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Department of

Pharmacology & Systems Physiology 

Photo of  Steven Kleene, PhD

Steven Kleene, PhD

Professor

Education/Credentials
  • BS: University of Michigan
  • PhD: University of Wisconsin
  • Postdoc: Northwestern University

Contact Information
  • Medical Sciences Building
  • Room G165
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0576
  • Office 513-558-6099
  • Fax 513-558-5738
  • Email Steven.Kleene@uc.edu

Peer Reviewed Publications

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Kleene, Steven J; Siroky, Brian J; Landero-Figueroa, Julio A; Dixon, Brian P; Pachciarz, Nolan W; Lu, Lu; and Kleene, Nancy K. 2019. The TRPP2-dependent channel of renal primary cilia also requires TRPM3 PLoS ONE, 14 , e0214053.

Kleene, Steven J; Kleene, Nancy K 2017. The native TRPP2-dependent channel of murine renal primary cilia American Journal of Physiology Renal Physiology, 309 , F96

Siroky, Brian J; Kleene, Nancy K; Kleene, Steven J; Varnell, Charles D; Comer, Raven G; Liu, Jialiu; Lu, Lu; Pachciarz, Nolan W; Bissler, John J; Dixon, Bradley P 2017. Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3 American Journal of Physiology Renal Physiology, 312 , F791

Nauli, Surya M; Pala, Rajasekharreddy; Kleene, Steven J 2016. Calcium channels in primary cilia Current Opinion in Nephrology and Hypertension, 25 , 452

Flannery, Richard J; Kleene, Nancy K; Kleene, Steven J 2015. A TRPM4-dependent current in murine renal primary cilia American Journal of Physiology Renal Physiology, 309 , F697

Kleene, Steven J; Van Houten, Judith L 2014. Electrical Signaling in Motile and Primary Cilia Bioscience, 64 , 1092-1102

Griff, Edwin R; Kleene, Nancy K; Kleene, Steven J 2012. A selective PMCA inhibitor does not prolong the electroolfactogram in mouse PLoS ONE, 7 , e37148

Kleene, Nancy K; Kleene, Steven J 2012. A method for measuring electrical signals in a primary cilium Cilia, 1 , 17

French, Donald A; Badamdorj, Dorjsuren; Kleene, Steven J 2010. Spatial distribution of calcium-gated chloride channels in olfactory cilia PLoS ONE, 5 , e15676

Kleene, Steven J 2009. Identifying olfaction's 'other channels' The Journal of Physiology, 587 , 4135-4136

Kleene, Steven J 2009. Limits of calcium clearance by plasma membrane calcium ATPase in olfactory cilia PLoS ONE, 4 , e5266

Badamdorj, Dorjsuren; Edwards, David A; French, Donald A; Kleene, Steven J 2008. Identification of Cl(Ca) channel distributions in olfactory cilia Mathematical Methods in the Applied Sciences, 31 , 1860-1873

Kleene, Steven J 2008. The electrochemical basis of odor transduction in vertebrate olfactory cilia Chemical Senses, 33 , 839-859

Smith, David W; Thach, Sokunthirith; Marshall, Erika L; Mendoza, Mary-Grace; Kleene, Steven J 2008. Mice lacking NKCC1 have normal olfactory sensitivity Physiology & Behavior, 93 , 44-49

Nickell, William T; Kleene, Nancy K; Kleene, Steven J 2007. Mechanisms of neuronal chloride accumulation in intact mouse olfactory epithelium The Journal of Physiology, 583 , 1005-1020

Flannery, Richard J; French, Donald A; Kleene, Steven J 2006. Clustering of cyclic-nucleotide-gated channels in olfactory cilia Biophysical Journal, 91 , 179-188

French, Donald A; Flannery, Richard J; Groetsch, Charles W; Krantz, Willam B; Kleene, Steven J 2006. Numerical approximation of solutions of a nonlinear inverse problem arising in olfaction experimentation Mathematical and Computer Modelling, 43 7-8, 945-956

Nickell, William T; Kleene, Nancy K; Gesteland, Robert C; Kleene, Steven J 2006. Neuronal chloride accumulation in olfactory epithelium of mice lacking NKCC1 Journal of Neurophysiology, 95 , 2003-2006

Pun, Raymund Y K; Kleene, Steven J 2004. An estimate of the resting membrane resistance of frog olfactory receptor neurones The Journal of Physiology, 559 , 535-542

Pun, Raymund Y K; Kleene, Steven J 2003. Contribution of cyclic-nucleotide-gated channels to the resting conductance of olfactory receptor neurons Biophysical Journal, 84 , 3425-3435

Nickell, W T; Pun, R Y K; Bargmann, C I; Kleene, S J 2002. Single ionic channels of two Caenorhabditis elegans chemosensory neurons in native membrane The Journal of Membrane Biology, 189 , 55-66

Pun, Raymund Y K; Kleene, Steven J 2002. Outward currents in olfactory receptor neurons activated by odorants and by elevation of cyclic AMP Cell Biochemistry and Biophysics, 37 , 15-26

Frings, S; Reuter, D; Kleene, S J 2000. Neuronal Ca2+ -activated Cl- channels--homing in on an elusive channel species Progress in Neurobiology, 60 , 247-289

Kleene, S J 2000. Spontaneous gating of olfactory cyclic-nucleotide-gated channels The Journal of Membrane Biology, 178 , 49-54

Kleene, S J 1999. Both external and internal calcium reduce the sensitivity of the olfactory cyclic-nucleotide-gated channel to cAMP Journal of Neurophysiology, 81 , 2675-2682

Kleene, S J 1997. High-gain, low-noise amplification in olfactory transduction Biophysical Journal, 73 , 1110-1117

Larsson, H P; Kleene, S J; Lecar, H 1997. Noise analysis of ion channels in non-space-clamped cables: estimates of channel parameters in olfactory cilia Biophysical Journal, 72 , 1193-1203

Kleene, S J; Pun, R Y 1996. Persistence of the olfactory receptor current in a wide variety of extracellular environments Journal of Neurophysiology, 75 , 1386-1391

Kleene, S J 1995. Block by external calcium and magnesium of the cyclic-nucleotide-activated current in olfactory cilia Neuroscience, 66 , 1001-1008

Kleene, S J 1994. Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists British Journal of Pharmacology, 111 , 469-472

Kleene, S J; Cejtin, H C 1994. Solving buffering problems with Mathematica software Analytical Biochemistry, 222 , 310-314

Kleene, S J; Gesteland, R C; Bryant, S H 1994. An electrophysiological survey of frog olfactory cilia The Journal of Experimental Biology, 195 , 307-328

Pun, R Y; Kleene, S J; Gesteland, R C 1994. Guanine nucleotides modulate steady-state inactivation of voltage-gated sodium channels in frog olfactory receptor neurons The Journal of Membrane Biology, 142 , 103-111

Kleene, S J 1993. Origin of the chloride current in olfactory transduction Neuron, 11 , 123-132

Kleene, S J 1993. The cyclic nucleotide-activated conductance in olfactory cilia: effects of cytoplasmic Mg2+ and Ca2+ The Journal of Membrane Biology, 131 , 237-243

Kleene, S J 1993. A simple intrapipette salt bridge Journal of Neuroscience Methods, 46 , 11-16

Kleene, S J 1992. Basal conductance of frog olfactory cilia Pflügers Archiv : European Journal of Physiology, 421 , 374-380

Kleene, S J; Gesteland, R C 1991. Calcium-activated chloride conductance in frog olfactory cilia The Journal of Neuroscience, 11 , 3624-3629

Kleene, S J; Gesteland, R C 1991. Transmembrane currents in frog olfactory cilia The Journal of Membrane Biology, 120 , 75-81

Lidow, M S; Gesteland, R C; Shipley, M T; Kleene, S J 1987. Comparative study of immature and mature olfactory receptor cells in adult frogs Developmental Brain Research, 31 , 243-258

Kleene, S J 1986. Bacterial chemotaxis and vertebrate olfaction Experientia, 42 , 241-250

Lidow, M S; Kleene, S J; Gesteland, R C 1986. Suppression of mitotic activity and synchronization of cell development in olfactory epithelium Developmental Brain Research, 28 , 145-162

Kleene, S J; Gesteland, R C 1983. Dissociation of frog olfactory epithelium Journal of Neuroscience Methods, 9 , 173-183

Kleene, S J; Gesteland, R C 1981. Dissociation of frog olfactory epithelium with N-ethylmaleimide Brain Research, 229 , 536-540

Kleene, S J; Hobson, A C; Adler, J 1979. Attractants and repellents influence methylation and demethylation of methyl-accepting chemotaxis proteins in an extract of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America, 76 , 6309-6313

Kleene, S J; Toews, M L; Adler, J 1977. Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis The Journal of Biological Chemistry, 252 , 3214-3218