sah, R; Geracioti, T D 2013. Neuropeptide Y and posttraumatic stress disorder. Molecular psychiatry, 18 6, 646-55

Vollmer LE, Ghosal S, Rush JA, Sallee FR, Herman JP, Weinert M, Sah R. 2013. Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice. Genes Brain & Behavior, 12 2, 241-249

Parker MS, Sah R, Parker SL. 2012. Surface masking shapes the traffic of the neuropeptide Y Y2 receptor. Peptides, 37 1, 40-48

Parker, Michael S; Sah, Renu; Parker, Steven L 2012. Surface masking shapes the traffic of the neuropeptide Y Y2 receptor. Peptides, 37 1, 40-8

McGuire JL, Larke LE, Sallee FR, Herman JP, Sah R. 2011. Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress. Front Behav Neurosci., 5 , 54

McGuire, Jennifer L; Larke, Lauren E; Sallee, Floyd R; Herman, James P; Sah, Renu 2011. Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress. Frontiers in behavioral neuroscience, 5 , 54

Parker, M S; Sah, R; Balasubramaniam, A; Sallee, F R; Zerbe, O; Parker, S L 2011. Non-specific binding and general cross-reactivity of Y receptor agonists are correlated and should importantly depend on their acidic sectors. Peptides, 32 2, 258-65

Estes, Anne-Marie; McAllen, Kathleen; Parker, Michael S; Sah, Renu; Sweatman, Trevor; Park, Edwards A; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Walker, Mary W; Parker, Steven L 2010. Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers. Amino acids, ,

McGuire, Jennifer; Herman, James P; Horn, Paul S; Sallee, Floyd R; Sah, Renu 2010. Enhanced fear recall and emotional arousal in rats recovering from chronic variable stress. Physiology & behavior, ,

McGuire, Jennifer; Herman, James P; Ghosal, Sriparna; Eaton, Katherine; Sallee, Floyd R; Sah, Renu 2009. Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain. Biochemical and biophysical research communications, 386 3, 420-5

Parker, M S; Sah, R; Park, E A; Sweatman, T; Balasubramaniam, A; Sallee, F R; Parker, S L 2009. Oligomerization of the heptahelical G protein coupling receptors: a case for association using transmembrane helices. Mini reviews in medicinal chemistry, 9 3, 329-39

Sah, Renu; Ekhator, Nosakhare N; Strawn, Jeffrey R; Sallee, Floyd R; Baker, Dewleen G; Horn, Paul S; Geracioti, Thomas D 2009. Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biological psychiatry, 66 7, 705-7

Parker, M S; Sah, R; Balasubramaniam, A; Sallee, F R; Sweatman, T; Park, E A; Parker, S L 2008. Dimers of the neuropeptide Y (NPY) Y2 receptor show asymmetry in agonist affinity and association with G proteins. Journal of receptor and signal transduction research, 28 5, 437-51

Parker, S L; Parker, M S; Estes, A M; Wong, Y Y; Sah, R; Sweatman, T; Park, E A; Balasubramaniam, A; Sallee, F R 2008. The neuropeptide Y (NPY) Y2 receptors are largely dimeric in the kidney, but monomeric in the forebrain. Journal of receptor and signal transduction research, 28 3, 245-63

Parker, Steven L; Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2008. Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells. European journal of pharmacology, 579 1-3, 13-25

Parker, Steven L; Parker, Michael S; Wong, Ying Y; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd 2008. Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor. European journal of pharmacology, 594 1-3, 26-31

Eaton, Katherine; Sallee, Floyd R; Sah, Renu 2007. Relevance of neuropeptide Y (NPY) in psychiatry. Current topics in medicinal chemistry, 7 17, 1645-59

Parker, S L; Parker, M S; Sah, R; Balasubramaniam, A; Sallee, F R 2007. Self-regulation of agonist activity at the Y receptors. Peptides, 28 2, 203-13

Parker, S L; Parker, M S; Sah, R; Sallee, F R; Balasubramaniam, A 2007. Parallel inactivation of Y2 receptor and G-proteins in CHO cells by pertussis toxin. Regulatory peptides, 139 1-3, 128-35

Sah, Rajan; Epstein, Laurence M; Kwong, Raymond Y 2007. Images in cardiovascular medicine. Intramural atrial hematoma after catheter ablation for atrial tachyarrhythmias. Circulation, 115 18, e446-7

Sah, Renu; Parker, Steven L; Sheriff, Sulaiman; Eaton, Katherine; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2007. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides, 28 2, 302-9

Li, Juan; Jadin, Kyle; Masuda, Koichi; Sah, Robert; Muehleman, Carol 2006. Characterization of lesions of the talus and description of tram-track lesions. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society, 27 5, 344-55

Trivieri, Maria Giovanna; Oudit, Gavin Y; Sah, Rajan; Kerfant, Benoit-Gilles; Sun, Hui; Gramolini, Anthony O; Pan, Yan; Wickenden, Alan D; Croteau, Walburga; Morreale de Escobar, Gabriella; Pekhletski, Roman; St Germain, Donald; Maclennan, David H; Backx, Peter H 2006. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proceedings of the National Academy of Sciences of the United States of America, 103 15, 6043-8

Brunskill, Eric W; Ehrman, Lisa A; Williams, Michael T; Klanke, Justin; Hammer, Daniel; Schaefer, Tori L; Sah, Renu; Dorn, Gerald W; Potter, S Steven; Vorhees, Charles V 2005. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. The European journal of neuroscience, 22 6, 1265-76

Parker, M S; Sah, R; Sheriff, S; Balasubramaniam, A; Parker, S L 2005. Internalization of cloned pancreatic polypeptide receptors is accelerated by all types of Y4 agonists. Regulatory peptides, 132 1-3, 91-101

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Steven L 2005. Lithium inhibits internalization and endosomal processing of both neuropeptide Y (NPY) Y1 and transferrin receptors. Neuroscience letters, 374 1, 43-6

Parker, Steven L; Parker, Michael S; Sah, Renu; Sallee, Floyd 2005. Angiogenesis and rhodopsin-like receptors: a role for N-terminal acidic residues? Biochemical and biophysical research communications, 335 4, 983-92

Sah, R; Pritchard, L M; Richtand, N M; Ahlbrand, R; Eaton, K; Sallee, F R; Herman, J P 2005. Expression of the glucocorticoid-induced receptor mRNA in rat brain. Neuroscience, 133 1, 281-92

Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Michael S; Sallee, Floyd; Parker, Steven L 2005. Neuropeptide Y as a partial agonist of the Y1 receptor. European journal of pharmacology, 525 1-3, 60-8

Singh, Kiran; Singh, S K; Sah, R; Singh, Indu; Raman, Rajiva 2005. Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population. International journal of andrology, 28 2, 115-9

Williams, Michael T; Schaefer, Tori L; Ehrman, Lisa A; Able, Jessica A; Gudelsky, Gary A; Sah, Renu; Vorhees, Charles V 2005. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. Brain research, 1039 1-2, 97-107

Galeffi, Francesca; Sah, Renu; Pond, Brooks B; George, Amanda; Schwartz-Bloom, Rochelle D 2004. Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 18, 4478-88

Crackower, Michael A; Oudit, Gavin Y; Kozieradzki, Ivona; Sarao, Renu; Sun, Hui; Sasaki, Takehiko; Hirsch, Emilio; Suzuki, Akira; Shioi, Tetsuo; Irie-Sasaki, Junko; Sah, Rajan; Cheng, Hai-Ying M; Rybin, Vitalyi O; Lembo, Giuseppe; Fratta, Luigi; Oliveira-dos-Santos, Antonio J; Benovic, Jeffery L; Kahn, C Ronald; Izumo, Seigo; Steinberg, Susan F; Wymann, Matthias P; Backx, Peter H; Penninger, Josef M 2002. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell, 110 6, 737-49

Davisson, Twana; Kunig, Sabine; Chen, Albert; Sah, Robert; Ratcliffe, Anthony 2002. Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 20 4, 842-8

Kaprielian, Roger; Sah, Rajan; Nguyen, Tin; Wickenden, Alan D; Backx, Peter H 2002. Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients. American journal of physiology. Heart and circulatory physiology, 283 3, H1157-68

Sah, Rajan; Oudit, Gavin Y; Nguyen, The-Tin T; Lim, Hae W; Wickenden, Alan D; Wilson, Gregory J; Molkentin, Jeffery D; Backx, Peter H 2002. Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation, 105 15, 1850-6

Sah, Rajan; Ramirez, Rafael J; Backx, Peter H 2002. Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circulation research, 90 2, 165-73

Sah, Renu; Galeffi, Francesca; Ahrens, Rebecca; Jordan, Gwendolyn; Schwartz-Bloom, Rochelle D 2002. Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. Journal of neurochemistry, 80 3, 383-91

Oudit, G Y; Kassiri, Z; Sah, R; Ramirez, R J; Zobel, C; Backx, P H 2001. The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. Journal of molecular and cellular cardiology, 33 5, 851-72

Sah, R; Ramirez, R J; Kaprielian, R; Backx, P H 2001. Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. The Journal of physiology, 533 Pt 1, 201-14

Schwartz-Bloom, R D; Sah, R 2001. gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. Journal of neurochemistry, 77 2, 353-71

Sah, R; Schwartz-Bloom, R D 1999. Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19 21, 9209-17

Wickenden, A D; Lee, P; Sah, R; Huang, Q; Fishman, G I; Backx, P H 1999. Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart. Circulation research, 85 11, 1067-76

Hanna, W J; Tsushima, R G; Sah, R; McCutcheon, L J; Marban, E; Backx, P H 1996. The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states. The Journal of physiology, 497 ( Pt 2) , 349-64

Akeson, Wayne H; Massie, Jennifer B; Huang, Bill; Giurea, Alexander; Sah, Robert; Garfin, Steven R; Kim, Choll W . Topical high-molecular-weight hyaluronan and a roofing barrier sheet equally inhibit postlaminectomy fibrosis. The spine journal : official journal of the North American Spine Society, 5 2, 180-90