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Department of

Pharmacology & Systems Physiology 

Photo of John Cuppoletti, PhD

John Cuppoletti, PhD

Professor Emeritus

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Peer Reviewed Publications

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Cuppoletti, John; Chakrabarti, Jayati; Tewari, Kirti P; Malinowska, Danuta H 2014. Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents. American journal of physiology. Cell physiology, 307 5, C479-92

Cuppoletti, John; Chakrabarti, Jayati; Tewari, Kirti; Malinowska, Danuta H 2013. Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell biochemistry and biophysics, 66 1, 53-63

Cuppoletti, John; Blikslager, Anthony T; Chakrabarti, Jayati; Nighot, Prashant K; Malinowska, Danuta H 2012. Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors. BMC pharmacology, 12 , 3

Cuppoletti, John; Malinowska, Danuta H; Tewari, Kirti P; Chakrabarti, Jayati; Ueno, Ryuji 2012. Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²?]i increases in human trabecular meshwork and smooth muscle. Investigative ophthalmology & visual science, 53 9, 5178-89

Duan, Yuanyuan; Sun, Ying; Zhang, Fan; Zhang, Wei Kevin; Wang, Dong; Wang, Yan; Cao, Xu; Hu, Wenbao; Xie, Changyan; Cuppoletti, John; Magin, Thomas M; Wang, Haixia; Wu, Zhenguo; Li, Ning; Huang, Pingbo 2012. Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch. The Journal of biological chemistry, 287 48, 40547-59

Szyma?ska, G; Kim, H W; Cuppoletti, J; Kranias, E G 1992. Regulation of the skeletal sarcoplasmic reticulum Ca(2+)-ATPase by phospholamban and negatively charged phospholipids in reconstituted phospholipid vesicles. Molecular and cellular biochemistry, 114 1-2, 65-71

Szyma?ska, G; Kim, H W; Cuppoletti, J; Kranias, E G . Regulation of the skeletal sarcoplasmic reticulum Ca2+ pump by phospholamban in reconstituted phospholipid vesicles. Membrane biochemistry, 9 3, 191-202

Published Abstracts

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Cuppoletti J, Malinowska DH & Chakrabarti J 2010. Lubiprostone, but not linoclatide, protects T84 cells against damage to barrier function by interferon-γ. Am College of Gastroenterology meeting 2010, San Antonio TX, October 2010. , ,


Cuppoletti J, Malinowska DH, Chakrabarti J, Sekida T & Ueno R 2010. Lubiprostone suppresses growth of colon cancer cells in vitro and in vivo. Am College of Gastroenterology meeting 2010, San Antonio TX, October 2010 , ,


Cuppoletti J, Malinowska DH, Tewari KP, Chakrabarti J & Ueno R 2010. Methadone, but not morphine inhibits stimulated chloride currents in ClC-2 transfected cells in culture. DDW 2010, New Orleans LA, May 2010. , ,