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Department of

Pharmacology & Systems Physiology 

Photo of  Mohammed Matlib, PhD

Mohammed Matlib, PhD

Education/Credentials
  • Ph.D.: University of Strathclyde
  • M.Sc.: Dacca University
  • B.Sc.: Dacca University
  • I.Sc.: Murari Chand College

Contact Information

Peer Reviewed Publications

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Hollie, Norris I; Cash, James G; Matlib, M Abdul; Wortman, Matthew; Basford, Joshua E; Abplanalp, William; Hui, David Y 2013. Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function. Biochimica et biophysica acta, ,

Gerber, Lamar K; Aronow, Bruce J; Matlib, Mohammed A 2006. Activation of a novel long-chain free fatty acid generation and export system in mitochondria of diabetic rat hearts. American journal of physiology. Cell physiology, 291 6, C1198-207

Zhong, Yan; Reiser, Peter J; Matlib, Mohammed A 2003. Gender differences in myosin heavy chain-beta and phosphorylated phospholamban in diabetic rat hearts. American journal of physiology. Heart and circulatory physiology, 285 6, H2688-93

Choi, Kin M; Zhong, Yan; Hoit, Brian D; Grupp, Ingrid L; Hahn, Harvey; Dilly, Keith W; Guatimosim, Silvia; Lederer, W Jonathan; Matlib, Mohammed A 2002. Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats. American journal of physiology. Heart and circulatory physiology, 283 4, H1398-408

Sánchez, J A; García, M C; Sharma, V K; Young, K C; Matlib, M A; Sheu, S S 2001. Mitochondria regulate inactivation of L-type Ca2+ channels in rat heart. The Journal of physiology, 536 Pt 2, 387-96

Zhong, Y; Ahmed, S; Grupp, I L; Matlib, M A 2001. Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts. American journal of physiology. Heart and circulatory physiology, 281 3, H1137-47

Hoit, B D; Castro, C; Bultron, G; Knight, S; Matlib, M A 1999. Noninvasive evaluation of cardiac dysfunction by echocardiography in streptozotocin-induced diabetic rats. Journal of cardiac failure, 5 4, 324-33

Spindler, M; Saupe, K W; Tian, R; Ahmed, S; Matlib, M A; Ingwall, J S 1999. Altered creatine kinase enzyme kinetics in diabetic cardiomyopathy. A(31)P NMR magnetization transfer study of the intact beating rat heart. Journal of molecular and cellular cardiology, 31 12, 2175-89

Matlib, M A; Zhou, Z; Knight, S; Ahmed, S; Choi, K M; Krause-Bauer, J; Phillips, R; Altschuld, R; Katsube, Y; Sperelakis, N; Bers, D M 1998. Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes. The Journal of biological chemistry, 273 17, 10223-31

Zhou, Z; Matlib, M A; Bers, D M 1998. Cytosolic and mitochondrial Ca2+ signals in patch clamped mammalian ventricular myocytes. The Journal of physiology, 507 ( Pt 2) , 379-403

Chu, G; Luo, W; Slack, J P; Tilgmann, C; Sweet, W E; Spindler, M; Saupe, K W; Boivin, G P; Moravec, C S; Matlib, M A; Grupp, I L; Ingwall, J S; Kranias, E G 1996. Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts. Circulation research, 79 6, 1064-76

Dhar, ; Grupp, ; Schwartz, ; Grupp, ; Matlib, 1996. Reduction of Carnitine Content by Inhibition of Its Biosynthesis Results in Protection of Isolated Guinea Pig Hearts Against Hypoxic Damage. Journal of cardiovascular pharmacology and therapeutics, 1 3, 235-242

Flarsheim, C E; Grupp, I L; Matlib, M A 1996. Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart. The American journal of physiology, 271 1 Pt 2, H192-202

Cox, D A; Conforti, L; Sperelakis, N; Matlib, M A 1993. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. Journal of cardiovascular pharmacology, 21 4, 595-9

Cox, D A; Matlib, M A 1993. Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na(+)-Ca2+ exchange. Trends in pharmacological sciences, 14 11, 408-13

Cox, D A; Matlib, M A 1993. A role for the mitochondrial Na(+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. The Journal of biological chemistry, 268 2, 938-47

Motley, E D; Paul, R J; Matlib, M A 1993. Role of Na(+)-Ca2+ exchange in the regulation of vascular smooth muscle tension. The American journal of physiology, 264 4 Pt 2, H1028-40

Cox, D A; Ellinor, P T; Kirley, T L; Matlib, M A 1991. Identification of a 17-kDa protein associated with the peripheral-type benzodiazepine receptor in vascular and other smooth muscle types. The Journal of pharmacology and experimental therapeutics, 258 2, 702-9

Matlib, M A 1991. Role of sarcolemmal membrane sodium-calcium exchange in vascular smooth muscle tension. Annals of the New York Academy of Sciences, 639 , 531-42

Matlib, M A; McFarland, K L 1991. Diltiazem inhibition of sodium-induced calcium release. Effects on energy metabolism of heart mitochondria. American journal of hypertension, 4 7 Pt 2, 435S-441S

Dunlap, E D; Matlib, M A; Millard, R W 1989. Protection of regional mechanics and mitochondrial oxidative phosphorylation by amlodipine in transiently ischemic myocardium. The American journal of cardiology, 64 17, 84I-91I; discussion

French, J F; Rapoport, R M; Matlib, M A 1989. Possible mechanism of benzodiazepine-induced relaxation of vascular smooth muscle. Journal of cardiovascular pharmacology, 14 3, 405-11

Matlib, M A 1989. Relaxation of potassium chloride-induced contractions by amlodipine and its interaction with the 1,4-dihydropyridine-binding site in pig coronary artery. The American journal of cardiology, 64 17, 51I-57I

Balasubramaniam, A; Grupp, I; Matlib, M A; Benza, R; Jackson, R L; Fischer, J E; Grupp, G 1988. Comparison of the effects of neuropeptide Y (NPY) and 4-norleucine-NPY on isolated perfused rat hearts; effects of NPY on atrial and ventricular strips of rat heart and on rabbit heart mitochondria. Regulatory peptides, 21 3-4, 289-99

French, J F; Matlib, M A 1988. Identification of a high-affinity peripheral-type benzodiazepine binding site in rat aortic smooth muscle membranes. The Journal of pharmacology and experimental therapeutics, 247 1, 23-8

Matlib, M A 1988. Na+-Ca2+ exchange in sarcolemmal membrane vesicles of dog mesenteric artery. The American journal of physiology, 255 3 Pt 1, C323-30

Matlib, M A 1988. On the existence of a Na+-Ca2+ exchange system in the cell membrane of vascular smooth muscle. Journal of cardiovascular pharmacology, 12 Suppl 6 , S60-2

Matlib, M A; French, J F; Grupp, I L; Van Gorp, C; Grupp, G; Schwartz, A 1988. Vasodilatory action of amlodipine on rat aorta, pig coronary artery, human coronary artery, and on isolated Langendorff rat heart preparations. Journal of cardiovascular pharmacology, 12 Suppl 7 , S50-4

Matlib, M A; Kihara, M; Farrell, C; Dage, R C 1988. The Na+-Ca2+ exchange system in vascular smooth muscle cell membrane vesicles isolated from cultured cells and from tissue is similar. Biochimica et biophysica acta, 939 1, 173-7

Grupp, I L; French, J F; Matlib, M A 1987. Benzodiazepine Ro 5-4864 increases coronary flow. European journal of pharmacology, 143 1, 143-7

Matlib, M A; Reeves, J P 1987. Solubilization and reconstitution of the sarcolemmal Na+-Ca2+ exchange system of vascular smooth muscle. Biochimica et biophysica acta, 904 1, 145-8

Matlib, M A; Whitmer, K R; MacCarthy, E P; Ooi, B S 1986. Sodium-calcium exchange exists across the cell membrane of intact vascular smooth muscle cells. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 4 5, S222-3

Matlib, M A 1985. Action of bepridil, a new calcium channel blocker on oxidative phosphorylation, oligomycin-sensitive adenosine triphosphatase activity, swelling, Ca++ uptake and Na+-induced Ca++ release processes of rabbit heart mitochondria in vitro. The Journal of pharmacology and experimental therapeutics, 233 2, 376-81

Matlib, M A; Doane, J D; Sperelakis, N; Riccippo-Neto, F 1985. Clonazepam and diltiazem both inhibit sodium-calcium exchange of mitochondria, but only diltiazem inhibits the slow action potentials of cardiac muscles. Biochemical and biophysical research communications, 128 1, 290-6

Matlib, M A; Dubé, G P; Millard, R W; Lathrop, D A; Baik, Y H; Sakai, K; DiSalvo, J; Schwartz, A 1985. Studies on the mode of action of isosorbide dinitrate: a physiologic and biochemical approach. American heart journal, 110 1 Pt 2, 204-12

Matlib, M A; Schwartz, A; Yamori, Y 1985. A Na+-Ca2+ exchange process in isolated sarcolemmal membranes of mesenteric arteries from WKY and SHR rats. The American journal of physiology, 249 1 Pt 1, C166-72

Schwartz, A; Matlib, M A; Balwierczak, J; Lathrop, D A 1985. Pharmacology of calcium antagonists. The American journal of cardiology, 55 7, 3C-7C

Schwartz, A; Wallick, E T; Lee, S W; Wang, T; Hosakawa, T; Whitmer, K R; Matlib, M A 1984. Studies on the mechanism of action of 3, 4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-qu inolinone (OPC-8212), a new positive inotropic drug. Enzyme activities and Ca2+ transport processes of sarcolemma and intracellular organelles. Arzneimittel-Forschung, 34 3A, 384-9

DePover, A; Lee, S W; Matlib, M A; Whitmer, K; Davis, B A; Powell, T; Schwartz, A 1983. [3H]nimodipine specific binding to cardiac myocytes and subcellular fractions. Biochemical and biophysical research communications, 113 1, 185-91

Matlib, M A; Lee, S W; Depover, A; Schwartz, A 1983. A specific inhibitory action of certain benzothiazepines and benzodiazepines on the sodium-calcium exchange process of heart and brain mitochondria. European journal of pharmacology, 89 3-4, 327-8

Matlib, M A; Rembert, J C; Millard, R W; Ashraf, M; Rouslin, W; Asano, G; Greenfield, J C; Schwartz, A 1983. Mitochondrial function in canine experimental cardiac hypertrophy. Journal of molecular and cellular cardiology, 15 4, 221-32

Matlib, M A; Schwartz, A 1983. Selective effects of diltiazem, a benzothiazepine calcium channel blocker, and diazepam, and other benzodiazepines on the Na+/Ca2+ exchange carrier system of heart and brain mitochondria. Life sciences, 32 25, 2837-42

Matlib, M A; Vaghy, P L; Epps, D E; Schwartz, A 1983. Actions of certain calcium channel blockers and calmodulin antagonists on inorganic phosphate-induced swelling and inhibition of oxidative phosphorylation of heart mitochondria. Biochemical pharmacology, 32 17, 2622-5

DePover, A; Matlib, M A; Lee, S W; Dubé, G P; Grupp, I L; Grupp, G; Schwartz, A 1982. Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem. Biochemical and biophysical research communications, 108 1, 110-7

Vághy, P L; Johnson, J D; Matlib, M A; Wang, T; Schwartz, A 1982. Selective inhibition of Na+-induced Ca2+ release from heart mitochondria by diltiazem and certain other Ca2+ antagonist drugs. The Journal of biological chemistry, 257 11, 6000-2

Matlib, M A; Rebman, D; Ashraf, M; Rouslin, W; Schwartz, A 1981. Differential activities of putative subsarcolemmal and interfibrillar mitochondria from cardiac muscle. Journal of molecular and cellular cardiology, 13 2, 163-70

Vághy, P L; Matlib, M A; Schwartz, A 1981. Phosphate induced swelling, inhibition and partial uncoupling of oxidative phosphorylation in heart mitochondria in the absence of external calcium and the presence of EGTA. Biochemical and biophysical research communications, 100 1, 37-44

Vághy, P L; Matlib, M A; Szekeres, L; Schwartz, A 1981. Protective effects on verapamil and diltiazem against inorganic phosphate induced impairment of oxidative phosphorylation of isolated heart mitochondria. Biochemical pharmacology, 30 18, 2603-10

Grupp, G; Grupp, I L; Johnson, C L; Matlib, M A; Rouslin, W; Schwartz, A; Wallick, E T; Wang, T; Wisler, P 1980. Effects of RMI 12330A, a new inhibitor of adenylate cyclase on myocardial function and subcellular activity. British journal of pharmacology, 70 3, 429-42

Nagao, T; Matlib, M A; Franklin, D; Millard, R W; Schwartz, A 1980. Effects of diltiazem, a calcium antagonist, on regional myocardial function and mitochondria after brief coronary occlusion. Journal of molecular and cellular cardiology, 12 1, 29-43

Matlib, M A; Crankshaw, J; Garfield, R E; Crankshaw, D J; Kwan, C Y; Branda, L Q; Daniel, E E 1979. Characterization of membrane fractions and isolation of purified plasma membranes from rat myometrium. The Journal of biological chemistry, 254 6, 1834-40

Matlib, M A; Frenkel, E P; Mukherjee, A; Henslee, J; Srere, P A 1979. Enzymatic properties of mitochondria isolated from normal and vitamin B12-deficient rats. Archives of biochemistry and biophysics, 197 2, 388-95

Matlib, M A; Shannon, W A; Srere, P A 1979. Measurement of matrix enzyme activity in situ in isolated mitochondria made permeable with toluene. Methods in enzymology, 56 , 544-50

Rouslin, W; Cubicciotti, R S; Edwards, W D; Matlib, M A; Wilson, D R; Hamrell, B B; Schwartz, A 1979. Phosphorylative respiratory activity of mitochondria isolated from the left and right ventricles of rabbit hearts following partial pulmonary trunk occlusion. Journal of molecular and cellular cardiology, 11 1, 91-9

Crankshaw, D J; Branda, L A; Matlib, M A; Daniel, E E 1978. Localization of the oxytocin receptor in the plasma membrane of rat myometrium. European journal of biochemistry / FEBS, 86 2, 481-6

Matlib, M A; Boesman-Finkelstein, M; Srere, P A 1978. The kinetics of rat liver citrate synthase in situ. Archives of biochemistry and biophysics, 191 2, 426-30

Matlib, M A; Rouslin, W; Kraft, G; Berner, P; Schwartz, A 1978. On the existence of two populations of mitochondria in a single organ. Respiration, calcium transport and enzyme activities. Biochemical and biophysical research communications, 84 2, 482-8

Matlib, M A; Shannon, W A; Srere, P A 1977. Measurement of matrix enzyme activity in isolated mitochondria made permeable with toluene. Archives of biochemistry and biophysics, 178 2, 396-407

Matlib, M A; O'Brien, P J 1976. Properties of rat liver mitochondria with intermembrane Cytochrome c. Archives of biochemistry and biophysics, 173 1, 27-33

Matlib, M A; Srere, P A 1976. Oxidative properties of swollen rat liver mitochondria. Archives of biochemistry and biophysics, 174 2, 705-12

Matlib, M A; O'Brien, P J 1975. Compartmentation of enzymes in the rat liver mitochondrial matrix. Archives of biochemistry and biophysics, 167 1, 193-202

Ngai, J H; Matlib, M A; Millard, R W . Contractile performance, mitochondrial function and blood flow distribution in porcine heart with induced coronary collateral circulation. Basic research in cardiology, 78 1, 62-76

Solaro, R J; Holroyde, M J; Wang, T; Matlib, M A; Grupp, I; Grupp, G; Schwartz, A . Effects of vanadate on biochemical and contractile properties of rabbit hearts. Journal of cardiovascular pharmacology, 2 4, 445-52