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Department of

Pharmacology & Systems Physiology 

Photo of  Litsa Kranias, PhD

Litsa Kranias, PhD

Hanna Professor Distinguished University Research Professor Director of Cardiovascular Biology Co-Director Cardiovascular Center of Excellence

Education/Credentials
  • MS: Northwestern University
  • PhD: Northwestern University
  • BA: University of Chicago
  • Secondary Education: Anatolia College

Contact Information
  • Cardiovacular Center
  • Room CVC 5960
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0575
  • Office 513-558-2377
  • Email Litsa.Kranias@uc.edu

Peer Reviewed Publications

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Bidwell, Philip A; Haghighi, Kobra; Kranias, Evangelia G 2018. The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart. The Journal of biological chemistry, 293 1, 359-367

Bidwell, Philip A; Liu, Guan-Sheng; Nagarajan, Narayani; Lam, Chi Keung; Haghighi, Kobra; Gardner, George; Cai, Wen-Feng; Zhao, Wen; Mugge, Luke; Vafiadaki, Elizabeth; Sanoudou, Despina; Rubinstein, Jack; Lebeche, Djamel; Hajjar, Roger; Sadoshima, Junichi; Kranias, Evangelia G 2018. HAX-1 regulates SERCA2a oxidation and degradation. Journal of molecular and cellular cardiology, 114 , 220-233

Liu, Guan-Sheng; Gardner, George; Adly, George; Jiang, Min; Cai, Wen-Feng; Lam, Chi Keung; Alogaili, Fawzi; Robbins, Nathan; Rubinstein, Jack; Kranias, Evangelia G 2018. A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. Journal of cellular and molecular medicine, ,

Liu, Guan-Sheng; Zhu, Hongyan; Cai, Wen-Feng; Wang, Xiaohong; Jiang, Min; Essandoh, Kobina; Vafiadaki, Elizabeth; Haghighi, Kobra; Lam, Chi Keung; Gardner, George; Adly, George; Nicolaou, Persoulla; Sanoudou, Despina; Liang, Qiangrong; Rubinstein, Jack; Fan, Guo-Chang; Kranias, Evangelia G 2018. Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant. Autophagy, 14 1, 80-97

Kranias, Evangelia G; Hajjar, Roger J 2017. The Phospholamban Journey 4 Decades After Setting Out for Ithaka. Circulation research, 120 5, 781-783

Pollak, Adam J; Haghighi, Kobra; Kunduri, Swati; Arvanitis, Demetrios A; Bidwell, Philip A; Liu, Guan-Sheng; Singh, Vivek P; Gonzalez, David J; Sanoudou, Despina; Wiley, Sandra E; Dixon, Jack E; Kranias, Evangelia G 2017. Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America, 114 34, 9098-9103

Tzimas, Christos; Johnson, Daniel M; Santiago, Demetrio J; Vafiadaki, Elizabeth; Arvanitis, Demetrios A; Davos, Constantinos H; Varela, Aimilia; Athanasiadis, Nikolaos C; Dimitriou, Constantinos; Katsimpoulas, Michalis; Sonntag, Stephan; Kryzhanovska, Mariya; Shmerling, Doron; Lehnart, Stephan E; Sipido, Karin R; Kranias, Evangelia G; Sanoudou, Despina 2017. Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant. Cardiovascular research, 113 11, 1403-1417

Watanabe, Shin; Ishikawa, Kiyotake; Fish, Kenneth; Oh, Jae Gyun; Motloch, Lukas J; Kohlbrenner, Erik; Lee, Philyoung; Xie, Chaoqin; Lee, Ahyoung; Liang, Lifan; Kho, Changwon; Leonardson, Lauren; McIntyre, Maritza; Wilson, Scott; Samulski, R Jude; Kranias, Evangelia G; Weber, Thomas; Akar, Fadi G; Hajjar, Roger J 2017. Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. Journal of the American College of Cardiology, 70 14, 1744-1756

Bidwell, Philip A; Kranias, Evangelia G 2016. Calcium Uptake in Crude Tissue Preparation. Methods in molecular biology (Clifton, N.J.), 1377 , 161-70

Mazzocchi, G; Sommese, L; Palomeque, J; Felice, J I; Di Carlo, M N; Fainstein, D; Gonzalez, P; Contreras, P; Skapura, D; McCauley, M D; Lascano, E C; Negroni, J A; Kranias, E G; Wehrens, X H T; Valverde, C A; Mattiazzi, A 2016. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. The Journal of physiology, 594 11, 3005-30

Stillitano, Francesca; Turnbull, Irene C; Karakikes, Ioannis; Nonnenmacher, Mathieu; Backeris, Peter; Hulot, Jean-Sébastien; Kranias, Evangelia G; Hajjar, Roger J; Costa, Kevin D 2016. Genomic correction of familial cardiomyopathy in human engineered cardiac tissues. European heart journal, 37 43, 3282-3284

Bibli SI, Andreadou I, Chatziananstasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo X, Kremastinos D, Iliodromitis E, Papapetropoulos A: 2015. Cardioprotection by H2S engages a cGMP-dependent protein kinase/ phospholamban pathway Cardiovascular Resarch, 106 3, 432-42

Cai W, Florea S, Qian J, Zhao W, Pritchard T, Lam CK, Lu LJ, Deng J, Fan GC, Hajjar RJ, Kranias EG 2015. Micro-RNA765 targets protein phophatase inhibitor-1 and suppresses contractility in cardiomyocytes European Journal of Heart Failure, ,

Cai, Wen-Feng; Liu, Guan-Sheng; Lam, Chi Keung; Florea, Stela; Qian, Jiang; Zhao, Wen; Pritchard, Tracy; Haghighi, Kobra; Lebeche, Djamel; Lu, Long Jason; Deng, Jingyuan; Fan, Guo-Chang; Hajjar, Roger J; Kranias, Evangelia G 2015. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. European journal of heart failure, 17 8, 782-93

Haghighi, Kobra; Pritchard, Tracy J; Liu, Guan-Sheng; Singh, Vivek P; Bidwell, Philip; Lam, Chi Keung; Vafiadaki, Elizabeth; Das, Parthib; Ma, Jianyong; Kunduri, Swati; Sanoudou, Despina; Florea, Stela; Vanderbilt, Erica; Wang, Hong-Shang; Rubinstein, Jack; Hajjar, Roger J; Kranias, Evangelia G 2015. Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias. Journal of molecular and cellular cardiology, 89 Pt B, 349-59

Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Armoundas AA, Kaneki M, Kranias E, Bloch D, Bloch KD, Doulias PT, Ischiropoulos H, Stamler J, Ichinose F 2015. S-Nitrosylation of calcium-handling proteins in cardiac adrenergic signaling and hypertrophy Circ Res, 117 , 793-803

Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JM, Tsiapras D, Vink A, Asselbergs FW, Hulot JS, Kranias EG, Hajjar RJ 2015. Correction of the human phospholamban R14del mutation associated with dilated cardiomyopathy using targeted nucleases and combination therapy Nature Communications, 6 , 6955

Karakikes, Ioannis; Stillitano, Francesca; Nonnenmacher, Mathieu; Tzimas, Christos; Sanoudou, Despina; Termglinchan, Vittavat; Kong, Chi-Wing; Rushing, Stephanie; Hansen, Jens; Ceholski, Delaine; Kolokathis, Fotis; Kremastinos, Dimitrios; Katoulis, Alexandros; Ren, Lihuan; Cohen, Ninette; Gho, Johannes M I H; Tsiapras, Dimitrios; Vink, Aryan; Wu, Joseph C; Asselbergs, Folkert W; Li, Ronald A; Hulot, Jean-Sebastien; Kranias, Evangelia G; Hajjar, Roger J 2015. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nature communications, 6 , 6955

Lam CK, Zhao W, Liu G, Gardner G, Adly G, Kranias EG. 2015. HAX-1 Is a New Regulator of Cyclpophilin-D Levels in the Mitochondrial Permeability Transition Pore in the Heart , ,

Lam, Chi Keung; Zhao, Wen; Liu, Guan-Sheng; Cai, Wen-Feng; Gardner, George; Adly, George; Kranias, Evangelia G 2015. HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart. Proceedings of the National Academy of Sciences of the United States of America, 112 47, E6466-75

Liu B, Ho HT, Brunello L, Kim DH, Janssen PML, Knollmann BC, Kranias EG, Gyorke S 2015. Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT. Cardiov Res. , 108 2, 299-311

Liu, Bin; Ho, Hsiang-Ting; Brunello, Lucia; Unudurthi, Sathya D; Lou, Qing; Belevych, Andriy E; Qian, Lan; Kim, Do Han; Cho, Chunghee; Janssen, Paul M L; Hund, Thomas J; Knollmann, Bjorn C; Kranias, Evangelia G; Györke, Sándor 2015. Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT. Cardiovascular research, 108 2, 299-311

Liu, Guan-Sheng; Morales, Ana; Vafiadaki, Elizabeth; Lam, Chi Keung; Cai, Wen-Feng; Haghighi, Kobra; Adly, George; Hershberger, Ray E; Kranias, Evangelia G 2015. A Novel Human R25C-Phospholamban Mutation Is Associated with Superinhibition of Calcium Cycling and Ventricular Arrhythmia. Cardiovascular research, ,

Pritchard TJ, Haghighi K, Singh VP, Bidwell P, Liu GS, Lam CK, Vafiadaki E, Das P, Florea S, Vanderbilt E, Rubinstein J, Hajjar R, Kranias EG 2015. Human G109E-Inhibitor-1 Impairs Cardiac Function and Promotes Arrhythmias , ,

Tzimas, Christos; Terrovitis, John; Lehnart, Stephan E; Kranias, Evangelia G; Sanoudou, Despina 2015. CaMKII inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart rhythm : the official journal of the Heart Rhythm Society, ,

Haghighi, Kobra; Bidwell, Philip; Kranias, Evangelia G 2014. Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend. Journal of molecular and cellular cardiology, 77 , 160-7

Ishikawa, Kiyotake; Fish, Kenneth M; Tilemann, Lisa; Rapti, Kleopatra; Aguero, Jaume; Santos-Gallego, Carlos G; Lee, Ahyoung; Karakikes, Ioannis; Xie, Chaoqin; Akar, Fadi G; Shimada, Yuichi J; Gwathmey, Judith K; Asokan, Aravind; McPhee, Scott; Samulski, Jade; Samulski, Richard Jude; Sigg, Daniel C; Weber, Thomas; Kranias, Evangelia G; Hajjar, Roger J 2014. Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure. Molecular therapy : the journal of the American Society of Gene Therapy, 22 12, 2038-45

Mattiazzi, Alicia; Kranias, Evangelia G 2014. The role of CaMKII regulation of phospholamban activity in heart disease. Frontiers in pharmacology, 5 , 5

Rubinstein, Jack; Lasko, Valerie M; Koch, Sheryl E; Singh, Vivek P; Carreira, Vinicius; Robbins, Nathan; Patel, Amit R; Jiang, Min; Bidwell, Philip; Kranias, Evangelia G; Jones, W Keith; Lorenz, John N 2014. Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. American journal of physiology. Heart and circulatory physiology, 306 4, H574-84

Vafiadaki, Elizabeth; Arvanitis, Demetrios A; Papalouka, Vasiliki; Terzis, Gerasimos; Roumeliotis, Theodoros I; Spengos, Konstantinos; Garbis, Spiros D; Manta, Panagiota; Kranias, Evangelia G; Sanoudou, Despina 2014. Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation. The FEBS journal, 281 14, 3261-79

Fish, Kenneth M; Ladage, Dennis; Kawase, Yoshiaki; Karakikes, Ioannis; Jeong, Dongtak; Ly, Hung; Ishikawa, Kiyotake; Hadri, Lahouaria; Tilemann, Lisa; Muller-Ehmsen, Jochen; Samulski, R Jude; Kranias, Evangelia G; Hajjar, Roger J 2013. AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling. Circulation. Heart failure, 6 2, 310-7

Lam, Chi Keung; Zhao, Wen; Cai, Wenfeng; Vafiadaki, Elizabeth; Florea, Stela M; Ren, Xiaoping; Liu, Yong; Robbins, Nathan; Zhang, Zhiguo; Zhou, Xiaoyang; Jiang, Min; Rubinstein, Jack; Jones, W Keith; Kranias, Evangelia G 2013. Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90. Circulation research, 112 1, 79-89

Maiellaro-Rafferty, K; Wansapura, J P; Mendsaikhan, U; Osinska, H; James, J F; Taylor, M D; Robbins, J; Kranias, E G; Towbin, J A; Purevjav, E 2013. Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy. Journal of molecular and cellular cardiology, 60 , 151-60

Park, Chang Sik; Chen, Shan; Lee, Hoyong; Cha, Hyeseon; Oh, Jae Gyun; Hong, Sunghee; Han, Peidong; Ginsburg, Kenneth S; Jin, Sora; Park, Inju; Singh, Vivek P; Wang, Hong-Sheng; Franzini-Armstrong, Clara; Park, Woo Jin; Bers, Donald M; Kranias, Evangelia G; Cho, Chunghee; Kim, Do Han 2013. Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Basic research in cardiology, 108 3, 344

Pritchard, Tracy J; Kawase, Yoshiaki; Haghighi, Kobra; Anjak, Ahmad; Cai, Wenfeng; Jiang, Min; Nicolaou, Persoulla; Pylar, George; Karakikes, Ioannis; Rapti, Kleopatra; Rubinstein, Jack; Hajjar, Roger J; Kranias, Evangelia G 2013. Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts. PloS one, 8 12, e80717

Singh, Vivek P; Rubinstein, Jack; Arvanitis, Demetrios A; Ren, Xiaoping; Gao, Xiaoqian; Haghighi, Kobra; Gilbert, Mark; Iyer, Venkat R; Kim, Do Han; Cho, Chunghee; Jones, Keith; Lorenz, John N; Armstrong, Clara F; Wang, Hong-Sheng; Gyorke, Sandor; Kranias, Evangelia G 2013. Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. Journal of the American Heart Association, 2 5, e000460

Sivakumaran, Vidhya; Stanley, Brian A; Tocchetti, Carlo G; Ballin, Jeff D; Caceres, Viviane; Zhou, Lufang; Keceli, Gizem; Rainer, Peter P; Lee, Dong I; Huke, Sabine; Ziolo, Mark T; Kranias, Evangelia G; Toscano, John P; Wilson, Gerald M; O'Rourke, Brian; Kass, David A; Mahaney, James E; Paolocci, Nazareno 2013. HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxidants & redox signaling, 19 11, 1185-97

Vafiadaki, Elizabeth; Arvanitis, Demetrios A; Sanoudou, Despina; Kranias, Evangelia G 2013. Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation. PloS one, 8 11, e80867

Boncompagni, Simona; Thomas, Monique; Lopez, Jose R; Allen, Paul D; Yuan, Qunying; Kranias, Evangelia G; Franzini-Armstrong, Clara; Perez, Claudio F 2012. Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. PloS one, 7 7, e39962

Cai, Wen-Feng; Pritchard, Tracy; Florea, Stela; Lam, Chi-Kueng; Han, Peidong; Zhou, Xiaoyang; Yuan, Qunying; Lehnart, Stephan E; Allen, Paul D; Kranias, Evangelia G 2012. Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovascular research, 94 2, 333-41

Florea, Stela; Anjak, Ahmad; Cai, Wen-Feng; Qian, Jiang; Vafiadaki, Elizabeth; Figueria, Sarah; Haghighi, Kobra; Rubinstein, Jack; Lorenz, John; Kranias, Evangelia G 2012. Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging. Basic research in cardiology, 107 5, 279

Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G 2012. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of molecular and cellular cardiology, 52 3, 773-82

Kranias, Evangelia G; Hajjar, Roger J 2012. Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circulation research, 110 12, 1646-60

Park, Chang Sik; Cha, Hyeseon; Kwon, Eun Jeong; Jeong, Dongtak; Hajjar, Roger J; Kranias, Evangelia G; Cho, Chunghee; Park, Woo Jin; Kim, Do Han 2012. AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure. PloS one, 7 8, e43282

Sassi, Yassine; Abi-Gerges, Aniella; Fauconnier, Jeremy; Mougenot, Nathalie; Reiken, Steven; Haghighi, Kobra; Kranias, Evangelia G; Marks, Andrew R; Lacampagne, Alain; Engelhardt, Stefan; Hatem, Stephane N; Lompre, Anne-Marie; Hulot, Jean-Sébastien 2012. Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26 3, 1009-17

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Kranias, Evangelia G; Tang, Yaoliang; Peng, Tianqing; Chang, Jiang; Fan, Guo-Chang 2012. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PloS one, 7 3, e32765

Altschafl, Beth A; Arvanitis, Demetrios A; Fuentes, Oscar; Yuan, Qunying; Kranias, Evangelia G; Valdivia, Héctor H 2011. Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. The Journal of physiology, 589 Pt 24, 6063-80

Arvanitis, Demetrios A; Vafiadaki, Elizabeth; Sanoudou, Despina; Kranias, Evangelia G 2011. Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling. Journal of molecular and cellular cardiology, 50 1, 43-9

Fan, Guo-Chang; Kranias, Evangelia G 2011. Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. Journal of molecular and cellular cardiology, 51 4, 574-7

Gaffin, Robert D; Peña, James R; Alves, Marco S L; Dias, Fernando A L; Chowdhury, Shamim A K; Heinrich, Lynley S; Goldspink, Paul H; Kranias, Evangelia G; Wieczorek, David F; Wolska, Beata M 2011. Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein. Journal of molecular and cellular cardiology, 51 5, 812-20

Goonasekera, Sanjeewa A; Lam, Chi K; Millay, Douglas P; Sargent, Michelle A; Hajjar, Roger J; Kranias, Evangelia G; Molkentin, Jeffery D 2011. Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of clinical investigation, 121 3, 1044-52

Han, Peidong; Cai, Wenfeng; Wang, Yanru; Lam, Chi Keung; Arvanitis, Demetrios A; Singh, Vivek P; Chen, Shan; Zhang, Huiliang; Zhang, Rongli; Cheng, Heping; Kranias, Evangelia G 2011. Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression. American journal of physiology. Heart and circulatory physiology, 301 4, H1588-95

Mattiazzi, Alicia; Kranias, Evangelia G 2011. CaMKII regulation of phospholamban and SR Ca2+ load. Heart rhythm : the official journal of the Heart Rhythm Society, 8 5, 784-7

Qian, Jiang; Vafiadaki, Elizabeth; Florea, Stela M; Singh, Vivek P; Song, Weizhong; Lam, Chi Kung; Wang, Yigang; Yuan, Qunying; Pritchard, Tracy J; Cai, Wenfeng; Haghighi, Kobra; Rodriguez, Patricia; Wang, Hong-Sheng; Sanoudou, Despina; Fan, Guo-Chang; Kranias, Evangelia G 2011. Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circulation research, 108 12, 1429-38

Wang, Hong-Sheng; Arvanitis, Demetrios A; Dong, Min; Niklewski, Paul J; Zhao, Wen; Lam, Chi Keung; Kranias, Evangelia G; Sanoudou, Despina 2011. SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts. Physiological genomics, 43 7, 357-64

Chen, Guoli; Zhou, Xiaoyang; Florea, Stela; Qian, Jiang; Cai, Wenfeng; Zhang, Zhiguo; Fan, Guo-Chang; Lorenz, John; Hajjar, Roger J; Kranias, Evangelia G 2010. Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Basic research in cardiology, 105 5, 573-81

Hadri, Lahouaria; Bobe, Regis; Kawase, Yoshiaki; Ladage, Dennis; Ishikawa, Kiyotake; Atassi, Fabrice; Lebeche, Djamel; Kranias, Evangelia G; Leopold, Jane A; Lompré, Anne-Marie; Lipskaia, Larissa; Hajjar, Roger J 2010. SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Molecular therapy : the journal of the American Society of Gene Therapy, 18 7, 1284-92

Lompré, Anne-Marie; Hajjar, Roger J; Harding, Sian E; Kranias, Evangelia G; Lohse, Martin J; Marks, Andrew R 2010. Ca2+ cycling and new therapeutic approaches for heart failure. Circulation, 121 6, 822-30

Salas, Margarita A; Valverde, Carlos A; Sánchez, Gina; Said, Matilde; Rodriguez, Jesica S; Portiansky, Enrique L; Kaetzel, Marcia A; Dedman, John R; Donoso, Paulina; Kranias, Evangelia G; Mattiazzi, Alicia 2010. The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury. Journal of molecular and cellular cardiology, 48 6, 1298-306

Vafiadaki, Elizabeth; Arvanitis, Demetrios A; Kranias, Evangelia G; Sanoudou, Despina 2010. Pharmacogenetically tailored treatments for heart disease. Current pharmaceutical design, 16 20, 2194-213

Zhang, Tong; Guo, Tao; Mishra, Shikha; Dalton, Nancy D; Kranias, Evangelia G; Peterson, Kirk L; Bers, Donald M; Brown, Joan Heller 2010. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circulation research, 106 2, 354-62

Chen, Guoli; Zhou, Xiaoyang; Pathak, Anand; Dorn, Gerald W; Kranias, Evangelia G 2009. The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure. Cardiology, 112 3, 224-31

Diwan, Abhinav; Matkovich, Scot J; Yuan, Qunying; Zhao, Wen; Yatani, Atsuko; Brown, Joan Heller; Molkentin, Jeffery D; Kranias, Evangelia G; Dorn, Gerald W 2009. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. The Journal of clinical investigation, 119 1, 203-12

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping 2009. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation, 120 11 Suppl, S1-9

Liu, Qinghang; Chen, Xiongwen; Macdonnell, Scott M; Kranias, Evangelia G; Lorenz, John N; Leitges, Michael; Houser, Steven R; Molkentin, Jeffery D 2009. Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation research, 105 2, 194-200

Nicolaou, Persoulla; Hajjar, Roger J; Kranias, Evangelia G 2009. Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology. Journal of molecular and cellular cardiology, 47 3, 365-71

Nicolaou, Persoulla; Kranias, Evangelia G 2009. Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology. Frontiers in bioscience : a journal and virtual library, 14 , 3571-85

Nicolaou, Persoulla; Rodriguez, Patricia; Ren, Xiaoping; Zhou, Xiaoyang; Qian, Jiang; Sadayappan, Sakthivel; Mitton, Bryan; Pathak, Anand; Robbins, Jeffrey; Hajjar, Roger J; Jones, Keith; Kranias, Evangelia G 2009. Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circulation research, 104 8, 1012-20

Papalouka, Vasiliki; Arvanitis, Demetrios A; Vafiadaki, Elizabeth; Mavroidis, Manolis; Papadodima, Stavroula A; Spiliopoulou, Chara A; Kremastinos, Dimitrios T; Kranias, Evangelia G; Sanoudou, Despina 2009. Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. Molecular and cellular biology, 29 22, 6046-58

Pritchard, Tracy J; Kranias, Evangelia G 2009. Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis. The Journal of physiology, 587 Pt 13, 3125-33

Qian, Jiang; Ren, Xiaoping; Wang, Xiaohong; Zhang, Pengyuan; Jones, W Keith; Molkentin, Jeffery D; Fan, Guo-Chang; Kranias, Evangelia G 2009. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation research, 105 12, 1223-31

Vafiadaki, Elizabeth; Arvanitis, Demetrios A; Pagakis, Stamatis N; Papalouka, Vasiliki; Sanoudou, Despina; Kontrogianni-Konstantopoulos, Aikaterini; Kranias, Evangelia G 2009. The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival. Molecular biology of the cell, 20 1, 306-18

Vafiadaki, Elizabeth; Papalouka, Vasiliki; Arvanitis, Demetrios A; Kranias, Evangelia G; Sanoudou, Despina 2009. The role of SERCA2a/PLN complex, Ca(2+) homeostasis, and anti-apoptotic proteins in determining cell fate. Pflügers Archiv : European journal of physiology, 457 3, 687-700

Waggoner, Jason R; Ginsburg, Kenneth S; Mitton, Bryan; Haghighi, Kobra; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G 2009. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport. American journal of physiology. Heart and circulatory physiology, 296 3, H698-703

Wang, Xiaohong; Zhao, Tiemin; Huang, Wei; Wang, Tao; Qian, Jiang; Xu, Meifeng; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang 2009. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem cells (Dayton, Ohio), 27 12, 3021-31

Wang, Xiaohong; Zingarelli, Basilia; O 2009. Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation. Journal of molecular and cellular cardiology, 47 3, 382-90

Yuan, Qunying; Han, Peidong; Dong, Min; Ren, Xiaoping; Zhou, Xiaoyang; Chen, Shan; Jones, W Keith; Chu, Guoxiang; Wang, Hong-Sheng; Kranias, Evangelia G 2009. Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice. American journal of physiology. Heart and circulatory physiology, 296 5, H1484-90

Zhao, Wen; Fan, Guo-Chang; Zhang, Zhi-Guo; Bandyopadhyay, Arun; Zhou, Xiaoyang; Kranias, Evangelia G 2009. Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic research in cardiology, 104 4, 377-89

Zhao, Wen; Waggoner, Jason R; Zhang, Zhi-Guo; Lam, Chi Keung; Han, Peidong; Qian, Jiang; Schroder, Paul M; Mitton, Bryan; Kontrogianni-Konstantopoulos, Aikaterini; Robia, Seth L; Kranias, Evangelia G 2009. The anti-apoptotic protein HAX-1 is a regulator of cardiac function. Proceedings of the National Academy of Sciences of the United States of America, ,

Arvanitis, Demetrios A; Sanoudou, Despina; Kolokathis, Fotis; Vafiadaki, Elizabeth; Papalouka, Vasiliki; Kontrogianni-Konstantopoulos, Aikaterini; Theodorakis, George N; Paraskevaidis, Ioannis A; Adamopoulos, Stamatios; Dorn, Gerald W; Kremastinos, Dimitrios Th; Kranias, Evangelia G 2008. The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. European heart journal, 29 20, 2514-25

Chen, Guoli; Zhou, Xiaoyang; Nicolaou, Persoulla; Rodriguez, Patricia; Song, Guojie; Mitton, Bryan; Pathak, Anand; Zachariah, Amit; Fan, Guo-Chang; Dorn, Gerald W; Kranias, Evangelia G 2008. A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22 6, 1790-6

Fan, Guo-Chang; Yuan, Qunying; Kranias, Evangelia G 2008. Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function. Trends in cardiovascular medicine, 18 1, 1-5

Fan, Guo-Chang; Zhou, Xiaoyang; Wang, Xiaohong; Song, Guojie; Qian, Jiang; Nicolaou, Persoulla; Chen, Guoli; Ren, Xiaoping; Kranias, Evangelia G 2008. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circulation research, 103 11, 1270-9

Haghighi, Kobra; Chen, Guoli; Sato, Yoji; Fan, Guo-Chang; He, Suiwen; Kolokathis, Fotis; Pater, Luke; Paraskevaidis, Ioannis; Jones, W Keith; Dorn, Gerald W; Kremastinos, Dimitrios Th; Kranias, Evangelia G 2008. A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids. Human mutation, 29 5, 640-7

Nicolaou, Persoulla; Knöll, Ralph; Haghighi, Kobra; Fan, Guo-Chang; Dorn, Gerald W; Hasenfub, Gerd; Kranias, Evangelia G 2008. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. The Journal of biological chemistry, 283 48, 33465-71

Pattison, James Scott; Waggoner, Jason R; James, Jeanne; Martin, Lisa; Gulick, James; Osinska, Hanna; Klevitsky, Raisa; Kranias, Evangelia G; Robbins, Jeffrey 2008. Phospholamban overexpression in transgenic rabbits. Transgenic research, 17 2, 157-70

Zhang, Yin Hua; Zhang, Mei Hua; Sears, Claire E; Emanuel, Krzysztof; Redwood, Charles; El-Armouche, Ali; Kranias, Evangelia G; Casadei, Barbara 2008. Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice. Circulation research, 102 2, 242-9

Arvanitis, Demetrios A; Vafiadaki, Elizabeth; Fan, Guo-Chang; Mitton, Bryan A; Gregory, Kimberly N; Del Monte, Federica; Kontrogianni-Konstantopoulos, Aikaterini; Sanoudou, Despina; Kranias, Evangelia G 2007. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. American journal of physiology. Heart and circulatory physiology, 293 3, H1581-9

Fan, Guo-Chang; Yuan, Qunying; Zhao, Wen; Chu, Guoxiang; Kranias, Evangelia G 2007. Junctin is a prominent regulator of contractility in cardiomyocytes. Biochemical and biophysical research communications, 352 3, 617-22

Kranias, E G; Bers, D M 2007. Calcium and cardiomyopathies. Sub-cellular biochemistry, 45 , 523-37

Mohler, Peter J; Healy, Jane A; Xue, Hui; Puca, Annibale A; Kline, Crystal F; Allingham, R Rand; Kranias, Evangelia G; Rockman, Howard A; Bennett, Vann 2007. Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. PloS one, 2 10, e1051

Pathak, Anand; Baldwin, Brent; Kranias, Evangelia G 2007. Key protein alterations associated with hyperdynamic cardiac function: insights based on proteomic analysis of the protein phosphatase 1 inhibitor-1 overexpressing hearts. Hellenic journal of cardiology : HJC, 48 1, 30-6

Rodriguez, Patricia; Mitton, Bryan; Nicolaou, Persoulla; Chen, Guoli; Kranias, Evangelia G 2007. Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes. American journal of physiology. Heart and circulatory physiology, 293 1, H762-9

Vafiadaki, Elizabeth; Sanoudou, Despina; Arvanitis, Demetrios A; Catino, Dawn H; Kranias, Evangelia G; Kontrogianni-Konstantopoulos, Aikaterini 2007. Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function. Journal of molecular biology, 367 1, 65-79

Vila-Petroff, Martin; Salas, Margarita A; Said, Matilde; Valverde, Carlos A; Sapia, Luciana; Portiansky, Enrique; Hajjar, Roger J; Kranias, Evangelia G; Mundiña-Weilenmann, Cecilia; Mattiazzi, Alicia 2007. CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovascular research, 73 4, 689-98

Yuan, Qunying; Fan, Guo-Chang; Dong, Min; Altschafl, Beth; Diwan, Abhinav; Ren, Xiaoping; Hahn, Harvey H; Zhao, Wen; Waggoner, Jason R; Jones, Larry R; Jones, W Keith; Bers, Donald M; Dorn, Gerald W; Wang, Hong-Sheng; Valdivia, Héctor H; Chu, Guoxiang; Kranias, Evangelia G 2007. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation, 115 3, 300-9

Zhou, Xiaoyang; Fan, Guo-Chang; Ren, Xiaoping; Waggoner, Jason R; Gregory, Kimberly N; Chen, Guoli; Jones, W Keith; Kranias, Evangelia G 2007. Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury. Cardiovascular research, 75 3, 487-97

Chu, Guoxiang; Kranias, Evangelia G 2006. Phospholamban as a therapeutic modality in heart failure. Novartis Foundation symposium, 274 , 156-71; discussion 1

Fan, Guo-Chang; Yuan, Qunying; Song, Guojie; Wang, Yigang; Chen, Guoli; Qian, Jiang; Zhou, Xiaoyang; Lee, Yong J; Ashraf, Muhammad; Kranias, Evangelia G 2006. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circulation research, 99 11, 1233-42

Gramolini, Anthony O; Trivieri, Maria G; Oudit, Gavin Y; Kislinger, Thomas; Li, Wenping; Patel, Mikin M; Emili, Andrew; Kranias, Evangelia G; Backx, Peter H; Maclennan, David H 2006. Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America, 103 7, 2446-51

Gregory, Kimberly N; Ginsburg, Kenneth S; Bodi, Ilona; Hahn, Harvey; Marreez, Yehia M A; Song, Qiujing; Padmanabhan, Prabhu A; Mitton, Bryan A; Waggoner, Jason R; Del Monte, Federica; Park, Woo Jin; Dorn, Gerald W; Bers, Donald M; Kranias, Evangelia G 2006. Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function. Journal of molecular and cellular cardiology, 40 5, 653-65

Gregory, Kimberly N; Kranias, Evangelia G 2006. Targeting sarcoplasmic reticulum calcium handling proteins as therapy for cardiac disease. Hellenic journal of cardiology : HJC, 47 3, 132-43

Haghighi, Kobra; Kolokathis, Fotis; Gramolini, Anthony O; Waggoner, Jason R; Pater, Luke; Lynch, Roy A; Fan, Guo-Chang; Tsiapras, Dimitris; Parekh, Rohan R; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios Th; Kranias, Evangelia G 2006. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America, 103 5, 1388-93

Ji, Yong; Zhao, Wen; Li, Bailing; Desantiago, Jaime; Picht, Eckard; Kaetzel, Marcia A; Schultz, Jo El J; Kranias, Evangelia G; Bers, Donald M; Dedman, John R 2006. Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility. American journal of physiology. Heart and circulatory physiology, 290 2, H599-606

Mattiazzi, A; Mundiña-Weilenmann, C; Vittone, L; Said, M; Kranias, E G 2006. The importance of the Thr17 residue of phospholamban as a phosphorylation site under physiological and pathological conditions. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], 39 5, 563-72

McGraw, Dennis W; Fogel, Kevin M; Kong, Sue; Litonjua, Augusto A; Kranias, Evangelia G; Aronow, Bruce J; Liggett, Stephen B 2006. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological genomics, 27 2, 171-7

Rodriguez, Patricia; Mitton, Bryan; Waggoner, Jason R; Kranias, Evangelia G 2006. Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function. The Journal of biological chemistry, 281 50, 38599-608

Valverde, Carlos A; Mundiña-Weilenmann, Cecilia; Reyes, Mariano; Kranias, Evangelia G; Escobar, Ariel L; Mattiazzi, Alicia 2006. Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart. Cardiovascular research, 70 2, 335-45

Wu, Yuejin; Shintani, Ayumi; Grueter, Chad; Zhang, Rong; Hou, Yue; Yang, Jinying; Kranias, Evangelia G; Colbran, Roger J; Anderson, Mark E 2006. Suppression of dynamic Ca(2+) transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition. Journal of molecular and cellular cardiology, 40 2, 213-23

Zhao, Wen; Yuan, Qunying; Qian, Jiang; Waggoner, Jason R; Pathak, Anand; Chu, Guoxiang; Mitton, Bryan; Sun, Xiaoyin; Jin, Jay; Braz, Julian C; Hahn, Harvey S; Marreez, Yehia; Syed, Faisal; Pollesello, Piero; Annila, Arto; Wang, Hong-Sheng; Schultz, Jo El J; Molkentin, Jeffery D; Liggett, Stephen B; Dorn, Gerald W; Kranias, Evangelia G 2006. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation, 113 7, 995-1004

Fan, Guo-Chang; Chu, Guoxiang; Kranias, Evangelia G 2005. Hsp20 and its cardioprotection. Trends in cardiovascular medicine, 15 4, 138-41

Fan, Guo-Chang; Ren, Xiaoping; Qian, Jiang; Yuan, Qunying; Nicolaou, Persoulla; Wang, Yang; Jones, W Keith; Chu, Guoxiang; Kranias, Evangelia G 2005. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation, 111 14, 1792-9

Mundiña-Weilenmann, Cecilia; Ferrero, Paola; Said, Matilde; Vittone, Leticia; Kranias, Evangelia G; Mattiazzi, Alicia 2005. Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis. Cardiovascular research, 66 1, 114-22

Pathak, Anand; del Monte, Federica; Zhao, Wen; Schultz, Jo-El; Lorenz, John N; Bodi, Ilona; Weiser, Doug; Hahn, Harvey; Carr, Andrew N; Syed, Faisal; Mavila, Nirmala; Jha, Leena; Qian, Jiang; Marreez, Yehia; Chen, Guoli; McGraw, Dennis W; Heist, E Kevin; Guerrero, J Luis; DePaoli-Roach, Anna A; Hajjar, Roger J; Kranias, Evangelia G 2005. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circulation research, 96 7, 756-66

Rodriguez, P; Kranias, E G 2005. Phospholamban: a key determinant of cardiac function and dysfunction. Archives des maladies du coeur et des vaisseaux, 98 12, 1239-43

Rodriguez, Patricia; Mitton, Bryan; Kranias, Evangelia G 2005. Phosphorylation of glutathione-S-transferase by protein kinase C-alpha implications for affinity-tag purification. Biotechnology letters, 27 23-24, 1869-73

Waggoner, Jason R; Kranias, Evangelia G 2005. Role of phospholamban in the pathogenesis of heart failure. Heart failure clinics, 1 2, 207-18

Braz, Julian C; Gregory, Kimberly; Pathak, Anand; Zhao, Wen; Sahin, Bogachan; Klevitsky, Raisa; Kimball, Thomas F; Lorenz, John N; Nairn, Angus C; Liggett, Stephen B; Bodi, Ilona; Wang, Su; Schwartz, Arnold; Lakatta, Edward G; DePaoli-Roach, Anna A; Robbins, Jeffrey; Hewett, Timothy E; Bibb, James A; Westfall, Margaret V; Kranias, Evangelia G; Molkentin, Jeffery D 2004. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature medicine, 10 3, 248-54

Chu, Guoxiang; Egnaczyk, Gregory F; Zhao, Wen; Jo, Su-Hyun; Fan, Guo-Chang; Maggio, John E; Xiao, Rui-Ping; Kranias, Evangelia G 2004. Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20. Circulation research, 94 2, 184-93

Chu, Guoxiang; Kerr, Jaclyn P; Mitton, Bryan; Egnaczyk, Gregory F; Vazquez, Jenny A; Shen, Meilan; Kilby, Greg W; Stevenson, Tracy I; Maggio, John E; Vockley, Jerry; Rapundalo, Stephen T; Kranias, Evangelia G 2004. Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 14, 1725-7

Engelhardt, Stefan; Hein, Lutz; Dyachenkow, Vitaly; Kranias, Evangelia G; Isenberg, Gerrit; Lohse, Martin J 2004. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation, 109 9, 1154-60

Fan, Guo-Chang; Chu, Guoxiang; Mitton, Bryan; Song, Qiujing; Yuan, Qunying; Kranias, Evangelia G 2004. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circulation research, 94 11, 1474-82

Fan, Guo-Chang; Gregory, Kimberly N; Zhao, Wen; Park, Woo Jin; Kranias, Evangelia G 2004. Regulation of myocardial function by histidine-rich, calcium-binding protein. American journal of physiology. Heart and circulatory physiology, 287 4, H1705-11

Gregory, Kimberly N; Hahn, Harvey; Haghighi, Kobra; Marreez, Yehia; Odley, Amy; Dorn, Gerald W; Kranias, Evangelia G 2004. Increased particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury. Journal of molecular and cellular cardiology, 36 2, 313-8

Haghighi, Kobra; Gregory, Kimberly N; Kranias, Evangelia G 2004. Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy. Biochemical and biophysical research communications, 322 4, 1214-22

Janczewski, Andrzej M; Zahid, Maliha; Lemster, Bonnie H; Frye, Carol S; Gibson, Gregory; Higuchi, Yoshihiro; Kranias, Evangelia G; Feldman, Arthur M; McTiernan, Charles F 2004. Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model. Cardiovascular research, 62 3, 468-80

Pan, Yan; Kislinger, Thomas; Gramolini, Anthony O; Zvaritch, Elena; Kranias, Evangelia G; MacLennan, David H; Emili, Andrew 2004. Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics. Proceedings of the National Academy of Sciences of the United States of America, 101 8, 2241-6

Song, Qiujing; Young, Karen B; Chu, Guoxiang; Gulick, James; Gerst, Michael; Grupp, Ingrid L; Robbins, Jeffrey; Kranias, Evangelia G 2004. Overexpression of phospholamban in slow-twitch skeletal muscle is associated with depressed contractile function and muscle remodeling. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 9, 974-6

Sutliff, Roy L; Conforti, Laura; Weber, Craig S; Kranias, Evangelia G; Paul, Richard J 2004. Regulation of the spontaneous contractile activity of the portal vein by the sarcoplasmic reticulum: evidence from the phospholamban gene-ablated mouse. Vascular pharmacology, 41 6, 197-204

Szentesi, Peter; Pignier, Christophe; Egger, Marcel; Kranias, Evangelia G; Niggli, Ernst 2004. Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circulation research, 95 8, 807-13

Yatani, Atsuko; Kim, Song-Jung; Kudej, Raymond K; Wang, Qian; Depre, Christophe; Irie, Keiichi; Kranias, Evangelia G; Vatner, Stephen F; Vatner, Dorothy E 2004. Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals. American journal of physiology. Heart and circulatory physiology, 286 6, H2219-28

Zhao, Wen; Uehara, Yoshiki; Chu, Guoxiang; Song, Qiujing; Qian, Jiang; Young, Karen; Kranias, Evangelia G 2004. Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility. Journal of molecular and cellular cardiology, 37 2, 607-12

Brittsan, Angela G; Ginsburg, Kenneth S; Chu, Guoxiang; Yatani, Atsuko; Wolska, Beata M; Schmidt, Albrecht G; Asahi, Michio; MacLennan, David H; Bers, Donald M; Kranias, Evangelia G 2003. Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circulation research, 92 7, 769-76

Cross, Heather R; Kranias, Evangelia G; Murphy, Elizabeth; Steenbergen, Charles 2003. Ablation of PLB exacerbates ischemic injury to a lesser extent in female than male mice: protective role of NO. American journal of physiology. Heart and circulatory physiology, 284 2, H683-90

Dash, Rajesh; Schmidt, Albrecht G; Pathak, Anand; Gerst, Michael J; Biniakiewicz, Danuta; Kadambi, Vivek J; Hoit, Brian D; Abraham, William T; Kranias, Evangelia G 2003. Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Cardiovascular research, 57 3, 704-14

Haghighi, Kobra; Kolokathis, Fotis; Pater, Luke; Lynch, Roy A; Asahi, Michio; Gramolini, Anthony O; Fan, Guo-Chang; Tsiapras, Dimitris; Hahn, Harvey S; Adamopoulos, Stamatis; Liggett, Stephen B; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios T; Kranias, Evangelia G 2003. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of clinical investigation, 111 6, 869-76

Isoda, Takayoshi; Paolocci, Nazareno; Haghighi, Kobra; Wang, Congrong; Wang, Yibin; Georgakopoulos, Dimitrios; Servillo, Giuseppe; Della Fazia, Maria Agnese; Kranias, Evangelia G; Depaoli-Roach, Anna A; Sassone-Corsi, Paolo; Kass, David A 2003. Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator). The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17 2, 144-51

MacLennan, David H; Kranias, Evangelia G 2003. Phospholamban: a crucial regulator of cardiac contractility. Nature reviews. Molecular cell biology, 4 7, 566-77

Said, M; Vittone, L; Mundina-Weilenmann, C; Ferrero, P; Kranias, E G; Mattiazzi, A 2003. Role of dual-site phospholamban phosphorylation in the stunned heart: insights from phospholamban site-specific mutants. American journal of physiology. Heart and circulatory physiology, 285 3, H1198-205

Sato, Yoji; Schmidt, Albrecht G; Kiriazis, Helen; Hoit, Brian D; Kranias, Evangelia G 2003. Compensated hypertrophy of cardiac ventricles in aged transgenic FVB/N mice overexpressing calsequestrin. Molecular and cellular biochemistry, 242 1-2, 19-25

Schmidt, Albrecht G; Haghighi, Kobra; Frank, Beate; Pater, Luke; Dorn, Gerald W; Walsh, Richard A; Kranias, Evangelia G 2003. Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure. Journal of molecular and cellular cardiology, 35 7, 867-70

Schmitt, Joachim P; Kamisago, Mitsuhiro; Asahi, Michio; Li, Guo Hua; Ahmad, Ferhaan; Mende, Ulrike; Kranias, Evangelia G; MacLennan, David H; Seidman, J G; Seidman, Christine E 2003. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (New York, N.Y.), 299 5611, 1410-3

Song, Qiujing; Schmidt, Albrecht G; Hahn, Harvey S; Carr, Andrew N; Frank, Beate; Pater, Luke; Gerst, Mike; Young, Karen; Hoit, Brian D; McConnell, Bradley K; Haghighi, Kobra; Seidman, Christine E; Seidman, Jonathan G; Dorn, Gerald W; Kranias, Evangelia G 2003. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. The Journal of clinical investigation, 111 6, 859-67

Zhao, Wen; Frank, Konrad F; Chu, Guoxiang; Gerst, Michael J; Schmidt, Albrecht G; Ji, Yong; Periasamy, Muthu; Kranias, Evangelia G 2003. Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state. Cardiovascular research, 57 1, 71-81

Brixius, Klara; Savvidou-Zaroti, Persephone; Mehlhorn, Uwe; Bloch, Wilhelm; Kranias, Evangelia G; Schwinger, Robert H G 2002. Increased Ca2+-sensitivity of myofibrillar tension in heart failure and its functional implication. Basic research in cardiology, 97 Suppl 1 , I111-7

Carr, Andrew N; Kranias, Evangelia G 2002. Thyroid hormone regulation of calcium cycling proteins. Thyroid : official journal of the American Thyroid Association, 12 6, 453-7

Carr, Andrew N; Schmidt, Albrecht G; Suzuki, Yoichi; del Monte, Federica; Sato, Yoji; Lanner, Carita; Breeden, Kristine; Jing, Shao-Ling; Allen, Patrick B; Greengard, Paul; Yatani, Atsuko; Hoit, Brian D; Grupp, Ingrid L; Hajjar, Roger J; DePaoli-Roach, Anna A; Kranias, Evangelia G 2002. Type 1 phosphatase, a negative regulator of cardiac function. Molecular and cellular biology, 22 12, 4124-35

Chu, Guoxiang; Carr, Andrew N; Young, Karen B; Lester, J William; Yatani, Atsuko; Sanbe, Atsushi; Colbert, Melissa C; Schwartz, Steven M; Frank, Konrad F; Lampe, Paul D; Robbins, Jeffrey; Molkentin, Jeffery D; Kranias, Evangelia G 2002. Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure. Cardiovascular research, 54 1, 105-16

Chu, Guoxiang; Haghighi, Kobra; Kranias, Evangelia G 2002. From mouse to man: understanding heart failure through genetically altered mouse models. Journal of cardiac failure, 8 6 Suppl, S432-49

Chu, Guoxiang; Kranias, Evangelia G 2002. Functional interplay between dual site phospholambam phosphorylation: insights from genetically altered mouse models. Basic research in cardiology, 97 Suppl 1 , I43-8

Frank, Konrad F; Bölck, Birgit; Brixius, Klara; Kranias, Evangelia G; Schwinger, Robert H G 2002. Modulation of SERCA: implications for the failing human heart. Basic research in cardiology, 97 Suppl 1 , I72-8

Kiriazis, Helen; Sato, Yoji; Kadambi, Vivek J; Schmidt, Albrecht G; Gerst, Michael J; Hoit, Brian D; Kranias, Evangelia G 2002. Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis. Cardiovascular research, 53 2, 372-81

Li, Yanxia; Kranias, Evangelia G; Mignery, Gregory A; Bers, Donald M 2002. Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circulation research, 90 3, 309-16

Paul, R J; Shull, G E; Kranias, E G 2002. The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice. Novartis Foundation symposium, 246 , 228-38; discussion 2

Pi, YeQing; Kemnitz, Kara R; Zhang, Dahua; Kranias, Evangelia G; Walker, Jeffery W 2002. Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice. Circulation research, 90 6, 649-56

Schmidt, Albrecht G; Gerst, Mike; Zhai, Jing; Carr, Andrew N; Pater, Luke; Kranias, Evangelia G; Hoit, Brian D 2002. Evaluation of left ventricular diastolic function from spectral and color M-mode Doppler in genetically altered mice. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 15 10 Pt 1, 1065-73

Schmidt, Albrecht G; Zhai, Jing; Carr, Andrew N; Gerst, Mike J; Lorenz, John N; Pollesello, Piero; Annila, Arto; Hoit, Brian D; Kranias, Evangelia G 2002. Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure. Cardiovascular research, 56 2, 248-59

Wolska, Beata M; Arteaga, Grace M; Peña, James R; Nowak, Grzegorz; Phillips, Ronald M; Sahai, Shalini; de Tombe, Pieter P; Martin, Anne F; Kranias, Evangelia G; Solaro, R John 2002. Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation. Circulation research, 90 8, 882-8

Carr, A N; Sutliff, R L; Weber, C S; Allen, P B; Greengard, P; de Lanerolle, P; Kranias, E G; Paul, R J 2001. Is myosin phosphatase regulated in vivo by inhibitor-1? Evidence from inhibitor-1 knockout mice. The Journal of physiology, 534 Pt. 2, 357-66

Dash, R; Frank, K F; Carr, A N; Moravec, C S; Kranias, E G 2001. Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium. Journal of molecular and cellular cardiology, 33 7, 1345-53

Dash, R; Kadambi, V; Schmidt, A G; Tepe, N M; Biniakiewicz, D; Gerst, M J; Canning, A M; Abraham, W T; Hoit, B D; Liggett, S B; Lorenz, J N; Dorn, G W; Kranias, E G 2001. Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality. Circulation, 103 6, 889-96

Frank, K F; Mesnard-Rouiller, L; Chu, G; Young, K B; Zhao, W; Haghighi, K; Sato, Y; Kranias, E G 2001. Structure and expression of the mouse cardiac calsequestrin gene. Basic research in cardiology, 96 6, 636-44

Freeman, K; Lerman, I; Kranias, E G; Bohlmeyer, T; Bristow, M R; Lefkowitz, R J; Iaccarino, G; Koch, W J; Leinwand, L A 2001. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. The Journal of clinical investigation, 107 8, 967-74

Haghighi, K; Schmidt, A G; Hoit, B D; Brittsan, A G; Yatani, A; Lester, J W; Zhai, J; Kimura, Y; Dorn, G W; MacLennan, D H; Kranias, E G 2001. Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure. The Journal of biological chemistry, 276 26, 24145-52

Nobe, K; Sutliff, R L; Kranias, E G; Paul, R J 2001. Phospholamban regulation of bladder contractility: evidence from gene-altered mouse models. The Journal of physiology, 535 Pt 3, 867-78

Sato, Y; Kiriazis, H; Yatani, A; Schmidt, A G; Hahn, H; Ferguson, D G; Sako, H; Mitarai, S; Honda, R; Mesnard-Rouiller, L; Frank, K F; Beyermann, B; Wu, G; Fujimori, K; Dorn, G W; Kranias, E G 2001. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. The Journal of biological chemistry, 276 12, 9392-9

Sato, Y; Schmidt, A G; Kiriazis, H; Hoit, B D; Kranias, E G 2001. Letter to the editor: Re-evaluation of heart failure in transgenic mice with impaired SR Ca2+ release. Journal of molecular and cellular cardiology, 33 9, 1757-9

Schmidt, A G; Edes, I; Kranias, E G 2001. Phospholamban: a promising therapeutic target in heart failure? Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 15 5, 387-96

Shannon, T R; Chu, G; Kranias, E G; Bers, D M 2001. Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump. The Journal of biological chemistry, 276 10, 7195-201

Slack, J P; Grupp, I L; Dash, R; Holder, D; Schmidt, A; Gerst, M J; Tamura, T; Tilgmann, C; James, P F; Johnson, R; Gerdes, A M; Kranias, E G 2001. The enhanced contractility of the phospholamban-deficient mouse heart persists with aging. Journal of molecular and cellular cardiology, 33 5, 1031-40

Bluhm, W F; Kranias, E G; Dillmann, W H; Meyer, M 2000. Phospholamban: a major determinant of the cardiac force-frequency relationship. American journal of physiology. Heart and circulatory physiology, 278 1, H249-55

Brittsan, A G; Carr, A N; Schmidt, A G; Kranias, E G 2000. Maximal inhibition of SERCA2 Ca(2+) affinity by phospholamban in transgenic hearts overexpressing a non-phosphorylatable form of phospholamban. The Journal of biological chemistry, 275 16, 12129-35

Brittsan, A G; Kranias, E G 2000. Phospholamban and cardiac contractile function. Journal of molecular and cellular cardiology, 32 12, 2131-9

Chu, G; Lester, J W; Young, K B; Luo, W; Zhai, J; Kranias, E G 2000. A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists. The Journal of biological chemistry, 275 49, 38938-43

Frank, K; Kranias, E G 2000. Phospholamban and cardiac contractility. Annals of medicine, 32 8, 572-8

Frank, K; Tilgmann, C; Shannon, T R; Bers, D M; Kranias, E G 2000. Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport. Biochemistry, 39 46, 14176-82

Hoit, B D; Kadambi, V J; Tramuta, D A; Ball, N; Kranias, E G; Walsh, R A 2000. Influence of sarcoplasmic reticulum calcium loading on mechanical and relaxation restitution. American journal of physiology. Heart and circulatory physiology, 278 3, H958-63

Kiriazis, H; Kranias, E G 2000. Genetically engineered models with alterations in cardiac membrane calcium-handling proteins. Annual review of physiology, 62 , 321-51

Kranias, E G 2000. Commentary on the special topic section on the use of transgenic models. Annual review of physiology, 62 , 965-9

Li, L; Desantiago, J; Chu, G; Kranias, E G; Bers, D M 2000. Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation. American journal of physiology. Heart and circulatory physiology, 278 3, H769-79

Schmidt, A G; Kadambi, V J; Ball, N; Sato, Y; Walsh, R A; Kranias, E G; Hoit, B D 2000. Cardiac-specific overexpression of calsequestrin results in left ventricular hypertrophy, depressed force-frequency relation and pulsus alternans in vivo. Journal of molecular and cellular cardiology, 32 9, 1735-44

Schwinger, R H; Brixius, K; Savvidou-Zaroti, P; Bölck, B; Zobel, C; Frank, K; Kranias, E G; Hoischen, S; Erdmann, E 2000. The enhanced contractility in phospholamban deficient mouse hearts is not associated with alterations in (Ca2+)-sensitivity or myosin ATPase-activity of the contractile proteins. Basic research in cardiology, 95 1, 12-8

Zhai, J; Schmidt, A G; Hoit, B D; Kimura, Y; MacLennan, D H; Kranias, E G 2000. Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo. The Journal of biological chemistry, 275 14, 10538-44

Zvaritch, E; Backx, P H; Jirik, F; Kimura, Y; de Leon, S; Schmidt, A G; Hoit, B D; Lester, J W; Kranias, E G; MacLennan, D H 2000. The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility. The Journal of biological chemistry, 275 20, 14985-91

Brittsan, A G; Kiss, E; Edes, I; Grupp, I L; Grupp, G; Kranias, E G 1999. The effect of isoproterenol on phospholamban-deficient mouse hearts with altered thyroid conditions. Journal of molecular and cellular cardiology, 31 9, 1725-37

Hoit, B D; Tramuta, D A; Kadambi, V J; Dash, R; Ball, N; Kranias, E G; Walsh, R A 1999. Influence of transgenic overexpression of phospholamban on postextrasystolic potentiation. Journal of molecular and cellular cardiology, 31 11, 2007-15

Kadambi, V J; Ball, N; Kranias, E G; Walsh, R A; Hoit, B D 1999. Modulation of force-frequency relation by phospholamban in genetically engineered mice. The American journal of physiology, 276 6 Pt 2, H2245-50

Lalli, M J; Shimizu, S; Sutliff, R L; Kranias, E G; Paul, R J 1999. [Ca2+]i homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice. The American journal of physiology, 277 3 Pt 2, H963-70

Minamisawa, S; Hoshijima, M; Chu, G; Ward, C A; Frank, K; Gu, Y; Martone, M E; Wang, Y; Ross, J; Kranias, E G; Giles, W R; Chien, K R 1999. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell, 99 3, 313-22

Pan, B S; Hannon, J D; Wiedmann, R; Potter, J D; Kranias, E G; Shen, Y T; Johnson, R G; Housmans, P R 1999. Effects of isoproterenol on twitch contraction of wild type and phospholamban-deficient murine ventricular myocardium. Journal of molecular and cellular cardiology, 31 1, 159-66

Sutliff, R L; Hoying, J B; Kadambi, V J; Kranias, E G; Paul, R J 1999. Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. Circulation research, 84 3, 360-4

Tepe, N M; Lorenz, J N; Yatani, A; Dash, R; Kranias, E G; Dorn, G W; Liggett, S B 1999. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. Biochemistry, 38 50, 16706-13

Yatani, A; Frank, K; Sako, H; Kranias, E G; Dorn, G W 1999. Cardiac-specific overexpression of Galphaq alters excitation-contraction coupling in isolated cardiac myocytes. Journal of molecular and cellular cardiology, 31 7, 1327-36

Chu, G; Ferguson, D G; Edes, I; Kiss, E; Sato, Y; Kranias, E G 1998. Phospholamban ablation and compensatory responses in the mammalian heart. Annals of the New York Academy of Sciences, 853 , 49-62

Chu, G; Li, L; Sato, Y; Harrer, J M; Kadambi, V J; Hoit, B D; Bers, D M; Kranias, E G 1998. Pentameric assembly of phospholamban facilitates inhibition of cardiac function in vivo. The Journal of biological chemistry, 273 50, 33674-80

Johnson, R G; Kranias, E G 1998. Cardiac sarcoplasmic reticulum function and regulation of contractility. Introduction. Annals of the New York Academy of Sciences, 853 , xi-xvi

Kadambi, V J; Koss, K L; Grupp, I L; Kranias, E G 1998. Phospholamban modulates murine atrial contractile parameters and responses to beta-adrenergic agonists. Journal of molecular and cellular cardiology, 30 7, 1275-84

Kadambi, V J; Kranias, E G 1998. Genetically engineered mice: model systems for left ventricular failure. Journal of cardiac failure, 4 4, 349-61

Kiss, E; Brittsan, A G; Edes, I; Grupp, I L; Grupp, G; Kranias, E G 1998. Thyroid hormone-induced alterations in phospholamban-deficient mouse hearts. Circulation research, 83 6, 608-13

Kristof, E; Szigeti, G; Papp, Z; Bodi, A; Facsko, A; Kovacs, L; Papp, J G; Kranias, E G; Edes, I 1998. Cardiac responses to calcium sensitizers and isoproterenol in intact guinea pig hearts. Effects on cyclic AMP levels, protein phosphorylation, myoplasmic calcium concentration, and left ventricular function. Annals of the New York Academy of Sciences, 853 , 316-9

Li, L; Chu, G; Kranias, E G; Bers, D M 1998. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. The American journal of physiology, 274 4 Pt 2, H1335-47

Luo, W; Chu, G; Sato, Y; Zhou, Z; Kadambi, V J; Kranias, E G 1998. Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. The Journal of biological chemistry, 273 8, 4734-9

Masaki, H; Sako, H; Kadambi, V J; Sato, Y; Kranias, E G; Yatani, A 1998. Overexpression of phospholamban alters inactivation kinetics of L-type Ca2+ channel currents in mouse atrial myocytes. Journal of molecular and cellular cardiology, 30 2, 317-25

Sato, Y; Ferguson, D G; Sako, H; Dorn, G W; Kadambi, V J; Yatani, A; Hoit, B D; Walsh, R A; Kranias, E G 1998. Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. The Journal of biological chemistry, 273 43, 28470-7

Takeishi, Y; Chu, G; Kirkpatrick, D M; Li, Z; Wakasaki, H; Kranias, E G; King, G L; Walsh, R A 1998. In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. The Journal of clinical investigation, 102 1, 72-8

Wiedmann, R T; Pan, B S; Kranias, E G; Motzel, S; Johnson, R G 1998. Phospholamban gene dosage effects in chemically permeabilized mouse cardiac muscle. Annals of the New York Academy of Sciences, 853 , 296-9

Zhou, M; Sutliff, R L; Paul, R J; Lorenz, J N; Hoying, J B; Haudenschild, C C; Yin, M; Coffin, J D; Kong, L; Kranias, E G; Luo, W; Boivin, G P; Duffy, J J; Pawlowski, S A; Doetschman, T 1998. Fibroblast growth factor 2 control of vascular tone. Nature medicine, 4 2, 201-7

Chu, G; Dorn, G W; Luo, W; Harrer, J M; Kadambi, V J; Walsh, R A; Kranias, E G 1997. Monomeric phospholamban overexpression in transgenic mouse hearts. Circulation research, 81 4, 485-92

Haghighi, K; Kadambi, V J; Koss, K L; Luo, W; Harrer, J M; Ponniah, S; Zhou, Z; Kranias, E G 1997. In vitro and in vivo promoter analyses of the mouse phospholamban gene. Gene, 203 2, 199-207

Harrer, J M; Haghighi, K; Kim, H W; Ferguson, D G; Kranias, E G 1997. Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart. The American journal of physiology, 272 1 Pt 2, H57-66

Kadambi, V J; Kranias, E G 1997. Phospholamban: a protein coming of age. Biochemical and biophysical research communications, 239 1, 1-5

Kiss, E; Edes, I; Sato, Y; Luo, W; Liggett, S B; Kranias, E G 1997. beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts. The American journal of physiology, 272 2 Pt 2, H785-90

Koss, K L; Grupp, I L; Kranias, E G 1997. The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility. Basic research in cardiology, 92 Suppl 1 , 17-24

Lalli, J; Harrer, J M; Luo, W; Kranias, E G; Paul, R J 1997. Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle. Circulation research, 80 4, 506-13

Liu, Y; Kranias, E G; Schneider, M F 1997. Regulation of Ca2+ handling by phosphorylation status in mouse fast- and slow-twitch skeletal muscle fibers. The American journal of physiology, 273 6 Pt 1, C1915-24

Lorenz, J N; Kranias, E G 1997. Regulatory effects of phospholamban on cardiac function in intact mice. The American journal of physiology, 273 6 Pt 2, H2826-31

Masaki, H; Sato, Y; Luo, W; Kranias, E G; Yatani, A 1997. Phospholamban deficiency alters inactivation kinetics of L-type Ca2+ channels in mouse ventricular myocytes. The American journal of physiology, 272 2 Pt 2, H606-12

Sako, H; Green, S A; Kranias, E G; Yatani, A 1997. Modulation of cardiac Ca2+ channels by isoproterenol studied in transgenic mice with altered SR Ca2+ content. The American journal of physiology, 273 5 Pt 1, C1666-72

Santana, L F; Gómez, A M; Kranias, E G; Lederer, W J 1997. Amount of calcium in the sarcoplasmic reticulum: influence on excitation-contraction coupling in heart muscle. Heart and vessels, Suppl 12 , 44-9

Santana, L F; Kranias, E G; Lederer, W J 1997. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. The Journal of physiology, 503 ( Pt 1) , 21-9

Slack, J P; Grupp, I L; Ferguson, D G; Rosenthal, N; Kranias, E G 1997. Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation. The Journal of biological chemistry, 272 30, 18862-8

Slack, J P; Grupp, I L; Luo, W; Kranias, E G 1997. Phospholamban ablation enhances relaxation in the murine soleus. The American journal of physiology, 273 1 Pt 1, C1-6

Chu, G; Luo, W; Slack, J P; Tilgmann, C; Sweet, W E; Spindler, M; Saupe, K W; Boivin, G P; Moravec, C S; Matlib, M A; Grupp, I L; Ingwall, J S; Kranias, E G 1996. Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts. Circulation research, 79 6, 1064-76

Hampton, T G; Kranias, E G; Morgan, J P 1996. Simultaneous measurement of intracellular calcium and ventricular function in the phospholamban-deficient mouse heart. Biochemical and biophysical research communications, 226 3, 836-41

Kadambi, V J; Ponniah, S; Harrer, J M; Hoit, B D; Dorn, G W; Walsh, R A; Kranias, E G 1996. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. The Journal of clinical investigation, 97 2, 533-9

Koss, K L; Kranias, E G 1996. Phospholamban: a prominent regulator of myocardial contractility. Circulation research, 79 6, 1059-63

Luo, W; Wolska, B M; Grupp, I L; Harrer, J M; Haghighi, K; Ferguson, D G; Slack, J P; Grupp, G; Doetschman, T; Solaro, R J; Kranias, E G 1996. Phospholamban gene dosage effects in the mammalian heart. Circulation research, 78 5, 839-47

Wolska, B M; Stojanovic, M O; Luo, W; Kranias, E G; Solaro, R J 1996. Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular Ca2+. The American journal of physiology, 271 1 Pt 1, C391-7

Edes, I; Kiss, E; Kitada, Y; Powers, F M; Papp, J G; Kranias, E G; Solaro, R J 1995. Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart. Circulation research, 77 1, 107-13

Harrer, J M; Kiss, E; Kranias, E G 1995. Application of the immunoblot technique for quantitation of protein levels in cardiac homogenates. BioTechniques, 18 6, 995-8

Harrer, J M; Ponniah, S; Ferguson, D G; Kranias, E G 1995. Expression of phospholamban in C2C12 cells and regulation of endogenous SERCA1 activity. Molecular and cellular biochemistry, 146 1, 13-21

Hoit, B D; Khoury, S F; Kranias, E G; Ball, N; Walsh, R A 1995. In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency. Circulation research, 77 3, 632-7

Kiss, E; Ball, N A; Kranias, E G; Walsh, R A 1995. Differential changes in cardiac phospholamban and sarcoplasmic reticular Ca(2+)-ATPase protein levels. Effects on Ca2+ transport and mechanics in compensated pressure-overload hypertrophy and congestive heart failure. Circulation research, 77 4, 759-64

Koss, K L; Ponniah, S; Jones, W K; Grupp, I L; Kranias, E G 1995. Differential phospholamban gene expression in murine cardiac compartments. Molecular and physiological analyses. Circulation research, 77 2, 342-53

Szymanska, G; Grupp, I L; Slack, J P; Harrer, J M; Kranias, E G 1995. Alterations in sarcoplasmic reticulum calcium uptake, relaxation parameters and their responses to beta-adrenergic agonists in the developing rabbit heart. Journal of molecular and cellular cardiology, 27 9, 1819-29

Harrer, J M; Kranias, E G 1994. Characterization of the molecular form of cardiac phospholamban. Molecular and cellular biochemistry, 140 2, 185-93

Jakab, G; Kiss, E; Kranias, E G; Edes, I 1994. Effect of thyroid status on basal phosphorylation of cardiac myofibrillar phosphoproteins in rats. Cardioscience, 5 1, 19-24

Kiss, E; Jakab, G; Kranias, E G; Edes, I 1994. Thyroid hormone-induced alterations in phospholamban protein expression. Regulatory effects on sarcoplasmic reticulum Ca2+ transport and myocardial relaxation. Circulation research, 75 2, 245-51

Luo, W; Grupp, I L; Harrer, J; Ponniah, S; Grupp, G; Duffy, J J; Doetschman, T; Kranias, E G 1994. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circulation research, 75 3, 401-9

Hardin, C D; Zhang, C; Kranias, E G; Steenaart, N A; Raeymaekers, L; Paul, R J 1993. Regulation of glycolytically fueled Ca2+ uptake in smooth muscle plasmalemmal vesicles by phosphorylation. The American journal of physiology, 265 4 Pt 2, H1326-33

Jakab, G; Kiss, E; Kranias, E G; Edes, I 1993. Effect of thyroid status on phosphatidylinositols in rat heart. Cardioscience, 4 4, 257-62

Talosi, L; Edes, I; Kranias, E G 1993. Intracellular mechanisms mediating reversal of beta-adrenergic stimulation in intact beating hearts. The American journal of physiology, 264 3 Pt 2, H791-7

Ganim, J R; Luo, W; Ponniah, S; Grupp, I; Kim, H W; Ferguson, D G; Kadambi, V; Neumann, J C; Doetschman, T; Kranias, E G 1992. Mouse phospholamban gene expression during development in vivo and in vitro. Circulation research, 71 5, 1021-30

Steenaart, N A; Ganim, J R; Di Salvo, J; Kranias, E G 1992. The phospholamban phosphatase associated with cardiac sarcoplasmic reticulum is a type 1 enzyme. Archives of biochemistry and biophysics, 293 1, 17-24

Szyma?ska, G; Kim, H W; Cuppoletti, J; Kranias, E G 1992. Regulation of the skeletal sarcoplasmic reticulum Ca(2+)-ATPase by phospholamban and negatively charged phospholipids in reconstituted phospholipid vesicles. Molecular and cellular biochemistry, 114 1-2, 65-71

Szymanska, G; Kim, H W; Cuppoletti, J; Kranias, E G 1992. Regulation of the skeletal sarcoplasmic reticulum Ca2+ pump by phospholamban in reconstituted phospholipid vesicles. Membrane biochemistry, 9 3, 191-202

Talosi, L; Kranias, E G 1992. Effect of alpha-adrenergic stimulation on activation of protein kinase C and phosphorylation of proteins in intact rabbit hearts. Circulation research, 70 4, 670-8

Zhang, C; Paul, R J; Kranias, E G 1992. Calmodulin stimulation of smooth muscle plasmalemmal vesicle Ca2+ uptake: direct or indirect effect? The American journal of physiology, 263 2 Pt 2, H366-71

Edes, I; Talosi, L; Kranias, E G 1991. The effect of alpha-adrenergic agents and protein kinase C activators on protein phosphorylation in isolated guinea pig hearts. European heart journal, 12 Suppl F , 143-4

Edes, I; Talosi, L; Kranias, E G 1991. Effect of alpha adrenergic agents and phorbol esters on phosphorylation of sarcolemmal proteins in beating guinea pig hearts. Cardiovascular research, 25 6, 510-5

Gupta, R C; Young, E F; Ferguson, D G; Kranias, E G 1991. Regulation of rat cardiac nuclei-associated Mg(2+)-NTPase by phosphorylation. Molecular and cellular biochemistry, 102 2, 165-72

Szymanska, G; Kim, H W; Kranias, E G 1991. Reconstitution of the skeletal sarcoplasmic reticulum Ca2(+)-pump: influence of negatively charged phospholipids. Biochimica et biophysica acta, 1091 2, 127-34

Davis, B A; Edes, I; Gupta, R C; Young, E F; Kim, H W; Steenaart, N A; Szymanska, G; Kranias, E G 1990. The role of phospholamban in the regulation of calcium transport by cardiac sarcoplasmic reticulum. Molecular and cellular biochemistry, 99 2, 83-8

Edes, I; Kranias, E G 1990. The effect of phorbol esters and diacylglycerol analogues on the basal phosphoinositide turnover in isolated guinea pig hearts. Cardioscience, 1 4, 265-74

Edes, I; Kranias, E G 1990. Phospholamban and troponin I are substrates for protein kinase C in vitro but not in intact beating guinea pig hearts. Circulation research, 67 2, 394-400

Edes, I; Kranias, E G 1990. Characterization of cytoplasmic and membrane-associated phosphatidylinositol 4,5-biphosphate phospholipase C activities in guinea pig ventricles. Basic research in cardiology, 85 1, 78-87

Kim, H W; Steenaart, N A; Ferguson, D G; Kranias, E G 1990. Functional reconstitution of the cardiac sarcoplasmic reticulum Ca2(+)-ATPase with phospholamban in phospholipid vesicles. The Journal of biological chemistry, 265 3, 1702-9

Edes, I; Kranias, E G 1989. Regulation of cardiac sarcoplasmic reticulum function by phospholamban. Membrane biochemistry, 7 3, 175-92

Edes, I; Solaro, R J; Kranias, E G 1989. Changes in phosphoinositide turnover in isolated guinea pig hearts stimulated with isoproterenol. Circulation research, 65 4, 989-96

Gupta, R C; Kranias, E G 1989. Purification and characterization of a calcium-calmodulin-dependent phospholamban kinase from canine myocardium. Biochemistry, 28 14, 5909-16

Rapundalo, S T; Solaro, R J; Kranias, E G 1989. Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins. Circulation research, 64 1, 104-11

Young, E F; McKee, M J; Ferguson, D G; Kranias, E G 1989. Structural characterization of phospholamban in cardiac sarcoplasmic reticulum membranes by cross-linking. Membrane biochemistry, 8 2, 95-106

Ferguson, D G; Young, E F; Raeymaekers, L; Kranias, E G 1988. Localization of phospholamban in smooth muscle using immunogold electron microscopy. The Journal of cell biology, 107 2, 555-62

Garvey, J L; Kranias, E G; Solaro, R J 1988. Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts. The Biochemical journal, 249 3, 709-14

Gupta, R C; Davis, B A; Kranias, E G 1988. Mechanism of the stimulation of cardiac sarcoplasmic reticulum calcium pump by calmodulin. Membrane biochemistry, 7 2, 73-86

Jakab, G; Kranias, E G 1988. Phosphorylation and dephosphorylation of purified phospholamban and associated phosphatidylinositides. Biochemistry, 27 10, 3799-806

Jakab, G; Rapundalo, S T; Solaro, R J; Kranias, E G 1988. Phosphorylation of phospholipids in isolated guinea pig hearts stimulated with isoprenaline. The Biochemical journal, 251 1, 189-94

Kranias, E G; Gupta, R C; Jakab, G; Kim, H W; Steenaart, N A; Rapundalo, S T 1988. The role of protein kinases and protein phosphatases in the regulation of cardiac sarcoplasmic reticulum function. Molecular and cellular biochemistry, 82 1-2, 37-44

Kranias, E G; Steenaart, N A; Di Salvo, J 1988. Purification and characterization of phospholamban phosphatase from cardiac muscle. The Journal of biological chemistry, 263 30, 15681-7

Kim, H W; Kim, D H; Ikemoto, N; Kranias, E G 1987. Lack of effects of calcium X calmodulin-dependent phosphorylation on Ca2+ release from cardiac sarcoplasmic reticulum. Biochimica et biophysica acta, 903 2, 333-40

Kranias, E G; Di Salvo, J 1986. A phospholamban protein phosphatase activity associated with cardiac sarcoplasmic reticulum. The Journal of biological chemistry, 261 22, 10029-32

Kranias, E G 1985. Regulation of calcium transport by protein phosphatase activity associated with cardiac sarcoplasmic reticulum. The Journal of biological chemistry, 260 20, 11006-10

Kranias, E G 1985. Regulation of Ca2+ transport by cyclic 3',5'-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Biochimica et biophysica acta, 844 2, 193-9

Kranias, E G 1985. Regulation of calcium transport by protein phosphatase activity associated with cardiac sarcoplasmic reticulum. The Journal of biological chemistry, 260 20, 11006-10

Kranias, E G 1985. Regulation of Ca2+ transport by cyclic 3',5'-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Biochimica et biophysica acta, 844 2, 193-9

Kranias, E G; Garvey, J L; Srivastava, R D; Solaro, R J 1985. Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoprenaline. The Biochemical journal, 226 1, 113-21

Kranias, E G; Garvey, J L; Srivastava, R D; Solaro, R J 1985. Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoprenaline. The Biochemical journal, 226 1, 113-21

Lee, S W; Wallick, E T; Schwartz, A; Kranias, E G 1985. Influence of protein kinase phosphorylation on isolated sarcolemmal membranes. Journal of molecular and cellular cardiology, 17 11, 1085-93

Lee, S W; Wallick, E T; Schwartz, A; Kranias, E G 1985. Influence of protein kinase phosphorylation on isolated sarcolemmal membranes. Journal of molecular and cellular cardiology, 17 11, 1085-93

Davis, B A; Schwartz, A; Samaha, F J; Kranias, E G 1983. Regulation of cardiac sarcoplasmic reticulum calcium transport by calcium-calmodulin-dependent phosphorylation. The Journal of biological chemistry, 258 22, 13587-91

Davis, B A; Schwartz, A; Samaha, F J; Kranias, E G 1983. Regulation of cardiac sarcoplasmic reticulum calcium transport by calcium-calmodulin-dependent phosphorylation. The Journal of biological chemistry, 258 22, 13587-91

Imai, K; Wang, T; Millard, R W; Ashraf, M; Kranias, E G; Asano, G; Grassi de Gende, A O; Nagao, T; Solaro, R J; Schwartz, A 1983. Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum. Cardiovascular research, 17 11, 696-709

Imai, K; Wang, T; Millard, R W; Ashraf, M; Kranias, E G; Asano, G; Grassi de Gende, A O; Nagao, T; Solaro, R J; Schwartz, A 1983. Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum. Cardiovascular research, 17 11, 696-709

Kranias, E G; Nakamura, J; Schwartz, A 1983. Phospholamban, the regulator of the cardiac sarcoplasmic reticulum calcium pump, does not copurify with the Ca2+-ATPase enzyme. Biochimica et biophysica acta, 749 1, 62-8

Kranias, E G; Nakamura, J; Schwartz, A 1983. Phospholamban, the regulator of the cardiac sarcoplasmic reticulum calcium pump, does not copurify with the Ca2+-ATPase enzyme. Biochimica et biophysica acta, 749 1, 62-8

Kranias, E G; Samaha, F J; Schwartz, A 1983. Mechanism of the stimulation of Ca2+-dependent ATPase of skeletal muscle sarcoplasmic reticulum by protein kinase. Biochimica et biophysica acta, 731 1, 79-87

Kranias, E G; Samaha, F J; Schwartz, A 1983. Mechanism of the stimulation of Ca2+-dependent ATPase of skeletal muscle sarcoplasmic reticulum by protein kinase. Biochimica et biophysica acta, 731 1, 79-87

Kranias, E G; Solaro, R J 1983. Coordination of cardiac sarcoplasmic reticulum and myofibrillar function by protein phosphorylation. Federation proceedings, 42 1, 33-8

Kranias, E G; Solaro, R J 1983. Coordination of cardiac sarcoplasmic reticulum and myofibrillar function by protein phosphorylation. Federation proceedings, 42 1, 33-8

Mandel, F; Kranias, E G; Schwartz, A 1983. The effect of cAMP-dependent protein kinase phosphorylation on the external Ca2+ binding sites of cardiac sarcoplasmic reticulum. Journal of bioenergetics and biomembranes, 15 4, 179-94

Mandel, F; Kranias, E G; Schwartz, A 1983. The effect of cAMP-dependent protein kinase phosphorylation on the external Ca2+ binding sites of cardiac sarcoplasmic reticulum. Journal of bioenergetics and biomembranes, 15 4, 179-94

Collins, J H; Zot, A S; Kranias, E G 1982. Isolation of two proteolipids from rabbit skeletal muscle sarcoplasmic reticulum. Preparative biochemistry, 12 3, 255-64

Collins, J H; Zot, A S; Kranias, E G 1982. Isolation of two proteolipids from rabbit skeletal muscle sarcoplasmic reticulum. Preparative biochemistry, 12 3, 255-64

Kranias, E G; Schwartz, A; Jungmann, R A 1982. Characterization of cyclic 3':5'-amp-dependent protein kinase in sarcoplasmic reticulum and cytosol of canine myocardium. Biochimica et biophysica acta, 709 1, 28-37

Kranias, E G; Schwartz, A; Jungmann, R A 1982. Characterization of cyclic 3':5'-amp-dependent protein kinase in sarcoplasmic reticulum and cytosol of canine myocardium. Biochimica et biophysica acta, 709 1, 28-37

Kranias, E G; Solaro, R J 1982. Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart. Nature, 298 5870, 182-4

Kranias, E G; Solaro, R J 1982. Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart. Nature, 298 5870, 182-4

Mandel, F; Kranias, E G; Grassi de Gende, A; Sumida, M; Schwartz, A 1982. The effect of pH on the transient-state kinetics of Ca2+-Mg2+-ATPase of cardiac sarcoplasmic reticulum. A comparison with skeletal sarcoplasmic reticulum. Circulation research, 50 2, 310-7

Mandel, F; Kranias, E G; Grassi de Gende, A; Sumida, M; Schwartz, A 1982. The effect of pH on the transient-state kinetics of Ca2+-Mg2+-ATPase of cardiac sarcoplasmic reticulum. A comparison with skeletal sarcoplasmic reticulum. Circulation research, 50 2, 310-7

Robertson, S P; Johnson, J D; Holroyde, M J; Kranias, E G; Potter, J D; Solaro, R J 1982. The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin. The Journal of biological chemistry, 257 1, 260-3

Robertson, S P; Johnson, J D; Holroyde, M J; Kranias, E G; Potter, J D; Solaro, R J 1982. The effect of troponin I phosphorylation on the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin. The Journal of biological chemistry, 257 1, 260-3

Bilezikjian, L M; Kranias, E G; Potter, J D; Schwartz, A 1981. Studies on phosphorylation of canine cardiac sarcoplasmic reticulum by calmodulin-dependent protein kinase. Circulation research, 49 6, 1356-62

Bilezikjian, L M; Kranias, E G; Potter, J D; Schwartz, A 1981. Studies on phosphorylation of canine cardiac sarcoplasmic reticulum by calmodulin-dependent protein kinase. Circulation research, 49 6, 1356-62

Collins, J H; Kranias, E G; Reeves, A S; Bilezikjian, L M; Schwartz, A 1981. Isolation of phospholamban and a second proteolipid component from canine cardiac sarcoplasmic reticulum. Biochemical and biophysical research communications, 99 3, 796-803

Collins, J H; Kranias, E G; Reeves, A S; Bilezikjian, L M; Schwartz, A 1981. Isolation of phospholamban and a second proteolipid component from canine cardiac sarcoplasmic reticulum. Biochemical and biophysical research communications, 99 3, 796-803

Kranias, E G; Bilezikjian, L M; Potter, J D; Piascik, M T; Schwartz, A 1980. The role of calmodulin in regulation of cardiac sarcoplasmic reticulum phosphorylation. Annals of the New York Academy of Sciences, 356 , 279-91

Kranias, E G; Bilezikjian, L M; Potter, J D; Piascik, M T; Schwartz, A 1980. The role of calmodulin in regulation of cardiac sarcoplasmic reticulum phosphorylation. Annals of the New York Academy of Sciences, 356 , 279-91

Kranias, E G; Mandel, F; Schwartz, A 1980. Involvement of cAMP-dependent protein kinase and pH on the regulation of cardiac sarcoplasmic reticulum. Biochemical and biophysical research communications, 92 4, 1370-6

Kranias, E G; Mandel, F; Schwartz, A 1980. Involvement of cAMP-dependent protein kinase and pH on the regulation of cardiac sarcoplasmic reticulum. Biochemical and biophysical research communications, 92 4, 1370-6

Kranias, E G; Mandel, F; Wang, T; Schwartz, A 1980. Mechanism of the stimulation of calcium ion dependent adenosine triphosphatase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase. Biochemistry, 19 23, 5434-9

Kranias, E G; Mandel, F; Wang, T; Schwartz, A 1980. Mechanism of the stimulation of calcium ion dependent adenosine triphosphatase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase. Biochemistry, 19 23, 5434-9

Kranias, E G; Jungmann, R A 1978. Phosphorylation of calf thymus RNA polymerase II by nuclear cyclic 3',5'-AMP-independent protein kinase. Biochimica et biophysica acta, 517 2, 439-46

Kranias, E G; Jungmann, R A 1978. Purification and properties of a cyclic AMP-independent protein kinase from calf thymus nuclei. Biochimica et biophysica acta, 517 2, 447-56

Kranias, E G; Jungmann, R A 1978. Phosphorylation of calf thymus RNA polymerase II by nuclear cyclic 3',5'-AMP-independent protein kinase. Biochimica et biophysica acta, 517 2, 439-46

Kranias, E G; Jungmann, R A 1978. Purification and properties of a cyclic AMP-independent protein kinase from calf thymus nuclei. Biochimica et biophysica acta, 517 2, 447-56

Kranias, E G; Schweppe, J S; Jungmann, R A 1977. Phosphorylative and functional modifications of nucleoplasmic RNA polymerase II by homologous adenosine 3':5'-monophosphate-dependent protein kinase from calf thymus and by heterologous phosphatase. The Journal of biological chemistry, 252 19, 6750-8

Kranias, E G; Schweppe, J S; Jungmann, R A 1977. Phosphorylative and functional modifications of nucleoplasmic RNA polymerase II by homologous adenosine 3':5'-monophosphate-dependent protein kinase from calf thymus and by heterologous phosphatase. The Journal of biological chemistry, 252 19, 6750-8

Jungmann, R A; Kranias, E G 1976. Cyclic AMP-mediated protein kinase activation and its regulatory effect on mammalian RNA polymerase. Advances in biochemical psychopharmacology, 15 , 413-28

Jungmann, R A; Kranias, E G 1976. Cyclic AMP-mediated protein kinase activation and its regulatory effect on mammalian RNA polymerase. Advances in biochemical psychopharmacology, 15 , 413-28

Kranias, E G; Dumas, L B 1975. Synthesis of complex forms of bacteriophage phiX174 double-stranded DNA in a temperature-sensitive dnaC mutant of Escherichia coli C. Journal of virology, 16 2, 412-9

Kranias, E G; Dumas, L B 1975. Synthesis of complex forms of bacteriophage phiX174 double-stranded DNA in a temperature-sensitive dnaC mutant of Escherichia coli C. Journal of virology, 16 2, 412-9

Kranias, E G; Dumas, L B 1974. Replication of bacteriophage phiX174 DNA in a temperature-sensitive dnaC mutant of escherichia coli C. Journal of virology, 13 1, 146-54

Kranias, E G; Dumas, L B 1974. Replication of bacteriophage phiX174 DNA in a temperature-sensitive dnaC mutant of escherichia coli C. Journal of virology, 13 1, 146-54

Published Abstracts

Display All

Bidwell P, Liu GS, Lam CK, Kranias EG. 2016. HAX-1 Regulates Contractile Recovery After Ischemia/Reperfusion Injury By Preventing SERCA2a Degradation. , ,


Gardner G, Liu GS, Qian J, Jiang M, Cai WF, Tranter M, Fan GC, Rubinstein J, Kranias EG. 2016. PKA-Phosphorylation of Hsp20 is Associated with Detrimental Cardiac Remodeling and Early Death. , ,


Tzimas C, Vafiadaki E, Arvanitis D, Davos C, Varela A, Athanasiadis N, Dimitriou C, Katsiboulas M, Sonntag S, Shmerling D, Lehnart S, Kranias E, Sanoudou D. 2016. The role of the human variant HRC-Ser96Ala to arrhythmias and sudden death, in a novel genetically modified mouse model. , ,


Lam CK, Zhao W, Liu GS, Cai WF, Gardner G, Kranias EG. 2015. HAX-1 is a new regulator of cyclophilin-D expression and the mitochondria permeability transition pore in the heart. JMCC, 85 S10,


Liu GS, Jiang M, Cai WF, Adly G, Gardner G, Lam CK, Rubinstein J, Kranias EG. 2015. A Novel Human S10F-Hsp20 Mutation Induces Lethal Peripartum Cardiomyopathy. Circulation , 132 A12702,


Liu GS, Zhao W, Vafiadaki E, Adly G, Lam CK, Cai WF, Nicolaou P, Jiang M, Rubinstein J, Fan GC, Dorn GW, Kranias EG. 2015. A human S10F-Hsp20 mutant abrogates the contractile and protective effects of Hsp20 in the heart. JMCC, 85 S9,


Onusko E, Liu GS, Koch S, Jiang M, Kranias EG, Rubinstein J. 2015. TRPV2 stimulation diminishes peripartum cardiomyopathy through increased ejection fraction and decreased dilation. JMCC, 85 S24,


Bidwell P, Lam CK, Mugge L, Vanderbilt E, Kranias EG 2014. Endogenous HAX-1 depresses the phospholamban inhibitory activity JMCC , 74 S30:, (P2-42)


Cai WF, Florea S, Qian J, Zhao W, Pritchard T, Lam CK, Liu G, Haghighi K, Lebeche D, Lu LJ Deng J, Fan GC, Hajjar RJ, Kranias EG 2014. Micro-RNA765 targets protein phosphatase inhibitor-1 and suppresses contractility JMCC, 74 S8, (P1-26)


Haghighi K, Pritchard TJ, Singh VP, Das P, Vanderbilt EL, Rubinstein J, Kranias EG. 2014. A Human G109E Polymorphism in Inhibitor-1 Compromises Cardiomyocyte Function and Induces Arrhythmias. Circulation, 115 , A34


Lam CK, Zhao W, Cai W, Liu G, Bidwell P, Gardner G, Adly G, Kranias EG 2014. HAX-1: A Novel Regulator of Energetics and Oxidative Stress in the Heart Circulation, 115 , A204


Liu G, Morales A, Vafiadaki E, Haghighi K, Hershberger RE, Adly G, Kranias EG 2014. A novel human R25C-phospholamban mutant is associated with superinhibition of calcium cycling and increased apoptosis JMCC, 74 S2:, (P1-05)


Liu G, Zhao W, Vafiadaki E, Lam CK, Jiang M, Rubinstein J, Adly G, Kranias EG 2014. A novel human mutation in Hsp20 (S10F) abrogates the contractile and protective effects of this protein in the heart JMCC, 74 S2:, P1-05)


Arvanitis DA, Vafiadaki E, Papalouka V, Kranias EG, Sanoudou D 2013. Spatio-Temporal Dynamic Interaction of Cardiac Muscle Lim Protein (MLP) and Cardiac Myosin Binding Protein C (cMyBPC3) During Myoblasts Differentiation to Myotubes Hellenic J Cardiology, 54 Supplement A:65,


Lam CK, Bidwell PA, Zhao W, Cai WF, Liu G, Kranias EG 2013. Inducible HAX-1 ablation enhances SR calcium cycling and potentiates mitochondria permeability transition in the adult heart JMCC, 65 , S1-S176


Tzimas C, Vafiadaki E, Arvanitis D, Sonntag S, Shmerling D, Sanoudou D, Kranias EG 2013. Initial characterization of a knock-in mouse model with an arrhythmogenic polymorfism in the HRC protein, which has been related to sudden cardiac death in patients with dialated cardiomyopathy Hellenic J Cardiology, 54 Supplement A:65,


Vafiadaki E, Arvanitis DA, Sanoudou D, Kranias 2013. Functional role of PP1 protein complexes in cardiac muscle Hellenic J Cardiology, 54 Supplement A:65,


Zhao W, Lv W, Cai W, Liu HM, Kranias EG 2013. Peroxiredoxin II, an antioxidant protein, is a new regulator of cardiac contractility through phospholamban Acta Pharmacologica Sinica., 34 Suppl:79 S6.112,


Zhao W, Lv W, Liu HM, Kranias EG 2013. The Regulatory Effects of Peroxiredoxin II on Cardiac Contractility and the Underlying Mechanisms Cardiology, 126 Suppl 1: 52,


Zhao W, Lv W, Liu HM, Kranias EG 2013. Peroxiredoxin II regulates cardiomyocyte contractility through phospholamban JMCC, 65 S54, PS2-P3


Tzimas C, Kostomitsopoulos N, Kremastinos D, Kranias EG, Sanoudou D 2012. Novel anti-arrhythmic drugs: evaluation of a known CAMKII inhibitor in a mouse model of ventricular arrhythmias Hellenic Journal of Cardiology, 53 Supplement A:36,


Vafiadaki E, Papalouka V, Arvanitis DA, Terzis G, Spengos K, Kranias EG, Manta P, Sanoudou D 2012. Molecular characterization of a novel Muscle Lim Protein isoform, with important implications in muscle physiology and pathophysiology Hellenic Journal of Cardiology, 53 Supplement A):36,


Lam C, Zhao W, Zhang G, Ren X, Zhou X, Maloyan A, Robbins J, Kranias EG 2010. Hax-1 protects hearts from ischemia/reperfusion injury in vivo , ,


Pritchard TJ, Dorn GW II, Singh VP, Kranias EG 2010. Human G109E inhibitor-1 depresses cardiomyocyte contractility and promotes aftercontractions , ,


Singh VP, Han P, Cai W, Kranias EG 2010. The functional role of Human S96A-RC genetic variant in the heat , ,


Singh VP, Han P, Cai W, Kranias EG 2010. The functional role of Human S96A-RC genetic variant in the heat , ,


307. Wang X, Zhao T, Wang T, Zhang P, Xu M, Kranias EG, Wang Y, and Fan GC 2009. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and secretion of growth factors Circulation, 120 , S721


Han P, Chen S, Arvanitis D, Cai, W, Robinson D, Cheng H, and Kranias EG 2009. The human histidine-rich Ca binding protein Ser96Ala variant enhances ryanodine receptor activity and induces arrhythmias Circulation, 120 , S708


Pritchard TJ, Dorn GW, and Kranias EG. 2009. A human inhibitor-1 polymorphism, G109E, impairs cardiomyocyte function and promotes susceptibility to arrhythmia Circulation, 120 , S763


Wang X, Zhao T, Wang T, Zhang P, Xu M, Kranias EG, Wang Y, and Fan GC 2009. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and secretion of growth factors cir, ,


Zhang P, Chen J, Ren X, Wang X, Kranias EG, Medvedvic M, and Fan GC 2009. MicroRNA expression profiling in the ischemic preconditioned heart: Functional Role of a MiR-1/GATA-4/MiR-144, -451, and -762 Circuit Circulation, 120 , S736


Fan GC, Wang X, Zhao T, Wang Y, Ashraf M, Kranias EG 2008. Hsp20 protects bone-morrow stem cells against oxidative stress via increasing the VEGF and FGF release. J Mol. Cell Cardiol, 44 , S6-P19


Fan GC, Wu J, Ren X, Wang X, Sator MA, Jones WK, Kranias EG. 2008. MiR-320, a microRNA down-regulated in the heart after ischemia/reperfusion in vivo, inhibits Hsp20 expression. J Mol. Cell Cardiol, 44 S40-p126,


Han P, Zhou X, Zhao W, Chen G, Chen S, Figueira S, Fan GC, Allen PD, and Kranias EG. 2008. Combined ablation of junctin and triadin is associated with leaky ryanodine receptors and depressed cardiac contractile function Circulation, 118 , S-541


Ren X, Fan GC, Kadeer N, Kranias EG, and Jones WK 2008. Nociceptive stimulation: a novel cardioprotective strategy. Circulation, 118 , S-705


Arvanitis, D., Zhao, W., Papalouka, V., Vafiadaki, E., Haghighi, K., Kranias, E.G., Sanoudou, D. 2007. Global gene expression analysis of the “humanized” PLN mouse model reveals significant cardiac electrophysiological alterations 59th National Conference of the Hellenic Society of Biochemistry & Molecular Biology Athens, ,


Arvanitis, D.A., Kolokathis, F., Sanoudou, D., Vafiadaki, E., Theodorakis, G.N., Kontrogianni-Konstantopoulos, A., Paraskevaidis, I.A., Adamopoulos, S., Dorn, G.W. II, Kremastinos, D.Th., Kranias, E.G. 2007. The role of Histidine-rich calcium binding protein (HRC) polymorphisms in the development of life-threatening ventricular arrhythmias in DCM patients 28th Hellenic Cardiological Conference; Rhodes, Greece, ,


Arvanitis, D.A., Vafiadaki, E., Fan, G.C., Mitton, B., Gregory, K.N., Del Monte, F., Kontrogianni- Konstantopoulos, A., Sanoudou, D.,. Kranias, E.G. 2007. HRC Protein Binds to SERCA2 Kavala at the National Conference for the Biological Sciences: April, ,


Arvanitis, D.A., Vafiadaki, E., Fan, G.C., Mitton, B.A., Gregory, K.N., Del Monte, F., Kontrogianni-Konstantopoulos, A., Kranias, E.G., Sanoudou, D. 2007. ‘A novel role for HRC in cardiomyocyte Ca2+ cycling through interaction with SERCA2’ 59th National Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, ,


Arvanitis, D.A., Vafiadaki, E., Mitton B.A., Gregory, K.N., Del Monte, F., Kontrogianni-Konstantopoulos, A., Kranias, E.G., Sanoudou, D. 2007. Histidine-Rich Calcium Interacts with SERCA2 in a Ca-dependent manner European Society of Human Genetics, Nice, ,


Arvanitis, D.A., Vafiadaki, E., Mitton, B., Gregory, K.N., Del Monte, F., Kontrogianni- Konstantopoulos, A., Sanoudou, D., Kranias, E.G. 2007. Histidine-Rich Calcium Binding Protein as Novel Mediator Between Sarcoplasmic Reticulum Ca2+ uptake and Release European Society of Cardiology meeting, Vienna, ,


Arvanitis, D.A., Zhao, W., Vafiadaki, E., Haghighi, K., Kranias, E.G., Sanoudou, D. 2007. Phospholamban: a single base difference between humans and other species alters cardiac gene expression profile and contractility European Society of Cardiology meeting, Vienna, ,


Chen, G., Rodriguez, P., Song, G., Mitton, B., Fan, G.C., Pathak, A., Zhou, X., Dorn G.W. II ,Kranias, E.G. 2007. A Human Polymorphism of Protein Phosphatase 1 Inhibitor 1 is Associated with Attenuated Cardiac Contractile Responses to Beta-adrenergic Stimulation The FASEB J, 21 6, 908.12


Chen, G., Zhou, X., Rodriguez, P., Song, G., Mitton, B., Pathak, A., Zachariah, A., Fan, G.C., Dorn, G.W. II, Kranias, E.G. 2007. A Human Polymorphism of Protein Phosphatase 1 Inhibitor 1 is Associated with Attenuated Contractile Responses to Beta-adrenergic Stimulation Circulation, 116 2, 46


Fan, G.C., Yuan, Q., Qian, J., Zhou, X., Waggoner, J.R., Chen, G., Kranias, E.G. 2007. Enhancement of Myocardial Function by Hsp20 is Associated with Decreased Type-1 Phosphatase Activity Circulation, 116 , 189


Fan, G.C., Zhou, X., Song, G., Qian, J., Figueria, S., Chen, G., Kranias, E.G. 2007. Hsp20 Inhibits Doxorubicin-triggered Cardiac Injury Via PI3 Kinase-Akt Dependent Pathway Circulation, 116 2, 9


Galata, Z., Papalouka, V., Oikonomaki, M., Arvanitis, D.A., Kolokathis, F., Kremastinos, D., Kranias, E.G., Sanoudou, D. 2007. Searching for cardiac Myosin Binding Protein C sequence variations in dilated cardiomyopathy patients 59th National Conference of the Hellenic Society of Biochemistry & Molecular Biology Athens, ,


Haghighi, K., Sato, Y., Fan G.C., He, S., Kolokathis F., Paraskevaidis I., Jones, W.K., Dorn, G.W. II, Kremastinos, D.T., Kranias, E.G. 2007. A Novel Human Phospholamban Promoter Polymorphism in Dilated Cardiomyopathy Alters Glucocorticoid Nuclear Receptor Mediated Transcription Regulation Circulation, 116 2, 605


Papalouka, V., Vafiadaki, E., Arvanitis, D.A., Oikonomaki, M., Kontrogianni-Konstantopoulos, A., Kranias, E.G., Sanoudou, D. 2007. MYBP-C3, a novel interacting partner of CSRP3 59th National Conference of the Hellenic Society of Biochemistry & Molecular Biology Athens, ,


Qian, J., Fan, G.C., Kranias, E.G. 2007. Phosphorylation of Small Heat Shock Protein 20 at Serine 16 Is Essential in Cardiac Protection against Ischemia/Reperfusion Injury Circulation, 116 2, 68


Vafiadaki, E., Sanoudou, D., Arvanitis, D.A., Catino, D.H., Konstantopoulos, A.K., Kranias, E.G. 2007. Identification of a Novel Interaction Between HAX-1 and Phospholamban in Cardiac Muscle and its Role in Cell Survival European Society of Cardiology meeting, Vienna, ,


Vafiadaki, E., Sanoudou, D., Arvanitis, D.A., Catino, D.H., Kranias, E.G. and Kontrogianni-Konstantopoulos, A. 2007. ‘HAX-1 interacts with phospholamban and represents a novel regulator of calcium homeostasis and cell survival in cardiac muscle’ 59th National Conference of the Hellenic Society of Biochemistry & Molecular Biology Athens, ,


Vafiadaki, E., Sanoudou, D., Arvanitis, D.A., Catino, D.H., Kranias, E.G., Konstantopoulos, A.K. 2007. Hax-1 is a new interacting protein of phospholamban and a novel regulator of calcium homeostasis and cardiac cell survival European Society of Human Genetics, Nice, ,


Vafiadaki, E., Sanoudou, D., Arvanitis, D.A., Catino, D.H., Kranias, E.G., Konstantopoulos, A.K. 2007. Hax-1 is a novel interacting protein of Phospholamban in cardiac muscle Kavala at the National Conference for the Biological Sciences: April, ,


Diwan, A., Marreez, Y.M., Koesters, A.G., Odley, A.M., Baines, C.P., Yuan, Q., Molkentin, J.D., Kranias, E.G., Dorn, G.W. II 2006. Nix in the Heart: Regulation of developmental apoptosis and sarcoplasmic reticular calcium stores explains its functional diversity Supplement to Circulation , 114 18, II-34


Kranias, E.G. 2006. Phospholamban as a therapeutic modality in heart failure Chinese Journal of Pathophysiology, 22 13, 2


Qian, J., Fan, G.C., Yuan, Q., Kranias, E.G. 2006. Phosphorylation of Small Heat Shock Protein 20 (Hsp20) at Serine 16 Modulates Cardiac Contractility Supplement to Circulation, 114 18, II-314


Rodríguez, P., Nicolaou, P., Qian, J., Mitton, B., Pathak, A., Robbins, J., and Kranias, E. G. 2006. Temporally Induced Expression of Active Protein Phosphatase Inhibitor-1 in the Adult Mouse Heart Enhances Cardiac Supplement to Circulation, 114 18, II-314


Zhu. Y., Gramolini, A., Sun, H., Takeuchi, J., Zhou, Y., Mori, A., Kranias, E.G., Olson, E.N., Henkellman, R.M., Backx, P., MacLennan, D.H., Bruneau, B. 2006. Cardiac specific deletion of Tbx5 causes left ventricular diastolic dysfunction that can be rescured by increased Serca2a activity Supplement to Circulation, 114 18, II-7


Arvanitis, D., Sanoudou, D., Vafiadaki, E., Haghighi, K., Kolokathis, F.,. Kremastinos, D.T., Kontrogianni-Konstantopoulos, A., Kranias, E.G. 2005. Genetic alterations identified in HRC and sANK1 genes in dilated cardiomyopathy patients 57th National conference of Biochemistry & Molecular Biology, Athens, ,


Fan, G., Chu, G., Mitton, B., Song, Q., Yuan, Q., Kranias, E.G. 2005. Small Heat-Shock Protein Hsp20 Phosphorylation Inhibits β-Agonist-Induced Cardiac Apoptosis The 4th Athens Exchange of Cardiovascular Research Ideas Syllabus, , 113


Fan, G., Yuan, Q., Qian, J., Nicolaou, P., Song, G., Chen, G., Chu, G., Kranias, E.G. 2005. Novel Cardioprotective Effects by the Small Heat Shock Protein Hsp20 Cir. Res., 97 2, 18


Gregory, K.N., Ginsburg, K.S., Bodi, I., Hahn, H.,Marreez, Y.M., Song, Q., Padmanabhan, P.A., Waggoner, J.R., Mitton, B.A., del Monte, F., Park, W., Bers, D.S., Dorn, G.W., Kranias, E.G. 2005. HRC: A Novel Regulator of Sarcoplasmic Reticulum Calcium Sequestration and Cardiac Function Cir. Res., 97 2, 44


Papalouka, V., Vafiadaki, E., Arvanitis, D. A., Kontrogianni-Konstantopoulos, A., Kranias, E. Sanoudou, D. 2005. Identifying new binding partners of CSRP3 through the yeast two-hybrid system 57th National conference of Biochemistry & Molecular Biology, ,


Rodriguez, P., Mitton, B., Kranias, E.G. 2005. Identification of Novel PKC-a Phosphorylation Sites on Human Inhibitor-1 Biophys. J., 88 1, 481A


Rodriguez, P., Mitton, B., Kranias, E.G. 2005. Functional Significance of a New PKC-α Phosphorylation Site on Inhibitor-1 of Cardiac Protein Phosphatase-1 Cir. Res., 97 2, 14-15


Vafiadaki, E., Arvanitis, D.A., Sanoudou, D., Papalouka, V., Kranias, E.G., Kontrogianni-Konstantopoulos, A. 2005. A Molecular Investigation of the Role of Phospholamban in Cardiac Muscle 57th National conference of Biochemistry & Molecular Biology, Athens, ,


Egger, M., Szentesi, P., Pignier, C., Kranias, E.G., and Niggli, E. 2004. SR Ca2+ Controls Recovery from Refractoriness and Termination of CICR in Cardiac Muscle 48th Biophysical Society Annual Meeting, ,


Fan, G., Ren, X., Quian, J., Yuan, J., Wang, Y., Jones, K., Chu, G., Kranias, E.G. 2004. Cardiac-specific overexpression of small heat-shock protein Hsp20 Alleviates ischemia/reperfusion injury and myocardial dysfunction Circulation, 110 17, 1439


Ferrero, P., Mundina-Weilenman, C., Said, M., Vittone, L., Kranias, E.G., Mattiazzi, A. 2004. Role of phosphorylation of Thr17 residue of phospholamban on the mechanical recovery during acidosis Heart Failure, , 27


Ferrero, P., Mundina-Weilenmann, C., Said, M., Vittone, L., Kranias, E.G., Mattiazzi, A. 2004. Role of phosphorylation of Thr17 residue of phospholamban on the mechanical recovery during acidosis J. Mol. Cell. Cardiology, 37 1, N07


Haghighi, K., Kolokathis, F., Fan, G., Sato, Y., Kremastinos D.T., Kranias, E.G. 2004. Phospholamban Mutations in Human Dilated Cardiomyopathy Circulation, 110 17, 1734


Kranias, E.G. 2004. Phospholamban and calcium cycling in heart failure J. Mol. Cell. Cardiology, 37 1, S10B


Mundina-Weilenmann, C., Vittone, L., Said, M., Kranias, E.G., Mattiazzi, A. 2004. CaMKII-dependent phospholamban phosphorylation as a mechanism to limit Ca2+ overload J. Mol. Cell. Cardiology, 37 1, S22B


O’Neal, E., Pathak, A., Carr, A., Kranias, E.G. 2004. Effects of Gender on Longevity of Mice with Cardiac Specific Overexpression of Protein Phosphatase 1 Circulation, ,


Pathak, A., Monte, F., Zhao, W., Carr. A., Schultz, J., Harvey, H., Syed, F., Marreexz, Y., DePaoli-Roach, A., Hajjar, R., Kranias, E.G. 2004. Therapeutic Targeting of the Type 1 Phosphatase Activity in Murine Models of Cardiomyopathy Circulation, 110 17, 96


Vangheluwe, P., Louch, W.E., Tjwa, M., Ver Heyen, M., Periasamy, M., Kranias, E.G., Carmeliet, P., Raeymaekers, L., Sipido, K., and Wuytack, F 2004. Phospholamban ablation and SERCA2b overexpression fail to prevent cardiac hypertrophy in SERCA2a deficient mice Keystone Symposium, ,


Yuan, Q., Fan, G., Sun, X., Zhao, W., Hongshen, W., Hahn, H., Jones, L., Chu, G.,Kranias, E.G. 2004. Ablation of Junction by Gene Targeting Results in Enhanced Cardiac Contractility and Ca 2+ Kinetics Circulation, 110 17, 622


Zhao, W., Yuan, Q., Pathak, A., Chu, G., Hahn, H., Dorn II, G.W., Kranias, E.G. 2004. Human (N27K) Phospholamban Exacerbates Stress-induced Cardiac Hypertrophy and Ischemic Injury Circulation, 110 17, 56


Fan, G., Gregory, K.N., Zhao, W., Park, W.J., and Kranias, E.G. 2003. HRC Overexpression Impairs SR Ca2+ Cycling by Upregulation of Junctin and Triadin J. Cardiac Failure, 9 5, S13


Gregory, K.N., Hahn, H.S., Haghighi, K., Marreez, Y., Odley, A., Kranias, E.G., and Dorn, G.W. II 2003. Perpetual Preconditioning by PKCe Reverses Susceptibility of Phospholamban Deficient Hearts to Ischemic Injury J. Cardiac Failure, 9 5, S14


Kranias, E.G. 2003. Targeting Phospholamban as a Therapeutic Modality in Heart Failure The J. of Heart Disease, 3 1, 69


Pathak, A., Zhao, W., Fan, G., Carr, A.N., Hahn, H.S., Ping, L., Syed, F., Colbert, M., DePaoli-Roach, A.A., del Monte, F., Hajjar, R., and Kranias, E.G. 2003. The Protein Phosphatase I Inhibitor-1: A Potent “Molecular Inotrope” in Cardiac Function J. Cardiac Failure, 9 5, S13


Zhao, W., Yuan, Q., Pathak, A., Chu, G., Hahn, H.S., Marreez, Y., Syed, F., Dorn, G.W. II, and Kranias, E.G. 2003. Human Phospholamban: A Superinhibitor of Cardiac Function J. Cardiac Failure, 9 5, S3


Chu, G., Egnaczyk, G., Zhao, W., Gerst, M., Maggio, J.E. and Kranias, E.G. 2002. Identification of a Novel Heat Shock-Like Phosphoprotein Associated with β-Adrenergic Signaling in Mouse Cardiomyocytes AHA Conf. on Advances in the Molecular and Cellular Mechanisms of Heart Failure, ,


Chu, G., Egnaczyk, G., Zhao, W., Gerst, M., Maggio, J.E. and Kranias, E.G. 2002. β-Adrenergic Signaling is Associated with De Novo Phosphorylation of a Heart Shock-Life Phosphoprotein in Mouse Cardiomyocytes J. Cardiac Failure, 8 4, S12


Chu, G., Egnaczyk, G., Zhao, W., Gerst, M., Maggio, J.E. and Kranias, E.G. 2002. Identification of a Novel Heat Shock-Like Phosphoprotein Associated with β-Adrenergic Signaling in Mouse Cardiomyocytes Circulation, 106 19, 129


Chu, G., Young, K., Marreez, Y., Brittsan, A., Hanh, H. and Kranias, E.G. 2002. Phospholamban Phosphorylation is Critical in Preserving Cardiac Function During Cardiac Remodeling Induced by Chronic Activation of -Adrenergic Signaling Circulation, 106 19, 510


Louch, W.E., Vangheluwe, P., Tjwa, M., Ver Heyen, M., Kranias, E.G., Wuytack, F., and Sipido, K 2002. Ablation of Phospholamban Reverses Slowed Relaxation but not Cardiac Hypertrophy in Mice Lacking SERCA2a Biophysical Society Meeting, ,


Pathak, A., Carr, A.N., del Monte, F., Hajjar, R.J., Depaoli-Roach, A.A. and Kranias, E.G. 2002. The Role of PP1 and its Inhibitor-1 in the Regulation of Cardiac Function AHA Conf. on Advances in the Molecular and Cellular Mechanisms of Heart Failure, ,


Song, Q., Hahn, H., Dorn, G.W. II and Kranias, E.G. 2002. Rescue of Cardiac Myocyte Dysfunction But Not Hypertrophy in the Gq Murine Model upon PLB Ablation J. Cardiac Failure, 8 4, 082


Song, Q., Hahn, H., Dorn, G.W. II and Kranias, E.G. 2002. Phospholamban Ablation Rescues Cardiomyocyte Dysfunction but not Hypertrophy Induced by Overexpression of Gq Circulation, 106 19, 503


Zhao, W., Uehara, Y., Chu, G., Young, K. and Kranias, E.G. 2002. Thr17 Phosphorylation of Phospholamban: A Major Determinant of Mouse Cardiomyocyte Force-Frequency Relationship Circulation, 106 19, 37


Zhao, W., Uehara, Y., Chu, G., Young, K. and Kranias, E.G. 2002. Thr17 Phosphorylation of Phospholamban: A Major Determinant of Mouse Cardiomyocyte Force-Frequency Relationship Circulation, 106 19, 37


Carr, A.N., Schmidt, A.G., Suzuki, Y., Del Monte, F. Allen, P.B., Greengard, P., Grupp, I.L., Hoit, B.D., Hajjar, R.J., Depaoli-Roach, A.A. and Kranias, E.G. 2001. The type-1 phosphatase activity is a critical determinant of cardiac function and remodeling in heart failure Circulation, 104 17, 398


Carr, A.N., Schmidt, A.G., Suzuki, Y., Del Monte, F., Allen, P.B., Greengard, P., Grupp, I.L., Hoit, B.D., Hajjar, R., Depaoli-Roach, A.A. and Kranias, E.G. 2001. The type-1 phosphatase activity is a critical determinant of cardiac contractile function and remodeling: New avenues for therapeutic approaches in heart failure J. Cardiac Failure, 7 3, 001


Chu, G., Egnaczyk, G., Maggio, J.E. and Kranias, E.G. 2001. 2-D mapping of phosphoproteins in mouse cardiomyocytes in response to -agonists J. Mol. Cell. Cardiol., 33 6, A-21


Chu, G., Egnaczyk, G., Maggio, J.E. and Kranias, E.G. 2001. Proteome analysis identifies mouse cardiomyocyte phosphoproteins associated with hyperdynamic contractility Circulation, 104 17, 1510


Chu, G., Egnaczyk, G., Maggio, J.E., and Kranias, E.G. 2001. Proteomic analysis of phosphorylation profile in the phospholamban deficient hypercontractile cardiomyocytes J. Cardiac Failure, 7 3, 023


Dash, R., Schmidt, A.G., Gerst, M.J., Biniakiewicz, D., Abraham, W.T. and Kranias, E.G. 2001. Estrogen-dependent modulation of MAP kinase protects against catecholamine-induced hypertrophy, but not depressed contractility, in phospholamban overexpression hearts Circulation, 104 17, 397


Haghighi, K., Schmidt, A.G., Hoit, B.D. and Kranias, E.G. 2001. Superinhibition of sarcoplasmic reticulum by phospholamban results in gender specific responses to hypertrophic cardiomyopathy and early mortality J. Cardiac Failure, 7 3, 048


Pi, Y.Q., Kemnitz, K.R., Kranias, E.G. and Walker, J.W. 2001. Regulation of cardiac twitch kinetics by troponin I phosphorylation Biophys. J., 80 1, 378-pos


Sato, Y., Schmidt, A.G., Kiriazis, H., Hoit, B.D. and Kranias, E.G. 2001. Cardiac hypertrophy of aged transgenic FVB/N mice overexpressing calsequestrin J. Mol. Cell. Cardiol., 33 6, A-106


Sato, Y., Schmidt, A.G., Kiriazis, H., Hoit, B.D. and Kranias, E.G. 2001. Cardiac hypertrophy of aged transgenic FVB/N mice overexpressing calsequestrin J. Mol. Cell. Cardiol., 33 , A-106


Schmidt, A.G., Carr, A.N., Frank, B., Gerst, M.J., Pater, L., Hahn, H. Hoit, B.D., McConnell, B.K., Seidman, J.G. and Kranias, E.G. 2001. Phospholamban ablation rescues intrinsic contractility but does not prevent remodeling in homozygous myosin binding protein –C mice Circulation, 104 17, 401


Schmidt, A.G., Zhai, J., Carr, A.N., Lorenz, J.N., Pollesello, P., Annila, A., Hoit, B.D. and Kranias, E.G. 2001. Impaired SR Ca2+ uptake is a sufficient primary cause of heart failure: Structural and functional implications of an Asp27 to Ala phospholamban mutant J. Cardiac Failure, 7 3, 022


Schmidt, A.G., Zhai, J., Carr, A.N., Lorenz, J.N., Pollesello, P., Annila, A., Hoit, B.D. and Kranias, E.G. 2001. Impaired SR Ca2+ uptake is a sufficient primary cause of heart failure: Structural and functional implications of an Asp27 to Ala phospholamban mutant J. Cardiac Failure, 7 3, 022


Wang, J., Maertz, N.A., Lokua, A.J., Kranias, E.G. and Valdivia, H.H. 2001. Regulation of cardiac ryanodine receptor activity by calsequestrin Biophys. J. Vol., 80 1, 2667-pos


Wellman, G.C., Santana, L.F., Kranias, E.G. and Nelson, M.T 2001. Role of Phospholamban in the modulation of Ca2+ sparks and Ca2+ activated K+ channels by cAMP Biophys. J., 80 1, 298


Young, K.B., Chu, G., Gerst, M.J., Song, Q., Robbins, J., Grupp, I.L. and Kranias, E.G. 2001. Overexpression of phospholamban in slow-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation J. Mol. Cell. Cardiol., 33 6, A-135


Zhao, W., Frank, K.F., Chu, G., Ji, Y., Periasamy, M. and Kranias, E.G. 2001. Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state J. Mol. Cell. Cardiol., 33 6, A-137


Brixius, K., Savvidou-Zaroti, P., Boelck, B., Frank, K., Kranias, E.G., and Schwinger, R.H.G. 2000. Increased Ca2+ sensitivity of force and myosin ATP-ase activity in cardiac skinned fiber preparations of transgenic mice overexpressing phospholamban Circulation, 102 18, 1046


Brixius, K., Savvidou-Zatori, Boelck, B., Frank, K., Kranias, E.G., Schwinger, R.H.G. 2000. An transgenen Mausen mit Uberexpression von Phospholamban ist die Ca2+-Sensitivitat der Kraft und der Myosin-ATPase erhoht Z Kardiol, 89 2, 813


Carr, A.N., Schmidt, A., Suzuki, Y., Lanner, C., Gerst, M., Grupp, I.L., Depaoli-Roach, A., Kranias, E.G. 2000. Ablation of the SR phosphatase targeting subunit, RGL, results in enhanced cardiac contractility J. Mol. Cell. Cardiol., 32 5, K-3


Chu, G., Egnaczyk, G., Marci, J., Loo, R., Rapundalo, S.T., Maggio, J., Kranias, E.G. 2000. Up-regulation and posttranslational modification of scad in hyperdynamic phospholamban knockout mouse hearts J. Mol. Cell. Cardiol., 32 5, K-4


Cross, H.R., Steenbergen, C., Kranias, E.G., and Murphy, E. 2000. Role of nitric oxide in protection from myocardial ischemic injury in female phospholamban (PLB) knockout mice Circulation, 102 18, 441


Frank, K., Mesnard-Rouiller, L., Chu, G., Young, K.B., Haghighi, K., Kranias, E.G. 2000. Structure and characterization of the murine cardiac calsequestrin gene J. Mol. Cell. Cardiol., 32 5, K-7


Freeman, K. Lerman, I.R., Bohlmeyer, T.J., Kranias, E.G., and Leinwand, L.A. 2000. Phospholamban ablation rescues cardiac dysfunction in a mouse model of hypertrophic cardiomyopathy Circulation, 102 18, 1057


Haghighi, K., Aronow, B., Dorn II, G.W., Wu, G., Schmidt, A., Sato, Y., Kranias, E.G. 2000. Microarray analyses of gene expression in hypertrophic transgenic mouse hearts J. Mol. Cell. Cardiol., 32 5, I-45


Kiriazis, H., Kadambi, V.J., Hoit, B.D., Sato, Y., Schmidt, A., Kranias, E.G. 2000. Long-term transverse aortic banding is associated with similar functional alterations in phospholamban knockout and wild-type mice J. Mol. Cell. Cardiol., 32 5, K-11


Kranias, E.G. 2000. Calcium regulatory mechanisms in cardiac function and dysfunction Molecular Biology of the Cardiovascular System, , 43


Macri, J., Chu, G., Dubay, T. Du, P., Stevenson, T.I., Kilby, G.W., Kranias, E.G., and Rapundalo, S.T. 2000. Proteomic analysis of phospholamban knockout mouse hearts: changes in protein expression Circulation, 102 18, 348


Nobe, K., Sutliff, R.L., Kranias, E.G., and Paul, R.J. 2000. Phospholamban (PLB) regulation of bladder contractility: evidence from gene targeted (PLB-KO) and smooth muscle specific expression (PLB-SMOE) of PLB in mice Biophys. J., 78 , 656


Pieske, B., Maier, L.S., Giannakos, A., Kranias, E.G., Schmidt, A. 2000. Einfluss von Calsequestrin-Uberexpression auf Kontraktilitat und Ca2+-Gehalt des sarkoplasmatischen Retikulums am isolierten Myokard transgener Mause Z Kardilol, 89 2, 489


Sato, Y., Kiriazis, H., Mitarai, S., Yatani, A., Dorn, G.W. and Kranias, E.G. 2000. Restoration of contractile parameters in calsequestrin overexpressing myocardium by phospholamban ablation Jpn. J. Pharmacology, 82 , 115


Schmidt, A.G., Zhai, J., Gerst, M., Kranias, E.G., Hoit, B.D. 2000. Echocardiographic assessment of LV diastolic function in genetically altered mice J. Mol. Cell. Cardiol., 32 5, D-13


Shannon, T.R., Kranias, E.G., and Bers, D.M. 2000. How does phospholamban decrease SR Ca content Biophys. J., 78 , 440


Young, K.B., Chu, G., Molkentin, J.D., Kranias, E.G. 2000. Enhanced sarcoplasmic reticulum Ca2+ signaling in calcineurin overexpression transgenic hearts J. Mol. Cell. Cardiol., 32 5, K-20


Zhai, J., MacLennan, D.H., Kranias, E.G. 2000. Phospholamban Asn27 to Ala mutant is associated with significant inhibition of cardiomyocyte mechanics and Ca2+ kinetics J. Mol. Cell. Cardiol., 32 5, K-21


Bluhm, W.F., Kranias, E.G., Meyer, M. and Dillmann, W.H. 1999. Phospholamban: The major determinant of the cardiac force-frequency relationship Intern. Soc. Heart Res., ,


Bluhm, W.F., Kranias, E.G., Meyer, M. and Dillmann, W.H. 1999. Phospholamban: The major determinant of the cardiac force-frequency relationship J. Mol. Cell. Cardiol., 31 7, A39


Brittsan, A.G., Schmidt, A., Grupp, I.L., Hoit, B.D., Kranias, E.G. 1999. Ablation of phospholamban phosphorylation sites in transgenic mouse hearts Circulation, 100 4028, I-763


Carr, A.N., Sato, Y., Neirouz, Y., Schmidt, A., Hoit, B.D., Grupp, I.L., Allen, P.B., Greengard, P. and Kranias, E.G. 1999. Protein phosphatase inhibitor-1 ablation results in depressed cardiac contractility in response to -adrenergic stimulation and decreased phosphorylation of phospholamban J. Cardiac Failure, 5 3, 019


Carr, A.N., Sato, Y., Neirouz, Y., Schmidt, A., Hoit, B.D., Grupp, I.L., Allen, P.B., Greengard, P., Kranias, E.G. 1999. Gene ablation of protein phosphatase inhibitor-1 is associated with depressed cardiac contractility and decreased phospholamban phosphorylation Circulation, 100 4026, I-763


Carr, A.N., Sutliff, R.L., Allen, P.B., Weber, C.S., Greengard, P., Kranias, E.G. and Paul, J.P. 1999. Protein phosphatase inhibitor-1 gene ablation does not affect tonic or phasic vascular smooth muscle contractility Biophys. J., 76 , A290


Carr, A.N., Suzuki, Y., Sato, Y., Schmidt, A., Kadambi, V.J., Hoit, B.D., Grupp, I.L., Jing, S-L., Field, L.J., Depaoli-Roach, A. and Kranias, E.G. 1999. Cardiac-specific overexpression of the sarcoplasmic reticulum and glycogen targeting subunit of the type I phosphatase does not result in altered cardiac contractility J. Cardiac Failure, 5 3, 018


Dash, R., Frank, K.F., Moravec, C.S., Kranias, E.G. 1999. Phospholamban phosphorylation and the apparent affinity of the sarcoplasmic Ca2+-ATPase for Ca2+ are depressed in failing human myocardium Circulation, 100 2202, I-419


Dash, R., Slack, J.P., Grupp, I.L., Holder, D., Tilgmann, C., Tamura, T., Johnson, R., Gerdes, A.M. and Kranias, E.G. 1999. Aging is associated with progressive increases in Na+/Ca+ exchanger and Na+/K+-ATPase protein levels in the murine heart J. Cardiac Failure, 5 3, 020


Dash, R., Slack, J.P., Grupp, I.L., Holder, D., Tilgmann, C., Tamura, T., Johnson, R.G. Jr., Gerdes, A.M., Kranias, E.G. 1999. Aging, hyperdynamic phospholamban knockout hearts exhibit progressive increases in Na+/K+-ATPase and Na+/Ca2+ exchanger protein levels Circulation, 100 622, I-120


Frank, K., Dash, R., Moravec, C.S. and Kranias, E.G. 1999. Human failing myocardium exhibits decreased Ser-16 and Thr-17 phospholamban phosphorylation and decreased apparent affinity of the sarcoplasmic Ca2+-ATPase for Ca2+ J. Cardiac Failure, 5 3, 022


Frank, K.F., Tilgmann, C., Kranias, E.G. 1999. Phospholamban ablation results in an enhanced efficiency of the sarcoplasmic reticulum Ca2+ transport Circulation, 100 4032, I-764


Haghighi, K., Brittsan, A., Lester, J.W. and Kranias, E.G. 1999. Cardiac overexpression of a mutant form of phospholamban results in depressed contractile function Intern. Soc. Heart Res., ,


Haghighi, K., Brittsan, A., Lester, J.W. and Kranias, E.G. 1999. Cardiac overexpression of a mutant form of phospholamban results in depressed contractile function J. Mol. Cell. Cardiol., 31 J-9, A42


Haghighi, K., Hoit, B.D., Schmidt, A., Kimura, Y., Brittsan, A.G., MacLennan, D.H. and Kranias, E.G. 1999. Cardiac overexpression of a mutant form of phospholamban is associated with depressed contractility and hypertrophy J. Cardiac Failure, 5 3, 036


Haghighi, K., Hoit, B.D., Schmidt, A., Yatani, A., Kimura, Y., Brittsan, A.G., MacLennan, D.H., Kranias, E.G. 1999. Cardiac overexpression of a mutant form of phospholamban induces fetal genes, hypertrophy and contractile failure in mice Circulation, 100 4015, I-761


Hoit, B.D., Tramuta, D.A., Kadambi, V.J., Walsh, R.A. and Kranias, E.G. 1999. Effect of altered phospholamban levels on the rate of relaxation restitution in vivo Intern. Soc. Heart Res., ,


Hoit, B.D., Tramuta, D.A., Kadambi, V.J., Walsh, R.A. and Kranias, E.G. 1999. Effect of altered phospholamban levels on the rate of relaxation restitution in vivo J. Mol. Cell. Cardiol., 31 I-8, A40


Kiriazis, H., Schmidt, A., Sato, Y., Kranias, E.G. and Hoit, B.D. 1999. Effects of aging on mouse hearts with cardiac-specific overexpression of murine cardiac calsequestrin J. Cardiac Failure, 5 3, 013


Lester, J.W., Molkentin, J.D. and Kranias, E.G. 1999. Myocyte function in calcineurin overexpression transgenic mice Intern. Soc. Heart Res., ,


Lester, J.W., Molkentin, J.D. and Kranias, E.G. 1999. Myocyte function in calcineurin overexpression transgenic mice J. Mol. Cell. Cardiol., 31 J-14, A43


Minamisawa, S., Hoshijima, M., Chu, G., Ward, C.A., Frank, K., Gu, Y., Ross, J. Jr., Giles, W.R., Kranias, E.G. and Chien, K.R. 1999. Genetic complementation identifies phospholamban- sarcoplasmic reticulum Ca ATPase interaction as the primary defect that drives the onset of heart failure in dilated cardiomyopathy J. Cardiac Failure, 5 3, 071


Schmidt, A., Dash, R., Kadambi, V.J., Hoit, B.D., Kranias, E.G. 1999. Aging is associated with hypertrophy and depressed contractility in four-fold phospholamban over-expression hearts Circulation, 100 4017, I-761


Schmidt, A., Zhai, J., Zvarich, E., MacLennan, D.H., Kranias, E.G. and Hoit, B.D. 1999. In vivo echocardiographic assessment of contractile dysfunction in transgenic mice overexpressing two different mutant forms of phospholamban J. Cardiac Failure, 5 3, 007


Schmidt, A., Zhai, J., Zvarich, E., MacLennan, D.H., Kranias, E.G., Hoit, B.D. 1999. Two mutant forms of phospholamban result in different effects on ventricular function and -adrenergic response in vivo Circulation, 100 4027, I-763


Shannon, T.R., Chu, G., Kranias, E.G. and Bers, D.M. 1999. Rate of SR Ca leak and the efficiency of the SR Ca pump in nonpentamer-forming phospholamban mutant mice Biophys. J., 76 , A297


Sutliff, R.L., Conforti, L., Kranias, E.G. and Paul, R.J. 1999. Mechanisms underlying altered portal vein mechanical activity in phospholamban gene-ablated mice FASEB J., 13 4, A93


Sutliff, R.L., Kadambi, V.J., Weber, C.S., Kranias, E.G. and Paul, R.J. 1999. Smooth muscle-targeted overexpression of phospholamban (PLB) increases sensitivity to contractile agents Biophys. J., 76 , A12


Tramuta, D., Kadambi, V.J., Ball, N., Kranias, E.G., Walsh, R.A. and Hoit, B.D. 1999. Genetically altered phospholamban levels modulate the rate of mechanical restitution in vivo ACC, ,


Tramuta, D.A., Kadambi, V.J., Ball, N., Dash, R., Kranias, E.G., Walsh, R.A. and Hoit, B.D. 1999. New Insights into calcium cycling using post-extrasystolic potentiation in phospholamban overexpression ACC, 222814 ,


Zhai, J., MacLennan, D.H. and Kranias, E.G. 1999. Overexpression of a phospholamban Asp27 to Ala mutant is associated with significant inhibition of cardiac function J. Cardiac Failure, 5 3, 021


Zhai, J., MacLennan, D.H., Kranias, E.G. 1999. Overexpression of a phospholamban Asp27 to Ala mutant is associated with significant inhibition of cardiac function Circulation, 100 3034, I-575


Banerjee, A., Joshi, P., Gabel, M., Harrer, J.M., Kranias, E.G. and Hoit, B.D. 1998. Pacing induced heart failure in immature goats: Physiological and molecular changes reflect impaired calcium cycling by sarcoplasmic reticulum J. Cardiac Failure, 4 3,


Bluhm, W.F., Meyer, M., Giordano, F.J., Kranias, E.G., Dillman, W.H. 1998. The Phospholamban to SERCA2a Ratio Modifies the Force-Frequency Relationship Circulation, 98 263, I-53


Brittsan, A.G., Kadambi, V.J., Hoit, B.D. and Kranias, E.G. 1998. Overexpression of a phospholamban phosphorylation mutant in transgenic mice Biophys. J., 74 2, A358


Brittsan, A.G., Kadambi, V.J., Hoit, B.D. and Kranias, E.G. 1998. Cardiac overexpression of a non-phosphorylatable form of phospholamban results in depressed contractile function and hypertrophy J. Cardiac Failure, 4 3, 072


Brittsan, A.G., Kadambi, V.J., Hoit, B.D., Kranias, E.G. 1998. Cardiac Overexpression of a Non-Phosphorylatable Form of Phospholamban Results in Depressed Contractile Function and Hypertrophy Circulation, 98 2577, I-490


Chu, G. and Kranias, E.G. 1998. Phospholamban: The key regulator of the SR calcium pump and contractility in cardiac muscle On-line Proceedings of the 5th Internet World Congress on Biochemical Sciences ’98 at McMaster Un., Canada, ,


Chu, G., Lester, J.W. Jr., Luo, W., Mesnard-Rouiller, L., Kranias, E.G. 1998. Genetically Engineered Mice Offer Unique Insights Into the Functional Significance of Dual Site Phospholamban Phosphorylation Circulation, 98 736, I-142


Chu, G., Lester, J.W., Luo, W., Mesnard-Roullier, L. and Kranias, E.G. 1998. Functional significance of dual site Phospholamban phosphorylation in transgenic mice J. Cardiac Failure, 4 3, 012


Chu, G., Luo, W., Sato, Y., Kadambi, V.J., and Kranias, E.G. 1998. Interplay between dual site phospholamban phosphorylation in transgenic mice J. Molec. Cell. Cardiol., 30 665, A169


Dash, R., Kadambi, V.J., Harrer, J.M., Hoit, B.D. and Kranias, E.G. 1998. Transgenic approaches to uncover the functional stoichiometry of phospholamban to sarcoplasmic reticulum Ca2+-ATPase in vivo J. Cardiac Failure, 4 3, 074


Dash, R., Kadambi, V.J., Harrer, J.M., Holt, B.D., Kranias, E.G. 1998. Transgenic Approaches to Uncover the Functional Stoichiometry of Phospholamban to Sarcoplasmic Reticulum Ca2+-ATPase in Vivo Circulation, 98 737, 1-142


Dash, R., Kadambi, V.J., Harrer, J.M., Johnson Jr., R.G. and Kranias, E.G. 1998. Subcellular characterization of a four-fold phospholamban overexpression mouse model Biophys. J., 74 2, A357


Kadambi, V.J., Ball, N., Banerjee, A., Kranias, E.G., Walsh, R.A. and Hoit, B.D. 1998. In Vivo modulation of mechanical restitution in genetically engineered mice with altered levels of phospholamban J. Cardiac Failure, 4 3, Y1


Kadambi, V.J., Ball, N., Banerjee, A., Kranias, E.G., Walsh, R.A., Holt, B.D. 1998. Genetically Altered Phospholamban Levels Modulate the Rate of Mechanical Restitution In Vivo Circulation, 98 734, I-142


Kadambi, V.J., Grupp, I.L. and Kranias, E.G. 1998. Transgenic approach to elucidate the role of phospholamban in modulating atrial contractility J. Molec. Cell. Cardiol., 30 177, A47


Kadambi, V.J., Sato, Y., Ball, N., Kranias, E.G., and Walsh, R.A. 1998. Transgenic overexpression of calsequestrin produces pulsus alternans J. Molec. Cell. Cardiol., 30 178, A47


Kiriazis, H., Kadambi, V.J., Holt, B.D., Suresh, D.P., Johnson, R.G, Jr., Kranias, E.G. 1998. Transverse Aortic Banding Leads to Depressed In Vivo Left Ventricular Function in Phospholamban Ablated Mice Circulation, 98 2576, I-489


Kiriazis, H., Kadambi, V.J., Suresh, D.P., Johnson Jr., R.G., Kranias, E.G. and Hoit, B.D. 1998. Transverse aortic banding leads to depressed in vivo left ventricular function in phospholamban ablated mice J. Cardiac Failure, 4 3, 018


Kranias, E.G. 1998. Cardiac function and dysfunction: molecular and cellular mechanisms J. Amer. Soc. Hyperten., 11 4, 235A


Li, L., Chu, G., Kranias, E.G. and Bers, D.M. 1998. Phosphorylation of phospholamban is more crucial than troponin I phosphorylation in PKA mediated acceleration of relaxation in cardiac myocytes Biophys. J., 74 2, A248


Sako, H., Sato, Y., Kranias, E.G., Yatani, A. 1998. Subcellular mechanisms in transgenic cardiac myocytes with altered excitation-contraction (E-C) coupling Circulation, 98 4006, I-764


Sato, Y., Kadambi, V.J., Ball, N., Hoit, B.D., Walsh, R.A. and Kranias, E.G. 1998. Calsequestrin overexpression produces left ventricular hypertrophy and increased fractional shortening J. Molec. Cell. Cardiol., 30 653, A166


Sato, Y., Yamamoto, S., Yatani, A. and Kranias, E.G. 1998. Rescue of the depressed contractile parameters in calsequestrin overexpressing hearts by phospholamban ablation J. Cardiac Failure, 4 3, 017


Sato, Y., Yamamoto, S., Yatani, A., Kranias, E.G. 1998. Rescue of the Depressed Contractile Parameters in Calsequestrin Overexpressing Hearts by Phospholamban Ablation Circulation, 98 265, I-53


Sutliff, R.L., Hoying, J.B., Kadambi, V.J., Kranias, E.G. and Paul, R.J. 1998. Phospholamban (PLB) modulates endothelial cell function: evidence from PLB-knockout mice J. Molec. Cell. Cardiol., 30 774, A196


Sutliff, R.L., Hoying, J.B., Kadambi, V.J., Kranias, E.G. and Paul, R.J. 1998. Phospholamban gene ablation alters endothelium-dependent relaxation of the mouse aorta Physiologist, 41 4, 17.14


Takeishi, Y., Chu, G., Kirkpatrick, D.M., Kranias, E.G., King, G.L. and Walsh, R.A. 1998. In Vivo phosphorylation of cardiac troponin I by PKC2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts J. Cardiac Failure, 4 3, 075


Takeishi, Y., Chu, G., Wakasaki, H., Hoit, B.D., Kranias, E., King, G.L. and Walsh, R.A. 1998. Targeted overexpression of protein kinase C 2 isoform in myocardium causes cardiomyopathy J. Molec. Cell. Cardiol., 30 49, A15


Yatani, A., Sato, Y., Sako, H. and Kranias, E.G. 1998. Subcellular mechanisms in transgenic cardiac myocytes with altered excitation-contraction (E-C) coupling J. Cardiac Failure, 4 3, 121


Banerjee, A., Shah, D.P., Kadambi, V.J., Manning, P.B., and Kranias, E.G. 1997. Changes in myosin isoforms, calcium handling proteins of the sarcoplasmic reticulum and function in right atria of children in response to pressure overload Circulation, 96 8, I-199


Chu, G., Dorn II, G.W., Luo, W., Harrer, J.M., Kadambi, V.J., Walsh, R.A., Kranias, E.G. 1997. Regulatory effects of phospholamban monomers in vivo New York Academy of Sciences Conference on “Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility”, #PI-9, ,


Chu, G., Sato, Y., Li, L., Luo, W., Kadambi, V.J., Bers, D.M., and Kranias, E.G. 1997. Pentameric assembly of phospholamban is necessary for its optimal regulation of myocardial relaxation Circulation, 96 8, I-178


Haghighi, K., Kadambi, V.J., Koss, K.L. and Kranias, E.G. 1997. Phospholamban gene expression in cells and transgenic mice Biophys. J., 72 2, A172


Hoit, B.D., Kadambi, V.J., Ball, N., Magorien, D., Kranias, E.G., and Walsh, R.A. 1997. Influence of phospholamban on force-frequency relations and isovolumic indices of ventricular function in the closed chest model Circulation, 96 8, I-569


Hoit, B.D., Kadambi, V.J., Magorein, D., Ball, N., Kranias, E.G., and Walsh, R.A. 1997. In vivo assessment of systolic and diastolic function in a novel mouse model of heart failure 1st Annual Meeting of the Heart Failure Society of America, #116, ,


Huser, J., Satoh, H., Bers, D.M., Kranias, E.G. and Blatter, L.A. 1997. Subcellular properties of [Ca]i transients in phospholamban deficient mouse ventricular myocytes Biophys. J., 72 2, A45


Kadambi, V.J., Ball, N., Luo, W., Kranias, E.G., Walsh, R.A., and Hoit, B.D. 1997. Modulation of the force-frequency relationship by phospholamban in genetically engineered closed-chested mice New York Academy of Sciences conference on “Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility”, #PI-15, ,


Kadambi, V.J., Hoit, B.D., Boivin, G.P., Dorn II, G.W., Walsh, R.A., and Kranias, E.G. 1997. Molecular and physiological analyses of a genetical heart failure mouse model 1st Annual Meeting of the Heart Failure Society of America, #177, ,


Kadambi, V.J., Masaki, H., Sato, Y., Kranias, E.G., and Yatani, A. 1997. Atrial over-expression of phospholamban alters inactivation kinetics of L-type Ca2+ -channel currents Circulation, 96 8, I-55


Kiss, E., Brittsan, A.G., Edes, I., Luo, W., Grupp, I.L., Grupp, G. and Kranias, E.G. 1997. Effects of thyroxine on cardiac function in phospholamban-deficient mouse hearts Biophys. J., 72 2, A167


Kranias, E.G. 1997. Phospholamban: From protein to transgenic mice New York Academy of Sciences conference on “Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility”, #6, ,


Li, L., Kranias, E.G. and Bers, D.M. 1997. Calcium transport in phospholamban knockout mouse: Relaxation and endogenous CaMKII effects Biophys. J., 72 2, A234


Liu, Y., Kranias, E.G. and Schneider, M.F. 1997. Dynamic regulation of calcium handling by phosphorylation and dephosphorylation in mouse single fast-twitch and slow-twitch skeletal muscle fibers Biophys. J., 72 2, A275


Luo, W., Sato, Y., Zhou, Z., Kadambi, V.J., and Kranias, E.G. 1997. Transgenic approach to elucidate the role of PLB Ser16 phosphorylation site in the mediation of -adrenergic stimulation Circulation, 96 8, I-181


Masaki, H., Kadambi, V.J., Luo, W., Sato, Y., Kranias, E.G. and Yatani, A. 1997. Inactivation kinetics of cardiac L-type Ca2+ channels is regulated by SR Ca2+ content, studied in transgenic mice Biophys. J., 72 2, A368


Pan, B-S., Wiedmann, R.T., Kadambi, V.J., Kranias, E.G., and Johnson, R.G. Jr. 1997. Demonstration of phospholamban gene-dosage effect in chemically skinned mouse ventricular muscles Circulation, 96 8, I-179


Santana, L.F., Gomez, A.M., Kranias, E.G. and Lederer, W.J. 1997. Isoproterenol changes in the kinetics of Ca2+ sparks in mouse ventricular myocytes Biophys. J., 72 2, A44


Santana, L.F., Neubauer, C.F., Kranias, E.G., and Lederer, W.J. 1997. Ca2+ release from the sarcoplasmic reticulum in cardiac myocytes depends on the amount of Ca2+ within the organelle New York Academy of Sciences conference on “Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility”, #16, ,


Santana, L.F., Shioya,M. T., Kranias, E.G. and Lederer, W.J. 1997. Ca2+ sparks and EC coupling in phospholamban-deficient ventricular myocytes Biophys. J., 72 2, A43


Sato, Y., Allen, P., Greengard, P., and Kranias, E.G. 1997. Targeted ablation of protein phosphatase inhibitor-1 is associated with alteration in cardiac response to -adrenergic agonists New York Academy of Sciences conference on “Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility”, #PI-25, ,


Sato, Y., Kadambi, V.J., Ferguson, D.G., Hoit, B.D., Walsh, R.A., and Kranias, E.G. 1997. Cardiac-specific overexpression of calsequestrin is associated with hypertrophy and enhanced contractility New York Academy of Sciences conference on “Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility, #PII-23”, ,


Sato, Y., Luo, W., Kadambi, V.J. and Kranias, E.G. 1997. Phospholamban inhibitory effects upon its reintroduction into the knockout background Biophys. J., 72 2, A172


Slack, J.P., Grupp, I.L., Tilgmann, C., Luo, W., Tamura, T., Gerdes, A.M., and Kranias, E.G. 1997. Effects of age on the hyperdynamic cardiac function of phospholamban knockout mice Circulation, 96 8, I-179


Yatani, A., Green, S.A., Kranias, E.G., and Sako, H. 1997. Modulation of cardiac L-type Ca2+ channel currents by isoproterenol studied in transgenic mouse myocytes with altered sarcoplasmic reticulum Ca2+ content Circulation, 96 8, I-422


Chu, G., Kadambi, V.J., Luo, W., Kirkpatrick, D.L., Walsh, R.A., Kranias, E.G. 1996. Cardiomyocyte mechanics in transgenic mice expressing monomeric phospholamban Circulation, 94 8, I-420


Chu, G., Luo, W., Matlib, M.A., Sweet, W.E., Ferguson, D.G., Boivin, G.P., Slack, J.P., Moravec, C.S., Grupp, I.L. and Kranias, E.G. 1996. Compensatory mechanisms in phospholamban knock-out mouse hearts Biophys. J., 70 2, A56


Desai, K.H., Schauble, E., Rohrer, D.K., Luo, W., Kranias, E.G., Bernstein, D. 1996. Alterations in basal cardiovascular parameters and response to treadmill exercise in phospholamban deficient (PLB-I-) mice Circulation, 94 8, I-309


Edes, I., Kiss, E., Grupp, I., Grupp, G. and Kranias, E.G. 1996. Thyroxin-induced alterations in the cardiac function and the expression of sarcoplasmic reticular proteins in phospholamban-deficient mouse hearts Eur. Heart J., 17 , 329


Haghighi, K., Koss, K.L., Kadambi, V.J., Ponniah, S. and Kranias, E.G. 1996. In vitro analysis of phospholamban gene expression J. Mol. Cell. Cardiol, 28 6, A171


Hampton, T.G., Kranias, E.G., Morgan, J.P. 1996. Intracellular calcium measured simultaneously with ventricular function in the phospholamban-deficient mouse heart Circulation, 94 8, I-159


Heiny, J., Masaki, H., Tilgmann, C., Harrer, J.M., Kranias, E.G. and Yatani, A. 1996. L-type Ca2+ currents in control and phospholamban-transfected C2C12 cells Biophys. J., 70 2, A56


Hoit, B., Kranias, E.G. and Walsh, R.A. 1996. Noninvasive cardiac functional analysis of genetically altered mice using imaging and doppler echo J. Mol. Cell. Cardiol., 28 6, A129


Housmans, P.R., Sieck, G.C., Hannon, J.D., Kranias, E.G. and Potter, J.D. 1996. Contraction and relaxation time course of wild type and phospholamban-less mouse ventricular myocardium after beta-adrenoceptor agonism Biophys. J., 70 2, A407


Kadambi, V.J., Koss, K.L., Haghighi, K., Ponniah, S. and Kranias, E.G. 1996. Analysis of the murine phospholamban gene promoter in cultured cells and transgenic mice Biophys. J., 70 2, A256


Luo, W., Sato, Y., Kadambi, V.J., Kranias, E.G. 1996. Re-introduction of wild-type and mutant phospholamban into phospholamban-deficient hearts reverses enhanced cardiac contractility Circulation, 94 8, I-310


Masaki, H., Sato, Y., Luo, W., Kranias, E.G. and Yatani, A. 1996. Characteristics of L-type Ca2+-channel and -adrenergic stimulation in wild-type and phospholamban-deficient mouse cardiac myocytes J. Mol. Cell. Cardiol., 28 6, A160


Pan, B.-S., Kranias, E., Shen, Y.-T. and Johnson, R.G. Jr. 1996. -Adrenergic stimulation on twitch contraction of isolated ventricular myocardium of phospholamban knockout mice Biophys. J., 70 2, A56


Slack, J.P., Grupp, I.L., Ferguson, D.G. and Kranias, E.G. 1996. Phospholamban expression in transgenic mice prolongs fast-twitch skeletal muscle relaxation Biophys. J., 70 2, A285


Edes, I., Kiss, E., Kranias, E.G. 1995. Effects of -adrenergic agents on protein phosphorylation in hearts with targeted ablation of phospholamban Eur. Heart J., 16 , 459


Grupp, I.L., Koss, K.L., Grupp, G., Luo, W. and Kranias, E.G. 1995. Ablation of the phospholamban (PLB) gene in murine atrium alters contractility and responses to -agonists J. Mol. Cell. Cardiol., 27 6, A364


Harrer, J.M., Haghighi, K., Kim, H.W. and Kranias, E.G. 1995. Coordinate expression of phospholamban (PLB) and sarcoplasmic reticulum (SR) Ca2+-ATPase during murine myocardial development J. Mol. Cell. Cardiol., 27 6, A79


Kiss, E., Edes, I., Luo, W. and Kranias, E.G. 1995. Effect of isoproterenol on protein phosphorylation in hearts deficient in phospholamban J. Mol. Cell. Cardiol., 27 6, A111


Kiss, E., Edes, I., Luo, W. and Kranias, E.G. 1995. Protein phosphorylation in phospholamban knockout hearts stimulated with isoproterenol Circulation, 92 , I-558


Koss, K.L., Grupp, I.L., Luo, W. and Kranias, E.G. 1995. Phospholamban gene ablation in mice enhances atrial relaxation and reduces atrial responses to -agonists Circulation, 92 ,


Koss, K.L., Ponniah, S., Grupp, I.L. and Kranias, E.G. 1995. Differential tension development is associated with the relative abundance of phospholamban and SERCA2 mRNAs in the murine atrium and ventricle J. Mol. Cell. Cardiol., 27 6, A135


Koss, K.L., Ponniah, S., Grupp, I.L., Jones, W.K. and Kranias, E.G. 1995. Molecular, biochemical, and physiological analyses of phospholamban (PLB) gene expression in murine cardiac compartments J. Mol. Cell. Cardiol., 27 6, A364


Kranias, E.G., Harrer, J.M., Szymanska, G., Slack, J. and Grupp, I.L. 1995. Phenotype of the relaxing system during cardiac development J. Mol. Cell. Cardiol, 27 6, A271


Lalli, J., Luo, W., Kranias, E.G. and Paul, R.J. 1995. Aorta from phospholamban-deficient transgenic mice have decreased sensitivity to phenylephrine (PE) and KCl but near normal SNP relaxation FASEB J., , A41


Lorenz, J.N. and Kranias, E.G. 1995. Ventricular function in the intact anesthetized phospholamban deficient mouse Circulation, ,


Luo, W., Wolska, B.M., Grupp, I.L., Slack, J., Harrer, J.M., Haghighi, K., Solaro, R.J. and Kranias, E.G. 1995. Phospholamban gene dosage effects in the murine heart J. Mol. Cell. Cardiol., 27 6, A134


Wolska, B.M., Luo, W., Kranias, E.G. and Solaro, R.J. 1995. Effects of -adrenergic agonists on contractility of cardiac myocytes isolated from wild-type and phospholamban deficient mice Biophys. J., 68 2, A180


Edes, I., Kiss, E., Kitada, Y., Papp, J.G., Kranias, E.G. and Solaro, R.J. 1994. Effects of Levosimendan, a new cardiotonic agent, on myofibrillar Ca2+-sensitivity, sarcoplasmic reticular (SR) function, and phosphorylation Circulation, 90 4, I-217


Harrer, J.M. and Kranias, E.G. 1994. Developmental regulation of phospholamban expression and sarcoplasmic reticulum function in murine hearts Biophys. J., 66 2, A202


Kadambi, V.J., Walsh, R.A., Ponniah, S., Dorn II, G.W. and Kranias, E.G. 1994. Overexpression of phospholamban in the mouse results in prolongation of Ca2+ transients and depressed contractility in isolated cardiomyocytes Circulation, 90 4, I-538


Kiss, E., Edes I. and Kranias, E.G. 1994. The effect of thyroid status on phospholamban protein expression in rat hearts Biophys. J., 66 2, A83


Koss, K.L., Ponniah, S., Jones, K.W. and Kranias, E.G. 1994. Differential expression of phospholamban gene transcripts in murine atrium and ventricle Biophys. J., 66 2, A372


Lalli, J., Luo, W., Kranias, E.G. and Paul, R.J. 1994. Decreased vascular sensitivity in aorta from transgenic, phospholamban-deficient mice Circulation, 90 4, I-356


Luo, W., Grupp, I.L., Harrer, J., Ponniah, S., Zhou, Z., Duffy, J.J., Grupp, G., Doetschman, T. and Kranias, E.G. 1994. Targeted disruption of the phospholamban gene in embryonic stem cells: A novel approach to understanding the role of phospholamban in vivo Cardiac Muscle Congress, ,


Luo, W., Grupp, I.L., Harrer, J.M., Slack, J.P., Grupp, G., Doetschman, T. and Kranias, E.G. 1994. Targeted disruption of the phospholamban gene is associated with enhanced sarcoplasmic reticulum Ca2+ transport and myocardial contractile parameters Circulation, 80 4, I-633


Slack, J.P., Grupp, I.L., Luo, W. and Kranias, E.G. 1994. Phospholamban ablation is associated with altered twitch dynamics in mouse slow-twitch skeletal muscle Circulation, 90 4, 1


Harrer, J.M., Ponniah, S., Ferguson, D. and Kranias, E.G. 1993. Functional expression of phospholamban in C2C12 cells Membrane Biophysics Subgroup, Biophys. Soc., Duke University Marine Lab, ,


Kiss, E., Ball, N.A., Kranias, E.G. and Walsh, R.A. 1993. Altered cardiac mechanics and sarcoplasmic reticulum function in pressure-overload hypertrophy with congestive heart failure Circulation , 88 4, 1


Kiss, E., Kranias, E.G. and Edes, I. 1993. The effect of thyroid states on the phosphatidylinositide-specific phospholipase C activity and on the basal phosphorylation of phospholipids in rat heart Membrane Biophysics Subgroup, Biophys. Soc., Duke University Marine Lab, ,


Kranias, E.G., Luo, W., Ganim, J.R., Kadambi, V. and Ponniah, S. 1993. Regulation of the cardiac sarcoplasmic reticulum Ca2+-ATPase Membrane Biophysics Subgroup, Biophys. Soc., Duke University Marine Lab, ,


Luo, W., Ponniah, S., Harrer, J., Doetschman, T. and Kranias, E.G. 1993. Gene targeting approaches for understanding the role of phospholamban in myocardial contractility Keystone Symposia on Molecular and Cellular Biology, Taos, New Mexico, ,


Luo, W., Ponniah, S., Harrer, J., Doetschman, T. and Kranias, E.G. 1993. Gene targeting approaches for understanding the role of phospholamban in myocardial contractility Circulation, 88 4, 1


Szymanska, G., Grupp, I. and Kranias, E.G. 1993. The role of sarcoplasmic reticulum function and phospholamban in the developing rabbit heart Biophys. J., 64 2, A382


Talosi, L. and Kranias, E.G. 1992. Intracellular mechanisms mediating the reversal of beta adrenergic stimulation in intact beating hearts European Society of Cardiology, Barcelona, Spain, ,


Edes, I., Talosi, L. and Kranias, E.G. 1991. Is protein phosphorylation involved in alpha-adrenergic inotropy? Eur. Heart J., 12 , 125a


Ganim, J.R., Luo, W., Kim, H.W., Grupp, I.L., Askew, R. and Kranias, E.G. 1991. cDNA cloning and sequencing of phospholamban from mouse cardiac muscle J. Mol. Cell. Cardiol., 23 , S.57


Harrer, J. and Kranias, E.G. 1991. Oligomeric form of purified or detergent solubilized phospholamban Membrane Transport and Signal Transduction Meeting, Duke University Marine Lab, ,


Harrer, J.M. and Kranias, E.G. 1991. Oligomeric form of phospholamban under non denaturing conditions J. Mol. Cell. Cardiol., 23 , S.77


Luo, W., Ganim, J., Ponniah, S., Kim, H.W., Grupp, I.L. and Kranias, E.G 1991. Phospholamban in the mouse heart: cDNA cloning and expression during development Membrane Transport and Signal Transduction Meeting, Duke University Marine Lab, ,


Steenaart, N.A.E., Di Salvo, J. and Kranias, E.G. 1991. Phospholamban phosphatase in cardiac sarcoplasmic reticulum Biophys. J., 59 2, 253a


Szymanska, G., Amler, E., Ball, W.J. and Kranias, E.G. 1991. Regulation of skeletal sarcoplasmic reticulum Ca2+ ATPase by phospholamban and negatively charged phospholipid Biophys. J., 59 2, 252a


Szymanska, G., Kim, H.W., Cuppoletti, J. and Kranias, E.G. 1991. Regulation of the skeletal sarcoplasmic reticulum Ca2+ ATPase by phospholamban and negatively charged phospholipids in reconstituted phospholipid vesicles Membrane Transport and Signal Transduction Meeting, Duke University Marine Lab, ,


Talosi, L. and Kranias, E.G. 1991. 1 adrenergic stimulation and protein phosphorylation in beating hearts J. Mol. Cell. Cardiol. , 23 , S.66


Talosi, L., Edes, I. and Kranias, E.G. 1991. Activation of protein kinase C in vivo by 1-adrenergic agonists is not associated with phosphorylation of phospholamban Biophys. J., 59 2, 253a


Zhang, C., Hardin, C.D., Paul, R.J. and Kranias, E.G. 1991. Mechanisms of calmodulin activation of Ca2+ uptake in plasmalemmal vesicles of porcine arterial smooth muscle FASEB J., 5 6, A1737


Zhang, C., Kranias, E.G. and Paul, R.J. 1991. Differential effects of calmodulin binding peptides, RS20 and melittin, on the plasma membrane Ca2+ pump from smooth muscle J. Mol. Cell. Cardiol. , 23 , S.88


Cuppoletti, J., Kim, H.W. and Kranias, E.G. 1990. Interaction of a synthetic phospholamban peptide with the cardiac sarcoplasmic reticulum Ca2+ ATPase Biophys. J., 57 2, 499a


Kim, H.W., Szymanska, G., Steenaart, N.A.E. and Kranias, E.G. 1990. Reconstitution of sarcoplasmic reticula Ca2+ ATPases from cardiac and skeletal muscle Biophys. J., 57 2, 502a


Szymanska, G., Kim, H.W. and Kranias, E.G. 1990. The effect of negatively charged phospholipids on the reconstituted Ca2+ ATPase from skeletal sarcoplasmic reticulum Biophys. J., 57 2, 501a


Edes, I., Solaro, R.J. and Kranias, E.G. 1989. Beta adrenergic receptor and phospho-inositide turnover in isolated perfused guinea pig hearts Biophys. J., 55 2, 480a


Edes, I., Steenaart, N.A.E. and Kranias, E.G. 1989. Effects of phorbol esters and diacylglycerol analogues on protein phosphorylation and phosphoinositide turnover in isolated beating guinea pig hearts Membrane Transport and Receptor Complexes Meeting, Duke University Marine Lab, ,


Gupta, R.C., Young, E.F., Ferguson, D.G. and Kranias, E.G. 1989. Phosphorylative modification of the Mg2+ ATPase associated with rat cardiac nuclei Biophys. J., 55 2, 597a


Kim, H.W., Steenaart, N.A.E., Szymanska, G. and Kranias, E.G. 1989. Regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase by phospholamban in reconstituted vesicles Biophys. J., 55 2, 481a


Kranias, E.G., Kim, H.W., Szymanska, G. and Davis, B.A. 1989. Regulation of Ca2+ transport in cardiac SR by protein kinases and phosphatases Membrane Transport and Receptor Complexes Meeting, Duke University Marine Lab, ,


Steenaart, N.A.E., Di Salvo, J. and Kranias, E.G. 1989. Phospholamban protein phosphatase purified from cardiac muscle International Conference on Protein Phosphatases, Cincinnati, Ohio, ,


Edes, I., Solaro, R.J. and Kranias, E.G. 1988. Beta adrenergic receptor mediated inhibition of phosphoinositide turnover in isolated perfused guinea pig hearts J. Molec. Cell. Cardiol. , , S.23


Ferguson, D.G., Young, E.F. and Kranias, E.G. 1988. Immunogold electron microscopic localization of phospholamban in neonatal skeletal muscle Biophys. J., 53 2, 135a


Gupta, R.C. and Kranias, E.G. 1988. Purification and characterization of a phospholamban Ca2+ calmodulin dependent protein kinase from canine cardiac cytosol Biophys. J., 53 2, 135a


Hardin, C., Kranias, E.G., Raymaekers, L., Steenaart, N.A.E. and Paul, R.J. 1988. Phosphorylation of a smooth muscle plasma membrane vesicle fraction is associated with an increased glycolytically supported calcium uptake FASEB J., 2 4, 2667


Kim, H.W., Jakab, G., Edes, I. and Kranias, E.G. 1988. Characterization of phospholipids associated with purified Ca2+ ATPase and phospholamban isolated from canine cardiac sarcoplasmic reticulum Biophys. J., 53 2, 135a


Rapundalo, S.T., Solaro, R.J. and Kranias, E.G. 1988. Phosphodiesterase inhibitors and phosphorylation of sarcoplasmic reticulum and myofilaments in intact myocardium Biophys. J., 53 2, 421a


Ferguson, D.G., Young, E.F. and Kranias, E.G. 1987. Immunogold localization of phospholamban like polypeptide in canine vascular and visceral smooth muscle homogenates Biophys. J., 51 2, 350a


Gupta, R.C., Davis, B.A. and Kranias, E.G. 1987. Effect of calmodulin and calmodulin dependent phosphorylation on the calcium pump of cardiac sarcoplasmic reticulum Biophys. J., 51 2, 403a


Jakab, G., Rapundalo, S.T., Solaro, R.J. and Kranias, E.G. 1987. Effects of beta adrenergic stimulation on phosphorylation of myofilaments, sarcoplasmic reticulum and phospholipids in perfused guinea pig hearts Biophys. J., 51 2, 371a


Kranias, E.G., Gupta, R.C., Jakab, G., Kim, H.W., Steenaart, N.E. and Rapundalo, S.T. 1987. Regulation of cardiac sarcoplasmic reticulum function by phospholamban and protein kinases and protein phosphatases Regulation of Transport Mechanisms, ,


Young, E.F., Ferguson, D.G. and Kranias, E.G. 1987. Immunogold localization of phospholamban in canine cardiac homogenates and microsomes Biophys. J., 51 2, 350a


Kim, D.H., Kim, H.W., Kranias, E.G. and Ikemoto, N. 1986. [Ca2+] dependence of Ca2+ release characteristics for cardiac sarcoplasmic reticulum (SR) Biophys. J., 49 2, 562a


Kim, H.W., Kim, D.H., Ikemoto, N. and Kranias, E.G. 1986. Regulation of calcium release from cardiac sarcoplasmic reticulum by calcium*calmodulin dependent phosphorylation Biophys. J., 49 2, 235a


Kranias, E.G. 1986. Regulation of cardiac sarcoplasmic reticulum function by protein kinases and protein phosphatases Intern. Symp. on Adaptive Mechanisms of Muscle, ,


Kranias, E.G. and DiSalvo, J. 1986. Characterization of a protein phosphatase activity associated with cardiac sarcoplasmic reticulum Biophys. J., 49 2, 591a


Kranias, E.G., Davis, B.A., DiSalvo, J. 1986. Protein kinases and protein phosphatases as regulatory enzymes for calcium transport in cardiac sarcoplasmic reticulum 6th International Conference on Cyclic Nucleotides, calcium and protein phosphorylation, ,


Davis, B.A. and Kranias, E.G. 1985. Regulation of cardiac sarcoplasmic reticulum function by a calcium calmodulin dependent protein kinase Biophys., 47 2, 452a


Kranias, E.G. and Blount, A.L. 1985. Regulation of calcium transport in the cardiac sarcoplasmic reticulum by protein kinases and protein phosphatases Advances in Protein Phosphatases, Koninlijke Academie voor Geneeskunde van Belgie, ,


Kranias, E.G., Garvey, J.L., Srivastava, R.D. and Solaro, R.J. 1985. In situ phosphorylation and functional modifications of cardiac sarcoplasmic reticulum and myofilaments Biophys. J., 47 2, 450a


Davis, B.A., Schwartz, A. and Kranias, E.G. 1984. Calcium calmodulin dependent regulation of cardiac sarcoplasmic reticulum function Biophysical J., 45 , 5a


Kranias, E.G. 1984. Properties of a phosphoprotein phosphatase activity associated with cardiac sarcoplasmic reticulum Biophysical J., 45 , 5a


Kranias, E.G. 1984. Regulation of Ca2+ transport by cyclic 3':5' AMP dependent and calcium calmodulin dependent phosphorylation of cardiac sarcoplasmic reticulum Biophysical. J., 45 , 6a


Kranias, E.G. 1984. Regulation of Ca2+ transport by cyclic AMP dependent and calcium calmodulin- dependent phosphorylation of cardiac sarcoplasmic reticulum Gordon Conference on Cyclic Nucleotides, ,


Kranias, E.G., Nakamura, J. and Schwartz, A. 1983. Association of phospholamban with a highly purified Ca2+ ATPase preparation from cardiac sarcoplasmic reticulum Biophysical J., 41 , 19a


Mandel, F., Kranias, E.G. and Schwartz, A. 1983. The effect of cAMP dependent phosphorylation on Ca2+ affinity of cardiac sarcoplasmic reticulum Biophysical J., 41 , 17a


Davis, B.A., Kranias, E.G., Potter, J.D., Samaha, F.J. and Schwartz, A. 1982. Regulation of cardiac sarcoplasmic reticulum by a Calmodulin dependent protein kinase Fed. Proc., 41 , 505


Kranias, E.G. and Schwartz, A. 1982. A comparison of cyclic AMP dependent protein kinases of sarcoplasmic reticulum and cytosol in heart Fed. Proc., 41 , 659


Collins, J.H., Kranias, E.G., Reeves, A.S., Bilezikjian, L.M. and Schwartz, A. 1981. Purification of phospholamban and another proteolipid fraction from cardiac sarco-plasmic reticulum Biophysical J., 33 , 89a


Kranias, E.G. and Solaro, R.J. 1981. Coordination of SR and myofibrillar function by protein phosphorylation Am. Physiol. Soc. Meeting, ,


Kranias, E.G., Samaha, F.J. and Schwartz, A. 1981. Regulation of the Ca2+-ATPase in skeletal sarcoplasmic reticulum by protein kinase(s) Biophysical J., 33 , 88a


Robertson, S.P., Johnson, J.D., Holroyde, M.J., Kranias, E.G., Solaro, R.J. and Potter, J.D. 1981. Troponin I phosphorylation modulates the calcium binding properties of cardiac troponin. Biophysical J., 33 , 146a


Bilezikjian, L., Kranias, E.G., Potter, J.D. and Schwartz, A. 1980. Calmodulin stimulated phosphorylation of cardiac sarcoplasmic reticulum Fed. Proc., 39 , 1663


Kranias, E.G., Bilezikjian, L., Potter, J.D. and Schwartz, A. 1980. The role of calmodulin in regulation of cardiac sarcoplasmic reticulum phosphorylation New York Academy of Sciences Meeting, ,


Kranias, E.G., Bilezikjian, L., Solaro, R.J., Potter, J.D. and Schwartz, A. 1980. Regulation of cardiac sarcoplasmic reticulum in vitro and in vivo Circulation, 62 , 18


Kranias, E.G., Bilezikjian, L.M., Mandel, F., Potter, J.D. and Schwartz, A. 1980. Regulation of cardiac sarcoplasmic reticulum by two endogenous protein kinases, cAMP and calmodulin dependent J. Cell. Bio., 87 , 2636


Kranias, E.G., Bilezikjian, L.M., Mandel, F., Potter, J.D. and Schwartz, A. 1980. Cyclic AMP and Calmodulin dependent phosphorylation of Cardiac sarcoplasmic reticulum Protein Phosphorylation, , 105


Kranias, E.G., Mandel, F., Tsai, L.I. and Schwartz, A 1980. Cyclic AMP regulation of Ca2+ ATPase of cardiac sarcoplasmic reticulum in transient state Fed. Proc., 39 , 2173


Mandel, F., Kranias, E. and Schwartz, A. 1980. Transient state kinetics of the sarcoplasmic reticulum Amer. Assoc. Adv. Sci., ,


E.G. Kranias 1979. The effects of protein kinase mediated phosphorylation and calmodulin on cardiac sarcoplasmic reticulum function Gordon Conference on cyclic nucleotides, ,


Imai, K., Gende, A., Kranias, E.G., Asano, G., Dunn, F., Nagao, T., Franklin, D., Adams, R., Wang, T., Solaro, J. and Schwartz, A. 1979. Biochemistry of sarcoplasmic reticulum isolated from endocardium and epicardium from dog ischemic heart. Fed. Proc, 38 , 976


Kranias, E., Wang, T., Mandel, F., Tsai, L.I. and Schwartz, A. 1979. The effects of protein kinase phosphorylation and pH on the transient state kinetics of Ca2+ ATPase in cardiac sarcoplasmic reticulum Am. J. Cardiol., 43 , 392


Matlib, M.A., Wilson, D., Rouslin, W., Kranias, E., Nagao, T. and Schwartz, A. 1978. Effect of cytochrome C on respiration and calcium transport of two putative populations of mitochondria from a single organ The Physiologist, 21 , 77


Rouslin, W., MacGee, J., Myers, B.L., Allen, K.G., Kranias, E.G., Nagao, T. and Schwartz, A. 1978. Ischemia induced changes in canine cardiac mitochondrial membrane bound and free fatty acids and cholesterol Circulation, 58 , 176


Kranias, E.G. and Jungmann, R.A. 1977. Phosphorylation of calf thymus ribonucleic acid polymerase II Fed. Proc. Abstracts, , 806


Kranias, E.G. and Dumas, L.B. 1973. The effect of the Escherichia coli C dna C gene product on bacteriophage *X174 DNA replication Abstracts of papers presented at the Bacteriophage Meeting, Cold Spring Harbor Lab, , 34


Haghighi K, Pritchard TJ, Singh VP, Das P, Vanderbilt EL, Rubinstein J, Kranias EG . A Human G109E Polymorphism in Inhibitor-1 Compromises Cardiomyocyte Function and Induces Arrhythmias. Circulation, 115 , A34


Luo, W., Grupp, I.L., Harrer, J., Ponniah, S., Zhou, Z., Duffy, J.J., Grupp, G., Doetschman, T. and Kranias, E.G. . Knocking out the mouse phospholamban gene results in increased basal myocardial contractility Can. J. Cardiol. , 10 , 86a


Pena, J.R., Goldspink, P.H., Heinrich, L.S., Kranias, E.G., Wieczorek. D.F., Wolska, and B.M. . Phsopholamban Knockout alters hypertrophic gene expression and improves cardiac function in HCM a-tropomyosin (Glu180Gly) mouse , ,