Education/CredentialsFellowship: National Institute of Allergy and Infectious Diseases (Medical Mycology)Doctorate: University of California (Microbiology and Immunology)M.S.: University of Oklahoma (Microbiology)B.S.: University of Oklahoma (Medical Technology) Contact Information Email rhodesj@ucmail.uc.edu Research InterestsThe long-term goal of the research in Dr. Rhodes’ laboratory was to understand the pathogenesis of fungal infections. Invasive aspergillosis, an often fatal infection of immunocompromised patients caused by the ubiquitous organism Aspergillus fumigatus, was the focus of studies. The Rhodes lab made significant contributions to the roles played by three different, but related, signal transduction pathways to determine their roles in the pathogenesis of invasive infections.<... Peer Reviewed Publications Lu, Yao; Deng, Jingyuan; Rhodes, Judith C; Lu, Hui; Lu, Long Jason 2014. Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus. Computational biology and chemistry, 50 , 29-40Patel, R, Rhodes, J, Spicknall, KE, Mortensen, J 2014. Case Twenty Nine: The Synergistic Role of Microbiology and Pathology J Continuing Education Topics & Issues, 16 3, 88Turner, K, Belludi, C, Hagen, M, Rhodes, J, Mortensen, J 2013. Case Twenty Six: Fatal Fungal meningitis in an Immunocompetent Patient J Continuing Education Topics & Issues, 15 3, 86Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S 2011. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS pathogens, 7 10, e1002330Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C 2011. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus Molecular microbiology, 79 4, 1045-62Richie, Daryl L; Feng, Xizhi; Hartl, Lukas; Aimanianda, Vishukumar; Krishnan, Karthik; Powers-Fletcher, Margaret V; Watson, Douglas S; Galande, Amit K; White, Stephanie M; Willett, Taryn; Latgé, Jean-Paul; Rhodes, Judith C; Askew, David S 2011. The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR) Virulence, 2 1, 12-21Fuller, Kevin K; Zhao, Wei; Askew, David S; Rhodes, Judith C 2009. Deletion of the protein kinase A regulatory subunit leads to deregulation of mitochondrial activation and nuclear duplication in Aspergillus fumigatus Eukaryotic cell, 8 3, 271-7Richie, Daryl L; Hartl, Lukas; Aimanianda, Vishukumar; Winters, Michael S; Fuller, Kevin K; Miley, Michael D; White, Stephanie; McCarthy, Jason W; Latgé, Jean-Paul; Feldmesser, Marta; Rhodes, Judith C; Askew, David S 2009. A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus PLoS pathogens, 5 1, e1000258Bhabhra, Ruchi; Richie, Daryl L; Kim, H Stanley; Nierman, William C; Fortwendel, Jarrod; Aris, John P; Rhodes, Judith C; Askew, David S 2008. Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus Eukaryotic cell, 7 4, 575-83Fortwendel, Jarrod R; Fuller, Kevin K; Stephens, Timothy J; Bacon, W Clark; Askew, David S; Rhodes, Judith C 2008. Aspergillus fumigatus RasA regulates asexual development and cell wall integrity Eukaryotic cell, 7 9, 1530-9Richie, Daryl L; Fuller, Kevin K; Fortwendel, Jarrod; Miley, Michael D; McCarthy, Jason W; Feldmesser, Marta; Rhodes, Judith C; Askew, David S 2007. Unexpected link between metal ion deficiency and autophagy in Aspergillus fumigatus Eukaryotic cell, 6 12, 2437-47Richie, Daryl L; Miley, Michael D; Bhabhra, Ruchi; Robson, Geoffrey D; Rhodes, Judith C; Askew, David S 2007. The Aspergillus fumigatus metacaspases CasA and CasB facilitate growth under conditions of endoplasmic reticulum stress Molecular microbiology, 63 2, 591-604Bhabhra, Ruchi; Zhao, Wei; Rhodes, Judith C; Askew, David S 2006. Nucleolar localization of Aspergillus fumigatus CgrA is temperature-dependent Fungal genetics and biology : FG & B, 43 1, 1-7Rhodes, Judith C 2006. Aspergillus fumigatus: growth and virulence Medical mycology : official publication of the International Society for Human and Animal Mycology, 44 Suppl 1 , S77-81Zhao, Wei; Panepinto, John C; Fortwendel, Jarrod R; Fox, Lauren; Oliver, Brian G; Askew, David S; Rhodes, Judith C 2006. Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence Infection and immunity, 74 8, 4865-74Fortwendel, Jarrod R; Zhao, Wei; Bhabhra, Ruchi; Park, Steven; Perlin, David S; Askew, David S; Rhodes, Judith C 2005. A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus. Eukaryotic cell, 4 12, 1982-9Vogt, Keith; Bhabhra, Ruchi; Rhodes, Judith C; Askew, David S 2005. Doxycycline-regulated gene expression in the opportunistic fungal pathogen Aspergillus fumigatus BMC microbiology, 5 , 1Bhabhra, Ruchi; Miley, Michael D; Mylonakis, Eleftherios; Boettner, Doug; Fortwendel, Jarrod; Panepinto, John C; Postow, Michael; Rhodes, Judith C; Askew, David S 2004. Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence. Infection and immunity, 72 8, 4731-40Fortwendel, Jarrod R; Panepinto, John C; Seitz, Amy E; Askew, David S; Rhodes, Judith C 2004. Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development. Fungal genetics and biology : FG & B, 41 2, 129-39Panepinto, John C; Oliver, Brian G; Fortwendel, Jarrod R; Smith, Darcey L H; Askew, David S; Rhodes, Judith C 2003. Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis. Infection and immunity, 71 5, 2819-26Moy, Terence I; Boettner, Douglas; Rhodes, Judith C; Silver, Pamela A; Askew, David S 2002. Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Microbiology (Reading, England), 148 Pt 4, 1081-90Oliver, Brian G; Panepinto, John C; Askew, David S; Rhodes, Judith C 2002. cAMP alteration of growth rate of Aspergillus fumigatus and Aspergillus niger is carbon-source dependent. Microbiology (Reading, England), 148 Pt 8, 2627-33Oliver, Brian G; Panepinto, John C; Fortwendel, Jarrod R; Smith, Darcey L; Askew, David S; Rhodes, Judith C 2002. Cloning and expression of pkaC and pkaR, the genes encoding the cAMP-dependent protein kinase of Aspergillus fumigatus. Mycopathologia, 154 2, 85-91Panepinto, John C; Oliver, Brian G; Amlung, Thomas W; Askew, David S; Rhodes, Judith C 2002. Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation. Fungal genetics and biology : FG & B, 36 3, 207-14
Research InterestsThe long-term goal of the research in Dr. Rhodes’ laboratory was to understand the pathogenesis of fungal infections. Invasive aspergillosis, an often fatal infection of immunocompromised patients caused by the ubiquitous organism Aspergillus fumigatus, was the focus of studies. The Rhodes lab made significant contributions to the roles played by three different, but related, signal transduction pathways to determine their roles in the pathogenesis of invasive infections.<...
Peer Reviewed Publications Lu, Yao; Deng, Jingyuan; Rhodes, Judith C; Lu, Hui; Lu, Long Jason 2014. Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus. Computational biology and chemistry, 50 , 29-40Patel, R, Rhodes, J, Spicknall, KE, Mortensen, J 2014. Case Twenty Nine: The Synergistic Role of Microbiology and Pathology J Continuing Education Topics & Issues, 16 3, 88Turner, K, Belludi, C, Hagen, M, Rhodes, J, Mortensen, J 2013. Case Twenty Six: Fatal Fungal meningitis in an Immunocompetent Patient J Continuing Education Topics & Issues, 15 3, 86Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S 2011. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS pathogens, 7 10, e1002330Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C 2011. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus Molecular microbiology, 79 4, 1045-62Richie, Daryl L; Feng, Xizhi; Hartl, Lukas; Aimanianda, Vishukumar; Krishnan, Karthik; Powers-Fletcher, Margaret V; Watson, Douglas S; Galande, Amit K; White, Stephanie M; Willett, Taryn; Latgé, Jean-Paul; Rhodes, Judith C; Askew, David S 2011. The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR) Virulence, 2 1, 12-21Fuller, Kevin K; Zhao, Wei; Askew, David S; Rhodes, Judith C 2009. Deletion of the protein kinase A regulatory subunit leads to deregulation of mitochondrial activation and nuclear duplication in Aspergillus fumigatus Eukaryotic cell, 8 3, 271-7Richie, Daryl L; Hartl, Lukas; Aimanianda, Vishukumar; Winters, Michael S; Fuller, Kevin K; Miley, Michael D; White, Stephanie; McCarthy, Jason W; Latgé, Jean-Paul; Feldmesser, Marta; Rhodes, Judith C; Askew, David S 2009. A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus PLoS pathogens, 5 1, e1000258Bhabhra, Ruchi; Richie, Daryl L; Kim, H Stanley; Nierman, William C; Fortwendel, Jarrod; Aris, John P; Rhodes, Judith C; Askew, David S 2008. Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus Eukaryotic cell, 7 4, 575-83Fortwendel, Jarrod R; Fuller, Kevin K; Stephens, Timothy J; Bacon, W Clark; Askew, David S; Rhodes, Judith C 2008. Aspergillus fumigatus RasA regulates asexual development and cell wall integrity Eukaryotic cell, 7 9, 1530-9Richie, Daryl L; Fuller, Kevin K; Fortwendel, Jarrod; Miley, Michael D; McCarthy, Jason W; Feldmesser, Marta; Rhodes, Judith C; Askew, David S 2007. Unexpected link between metal ion deficiency and autophagy in Aspergillus fumigatus Eukaryotic cell, 6 12, 2437-47Richie, Daryl L; Miley, Michael D; Bhabhra, Ruchi; Robson, Geoffrey D; Rhodes, Judith C; Askew, David S 2007. The Aspergillus fumigatus metacaspases CasA and CasB facilitate growth under conditions of endoplasmic reticulum stress Molecular microbiology, 63 2, 591-604Bhabhra, Ruchi; Zhao, Wei; Rhodes, Judith C; Askew, David S 2006. Nucleolar localization of Aspergillus fumigatus CgrA is temperature-dependent Fungal genetics and biology : FG & B, 43 1, 1-7Rhodes, Judith C 2006. Aspergillus fumigatus: growth and virulence Medical mycology : official publication of the International Society for Human and Animal Mycology, 44 Suppl 1 , S77-81Zhao, Wei; Panepinto, John C; Fortwendel, Jarrod R; Fox, Lauren; Oliver, Brian G; Askew, David S; Rhodes, Judith C 2006. Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence Infection and immunity, 74 8, 4865-74Fortwendel, Jarrod R; Zhao, Wei; Bhabhra, Ruchi; Park, Steven; Perlin, David S; Askew, David S; Rhodes, Judith C 2005. A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus. Eukaryotic cell, 4 12, 1982-9Vogt, Keith; Bhabhra, Ruchi; Rhodes, Judith C; Askew, David S 2005. Doxycycline-regulated gene expression in the opportunistic fungal pathogen Aspergillus fumigatus BMC microbiology, 5 , 1Bhabhra, Ruchi; Miley, Michael D; Mylonakis, Eleftherios; Boettner, Doug; Fortwendel, Jarrod; Panepinto, John C; Postow, Michael; Rhodes, Judith C; Askew, David S 2004. Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence. Infection and immunity, 72 8, 4731-40Fortwendel, Jarrod R; Panepinto, John C; Seitz, Amy E; Askew, David S; Rhodes, Judith C 2004. Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development. Fungal genetics and biology : FG & B, 41 2, 129-39Panepinto, John C; Oliver, Brian G; Fortwendel, Jarrod R; Smith, Darcey L H; Askew, David S; Rhodes, Judith C 2003. Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis. Infection and immunity, 71 5, 2819-26Moy, Terence I; Boettner, Douglas; Rhodes, Judith C; Silver, Pamela A; Askew, David S 2002. Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Microbiology (Reading, England), 148 Pt 4, 1081-90Oliver, Brian G; Panepinto, John C; Askew, David S; Rhodes, Judith C 2002. cAMP alteration of growth rate of Aspergillus fumigatus and Aspergillus niger is carbon-source dependent. Microbiology (Reading, England), 148 Pt 8, 2627-33Oliver, Brian G; Panepinto, John C; Fortwendel, Jarrod R; Smith, Darcey L; Askew, David S; Rhodes, Judith C 2002. Cloning and expression of pkaC and pkaR, the genes encoding the cAMP-dependent protein kinase of Aspergillus fumigatus. Mycopathologia, 154 2, 85-91Panepinto, John C; Oliver, Brian G; Amlung, Thomas W; Askew, David S; Rhodes, Judith C 2002. Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation. Fungal genetics and biology : FG & B, 36 3, 207-14
Lu, Yao; Deng, Jingyuan; Rhodes, Judith C; Lu, Hui; Lu, Long Jason 2014. Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus. Computational biology and chemistry, 50 , 29-40Patel, R, Rhodes, J, Spicknall, KE, Mortensen, J 2014. Case Twenty Nine: The Synergistic Role of Microbiology and Pathology J Continuing Education Topics & Issues, 16 3, 88Turner, K, Belludi, C, Hagen, M, Rhodes, J, Mortensen, J 2013. Case Twenty Six: Fatal Fungal meningitis in an Immunocompetent Patient J Continuing Education Topics & Issues, 15 3, 86Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S 2011. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS pathogens, 7 10, e1002330Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C 2011. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus Molecular microbiology, 79 4, 1045-62Richie, Daryl L; Feng, Xizhi; Hartl, Lukas; Aimanianda, Vishukumar; Krishnan, Karthik; Powers-Fletcher, Margaret V; Watson, Douglas S; Galande, Amit K; White, Stephanie M; Willett, Taryn; Latgé, Jean-Paul; Rhodes, Judith C; Askew, David S 2011. The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR) Virulence, 2 1, 12-21Fuller, Kevin K; Zhao, Wei; Askew, David S; Rhodes, Judith C 2009. Deletion of the protein kinase A regulatory subunit leads to deregulation of mitochondrial activation and nuclear duplication in Aspergillus fumigatus Eukaryotic cell, 8 3, 271-7Richie, Daryl L; Hartl, Lukas; Aimanianda, Vishukumar; Winters, Michael S; Fuller, Kevin K; Miley, Michael D; White, Stephanie; McCarthy, Jason W; Latgé, Jean-Paul; Feldmesser, Marta; Rhodes, Judith C; Askew, David S 2009. A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus PLoS pathogens, 5 1, e1000258Bhabhra, Ruchi; Richie, Daryl L; Kim, H Stanley; Nierman, William C; Fortwendel, Jarrod; Aris, John P; Rhodes, Judith C; Askew, David S 2008. Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus Eukaryotic cell, 7 4, 575-83Fortwendel, Jarrod R; Fuller, Kevin K; Stephens, Timothy J; Bacon, W Clark; Askew, David S; Rhodes, Judith C 2008. Aspergillus fumigatus RasA regulates asexual development and cell wall integrity Eukaryotic cell, 7 9, 1530-9Richie, Daryl L; Fuller, Kevin K; Fortwendel, Jarrod; Miley, Michael D; McCarthy, Jason W; Feldmesser, Marta; Rhodes, Judith C; Askew, David S 2007. Unexpected link between metal ion deficiency and autophagy in Aspergillus fumigatus Eukaryotic cell, 6 12, 2437-47Richie, Daryl L; Miley, Michael D; Bhabhra, Ruchi; Robson, Geoffrey D; Rhodes, Judith C; Askew, David S 2007. The Aspergillus fumigatus metacaspases CasA and CasB facilitate growth under conditions of endoplasmic reticulum stress Molecular microbiology, 63 2, 591-604Bhabhra, Ruchi; Zhao, Wei; Rhodes, Judith C; Askew, David S 2006. Nucleolar localization of Aspergillus fumigatus CgrA is temperature-dependent Fungal genetics and biology : FG & B, 43 1, 1-7Rhodes, Judith C 2006. Aspergillus fumigatus: growth and virulence Medical mycology : official publication of the International Society for Human and Animal Mycology, 44 Suppl 1 , S77-81Zhao, Wei; Panepinto, John C; Fortwendel, Jarrod R; Fox, Lauren; Oliver, Brian G; Askew, David S; Rhodes, Judith C 2006. Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence Infection and immunity, 74 8, 4865-74Fortwendel, Jarrod R; Zhao, Wei; Bhabhra, Ruchi; Park, Steven; Perlin, David S; Askew, David S; Rhodes, Judith C 2005. A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus. Eukaryotic cell, 4 12, 1982-9Vogt, Keith; Bhabhra, Ruchi; Rhodes, Judith C; Askew, David S 2005. Doxycycline-regulated gene expression in the opportunistic fungal pathogen Aspergillus fumigatus BMC microbiology, 5 , 1Bhabhra, Ruchi; Miley, Michael D; Mylonakis, Eleftherios; Boettner, Doug; Fortwendel, Jarrod; Panepinto, John C; Postow, Michael; Rhodes, Judith C; Askew, David S 2004. Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence. Infection and immunity, 72 8, 4731-40Fortwendel, Jarrod R; Panepinto, John C; Seitz, Amy E; Askew, David S; Rhodes, Judith C 2004. Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development. Fungal genetics and biology : FG & B, 41 2, 129-39Panepinto, John C; Oliver, Brian G; Fortwendel, Jarrod R; Smith, Darcey L H; Askew, David S; Rhodes, Judith C 2003. Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis. Infection and immunity, 71 5, 2819-26Moy, Terence I; Boettner, Douglas; Rhodes, Judith C; Silver, Pamela A; Askew, David S 2002. Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Microbiology (Reading, England), 148 Pt 4, 1081-90Oliver, Brian G; Panepinto, John C; Askew, David S; Rhodes, Judith C 2002. cAMP alteration of growth rate of Aspergillus fumigatus and Aspergillus niger is carbon-source dependent. Microbiology (Reading, England), 148 Pt 8, 2627-33Oliver, Brian G; Panepinto, John C; Fortwendel, Jarrod R; Smith, Darcey L; Askew, David S; Rhodes, Judith C 2002. Cloning and expression of pkaC and pkaR, the genes encoding the cAMP-dependent protein kinase of Aspergillus fumigatus. Mycopathologia, 154 2, 85-91Panepinto, John C; Oliver, Brian G; Amlung, Thomas W; Askew, David S; Rhodes, Judith C 2002. Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation. Fungal genetics and biology : FG & B, 36 3, 207-14