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Department of

Pharmacology & Systems Physiology 

Photo of  Marshall Montrose, PhD

Marshall Montrose, PhD

Professor and Dean of the Graduate School

Education/Credentials
  • Bachelor's Degree: University of Maryland
  • Bachelor's Degree: University of Maryland
  • Master's Degree: University of Rochester
  • Doctoral Degree: University of Rochester

Research/Clinical Interests

Our laboratory is interested in the cellular and sub-cellular physiology of epithelial cells lining the gastrointestinal tract. We have a number of ongoing projects which are described briefly below. In all our projects we explore the role of specific proteins thru the use of normal and mutant mice as well as tissue culture models. Our favorite tool is the use of high resolution (confocal and two-photon) light microscopy, to help us explore events in living cells and tissues. In the small and large intestines, epithelial cells are responsible for the absorption of nutrients and fluid. Within this topic area, we want to know how sodium absorption in the large intestine (colon) is stimulated by short-chain fatty acids (abundant monocarboxylates created from bacterial fermentation in the colonic lumen). More specifically, we are investigating two questions concerning (1) which Na/H exchanger isoforms are responsible for sodium absorption in the colon, and (2) how these sodium transporters are differentially regulated by the short-chain fatty acids. We have found that the NHE2 isoform has previously unsuspected roles in sodium transport in the colonic crypt, and have also identifed two general mechanisms that lead to activation of this and other NHE isoforms. First, microdomains of pH in the extracellular and intracellular environment near the transport proteins provide unusual kinetic activation of the exchangers. In other words, the pH that the Na/H exchanger sees is not the same as the bulk pH in either the cytosol or the outside bathing solution. The second mechanism is a translocation of the Na/H exchangers in response to ionic conditions that signal a need for altered absorption. In the stomach, we are exploring the reason that the stomach does not digest itself despite having a caustic environment imposed on the epithelial cells lining the stomach. Part of the gastric defenses include pH microdomain near the tissue surface, which we detect with confocal microscopy in vivo. The epithelial cells are responsible for both acid and alkali secretion, and here we are exploring how changes in the luminal pH of the stomach regulate the dramatic transition from net-acid to net-alkali secretion, and its impact on gastric defense. We are also using the two-photon microscope to cause microlesions in the stomach (damaging 2-5 cells) and following in real-time the process of expanding damage and repair. Since all the epithelial cells lining the GI tract are being constantly replaced every week, we are also fascinated with the mechanisms which allow cell proliferation, death, migration and differentiation to occur during normal tissue function. We are questioning the sites and extent of apoptosis and cell shedding in living tissue. Our initial work has focused on the small intestine but we hope to expand studies to other tissues as our knowledge expands.

Contact Information
  • Van Wormer Hall
  • Room 210
  • 2614 McMicken Circle
  • Cincinnati, Ohio 45221-0097
  • Fax 513-558-7861
  • Email marshall.montrose@uc.edu

Peer Reviewed Publications

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Schumacher, Michael A; Aihara, Eitaro; Feng, Rui; Engevik, Amy; Shroyer, Noah F; Ottemann, Karen M; Worrell, Roger T; Montrose, Marshall H; Shivdasani, Ramesh A; Zavros, Yana 2015. The use of murine-derived fundic organoids in studies of gastric physiology. The Journal of physiology, 593 8, 1809-27

Schumacher, Michael A; Feng, Rui; Aihara, Eitaro; Engevik, Amy C; Montrose, Marshall H; Ottemann, Karen M; Zavros, Yana 2015. Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NF?B pathway activation: the use of a novel in vitro model to study epithelial response to infection. Helicobacter, 20 1, 19-28

Wroblewski, Lydia E; Piazuelo, M Blanca; Chaturvedi, Rupesh; Schumacher, Michael; Aihara, Eitaro; Feng, Rui; Noto, Jennifer M; Delgado, Alberto; Israel, Dawn A; Zavros, Yana; Montrose, Marshall H; Shroyer, Noah; Correa, Pelayo; Wilson, Keith T; Peek, Richard M 2015. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut, 64 5, 720-30

Aihara, Eitaro; Closson, Chet; Matthis, Andrea L; Schumacher, Michael A; Engevik, Amy C; Zavros, Yana; Ottemann, Karen M; Montrose, Marshall H 2014. Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori. PLoS pathogens, 10 7, e1004275

Aihara, Eitaro; Montrose, Marshall H 2014. Importance of Ca(2+) in gastric epithelial restitution-new views revealed by real-time in vivo measurements. Current opinion in pharmacology, 19 , 76-83

Feng, Rui; Aihara, Eitaro; Kenny, Susan; Yang, Li; Li, Jing; Varro, Andrea; Montrose, Marshall H; Shroyer, Noah F; Wang, Timothy C; Shivdasani, Ramesh A; Zavros, Yana 2014. Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology, 147 3, 655-666.e9

Moore, Sean R; Pruszka, Jill; Vallance, Jefferson; Aihara, Eitaro; Matsuura, Toru; Montrose, Marshall H; Shroyer, Noah F; Hong, Christian I 2014. Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine. Disease models & mechanisms, 7 9, 1123-30

Ramírez-Alcántara, Verónica; Montrose, Marshall H 2014. Acute murine colitis reduces colonic 5-aminosalicylic acid metabolism by regulation of N-Acetyltransferase-2. American journal of physiology. Gastrointestinal and liver physiology, ,

Aihara, Eitaro; Hentz, Courtney L; Korman, Abraham M; Perry, Nicholas P J; Prasad, Vikram; Shull, Gary E; Montrose, Marshall H 2013. In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium. The Journal of biological chemistry, 288 47, 33585-97

Engevik, Melinda A; Aihara, Eitaro; Montrose, Marshall H; Shull, Gary E; Hassett, Daniel J; Worrell, Roger T 2013. Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth. American journal of physiology. Gastrointestinal and liver physiology, 305 10, G697-711

Mahé, Maxime M; Aihara, Eitaro; Schumacher, Michael A; Zavros, Yana; Montrose, Marshall H; Helmrath, Michael A; Sato, Toshiro; Shroyer, Noah F 2013. Establishment of gastrointestinal epithelial organoids. Current protocols in mouse biology, 3 , 217-240

Barrett, Kim E; Montrose, Marshall H 2012. Success as a PhD in Gastroenterology. Gastroenterology, 143 2, 278-81

Demitrack, Elise S; Aihara, Eitaro; Kenny, Susan; Varro, Andrea; Montrose, Marshall H 2012. Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage. Gut, 61 6, 804-11

Guan, Yanfang; Watson, Alastair J M; Marchiando, Amanda M; Bradford, Emily; Shen, Le; Turner, Jerrold R; Montrose, Marshall H 2011. Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells. American journal of physiology. Cell physiology, 300 6, C1404-14

Han, Xiaonan; Mann, Elizabeth; Gilbert, Shila; Guan, Yanfang; Steinbrecher, Kris A; Montrose, Marshall H; Cohen, Mitchell B 2011. Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier. PloS one, 6 1, e16139

Marchiando, Amanda M; Shen, Le; Graham, W Vallen; Edelblum, Karen L; Duckworth, Carrie A; Guan, Yanfang; Montrose, Marshall H; Turner, Jerrold R; Watson, Alastair J M 2011. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology, 140 4, 1208-1218.e1-2

Xue, Lin; Aihara, Eitaro; Wang, Timothy C; Montrose, Marshall H 2011. Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair. The Journal of biological chemistry, 286 44, 38375-82

Demitrack, Elise S; Soleimani, Manoocher; Montrose, Marshall H 2010. Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl(-)/HCO(3)(-). American journal of physiology. Gastrointestinal and liver physiology, 299 1, G255-64

Guan, Yan-Fang; Pritts, Timothy A; Montrose, Marshall H 2010. Ischemic post-conditioning to counteract intestinal ischemia/reperfusion injury. World journal of gastrointestinal pathophysiology, 1 4, 137-43

Marchiando, Amanda M; Shen, Le; Graham, W Vallen; Weber, Christopher R; Schwarz, Brad T; Austin, Jotham R; Raleigh, David R; Guan, Yanfang; Watson, Alastair J M; Montrose, Marshall H; Turner, Jerrold R 2010. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. The Journal of cell biology, 189 1, 111-26

Xue, Lin; Aihara, Eitaro; Podolsky, Daniel K; Wang, Timothy C; Montrose, Marshall H 2010. In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase. Gut, 59 9, 1184-91

Guan, Yanfang; Worrell, Roger T; Pritts, Timothy A; Montrose, Marshall H 2009. Intestinal ischemia-reperfusion injury: reversible and irreversible damage imaged in vivo. American journal of physiology. Gastrointestinal and liver physiology, 297 1, G187-96

Watson, Alastair J M; Duckworth, Carrie A; Guan, Yanfang; Montrose, Marshall H 2009. Mechanisms of epithelial cell shedding in the Mammalian intestine and maintenance of barrier function. Annals of the New York Academy of Sciences, 1165 , 135-42

Shen, Fei; Chu, Shaoyou; Bence, Aimee K; Bailey, Barbara; Xue, Xinjian; Erickson, Priscilla A; Montrose, Marshall H; Beck, William T; Erickson, Leonard C 2008. Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. The Journal of pharmacology and experimental therapeutics, 324 1, 95-102

Starodub, Olga T; Demitrack, Elise S; Baumgartner, Heidi K; Montrose, Marshall H 2008. Disruption of the Cox-1 gene slows repair of microscopic lesions in the mouse gastric epithelium. American journal of physiology. Cell physiology, 294 1, C223-32

Gens, J Scott; Du, Hongwei; Tackett, Lixuan; Kong, Shen-Shen; Chu, Shaoyou; Montrose, Marshall H 2007. Different ionic conditions prompt NHE2 and NHE3 translocation to the plasma membrane. Biochimica et biophysica acta, 1768 5, 1023-35

Kiesslich, Ralf; Goetz, Martin; Angus, Elizabeth M; Hu, Qiuping; Guan, Yanfang; Potten, Chris; Allen, Terry; Neurath, Markus F; Shroyer, Noah F; Montrose, Marshall H; Watson, Alastair J M 2007. Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology, 133 6, 1769-78

Bullen, Tim F; Forrest, Sharon; Campbell, Fiona; Dodson, Andrew R; Hershman, Michael J; Pritchard, D Mark; Turner, Jerrold R; Montrose, Marshall H; Watson, Alastair J M 2006. Characterization of epithelial cell shedding from human small intestine. Laboratory investigation; a journal of technical methods and pathology, 86 10, 1052-63

Guan, Yanfang; Dong, Jin; Tackett, Lixuan; Meyer, Jamie W; Shull, Gary E; Montrose, Marshall H 2006. NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice. American journal of physiology. Gastrointestinal and liver physiology, 291 4, G689-99

Yang, Vincent W; Montrose, Marshall H 2006. Our new president--Mark Donowitz, MD. Gastroenterology, 130 6, 1904-11

Kempson, Stephen A; Beck, Jeffrey A; Lammers, Philip E; Gens, J Scott; Montrose, Marshall H 2005. Membrane insertion of betaine/GABA transporter during hypertonic stress correlates with nuclear accumulation of TonEBP. Biochimica et biophysica acta, 1712 1, 71-80

Watson, Alastair J M; Chu, Shaoyou; Sieck, Leah; Gerasimenko, Oleg; Bullen, Tim; Campbell, Fiona; McKenna, Michael; Rose, Tracy; Montrose, Marshall H 2005. Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology, 129 3, 902-12

Baumgartner, H K; Starodub, O T; Joehl, J S; Tackett, L; Montrose, M H 2004. Cyclooxygenase 1 is required for pH control at the mouse gastric surface. Gut, 53 12, 1751-7

Baumgartner, Heidi K; Montrose, Marshall H 2004. Regulated alkali secretion acts in tandem with unstirred layers to regulate mouse gastric surface pH. Gastroenterology, 126 3, 774-83

Hirokawa, Masahiko; Takeuchi, Tetsu; Chu, Sahaoyou; Akiba, Yasutada; Wu, Vincent; Guth, Paul H; Engel, Eli; Montrose, Marshall H; Kaunitz, Jonathan D 2004. Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum. Gastroenterology, 127 4, 1162-73

Kempson, Stephen A; Montrose, Marshall H 2004. Osmotic regulation of renal betaine transport: transcription and beyond. Pflügers Archiv : European journal of physiology, 449 3, 227-34

Montrose, Marshall H 2004. The basis for transport across epithelial cells. American journal of physiology. Gastrointestinal and liver physiology, 287 5, G941-2

Kempson, Stephen A; Parikh, Vaibhave; Xi, Lixuan; Chu, Shaoyou; Montrose, Marshall H 2003. Subcellular redistribution of the renal betaine transporter during hypertonic stress. American journal of physiology. Cell physiology, 285 5, C1091-100

Montrose, Marshall H 2003. The future of GI and liver research: editorial perspectives: I. Visions of epithelial research. American journal of physiology. Gastrointestinal and liver physiology, 284 4, G547-50

Tanaka, S; Chu, S; Hirokawa, M; Montrose, M H; Kaunitz, J D 2003. Direct measurement of acid permeation into rat oesophagus. Gut, 52 6, 775-83

Baumgartner, Heidi K; Kirbiyik, Uzay; Coskun, Tamer; Chu, Shaoyou; Montrose, Marshall H 2002. Endogenous cyclo-oxygenase activity regulates mouse gastric surface pH. The Journal of physiology, 544 Pt 3, 871-82

Chu, Jingsong; Chu, Shaoyou; Montrose, Marshall H 2002. Apical Na+/H+ exchange near the base of mouse colonic crypts. American journal of physiology. Cell physiology, 283 1, C358-72

Coskun, Tamer; Baumgartner, Heidi K; Chu, Shaoyou; Montrose, Marshall H 2002. Coordinated regulation of gastric chloride secretion with both acid and alkali secretion. American journal of physiology. Gastrointestinal and liver physiology, 283 5, G1147-55

Hanson, George T; McAnaney, Tim B; Park, Eun Sun; Rendell, Marla E P; Yarbrough, Daniel K; Chu, Shaoyou; Xi, Lixuan; Boxer, Steven G; Montrose, Marshall H; Remington, S James 2002. Green fluorescent protein variants as ratiometric dual emission pH sensors. 1. Structural characterization and preliminary application. Biochemistry, 41 52, 15477-88

Coskun, T; Chu, S; Montrose, M H 2001. Intragastric pH regulates conversion from net acid to net alkaline secretion by the rat stomach. American journal of physiology. Gastrointestinal and liver physiology, 281 4, G870-7

Lyall, V; Alam, R I; Phan, D Q; Ereso, G L; Phan, T H; Malik, S A; Montrose, M H; Chu, S; Heck, G L; Feldman, G M; DeSimone, J A 2001. Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. American journal of physiology. Cell physiology, 281 3, C1005-13

Montrose, M H 2001. Choosing sides in the battle against gastric acid. The Journal of clinical investigation, 108 12, 1743-4

Maouyo, D; Chu, S; Montrose, M H 2000. pH heterogeneity at intracellular and extracellular plasma membrane sites in HT29-C1 cell monolayers. American journal of physiology. Cell physiology, 278 5, C973-81

Bamford, O S; Sterni, L M; Wasicko, M J; Montrose, M H; Carroll, J L 1999. Postnatal maturation of carotid body and type I cell chemoreception in the rat. The American journal of physiology, 276 5 Pt 1, L875-84

Chu, S; Montrose, M H 1999. The glow of the colonic pH microclimate kindled by short-chain fatty acids, chloride and bicarbonate. The Journal of physiology, 517 ( Pt 2) , 315

Chu, S; Tanaka, S; Kaunitz, J D; Montrose, M H 1999. Dynamic regulation of gastric surface pH by luminal pH. The Journal of clinical investigation, 103 5, 605-12

Gonda, T; Maouyo, D; Rees, S E; Montrose, M H 1999. Regulation of intracellular pH gradients by identified Na/H exchanger isoforms and a short-chain fatty acid. The American journal of physiology, 276 1 Pt 1, G259-70

Janecki, A J; Montrose, M H; Tse, C M; de Medina, F S; Zweibaum, A; Donowitz, M 1999. Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of caco-2 cells. The American journal of physiology, 277 2 Pt 1, G292-305

Wasicko, M J; Sterni, L M; Bamford, O S; Montrose, M H; Carroll, J L 1999. Resetting and postnatal maturation of oxygen chemosensitivity in rat carotid chemoreceptor cells. The Journal of physiology, 514 ( Pt 2) , 493-503

Janecki, A J; Montrose, M H; Zimniak, P; Zweibaum, A; Tse, C M; Khurana, S; Donowitz, M 1998. Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. The Journal of biological chemistry, 273 15, 8790-8

Montrose, M H 1998. Imaging drug therapy and pH in gastrointestinal tissue with confocal and two-photon microscopy. Scanning, 20 3, 148-9

Yang, H; Egan, J M; Wang, Y; Moyes, C D; Roth, J; Montrose, M H; Montrose-Rafizadeh, C 1998. GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. The American journal of physiology, 275 3 Pt 1, C675-83

Chen, Q; Benson, R S; Whetton, A D; Brant, S R; Donowitz, M; Montrose, M H; Dive, C; Watson, A J 1997. Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase. Journal of cell science, 110 ( Pt 3) , 379-87

Chu, S; Montrose, M H 1997. Transepithelial SCFA fluxes link intracellular and extracellular pH regulation of mouse colonocytes. Comparative biochemistry and physiology. Part A, Physiology, 118 2, 403-5

Montrose, M H 1997. Multiple targets for endothelin-1 in human intestine. The Journal of physiology, 499 ( Pt 2) , 289

Montrose, M H; Chu, S 1997. Transepithelial SCFA gradients regulate polarized Na/H exchangers and pH microdomains in colonic epithelia. Comparative biochemistry and physiology. Part A, Physiology, 118 2, 389-93

Montrose-Rafizadeh, C; Kole, J; Bartkowski, L M; Lee, L H; Blackmon, D L; Behnken, S E; Gearhart, J D; Cohn, J A; Montrose, M H 1997. Gene targeting of a CFTR allele in HT29 human epithelial cells. Journal of cellular physiology, 170 3, 299-308

Montrose-Rafizadeh, C; Yang, H; Wang, Y; Roth, J; Montrose, M H; Adams, L G 1997. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. Journal of cellular physiology, 172 3, 275-83

Saidi, R F; Jaeger, K; Montrose, M H; Wu, S; Sears, C L 1997. Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content. Cell motility and the cytoskeleton, 37 2, 159-65

Carroll, J L; Sterni, L M; Bamford, O S; Montrose, M H 1996. Mechanisms of carotid chemoreceptor resetting after birth. In vitro studies. Advances in experimental medicine and biology, 410 , 73-7

Chu, S; Montrose, M H 1996. Non-ionic diffusion and carrier-mediated transport drive extracellullar pH regulation of mouse colonic crypts. The Journal of physiology, 494 ( Pt 3) , 783-93

Koshy, S S; Montrose, M H; Sears, C L 1996. Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis. Infection and immunity, 64 12, 5022-8

Nath, S K; Hang, C Y; Levine, S A; Yun, C H; Montrose, M H; Donowitz, M; Tse, C M 1996. Hyperosmolarity inhibits the Na+/H+ exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1. The American journal of physiology, 270 3 Pt 1, G431-41

Ubol, S; Park, S; Budihardjo, I; Desnoyers, S; Montrose, M H; Poirier, G G; Kaufmann, S H; Griffin, D E 1996. Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells. Journal of virology, 70 4, 2215-20

Chu, S; Brownell, W E; Montrose, M H 1995. Quantitative confocal imaging along the crypt-to-surface axis of colonic crypts. The American journal of physiology, 269 6 Pt 1, C1557-64

Chu, S; Montrose, M H 1995. An Na(+)-independent short-chain fatty acid transporter contributes to intracellular pH regulation in murine colonocytes. The Journal of general physiology, 105 5, 589-615

Chu, S; Montrose, M H 1995. Extracellular pH regulation in microdomains of colonic crypts: effects of short-chain fatty acids. Proceedings of the National Academy of Sciences of the United States of America, 92 8, 3303-7

Fine, D M; Lo, C F; Aguillar, L; Blackmon, D L; Montrose, M H 1995. Cellular chloride depletion inhibits cAMP-activated electrogenic chloride fluxes in HT29-18-C1 cells. The Journal of membrane biology, 145 2, 129-41

Sterni, L M; Bamford, O S; Tomares, S M; Montrose, M H; Carroll, J L 1995. Developmental changes in intracellular Ca2+ response of carotid chemoreceptor cells to hypoxia. The American journal of physiology, 268 5 Pt 1, L801-8

Rowe, W A; Lesho, M J; Montrose, M H 1994. Polarized Na+/H+ exchange function is pliable in response to transepithelial gradients of propionate. Proceedings of the National Academy of Sciences of the United States of America, 91 13, 6166-70

Sterni, L M; Montrose, M H; Bamford, O S; Tomares, S M; Carroll, J L 1994. Intracellular calcium responses to hypoxia and cyanide in cultured type I cells from newborn and adult rabbits. Advances in experimental medicine and biology, 360 , 325-8

Watson, A J; Montrose, M H 1994. Rapid computerized analysis of Na+/H+ exchange flux. Biochimica et biophysica acta, 1193 2, 316-22

Bagnasco, S M; Montrose, M H; Handler, J S 1993. Role of calcium in organic osmolyte efflux when MDCK cells are shifted from hypertonic to isotonic medium. The American journal of physiology, 264 5 Pt 1, C1165-70

Levine, S A; Montrose, M H; Tse, C M; Donowitz, M 1993. Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line. The Journal of biological chemistry, 268 34, 25527-35

Rowe, W A; Blackmon, D L; Montrose, M H 1993. Propionate activates multiple ion transport mechanisms in the HT29-18-C1 human colon cell line. The American journal of physiology, 265 3 Pt 1, G564-71

Tse, C M; Levine, S A; Yun, C H; Brant, S R; Pouyssegur, J; Montrose, M H; Donowitz, M 1993. Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C. Proceedings of the National Academy of Sciences of the United States of America, 90 19, 9110-4

Tse, C M; Levine, S A; Yun, C H; Montrose, M H; Little, P J; Pouyssegur, J; Donowitz, M 1993. Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). The Journal of biological chemistry, 268 16, 11917-24

Blackmon, D L; Watson, A J; Montrose, M H 1992. Assay of apical membrane enzymes based on fluorogenic substrates. Analytical biochemistry, 200 2, 352-8

Watson, A J; Levine, S; Donowitz, M; Montrose, M H 1992. Serum regulates Na+/H+ exchange in Caco-2 cells by a mechanism which is dependent on F-actin. The Journal of biological chemistry, 267 2, 956-62

Zeitlin, P L; Crawford, I; Lu, L; Woel, S; Cohen, M E; Donowitz, M; Montrose, M H; Hamosh, A; Cutting, G R; Gruenert, D 1992. CFTR protein expression in primary and cultured epithelia. Proceedings of the National Academy of Sciences of the United States of America, 89 1, 344-7

Zimolo, Z; Montrose, M H; Murer, H 1992. H+ extrusion by an apical vacuolar-type H(+)-ATPase in rat renal proximal tubules. The Journal of membrane biology, 126 1, 19-26

Casavola, V; Helmle-Kolb, C; Montrose, M H; Murer, H 1991. Polarized expression of Na+/H+ exchange activities in clonal LLC-PK1 cells (Clone4 and PKE20) I. Basic characterization. Pflügers Archiv : European journal of physiology, 418 3, 276-83

Krayer-Pawlowska, D; Helmle-Kolb, C; Montrose, M H; Krapf, R; Murer, H 1991. Studies on the kinetics of Na+/H+ exchange in OK cells: introduction of a new device for the analysis of polarized transport in cultured epithelia. The Journal of membrane biology, 120 2, 173-83

Montrose-Rafizadeh, C; Guggino, W B; Montrose, M H 1991. Cellular differentiation regulates expression of Cl- transport and cystic fibrosis transmembrane conductance regulator mRNA in human intestinal cells. The Journal of biological chemistry, 266 7, 4495-9

Tse, C M; Ma, A I; Yang, V W; Watson, A J; Levine, S; Montrose, M H; Potter, J; Sardet, C; Pouyssegur, J; Donowitz, M 1991. Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger. The EMBO journal, 10 8, 1957-67

Watson, A J; Levine, S; Donowitz, M; Montrose, M H 1991. Kinetics and regulation of a polarized Na(+)-H+ exchanger from Caco-2 cells, a human intestinal cell line. The American journal of physiology, 261 2 Pt 1, G229-38

Helmle-Kolb, C; Montrose, M H; Murer, H 1990. Parathyroid hormone regulation of Na+/H+ exchange in opossum kidney cells: polarity and mechanisms. Pflügers Archiv : European journal of physiology, 416 6, 615-23

Helmle-Kolb, C; Montrose, M H; Stange, G; Murer, H 1990. Regulation of Na+/H+ exchange in opossum kidney cells by parathyroid hormone, cyclic AMP and phorbol esters. Pflügers Archiv : European journal of physiology, 415 4, 461-70

Montrose, M H; Murer, H 1990. Regulation of intracellular pH by cultured opossum kidney cells. The American journal of physiology, 259 1 Pt 1, C110-20

Montrose, M H; Murer, H 1990. Polarity and kinetics of Na(+)-H+ exchange in cultured opossum kidney cells. The American journal of physiology, 259 1 Pt 1, C121-33

Knoblauch, C; Montrose, M H; Murer, H 1989. Regulatory volume decrease by cultured renal cells. The American journal of physiology, 256 2 Pt 1, C252-9

Montrose, M H; Condrau, M A; Murer, H 1989. Flow cytometric analysis of intracellular pH in cultured opossum kidney (OK) cells. The Journal of membrane biology, 108 1, 31-43

Montrose, M H; Knoblauch, C; Murer, H 1988. Separate control of regulatory volume increase and Na+-H+ exchange by cultured renal cells. The American journal of physiology, 255 1 Pt 1, C76-85

Montrose, M H; Lester, R; Zimniak, P; Anwer, M S; Murer, H 1988. Bile acids increase cellular free calcium in cultured kidney cells (LLC-PK). Pflügers Archiv : European journal of physiology, 412 1-2, 164-71

Moran, A; Montrose, M H; Murer, H 1988. Regulation of Na+-H+ exchange in cultured opossum kidney cells by parathyroid hormone, atrial natriuretic peptide and cyclic nucleotides. Biochimica et biophysica acta, 969 1, 48-56

Montrose, M H; Friedrich, T; Murer, H 1987. Measurements of intracellular pH in single LLC-PK1 cells: recovery from an acid load via basolateral Na+/H+ exchange. The Journal of membrane biology, 97 1, 63-78

Montrose, M H; Kimmich, G A 1986. Quantitative use of weak bases for estimation of cellular pH gradients. The American journal of physiology, 250 3 Pt 1, C418-22

Montrose, M H; Murer, H 1986. Regulation of intracellular pH in LLC-PK1 cells by Na+/H+ exchange. The Journal of membrane biology, 93 1, 33-42

Montrose, M H; Bebernitz, G; Kimmich, G A 1985. Evaluation of ion gradient-dependent H+ transport systems in isolated enterocytes from the chick. The Journal of membrane biology, 88 1, 55-66

Montrose, M H; Kimmich, G A 1985. Relative rates of Na+-H+ and Cl(-)-OH- exchange reactions in isolated intestinal cells. Annals of the New York Academy of Sciences, 456 , 232-4