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Department of

Pharmacology & Systems Physiology 

Photo of  Guo-Chang Fan, PhD

Guo-Chang Fan, PhD

Professor

Education/Credentials
  • Doctoral Degree: Zhejiang University
  • Master's Degree: Chinese Academy of Sciences
  • Bachelor's Degree: Nanjing Normal University

Research/Clinical Interests

MicroRNAs, Exosomes, Myocardial Angiogenesis, Cardiomyopathy, Hsp20, Inflammation, Sepsis, Diabetes, Myocardial Ischemia-reperfusion, Cardioprotection.

Contact Information
  • Cardiovascular Center Building
  • Room 5923
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0575
  • Office 513-558-2340
  • Email guochang.fan@uc.edu

Peer Reviewed Publications

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Chen, Yanfang; Tang, Yaoliang; Fan, Guo-Chang; Duan, Dayue Darrel 2018. Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases. Acta pharmacologica Sinica, 39 4, 499-500

Hong, Guangliang; Zheng, Dong; Zhang, Lulu; Ni, Rui; Wang, Grace; Fan, Guo-Chang; Lu, Zhongqiu; Peng, Tianqing 2018. Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis. Free radical biology & medicine, 123 , 125-137

Liu, Guan-Sheng; Zhu, Hongyan; Cai, Wen-Feng; Wang, Xiaohong; Jiang, Min; Essandoh, Kobina; Vafiadaki, Elizabeth; Haghighi, Kobra; Lam, Chi Keung; Gardner, George; Adly, George; Nicolaou, Persoulla; Sanoudou, Despina; Liang, Qiangrong; Rubinstein, Jack; Fan, Guo-Chang; Kranias, Evangelia G 2018. Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant. Autophagy, 14 1, 80-97

Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620

Yu, You-Jiang; Wang, Xiao-Hong; Fan, Guo-Chang 2018. Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases. Acta pharmacologica Sinica, 39 4, 514-533

Mu, Xingjiang; Wang, Xiaohong; Huang, Wei; Wang, Rui-Tao; Essandoh, Kobina; Li, Yutian; Pugh, Amanda M; Peng, Jiangtong; Deng, Shan; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Yu, Kai-Jiang; Fan, Guo-Chang 2017. Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation. Shock (Augusta, Ga.), ,

Salem, Esam S B; Fan, Guo-Chang 2017. Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy. Advances in experimental medicine and biology, 998 , 113-138

Essandoh, Kobina; Li, Yutian; Huo, Jiuzhou; Fan, Guo-Chang 2016. MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response. Shock (Augusta, Ga.), 46 2, 122-31

Hu, Jing; Al-Waili, Daniah; Hassan, Aishlin; Fan, Guo-Chang; Xin, Mei; Hao, Jiukuan 2016. Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex. Neuroscience, 329 , 30-42

Li, Shengcun; Zhang, Lulu; Ni, Rui; Cao, Ting; Zheng, Dong; Xiong, Sidong; Greer, Peter A; Fan, Guo-Chang; Peng, Tianqing 2016. Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress. Biochimica et biophysica acta, 1862 11, 2023-2033

Liu, Zhi-Feng; Zheng, Dong; Fan, Guo-Chang; Peng, Tianqing; Su, Lei 2016. Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling. Apoptosis : an international journal on programmed cell death, 21 8, 896-904

Ni, Rui; Cao, Ting; Xiong, Sidong; Ma, Jian; Fan, Guo-Chang; Lacefield, James C; Lu, Yanrong; Le Tissier, Sydney; Peng, Tianqing 2016. Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy. Free radical biology & medicine, 90 , 12-23

Ni, Rui; Zheng, Dong; Xiong, Sidong; Hill, David J; Sun, Tao; Gardiner, Richard B; Fan, Guo-Chang; Lu, Yanrong; Abel, E Dale; Greer, Peter A; Peng, Tianqing 2016. Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes, 65 1, 255-68

Qin, Dongze; Wang, Xiaohong; Li, Yutian; Yang, Liwang; Wang, Ruitao; Peng, Jiangtong; Essandoh, Kobina; Mu, Xingjiang; Peng, Tianqing; Han, Qinghua; Yu, Kai-Jiang; Fan, Guo-Chang 2016. MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts. The Journal of biological chemistry, 291 38, 20247-59

Wang, Xiaohong; Gu, Haitao; Huang, Wei; Peng, Jiangtong; Li, Yutian; Yang, Liwang; Qin, Dongze; Essandoh, Kobina; Wang, Yigang; Peng, Tianqing; Fan, Guo-Chang 2016. Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice. Diabetes, 65 10, 3111-28

Yang, Liwang; Li, Yutian; Wang, Xiaohong; Mu, Xingjiang; Qin, Dongze; Huang, Wei; Alshahrani, Saeed; Nieman, Michelle; Peng, Jiangtong; Essandoh, Kobina; Peng, Tianqing; Wang, Yigang; Lorenz, John; Soleimani, Manoocher; Zhao, Zhi-Qing; Fan, Guo-Chang 2016. Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy. The Journal of biological chemistry, 291 30, 15700-13

Zheng, Dong; Yu, Yong; Li, Minghui; Wang, Grace; Chen, Ruizhen; Fan, Guo-Chang; Martin, Claudio; Xiong, Sidong; Peng, Tianqing 2016. Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis. The Journal of infectious diseases, 213 10, 1661-70

Ailawadi, Shaina; Wang, Xiaohong; Gu, Haitao; Fan, Guo-Chang 2015. Pathologic function and therapeutic potential of exosomes in cardiovascular disease. Biochimica et biophysica acta, 1852 1, 1-11

Cai, Wen-Feng; Liu, Guan-Sheng; Lam, Chi Keung; Florea, Stela; Qian, Jiang; Zhao, Wen; Pritchard, Tracy; Haghighi, Kobra; Lebeche, Djamel; Lu, Long Jason; Deng, Jingyuan; Fan, Guo-Chang; Hajjar, Roger J; Kranias, Evangelia G 2015. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. European journal of heart failure, 17 8, 782-93

Essandoh, Kobina; Yang, Liwang; Wang, Xiaohong; Huang, Wei; Qin, Dongze; Hao, Jiukuan; Wang, Yigang; Zingarelli, Basilia; Peng, Tianqing; Fan, Guo-Chang 2015. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochimica et biophysica acta, 1852 11, 2362-71

Ni, Rui; Zheng, Dong; Wang, Qiang; Yu, Yong; Chen, Ruizhen; Sun, Tao; Wang, Wang; Fan, Guo-Chang; Greer, Peter A; Gardiner, Richard B; Peng, Tianqing 2015. Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation. Circulation. Heart failure, 8 5, 988-96

Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang 2015. Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis. Scientific reports, 5 , 13721

Zheng, Dong; Ma, Jian; Yu, Yong; Li, Minghui; Ni, Rui; Wang, Grace; Chen, Ruizhen; Li, Jianmin; Fan, Guo-Chang; Lacefield, James C; Peng, Tianqing 2015. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice. Diabetologia, 58 8, 1949-58

Zheng, Dong; Wang, Grace; Li, Shuai; Fan, Guo-Chang; Peng, Tianqing 2015. Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation. Biochimica et biophysica acta, 1852 5, 882-92

Essandoh, Kobina; Fan, Guo-Chang 2014. Role of extracellular and intracellular microRNAs in sepsis. Biochimica et biophysica acta, 1842 11, 2155-2162

Essandoh, Kobina; Fan, Guo-Chang 2014. Role of extracellular and intracellular microRNAs in sepsis. Biochimica et biophysica acta, 1842 11, 2155-2162

Fan, Guo-Chang 2014. Hypoxic exosomes promote angiogenesis. Blood, 124 25, 3669-70

Jiang, Ding-Sheng; Liu, Yu; Zhou, Heng; Zhang, Yan; Zhang, Xiao-Dong; Zhang, Xiao-Fei; Chen, Ke; Gao, Lu; Peng, Juan; Gong, Hui; Chen, Yingjie; Yang, Qinglin; Liu, Peter P; Fan, Guo-Chang; Zou, Yunzeng; Li, Hongliang 2014. Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy. Hypertension, ,

Jiang, Ding-Sheng; Wei, Xiang; Zhang, Xiao-Fei; Liu, Yu; Zhang, Yan; Chen, Ke; Gao, Lu; Zhou, Heng; Zhu, Xue-Hai; Liu, Peter P; Bond Lau, Wayne; Ma, Xinliang; Zou, Yunzeng; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang 2014. IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling. Nature communications, 5 , 3303

Li, Shang-Ze; Zhang, Hui-Hui; Liang, Jun-Bo; Song, Yang; Jin, Bing-Xue; Xing, Na-Na; Fan, Guo-Chang; Du, Run-Lei; Zhang, Xiao-Dong 2014. Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK?. Biochimica et biophysica acta, 1843 7, 1365-72

Liu, Yi; Jiang, Xiao-Li; Liu, Yu; Jiang, Ding-Sheng; Zhang, Yan; Zhang, Rui; Chen, Yingjie; Yang, Qinglin; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang 2014. Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice. Cardiovascular research, 101 1, 87-96

Wang, Xiaohong; Huang, Wei; Liu, Guansheng; Cai, Wenfeng; Millard, Ronald W; Wang, Yigang; Chang, Jiang; Peng, Tianqing; Fan, Guo-Chang 2014. Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. Journal of molecular and cellular cardiology, ,

Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang 2014. Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis. Biochimica et biophysica acta, 1842 5, 701-711

Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang 2014. MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF. PloS one, 9 9, e104666

Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang 2014. MicroRNA-377 Regulates Mesenchymal Stem Cell-Induced Angiogenesis in Ischemic Hearts by Targeting VEGF. PloS one, 9 9, e104666

Yue, X; Yang, X; Lin, X; Yang, T; Yi, X; Dai, Y; Guo, J; Li, T; Shi, J; Wei, L; Fan, G-C; Chen, C; Chang, J 2014. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell death & disease, 5 , e1284

Zhang, Yan; Liu, Yu; Zhu, Xue-Hai; Zhang, Xiao-Dong; Jiang, Ding-Sheng; Bian, Zhou-Yan; Zhang, Xiao-Fei; Chen, Ke; Wei, Xiang; Gao, Lu; Zhu, Li-Hua; Yang, Qinglin; Fan, Guo-Chang; Lau, Wayne B; Ma, Xinliang; Li, Hongliang 2014. Dickkopf-3 attenuates pressure overload-induced cardiac remodelling. Cardiovascular research, ,

Zhang, Yan; Zhang, Xiao-Fei; Gao, Lu; Liu, Yu; Jiang, Ding-Sheng; Chen, Ke; Yang, Qinglin; Fan, Guo-Chang; Zhang, Xiao-Dong; Huang, Congxin 2014. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Biochimica et biophysica acta, 1842 2, 232-44

Jiang, Ding-Sheng; Bian, Zhou-Yan; Zhang, Yan; Zhang, Shu-Min; Liu, Yi; Zhang, Rui; Chen, Yingjie; Yang, Qinglin; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang 2013. Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy. Hypertension, 61 6, 1193-202

Jiang, Ding-Sheng; Luo, Yu-Xuan; Zhang, Ran; Zhang, Xiao-Dong; Chen, Hou-Zao; Zhang, Yan; Chen, Ke; Zhang, Shu-Min; Fan, Guo-Chang; Liu, Peter P; Liu, De-Pei; Li, Hongliang 2013. Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin. Hypertension, ,

Jiang, Ding-Sheng; Zhang, Xiao-Fei; Gao, Lu; Zong, Jing; Zhou, Heng; Liu, Yu; Zhang, Yan; Bian, Zhou-Yan; Zhu, Li-Hua; Fan, Guo-Chang; Zhang, Xiao-Dong; Li, Hongliang 2013. Signal Regulatory Protein-? Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling. Hypertension, ,

Li, Qi; Guo, Junli; Lin, Xi; Yang, Xiangsheng; Ma, Yanlin; Fan, Guo-Chang; Chang, Jiang 2013. An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression. PloS one, 8 9, e75470

Lu, Yan-Yun; Li, Zuo-Zhi; Jiang, Ding-Sheng; Wang, Lang; Zhang, Yan; Chen, Ke; Zhang, Xiao-Fei; Liu, Yi; Fan, Guo-Chang; Chen, Yingjie; Yang, Qinglin; Zhou, Yan; Zhang, Xiao-Dong; Liu, De-Pei; Li, Hongliang 2013. TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death. Nature communications, 4 , 2852

Ribeiro, Mara Fernandes; Zhu, Hongyan; Millard, Ronald W; Fan, Guo-Chang 2013. Exosomes Function in Pro- and Anti-Angiogenesis. Current angiogenesis, 2 1, 54-59

Zhu, Hongyan; Fan, Guo-Chang 2013. Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction. Journal of biomarkers in drug development, 1 1,

Zhu, Hongyan; Fan, Guo-Chang 2013. Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction. Journal of biomarkers in drug development, 1 1,

Fan, Guo-Chang 2012. Role of heat shock proteins in stem cell behavior. Progress in molecular biology and translational science, 111 , 305-22

Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G 2012. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of molecular and cellular cardiology, 52 3, 773-82

Huang, Wei; Wang, Tao; Zhang, Dongsheng; Zhao, Tiemin; Dai, Bo; Ashraf, Atif; Wang, Xiaohong; Xu, Meifeng; Millard, Ronald W; Fan, Guo-Chang; Ashraf, Muhammad; Yu, Xi-Yong; Wang, Yigang 2012. Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9. Stem cells and development, 21 5, 778-89

Ma, Jian; Wei, Meng; Wang, Qiang; Li, Jianmin; Wang, Hao; Liu, Weihua; Lacefield, James C; Greer, Peter A; Karmazyn, Morris; Fan, Guo-Chang; Peng, Tianqing 2012. Deficiency of Capn4 gene inhibits nuclear factor-?B (NF-?B) protein signaling/inflammation and reduces remodeling after myocardial infarction. The Journal of biological chemistry, 287 33, 27480-9

Ma, Yonggang; Zhang, Xiaowei; Bao, Huayan; Mi, Su; Cai, Wenfeng; Yan, Huimin; Wang, Qingqing; Wang, Ziyan; Yan, Jun; Fan, Guo-Chang; Fan, Guochang; Lindsey, Merry L; Hu, Zhuowei 2012. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PloS one, 7 7, e40763

Wang, Xiaohong; Zhu, Hongyan; Zhang, Xiaowei; Liu, Yong; Chen, Jing; Medvedovic, Mario; Li, Hongliang; Weiss, Mitchell J; Ren, Xiaoping; Fan, Guo-Chang 2012. Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1. Cardiovascular research, 94 2, 379-90

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Kranias, Evangelia G; Tang, Yaoliang; Peng, Tianqing; Chang, Jiang; Fan, Guo-Chang 2012. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PloS one, 7 3, e32765

Zhu, Hongyan; Fan, Guo-Chang 2012. Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovascular research, 94 2, 284-92

Zuo, Shi; Jones, W Keith; Li, Hongxia; He, Zhisong; Pasha, Zeeshan; Yang, Yueting; Wang, Yigang; Fan, Guo-Chang; Ashraf, Muhammad; Xu, Meifeng 2012. Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury. Stem cells and development, 21 4, 598-608

Qian, Jiang; Vafiadaki, Elizabeth; Florea, Stela M; Singh, Vivek P; Song, Weizhong; Lam, Chi Kung; Wang, Yigang; Yuan, Qunying; Pritchard, Tracy J; Cai, Wenfeng; Haghighi, Kobra; Rodriguez, Patricia; Wang, Hong-Sheng; Sanoudou, Despina; Fan, Guo-Chang; Kranias, Evangelia G 2011. Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circulation research, 108 12, 1429-38

Zhu, Hongyan; Fan, Guo-Chang 2011. Extracellular/circulating microRNAs and their potential role in cardiovascular disease. American journal of cardiovascular disease, 1 2, 138-149

Chen, Guoli; Zhou, Xiaoyang; Florea, Stela; Qian, Jiang; Cai, Wenfeng; Zhang, Zhiguo; Fan, Guo-Chang; Lorenz, John; Hajjar, Roger J; Kranias, Evangelia G 2010. Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Basic research in cardiology, 105 5, 573-81

Fan, Guo-Chang; Kranias, Evangelia G 2010. Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. Journal of molecular and cellular cardiology, ,

Huang, Wei; Zhang, Dongsheng; Millard, Ronald W; Wang, Tao; Zhao, Tiemin; Fan, Guo-Chang; Ashraf, Atif; Xu, Meifeng; Ashraf, Muhammad; Wang, Yigang 2010. Gene manipulated peritoneal cell patch repairs infarcted myocardium. Journal of molecular and cellular cardiology, 48 4, 702-12

Wang, Xiaohong; Zhang, Xiaowei; Ren, Xiao-Ping; Chen, Jing; Liu, Hongzhu; Yang, Junqi; Medvedovic, Mario; Hu, Zhuowei; Fan, Guo-Chang 2010. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation, 122 13, 1308-18

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Zhu, Cheng; Wang, Yigang; Pu, William T; Jegga, Anil G; Fan, Guo-Chang 2010. Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. Journal of molecular and cellular cardiology, 49 5, 841-50

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping 2009. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation, 120 11 Suppl, S1-9

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping 2009. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation, 120 11 Suppl, S1-9

Qian, Jiang; Ren, Xiaoping; Wang, Xiaohong; Zhang, Pengyuan; Jones, W Keith; Molkentin, Jeffery D; Fan, Guo-Chang; Kranias, Evangelia G 2009. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation research, 105 12, 1223-31

Ren, Xiao-Ping; Wu, Jinghai; Wang, Xiaohong; Sartor, Maureen A; Qian, Jiang; Jones, Keith; Nicolaou, Persoulla; Pritchard, Tracy J; Fan, Guo-Chang 2009. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation, 119 17, 2357-66

Wang, Xiaohong; Zhao, Tiemin; Huang, Wei; Wang, Tao; Qian, Jiang; Xu, Meifeng; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang 2009. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem cells (Dayton, Ohio), 27 12, 3021-31

Wang, Xiaohong; Zingarelli, Basilia; O'Connor, Michael; Zhang, Pengyuan; Adeyemo, Adeola; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang 2009. Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation. Journal of molecular and cellular cardiology, 47 3, 382-90

Zhao, Wen; Fan, Guo-Chang; Zhang, Zhi-Guo; Bandyopadhyay, Arun; Zhou, Xiaoyang; Kranias, Evangelia G 2009. Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic research in cardiology, 104 4, 377-89

Chen, Guoli; Zhou, Xiaoyang; Nicolaou, Persoulla; Rodriguez, Patricia; Song, Guojie; Mitton, Bryan; Pathak, Anand; Zachariah, Amit; Fan, Guo-Chang; Dorn, Gerald W; Kranias, Evangelia G 2008. A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22 6, 1790-6

Fan, Guo-Chang; Yuan, Qunying; Kranias, Evangelia G 2008. Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function. Trends in cardiovascular medicine, 18 1, 1-5

Fan, Guo-Chang; Zhou, Xiaoyang; Wang, Xiaohong; Song, Guojie; Qian, Jiang; Nicolaou, Persoulla; Chen, Guoli; Ren, Xiaoping; Kranias, Evangelia G 2008. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circulation research, 103 11, 1270-9

Haghighi, Kobra; Chen, Guoli; Sato, Yoji; Fan, Guo-Chang; He, Suiwen; Kolokathis, Fotis; Pater, Luke; Paraskevaidis, Ioannis; Jones, W Keith; Dorn, Gerald W; Kremastinos, Dimitrios Th; Kranias, Evangelia G 2008. A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids. Human mutation, 29 5, 640-7

Nicolaou, Persoulla; Knöll, Ralph; Haghighi, Kobra; Fan, Guo-Chang; Dorn, Gerald W; Hasenfub, Gerd; Kranias, Evangelia G 2008. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. The Journal of biological chemistry, 283 48, 33465-71

Zhang, Dongsheng; Fan, Guo-Chang; Zhou, Xiaoyang; Zhao, Tiemin; Pasha, Zeeshan; Xu, Meifeng; Zhu, Yi; Ashraf, Muhammad; Wang, Yigang 2008. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. Journal of molecular and cellular cardiology, 44 2, 281-92

Arvanitis, Demetrios A; Vafiadaki, Elizabeth; Fan, Guo-Chang; Mitton, Bryan A; Gregory, Kimberly N; Del Monte, Federica; Kontrogianni-Konstantopoulos, Aikaterini; Sanoudou, Despina; Kranias, Evangelia G 2007. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. American journal of physiology. Heart and circulatory physiology, 293 3, H1581-9

Fan, Guo-Chang; Yuan, Qunying; Zhao, Wen; Chu, Guoxiang; Kranias, Evangelia G 2007. Junctin is a prominent regulator of contractility in cardiomyocytes. Biochemical and biophysical research communications, 352 3, 617-22

Yuan, Qunying; Fan, Guo-Chang; Dong, Min; Altschafl, Beth; Diwan, Abhinav; Ren, Xiaoping; Hahn, Harvey H; Zhao, Wen; Waggoner, Jason R; Jones, Larry R; Jones, W Keith; Bers, Donald M; Dorn, Gerald W; Wang, Hong-Sheng; Valdivia, Héctor H; Chu, Guoxiang; Kranias, Evangelia G 2007. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation, 115 3, 300-9

Zhou, Xiaoyang; Fan, Guo-Chang; Ren, Xiaoping; Waggoner, Jason R; Gregory, Kimberly N; Chen, Guoli; Jones, W Keith; Kranias, Evangelia G 2007. Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury. Cardiovascular research, 75 3, 487-97

Fan, Guo-Chang; Yuan, Qunying; Song, Guojie; Wang, Yigang; Chen, Guoli; Qian, Jiang; Zhou, Xiaoyang; Lee, Yong J; Ashraf, Muhammad; Kranias, Evangelia G 2006. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circulation research, 99 11, 1233-42

Haghighi, Kobra; Kolokathis, Fotis; Gramolini, Anthony O; Waggoner, Jason R; Pater, Luke; Lynch, Roy A; Fan, Guo-Chang; Tsiapras, Dimitris; Parekh, Rohan R; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios Th; Kranias, Evangelia G 2006. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America, 103 5, 1388-93

Fan, Guo-Chang; Chu, Guoxiang; Kranias, Evangelia G 2005. Hsp20 and its cardioprotection. Trends in cardiovascular medicine, 15 4, 138-41

Fan, Guo-Chang; Ren, Xiaoping; Qian, Jiang; Yuan, Qunying; Nicolaou, Persoulla; Wang, Yang; Jones, W Keith; Chu, Guoxiang; Kranias, Evangelia G 2005. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation, 111 14, 1792-9

Chu, Guoxiang; Egnaczyk, Gregory F; Zhao, Wen; Jo, Su-Hyun; Fan, Guo-Chang; Maggio, John E; Xiao, Rui-Ping; Kranias, Evangelia G 2004. Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20. Circulation research, 94 2, 184-93

Fan, Guo-Chang; Chu, Guoxiang; Mitton, Bryan; Song, Qiujing; Yuan, Qunying; Kranias, Evangelia G 2004. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circulation research, 94 11, 1474-82

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Fan, Guo-Chang; Singh, Ram Raj 2002. Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus. The Journal of experimental medicine, 196 6, 731-41