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Department of

Pharmacology & Systems Physiology 

Photo of Judith Heiny, PhD

Judith Heiny, PhD

Education/Credentials
  • PhD: University of Cincinnati

Research/Clinical Interests

skeletal muscle, Na,K-ATPase isoforms, muscle fatigue, endogenous cardiotonic steroids

Contact Information

Peer Reviewed Publications

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Petrov, Alexey M; Kravtsova, Violetta V; Matchkov, Vladimir V; Vasiliev, Alexander N; Zefirov, Andrey L; Chibalin, Alexander V; Heiny, Judith A; Krivoi, Igor I 2017. Membrane lipid rafts are disturbed in the response of rat skeletal muscle to short-term disuse. American journal of physiology. Cell physiology, 312 5, C627-C637

Figueroa, Julio A Landero; Stiner, Cory A; Radzyukevich, Tatiana L; Heiny, Judith A 2016. Metal ion transport quantified by ICP-MS in intact cells. Scientific reports, 6 , 20551

Kravtsova, Violetta V; Petrov, Alexey M; Matchkov, Vladimir V; Bouzinova, Elena V; Vasiliev, Alexander N; Benziane, Boubacar; Zefirov, Andrey L; Chibalin, Alexander V; Heiny, Judith A; Krivoi, Igor I 2016. Distinct ?2 Na,K-ATPase membrane pools are differently involved in early skeletal muscle remodeling during disuse. The Journal of general physiology, 147 2, 175-88

DiFranco, Marino; Hakimjavadi, Hesamedin; Lingrel, Jerry B; Heiny, Judith A 2015. Na,K-ATPase ?2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K+. The Journal of general physiology, 146 4, 281-94

Kravtsova, Violetta V; Matchkov, Vladimir V; Bouzinova, Elena V; Vasiliev, Alexander N; Razgovorova, Irina A; Heiny, Judith A; Krivoi, Igor I 2015. Isoform-specific Na,K-ATPase alterations precede disuse-induced atrophy of rat soleus muscle. BioMed research international, 2015 , 720172

Manoharan, Palanikumar; Radzyukevich, Tatiana L; Hakim Javadi, Hesamedin; Stiner, Cory A; Landero Figueroa, Julio A; Lingrel, Jerry B; Heiny, Judith A 2015. Phospholemman is not required for the acute stimulation of Na?-K?-ATPase ??-activity during skeletal muscle fatigue. American journal of physiology. Cell physiology, 309 12, C813-22

Naticchioni, Mindi; Karani, Rajiv; Smith, Margaret A; Onusko, Evan; Robbins, Nathan; Jiang, Min; Radzyukevich, Tatiana; Fulford, Logan; Gao, Xu; Apel, Ryan; Heiny, Judith; Rubinstein, Jack; Koch, Sheryl E 2015. Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise. PloS one, 10 9, e0136901

De Bellis, Michela; De Luca, Annamaria; Desaphy, Jean F; Carbonara, Roberta; Heiny, Judith A; Kennedy, Ann; Carocci, Alessia; Cavalluzzi, Maria M; Lentini, Giovanni; Franchini, Carlo; Camerino, Diana Conte 2013. Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels. Biophysical journal, 104 2, 344-54

Heiny, Judith 2013. Pumped up and pregnant. Experimental physiology, 98 1, 48

Lauf, Peter K; Heiny, Judith; Meller, Jarek; Lepera, Michael A; Koikov, Leonid; Alter, Gerald M; Brown, Thomas L; Adragna, Norma C 2013. Canonical Bcl-2 motifs of the Na+/K+ pump revealed by the BH3 mimetic chelerythrine: early signal transducers of apoptosis? Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 31 2-3, 257-76

Radzyukevich, Tatiana L; Neumann, Jonathon C; Rindler, Tara N; Oshiro, Naomi; Goldhamer, David J; Lingrel, Jerry B; Heiny, Judith A 2013. Tissue-specific role of the Na,K-ATPase ?2 isozyme in skeletal muscle. The Journal of biological chemistry, 288 2, 1226-37

Camerino, C; Zayzafoon, M; Rymaszewski, M; Heiny, J; Rios, M; Hauschka, P V 2012. Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype. Endocrinology, 153 11, 5394-405

Chibalin, Alexander V; Heiny, Judith A; Benziane, Boubacar; Prokofiev, Alexander V; Vasiliev, Alexander V; Kravtsova, Violetta V; Krivoi, Igor I 2012. Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman. PloS one, 7 3, e33719

Heiny, Judith A 2010. S100A1: a physiological modulator of RYR1, Ca2+ release, and contractility in skeletal muscle. Focus on "S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle". American journal of physiology. Cell physiology, 299 5, C882-4

Heiny, Judith A; Kravtsova, Violetta V; Mandel, Frederic; Radzyukevich, Tatiana L; Benziane, Boubacar; Prokofiev, Alexander V; Pedersen, Steen E; Chibalin, Alexander V; Krivoi, Igor I 2010. The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle. The Journal of biological chemistry, 285 37, 28614-26

Radzyukevich, T L; Lingrel, J B; Heiny, J A 2009. The cardiac glycoside binding site on the Na,K-ATPase alpha2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 106 8, 2565-70

Radzyukevich, Tatiana L; Cougnon, Marc H; Moseley, Amy E; Heiny, Judith A 2004. Developmental induction of DHPR alpha 1s and RYR1 gene expression does not require neural or mechanical signals. Journal of muscle research and cell motility, 25 1, 87-94

Radzyukevich, Tatiana L; Heiny, Judith A 2004. Regulation of dihydropyridine receptor gene expression in mouse skeletal muscles by stretch and disuse. American journal of physiology. Cell physiology, 287 5, C1445-52

Radzyukevich, Tatiana L; Moseley, Amy E; Shelly, Daniel A; Redden, Gregory A; Behbehani, Michael M; Lingrel, Jerry B; Paul, Richard J; Heiny, Judith A 2004. The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm. American journal of physiology. Cell physiology, 287 5, C1300-10

Cougnon, Marc H; Moseley, Amy E; Radzyukevich, Tatiana L; Lingrel, Jerry B; Heiny, Judith A 2002. Na,K-ATPase alpha- and beta-isoform expression in developing skeletal muscles: alpha(2) correlates with t-tubule formation. Pflügers Archiv : European journal of physiology, 445 1, 123-31

Heiny, J S; Tate, C M 1997. Concentration, distribution, and comparison of selected trace elements in bed sediment and fish tissue in the South Platte River Basin, USA, 1992-1993. Archives of environmental contamination and toxicology, 32 3, 246-59

Jong, D S; Stroffekova, K; Heiny, J A 1997. A surface potential change in the membranes of frog skeletal muscle is associated with excitation-contraction coupling. The Journal of physiology, 499 ( Pt 3) , 787-808

Stroffekova, K; Heiny, J A 1997. Stimulation-dependent redistribution of charge movement between unavailable and available states. General physiology and biophysics, 16 1, 79-89

Stroffekova, K; Heiny, J A 1997. Triadic Ca2+ modulates charge movement in skeletal muscle. General physiology and biophysics, 16 1, 59-77

Yamamoto, S; Askew, G R; Heiny, J; Masaki, H; Yatani, A 1996. Modulation of pump function by mutations in the first transmembrane region of Na(+)-K(+)-ATPase alpha 1-subunit. The American journal of physiology, 270 2 Pt 1, C457-64

Masaki, H; Green, S A; Heiny, J A; Yatani, A 1995. Beta 2-adrenergic receptor regulation of the cardiac L-type Ca2+ channel coexpressed in a fibroblast cell line. Receptor, 5 4, 219-31

Kokate, T G; Heiny, J A; Sperelakis, N 1993. Stimulation of the slow calcium current in bullfrog skeletal muscle fibers by cAMP and cGMP. The American journal of physiology, 265 1 Pt 1, C47-53

Heiny, J A; Jong, D S 1990. A nonlinear electrostatic potential change in the T-system of skeletal muscle detected under passive recording conditions using potentiometric dyes. The Journal of general physiology, 95 1, 147-75

Heiny, J A; Jong, D; Bryant, S H; Conte-Camerino, D; Tortorella, V 1990. Enantiomeric effects on excitation-contraction coupling in frog skeletal muscle by a chiral phenoxy carboxylic acid. Biophysical journal, 57 1, 147-52

Heiny, J A; Valle, J R; Bryant, S H 1990. Optical evidence for a chloride conductance in the T-system of frog skeletal muscle. Pflügers Archiv : European journal of physiology, 416 3, 288-95

Moczydlowski, E; Uehara, A; Guo, X; Heiny, J 1986. Isochannels and blocking modes of voltage-dependent sodium channels. Annals of the New York Academy of Sciences, 479 , 269-92

Ashcroft, F M; Heiny, J A; Vergara, J 1985. Inward rectification in the transverse tubular system of frog skeletal muscle studied with potentiometric dyes. The Journal of physiology, 359 , 269-91

Heiny, J A; Vergara, J 1984. Dichroic behavior of the absorbance signals from dyes NK2367 and WW375 in skeletal muscle fibers. The Journal of general physiology, 84 5, 805-37

Heiny, J A; Ashcroft, F M; Vergara, J 1983. T-system optical signals associated with inward rectification in skeletal muscle. Nature, 301 5896, 164-6

Heiny, J A; Vergara, J 1982. Optical signals from surface and T system membranes in skeletal muscle fibers. Experiments with the potentiometric dye NK2367. The Journal of general physiology, 80 2, 203-30

DECKER, K; HEINY, J 1956. [X-ray diagnosis of cerebral metastases of hypernephroma]. Deutsche Zeitschrift für Nervenheilkunde, 174 2, 107-22

Published Abstracts

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Judith A. Heiny, Violetta V. Kravtsova, Frederic Mandel, Tatiana L. Radzyukevich, Boubacar Benziane, Alexander V. Prokofiev, Alexander V. Chibalin, and Igor I. Krivoi. . The Nicotinic Acetylcholine Receptor and the Na,K-ATPase 2 Isoform Interact at the Neuromuscular Junction to Regulate Membrane Electrogenesis. , ,