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Department of

Pharmacology & Systems Physiology 

Photo of  Robert Rapoport, PhD

Robert Rapoport, PhD

Associate Professor of Pharmacology and Cell Biophysics

Education/Credentials
  • Bachelor's Degree: University of California
  • PhD: University of California Los Angeles

Research/Clinical Interests

Nitric Oxide and Endothelin-1 in Peripheral and Cerebral Vascular Pathophysiologies

Contact Information
  • Vontz
  • Room 2121
  • 3125 Eden Avenue
  • Cincinnati, Ohio 45267-0575
  • Office 513-558-7554
  • Fax 513-558-9969
  • Email robert.rapoport@uc.edu

Peer Reviewed Publications

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Rapoport, Robert M 2014. Acute nitric oxide synthase inhibition and endothelin-1-dependent arterial pressure elevation. Frontiers in pharmacology, 5 , 57

Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Sensory nerves and transient receptor potential vanilloid 1 channels in CO2 regulation of cerebrovascular tone. Respiratory physiology & neurobiology, ,

Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2014. Cocaine Constriction of Rat Basilar Artery in situ: Roles of Nitric Oxide and Endothelin-1. Pharmacology, 93 3-4, 151-154

Rapoport, Robert M; Zuccarello, Mario 2012. EndothelinA-EndothelinB Receptor Cross Talk in Endothelin-1-Induced Contraction of Smooth Muscle. Journal of cardiovascular pharmacology, 60 5, 483-94

Yoon, Seonghun; Zuccarello, Mario; Rapoport, Robert M 2012. pCO(2) and pH regulation of cerebral blood flow. Frontiers in physiology, 3 , 365

Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2012. EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn-Schmiedeberg's archives of pharmacology, 385 4, 437-41

Rapoport, Robert M; Zuccarello, Mario 2011. Endothelin(A)-endothelin(B) receptor cross-talk and endothelin receptor binding. The Journal of pharmacy and pharmacology, 63 11, 1373-7

Fandino, Javier; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2003. Cocaine-induced endothelin-1-dependent spasm in rabbit basilar artery in vivo. Journal of cardiovascular pharmacology, 41 2, 158-61

Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway. Neurological research, 25 3, 268-70

Yoon, SeongHun; Zuccarello, Mario; Rapoport, Robert M 2003. Repeated constriction to respiration-induced hypocapnia is not mimicked by isocapnic alkaline solution in rabbit basilar artery in situ. Vascular pharmacology, 40 1, 7-11

Yoon, Seonghun; Sherman, Jonathan D; Zuccarello, Mario; Rapoport, Robert M 2002. Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway. Neurological research, 24 4, 392-4

Rapoport, R M; Campbell, A K; Chang, K C 2000. Differential regulation of norepinephrine- and prostaglandin F2alpha-induced contraction by extracellular Na+ in rat aorta. Journal of cardiovascular pharmacology, 36 3, 288-96

Rapoport, R M; Williams, S P; Campbell, A K 2000. Phorbol ester-induced phosphoinositide hydrolysis in rat aorta: role of cyclooxygenase products. Life sciences, 67 15, 1815-24

Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces endothelin-dependent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 333-40

Yoon, S H; Zuccarello, M; Rapoport, R M 2000. Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis. General pharmacology, 35 6, 325-32

Zuccarello, M; Boccaletti, R; Rapoport, R M 2000. Role of NO in endothelium-dependent relaxation of rabbit basilar artery in situ. Neurological research, 22 2, 204-8

Zuccarello, M; Lee, B H; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by N(G)-monomethyl-L-arginine monoacetate and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 401 2, 213-9

Zuccarello, M; Lee, B H; Rapoport, R M 2000. Reduced verapamil inhibition of endothelin-1-constricted rabbit basilar artery due to enhanced non L-type Ca(2+)-channel-dependent constriction. General pharmacology, 35 1, 11-5

Zuccarello, M; Lee, B H; Rapoport, R M 2000. Endothelin-1 mediates hypocapnic constriction of the rabbit basilar artery in-vitro. The Journal of pharmacy and pharmacology, 52 2, 225-6

Zuccarello, M; Lee, B; Rapoport, R M 2000. Hypocapnic constriction in rabbit basilar artery in vitro: triggering by serotonin and dependence on endothelin-1 and alkalosis. European journal of pharmacology, 407 1-2, 191-5

Zuccarello, M; Boccaletti, R; Rapoport, R M 1999. Does blockade of endothelinB1-receptor activation increase endothelinB2/endothelinA receptor-mediated constriction in the rabbit basilar artery? Journal of cardiovascular pharmacology, 33 5, 679-84

Tosun, M; Paul, R J; Rapoport, R M 1998. Coupling of store-operated Ca++ entry to contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 285 2, 759-66

Tosun, M; Paul, R J; Rapoport, R M 1998. Role of extracellular Ca++ influx via L-type and non-L-type Ca++ channels in thromboxane A2 receptor-mediated contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, 284 3, 921-8

Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B1) receptor-mediated relaxation of rabbit basilar artery. European journal of pharmacology, 357 1, 67-71

Zuccarello, M; Boccaletti, R; Rapoport, R M 1998. Endothelin ET(B) receptor-mediated constriction in the rabbit basilar artery. European journal of pharmacology, 350 1, R7-9

Zuccarello, M; Boccaletti, R; Romano, A; Rapoport, R M 1998. Endothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm. Stroke; a journal of cerebral circulation, 29 9, 1924-9

Chuprun, J K; Rapoport, R M 1997. Protein kinase C regulation of ATP-induced phosphoinositide hydrolysis in bovine aorta endothelial cells. Journal of receptor and signal transduction research, 17 6, 787-814

Tosun, M; Paul, R J; Rapoport, R M 1997. Intracellular Ca2+ elevation and contraction due to prostaglandin F2alpha in rat aorta. European journal of pharmacology, 340 2-3, 203-8

Bazan, E; Rapoport, R M 1996. Methodological considerations for the measurement of protein kinase C translocation in intact smooth muscle. Journal of pharmacological and toxicological methods, 36 2, 87-95

Rapoport, R M; Williams, S P 1996. Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension, 28 1, 64-75

Zuccarello, M; Boccaletti, R; Tosun, M; Rapoport, R M 1996. Role of extracellular Ca2+ in subarachnoid hemorrhage-induced spasm of the rabbit basilar artery. Stroke; a journal of cerebral circulation, 27 10, 1896-902

Zuccarello, M; Bonasso, C L; Lewis, A I; Sperelakis, N; Rapoport, R M 1996. Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim. Stroke; a journal of cerebral circulation, 27 2, 311-6

Zuccarello, M; Soattin, G B; Lewis, A I; Breu, V; Hallak, H; Rapoport, R M 1996. Prevention of subarachnoid hemorrhage-induced cerebral vasospasm by oral administration of endothelin receptor antagonists. Journal of neurosurgery, 84 3, 503-7

Bazan, E; Campbell, A K; Rapoport, R M 1995. Time course of phorbol ester-induced contraction and protein kinase C activation in rat aorta. European journal of pharmacology, 290 3, 253-7

Rapoport, R M; Campbell, A K; Bazan, E 1995. Effects of PKC downregulation on norepinephrine- and prostaglandin F2 alpha-induced contraction in rat aorta. The American journal of physiology, 269 2 Pt 2, H590-8

Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Decreased endothelium-dependent relaxation in subarachnoid hemorrhage-induced vasospasm: role of ET-1. The American journal of physiology, 269 3 Pt 2, H1009-15

Zuccarello, M; Romano, A; Passalacqua, M; Rapoport, R M 1995. Endothelin-1-induced endothelin-1 release causes cerebral vasospasm in-vivo. The Journal of pharmacy and pharmacology, 47 8, 702

Baik, Y H; French, J F; Schwartz, A; Rapoport, R M 1994. Dihydropyridine Ca2+ channel agonists and antagonists potentiate ultraviolet light-induced relaxation through cyclic GMP formation in porcine coronary artery. Journal of cardiovascular pharmacology, 23 5, 785-91

Bazan, E; Campbell, A K; Rapoport, R M 1994. Effects of phorbol esters on contraction and protein kinase C activation in rabbit aorta. Life sciences, 54 2, PL29-33

Williams, S P; Campbell, A K; Roszell, N; Myatt, L; Leikauf, G D; Rapoport, R M 1994. Modulation of phorbol ester-induced contraction by endogenously released cyclooxygenase products in rat aorta. The American journal of physiology, 267 5 Pt 2, H1654-62

Williams, S P; Dorn, G W; Rapoport, R M 1994. Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle. The American journal of physiology, 267 2 Pt 2, H796-803

Zuccarello, M; Lewis, A I; Rapoport, R M 1994. Endothelin ETA and ETB receptors in subarachnoid hemorrhage-induced cerebral vasospasm. European journal of pharmacology, 259 1, R1-2

Bazan, E; Campbell, A K; Rapoport, R M 1993. Effects of protein kinase C activation on norepinephrine-induced phosphatidylinositide hydrolysis in intact rat aorta. European journal of pharmacology, 245 2, 173-7

Rapoport, R M 1993. Potentiation of norepinephrine-induced contraction by primary prostaglandin receptor activation in rat aorta. European journal of pharmacology, 243 2, 207-10

Rapoport, R M 1993. Regulation of vascular smooth muscle contraction by extracellular Na+. General pharmacology, 24 3, 531-7

Bazan, E; Campbell, A K; Rapoport, R M 1992. Protein kinase C activity in blood vessels from normotensive and spontaneously hypertensive rats. European journal of pharmacology, 227 3, 343-8

Chuprun, J K; Bazan, E; Chang, K C; Campbell, A K; Rapoport, R M 1991. Inhibition of phorbol ester-induced contraction by calmodulin antagonists in rat aorta. The American journal of physiology, 261 4 Pt 1, C675-84

Rapoport, R M 1991. Inhibitory effects of cyclic AMP-elevating agents on norepinephrine-induced phosphatidylinositide hydrolysis and contraction in rat aorta. General pharmacology, 22 3, 449-58

Rapoport, R M; Campbell, A K 1991. Norepinephrine-induced phosphatidylcholine hydrolysis in intact rat aorta. European journal of pharmacology, 208 1, 89-92

Rapoport, R M; Stauderman, K A; Highsmith, R F 1990. Effects of EDCF and endothelin on phosphatidylinositol hydrolysis and contraction in rat aorta. The American journal of physiology, 258 1 Pt 1, C122-31

Rapoport, R M; Van Gorp, C; Chang, K C 1990. Inositol uptake in rat aorta. Life sciences, 46 23, 1715-25

French, J F; Rapoport, R M; Matlib, M A 1989. Possible mechanism of benzodiazepine-induced relaxation of vascular smooth muscle. Journal of cardiovascular pharmacology, 14 3, 405-11

Highsmith, R F; Pang, D C; Rapoport, R M 1989. Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. Journal of cardiovascular pharmacology, 13 Suppl 5 , S36-44; discussion S

Rapoport, R M; Ashraf, M; Murad, F 1989. Effects of melittin on endothelium-dependent relaxation and cyclic GMP levels in rat aorta. Circulation research, 64 3, 463-73

Waldman, S A; Rapoport, R M; Fiscus, R R; Leitman, D C; Chang, L Y; Murad, F 1989. Regulation of particulate guanylate cyclase by atriopeptins: relation between peptide structure, receptor binding, and enzyme kinetics. Biochimica et biophysica acta, 999 2, 157-62

Rapoport, R M; Murad, F 1988. Effects of ethacrynic acid and cystamine on sodium nitroprusside-induced relaxation, cyclic GMP levels and guanylate cyclase activity in rat aorta. General pharmacology, 19 1, 61-5

Chuprun, J K; Rapoport, R M 1987. Nitroglycerin-induced desensitization of vascular smooth muscle may be mediated through cyclic GMP-disinhibition of phosphatidylinositol hydrolysis. Experientia, 43 3, 316-8

Molina, C R; Andresen, J W; Rapoport, R M; Waldman, S; Murad, F 1987. Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. Journal of cardiovascular pharmacology, 10 4, 371-8

Rapoport, R M 1987. Effects of norepinephrine on contraction and hydrolysis of phosphatidylinositols in rat aorta. The Journal of pharmacology and experimental therapeutics, 242 1, 188-94

Rapoport, R M; Waldman, S A; Ginsburg, R; Molina, C R; Murad, F 1987. Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery. Journal of cardiovascular pharmacology, 10 1, 82-9

Draznin, M B; Rapoport, R M; Murad, F 1986. Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta. The International journal of biochemistry, 18 10, 917-28

Murad, F; Waldman, S A; Fiscus, R R; Rapoport, R M 1986. Regulation of cyclic GMP synthesis and the interactions with calcium. Journal of cardiovascular pharmacology, 8 Suppl 8 , S57-60

Rapoport, R M 1986. Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta. Circulation research, 58 3, 407-10

Rapoport, R M; Ginsburg, R; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro. European journal of pharmacology, 124 1-2, 193-6

Rapoport, R M; Winquist, R J; Baskin, E P; Faison, E P; Waldman, S A; Murad, F 1986. Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas. European journal of pharmacology, 120 1, 123-6

Waldman, S A; Rapoport, R M; Ginsburg, R; Murad, F 1986. Desensitization to nitroglycerin in vascular smooth muscle from rat and human. Biochemical pharmacology, 35 20, 3525-31

Fiscus, R R; Rapoport, R M; Waldman, S A; Murad, F 1985. Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. Biochimica et biophysica acta, 846 1, 179-84

Leitman, D C; Waldman, S A; Rapoport, R M; Murad, F 1985. Specific atrial natriuretic factor receptors mediate increased cyclic GMP accumulation in cultured bovine aortic endothelial and smooth muscle cells. Transactions of the Association of American Physicians, 98 , 243-52

Murad, F; Rapoport, R M; Fiscus, R 1985. Role of cyclic-GMP in relaxations of vascular smooth muscle. Journal of cardiovascular pharmacology, 7 Suppl 3 , S111-8

Rapoport, R M; Schwartz, K; Murad, F 1985. Effect of sodium-potassium pump inhibitors and membrane-depolarizing agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circulation research, 57 1, 164-70

Rapoport, R M; Schwartz, K; Murad, F 1985. Effects of Na+,K+-pump inhibitors and membrane depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP accumulation in rat aorta. European journal of pharmacology, 110 2, 203-9

Rapoport, R M; Waldman, S A; Schwartz, K; Winquist, R J; Murad, F 1985. Effects of atrial natriuretic factor, sodium nitroprusside, and acetylcholine on cyclic GMP levels and relaxation in rat aorta. European journal of pharmacology, 115 2-3, 219-29

Waldman, S A; Rapoport, R M; Fiscus, R R; Murad, F 1985. Effects of atriopeptin on particulate guanylate cyclase from rat adrenal. Biochimica et biophysica acta, 845 2, 298-303

Rapoport, R M; Draznin, M B; Murad, F 1984. Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Circulation research, 55 4, 468-79

Rapoport, R M; Murad, F 1984. Effect of cyanide on nitrovasodilator-induced relaxation, cyclic GMP accumulation and guanylate cyclase activation in rat aorta. European journal of pharmacology, 104 1-2, 61-70

Waldman, S A; Rapoport, R M; Murad, F 1984. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. The Journal of biological chemistry, 259 23, 14332-4

Winquist, R J; Faison, E P; Waldman, S A; Schwartz, K; Murad, F; Rapoport, R M 1984. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proceedings of the National Academy of Sciences of the United States of America, 81 23, 7661-4

Rapoport, R M; Bevan, J A 1983. Effect of contraction on the subsequent responsiveness and maximum contractility of the rabbit ear artery and saphenous vein in vitro. Blood vessels, 20 1, 44-55

Rapoport, R M; Draznin, M B; Murad, F 1983. Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Transactions of the Association of American Physicians, 96 , 19-30

Rapoport, R M; Murad, F 1983. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circulation research, 52 3, 352-7

Rapoport, R M; Murad, F 1983. Effect of ouabain and alterations in potassium concentration on relaxation induced by sodium nitroprusside. Blood vessels, 20 5, 255-64

Rapoport, R M; Murad, F 1983. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. Journal of cyclic nucleotide and protein phosphorylation research, 9 4-5, 281-96

Rapoport, R M; Bevan, J A 1982. Increased contractility induced in rabbit ear artery by prior exposure to serotonin masks concomitant desensitization to norepinephrine. The Journal of pharmacology and experimental therapeutics, 222 2, 338-43

Rapoport, R M; Draznin, M B; Murad, F 1982. Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proceedings of the National Academy of Sciences of the United States of America, 79 21, 6470-4

Rapoport, R M; Bevan, J A 1981. Mechanism of electrical stimulation-induced subsensitivity of vascular smooth muscle. The Journal of pharmacology and experimental therapeutics, 218 2, 382-9

Rapoport, R M; Bevan, J A 1981. Vascular smooth muscle contraction induced by direct electrical stimulation and its subsequent effect of reactivity to agonists. The Journal of pharmacology and experimental therapeutics, 218 2, 375-81

Rapoport, R M; Takimoto, G S; Cho, A K 1981. Compartmental analysis of tyramine-induced norepinephrine depletion. Pharmacology, 22 4, 235-42

Rapoport, R M 1978. [Hygienic evaluation of the working conditions at a pilot factory for spindleless spinning]. Gigiena truda i professional'nye zabolevaniia, 4, 51-2

Brusova, L A; Iuzhelevski?, Iu A; Rapoport, R M; Poiurovskaia, I Ia; Panikarovski?, V V; Antipova, Z P; Shitsel', L A; Tuzanova, L I . [A new siloxane material for eliminating defects of the soft facial tissues by an injection method. I. The laboratory and experimental research]. Stomatologii?a, 4, 13-5

Fiscus, R R; Rapoport, R M; Murad, F . Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta. Journal of cyclic nucleotide and protein phosphorylation research, 9 6, 415-25

Motz, Gregory T; Zuccarello, Mario; Rapoport, Robert M . Alkaline pH-induced extracellular regulated protein kinase activation in brain microvascular endothelial cells: differential effects of Tris and lowered CO2. Endothelium : journal of endothelial cell research, 13 5, 313-6

Poiurovskaia, I Ia; Rapoport, R M; Nechaenko, N A; Tagiev, A I . [Comparative laboratory evaluation of silicone impression materials used in preparing metalloceramic dentures]. Stomatologii?a, 67 3, 56-8

Rapoport, R M; Draznin, M B; Murad, F . Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature, 306 5939, 174-6

Yoon, Seong Hun; Zuccarello, Mario; Rapoport, Robert M . Acute cocaine induces endothelin-1-dependent constriction of rabbit basilar artery. Endothelium : journal of endothelial cell research, 14 3, 137-9

Published Abstracts

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Yoon SH, Zuccarello M, Rapoport RM 2003. Respiratory induced hypocapnic constriction of rat basilar artery: dependence on endothelin-1 FASEB, ,


Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Cerebral Vasospasm: Advances in Research and Treatment, , 75-78


Fandino, J., Gariepy, C, Yanagisawa, M, Rapoport, RM, and Zuccarello, M. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo Congress Neurological Surgeons, ,


Fandino, J., Sherman, D., Zuccarello, M., and Rapoport, R.M. 2000. Endothelin-1 mediates cocaine-induced cerebrovasospasm 7th International Conference on Cerebral Vasospasm, , 6


Sherman, J.D., Fandino, J., Zuccarello, M., and Rapoport, R.M. 2000. Cocaine-induced cerebral vasospasm in vivo: mediated by endothelin-1 Stroke, ,


Zuccarello, M., Sherman, J., and Rapoport, R.M. 2000. Subarachnoid hemorrhage-induced vasospasm: role of calcium sensitization 6th Internet World Congress for Biomedical Sciences, ,


Sherman, J.D., Zuccarello, M., and Rapoport, R.M. 1999. Role of calcium sensitization in cerebral vasospasm Congress Neurological Surgeons, ,


Sherman, J.D., Rapoport, R.M., and Zuccarello, M. 1998. The role of endothelin-1 in subarachnoid hemorrhage-induced vasospasm INABIS ’98 - 5th Internet World Congress on Biomedical Sciences at McMater University, Canada, ,


Tosun, M., Paul, R.J., and Rapoport, R.M. 1998. Coupling of store-operated Ca2+ entry to contraction in rat aorta FASEB J., ,


Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelium-derived nitric oxide regulates endothelin A versus endothelin B receptor-mediated constriction in rabbit basilar artery in situ Stroke, 29 , 323


Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1998. Endothelin B receptor antagonists prevent subarachnoid hemorrhage-induced spasm in rabbit basilar artery in vivo Congress Neurological Surgeons, Seattle, WA, ,


Zuccarello, M., Boccaletti, R., and Rapoport, R.M. 1997. Endothelin B1 receptor-mediated endothelin-1 release maintains subarachnoid hemorrhage-induced spasm of rabbit basilar 18th Int. Symp. Cerebral Blood Flow and Metabolism, 17 , S471


Zuccarello, M. Boccaletti, R., and Rapoport, R.M. 1995. Ca2+ Influx Through Non-L-Type Ca2+ Channels Mediates Subarachnoid Hemorrhage-Induced Vasospasm: Role of Endothelin-1 (ET-1) Stroke, ,


Zuccarello, M., Soattin, G.B., Lewis, A.I., and Rapoport, R.M. 1995. Oral Bosentan, an endothelin (ET)A and ETB receptor antagonist, prevents subarachnoid hemorrhage (SAH)-induced cerebral vasospasm The Fourth International Workshop on Cerebrovascular Surgery (INCVS), Chicago, Illinois, ,


Zuccarello, M., Rapoport, R.M., and Romano, A. 1994. Subarachnoid hemorrhage (SAH)-induced vasospasm may be due to endothelin (ET) release and not decreased endothelium-dependent relaxation (EDR) Stroke, 25 , 136


Zuccarello, M. and Rapoport, R.M. 1993. Role of K+ channels in vasospasm after subarachnoid hemorrhage Stroke, 24 , 168


Zuccarello, M., Bonasso, C., Rapoport, R.M., and Sperelakis, N. 1993. Role of membrane potential in vasospasm after subarachnoid hemorrhage (SAH) Vth Int. Symp. Cerebral Vasospasm, Edmonton, ,


Williams, S.P., Dorn, G.W., II, Campbell, A.K., Leikauf, G.O., Myatt, L., and Rapoport, R.M. 1992. Prostaglandin I2 (PGI2) may mediate phorbol ester induced increased inositol phosphate levels FASEB, ,


Chuprun, J.K. and Rapoport, R.M. 1991. Protein kinase C attenuates agonist and G protein stimulated phospholipase C activity in endothelial cell membranes FASEB J., 5 , A1598


Rapoport, R.M., Bazan, E., and Campbell, A.K. 1991. Relationship between protein kinase C (PKC) activation, phosphoinositide hydrolysis and contraction in rat aorta J. Mol. Cell. Cardiol, 23 , S12


Williams, S.P., Dorn, G.W. II, Campbell, A.K., Leikauf, G.D., Myatt, L. and Rapoport, R.M. 1991. Phorbol ester induced phosphatidylinositide hydrolysis in rat aorta: potential role of prostacyclin (PGI2) J. Molec. Cell. Cardiol., 23 , S65


Chuprun, J.K., and Rapoport, R.M. 1990. Regulation of endothelial cell membrane phospholipase C activity by protein kinase C 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, ,


Williams, S.P., Campbell, A.K., Leikauf, G.D., and Rapoport, R.M. 1990. Phorbol esters induce phosphatidylinositide hydrolysis and arachidonic acid metabolism in rat aorta 6th International Symposium on Cellular Endocrinology, Lake Placid, New York, ,


Highsmith, R.F., Pang, D., Schmidt, D., and Rapoport, R. 1989. Mechanisms of action of endothelial cell derived constricting factors J. Vascular Medicine Biology, 1 , 92


Highsmith, R.F., Koth, D.M., Westrich, L.A., and Rapoport, R.M. 1987. Vasoconstriction induced by endothelium derived constricting factor (EDCF) may be mediated through phosphatidylinositol (PI) turnover Circulation, 15 ,


Chuprun, J.K. and Rapoport, R.M. 1986. Nitroglycerin induced desensitization of vascular smooth muscle may be mediated through cyclic GMP disinhibition of phosphatidylinositol hydrolysis 27th National Student Research Forum, , 17


Rapoport, R.M. 1986. Effects of norepinephrine on contraction and hydrolysis of phospha-tidylinositides in rat aorta Veterans Administration National Research and Development Conference, Las Vegas, Nevada, ,


Baik, Y.H., Dube, G., Vaghy, P., Rapoport, R., and Schwartz, A. 1985. Modification of effects of the enantiomers of a 1,4 dihydropyridine (202 791) by endothelium and light in pig coronary artery Pharmacology, ,


Fiscus, R.R., Robles, B.T., Rapoport, R.M., Waldman, S.A., and Murad, F. 1985. Atrial natriuretic factor elevates cyclic GMP and activates cyclic GMP dependent protein kinase in rat aorta: potential mechanism of vasodilation Fed. Proc., 44 , 698


Molina, C.R., Andresen, J.W., Rapoport, R., Waldman, S., and Murad, F. 1985. The effect of in vivo nitroglycerin therapy on endothelium dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta Clin. Res., ,


Murad, F., Rapoport, R.M., Waldman, S.A., Fiscus, R.R., and Leitman, D.C. 1985. The role of cyclic GMP in endothelium dependent, nitrovasodilator and atriopeptin mediated vascular relaxation , ,


Fiscus, R.R., Rapoport, R.M., and Murad, F. 1984. Activation of cyclic GMP dependent protein kinase in rat aorta by sodium nitroprusside and endothelium dependent vasodilators Clin. Res., 32 , 5A


Draznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Effects of norepi-nephrine, sodium nitroprusside, calcium free buffer and a calmodulin inhibitor on protein phosphorylation related to contraction and relaxation in intact rat aorta Clin. Res., 31 , 6A


Draznin, M.B., Rapoport, R.M., Martinez, G.A., and Murad, F. 1983. Myosin light chain dephosphorylation in intact rat thoracic aorta treated with sodium nitroprusside: role of cyclic GMP Clin. Res., 31 , 466A


Rapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Effect of endothelium dependent vasodilators on relaxation, cyclic GMP levels and protein phosphorylation in rat thoracic aorta Clin. Res., 3l , 16A


Rapoport, R.M., Draznin, M.B., Martinez, G.A., and Murad, F. 1983. Endothelium dependent vascular relaxation may be mediated through cyclic GMP dependent protein phosphorylation Clin. Res., 31 , 526A


Draznin, M.B., Rapoport, R.M., and Murad, F. 1982. Vascular smooth muscle protein phosphorylation following sodium nitroprusside treatment: possible role in smooth muscle relaxation Clin. Res., 30 , 6A


Rapoport, R.M. and Murad, F. 1982. Ouabain inhibits relaxation by nitroprusside and 8 bromo cyclic GMP in rat aorta Clin. Res., 30 , 18A


Rapoport, R.M., Draznin, M.B., and Murad, F. 1982. Sodium nitroprusside induced protein phosphorylation in intact rat aorta is mimicked by 8 bromo cyclic GMP Clin. Res., 30 , 484A


Rapoport, R.M., Brandwein, H.J., and Murad, F. 1981. Cystamine inhibits relaxation, increases in cyclic GMP accumulation, and guanylate cyclase activation induced by nitroprusside in rat aorta Fed. Proc., 40 , 690


Rapoport, R.M., Lewicki, J.A., and Murad, F. 1981. Cyanide inhibits relaxation, increases in cyclic GMP accumulation and guanylate cyclase activation induced by nitroprusside in rat aorta Circulation, 64 , 70


Duckles, S.P. and Rapoport, R. 1980. Lack of effect of clonidine on norepinephrine (NE) release from a rabbit cerebral artery Fed. Proc., 38 , 367


Rapoport, R.M. and Bevan, J.A. 1980. Sympathetic nerve activity desensitizes vascular smooth muscle in vitro Fed. Proc., 38 , 367


Rapoport, R.M. and Bevan, J.A. 1980. Electrical stimulation of vascular smooth muscle induces subsensitivity in vitro Fed. Proc., 39 , 1071


Bevan, J.A., Bevan, R.D., Pascual, R., and Rapoport, R. 1978. Some anatomical and functional factors influencing vascular smooth muscle sensitivity to norepinephrine 7th International Congress on Pharmacology, , 36


Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Release of norepinephrine (NE) from cerebral blood vessels: correlation of two techniques 7th International Congress on Pharmacology, , 36


Duckles, S.P., Rapoport, R.M., and Oberhammer, I. 1978. Nerve stimulation of cerebral arteries releases endogenous norepinephrine (NE): confirmation by radioenzymatic assay of adrenergic nerve function 3rd International Symposium on Vascular Neuroeffector Mechanisms, , 28-29


Molina, C.R., Andresen, J.W., Rapoport, R.M., and Murad, F. . The effect of nitroglycerin tolerance on endothelium dependent vascular relaxation Circulation, 74 , 287