• Emily DeFranco
  • Associate Professor, Maternal Fetal Medicine
  • Academic Location:
    Medical Sciences Building
    231 Albert Sabin Way
    Cincinnati, OH 45267-0526
  • Clinical Location:
    Hoxworth Center
    234 Goodman Street
    Cincinnati, OH 45219
  • Phone: (513) 558-6983
  • Email: emily.defranco@uc.edu

    Research/Clinical Interests:

  • Prevention and prediction of preterm birth
    Genetics of preterm birth
    Stillbirth and infant mortality
    Perinatal epidemiology

    Education/Credentials:

  • Bachelor of Science: Missouri Southern State University, 1992
  • Doctor of Osteopathic Medicine: Kansas City University of Medicine and Biosciences, 1998
  • Residency: University of Kentucky, 2002
  • Fellowship: Washington University School of Medicine, 2008
  • Master of Science : University of Cincinnati , 2010
  • Maternal-Fetal Medicine 2014, American Board of Obstetrics and Gynecology, 2004
  • Ohio State Medical License, 2014
  • Missouri State Medical License, 2014

Peer Reviewed Publications (in chronological order):

  • Wolfe K, Tabangin M, Meinzen-Derr J. Snyder C. Lewis D, DeFranco E (2103). Neonatal morbidity by week gestational age for twin gestations compared to singletons: a population-based cohort study. . Am J Perinatol.
  • DeFranco, E., Ehrlich, S., & Muglia, L. (2014). Influence of interpregnancy interval on birth timing. . BJOG : An International Journal of Obstetrics and Gynaecology.
  • Kamath-Rayne, B. D., & DeFranco, E. A. (2014). Amniocentesis for fetal lung maturity testing. . American Journal of Obstetrics and Gynecology , 210 (6) , 588-9.
  • Kamath-Rayne BD, Habli M, Rodriquez Z, Wu M, Gresh J, DeFranco, E (2014). (In Press). Antenatal exposure to sulindac and risk of necrotizing enterocolitis . AJOG.
  • Nassar R, DeFranco E (2014). (In Press). Turner Syndrome Presenting with Echogenic Fetal lungs on First Trimester . J Ultrasound Med.
  • Chen, A., Park, J., Linderholm, L., Rhee, A., Petreas, M., Defranco, E. A., Dietrich, K. N., & Ho, S. (2013). Hydroxylated polybrominated diphenyl ethers in paired maternal and cord sera. . Environmental Science & Technology , 47 (8) , 3902-8.
  • DeFranco, E. A., Lewis, D. F., & Odibo, A. O. (2013). Improving the screening accuracy for preterm labor: is the combination of fetal fibronectin and cervical length in symptomatic patients a useful predictor of preterm birth? A systematic review. . American Journal of Obstetrics and Gynecology , 208 (3) , 233.e1-6.
  • Kamath-Rayne, B. D., & Defranco, E. A. (2013). Cohort study finds newborn respiratory complications less common when mothers of babies with fetal lung immaturity at 34-37 weeks' gestation given antenatal steroids. . Evidence-based Nursing.
  • Defranco, E. A., Valent, A. M., Newman, T., Regan, J., Smith, J., & Muglia, L. J. (2013). Adjunctive therapies to cerclage for the prevention of preterm birth: a systematic review. . Obstetrics and Gynecology International , 2013 , 528158.
  • Warshak, C. R., Wolfe, K. B., Russell, K. A., Habli, M., Lewis, D. F., & Defranco, E. A. (2013). Influence of adolescence and obesity on the rate of stillbirth. . Paediatric and Perinatal Epidemiology , 27 (4) , 346-52.
  • Regan J, Thompson A, DeFranco E (2013). The influence of mode of delivery on breastfeeding initiation in women with a prior cesarean delivery: A population based study. . Breastfeeding Med , 181-6.
  • Apostolakis-Kyrus K, Valentine C, DeFranco E (2013). Factors Associated with Breastfeeding Initiation in Adolescent Mothers . J Pediatrics.
  • Kamath-Rayne, B. D., DeFranco, E. A., & Marcotte, M. P. (2012). Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. . Obstetrics and Gynecology , 119 (5) , 909-16.
  • Loftin, R., Chen, A., Evans, A., & DeFranco, E. (2012). Racial differences in gestational age-specific neonatal morbidity: further evidence for different gestational lengths. . American Journal of Obstetrics and Gynecology , 206 (3) , 259.e1-6.
  • Kamath-Rayne, BD, DeFranbco, EA, Chung, E, Chen, A (2012). (In Press). Subtypes of Preterm Birth and the Risk of Postneonatal Death . Journal of Pediatrics.
  • Pakrashi, T., & Defranco, E. A. (2012). The Relative Proportion of Preterm Births Complicated by Premature Rupture of Membranes in Multifetal Gestations: A Population-Based Study. . American Journal of Perinatology.
  • Kamath-Rayne, B. D., Defranco, E. A., Chung, E., & Chen, A. (2012). Subtypes of Preterm Birth and the Risk of Postneonatal Death. . The Journal of Pediatrics.
  • Snyder, C. C., Wolfe, K. B., Loftin, R. W., Tabbah, S., Lewis, D. F., & Defranco, E. A. (2011). The influence of hospital type on induction of labor and mode of delivery. . American Journal of Obstetrics and Gynecology , 205 (4) , 346.e1-346.e4.
  • Chen, A., Chung, E., Defranco, E. A., Pinney, S. M., & Dietrich, K. N. (2011). Serum PBDEs and age at menarche in adolescent girls: Analysis of the National Health and Nutrition Examination Survey 2003-2004. . Environmental Research.
  • Kamath, B. D., Marcotte, M. P., & Defranco, E. A. (2011). Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants . American Journal of Obstetrics and Gynecology , 204 (6) , 518.e1-518.e8.
  • Plunkett, J., Doniger, S., Orabona, G., Morgan, T., Haataja, R., Hallman, M., Puttonen, H., Menon, R., Kuczynski, E., Norwitz, E., Snegovskikh, V., Palotie, A., Peltonen, L., Fellman, V., DeFranco, E. A., Chaudhari, B. P., McGregor, T. L., McElroy, J. J., Oetjens, M. T., Teramo, K., Borecki, I., Fay, J., & Muglia, L. (2011). An evolutionary genomic approach to identify genes involved in human birth timing. . PLoS Genetics , 7 (4) , e1001365.
  • Defranco, E. A., Jacobs, T. S., Plunkett, J., Chaudhari, B. P., Huettner, P. C., & Muglia, L. J. (2011). Placental pathologic aberrations in cases of familial idiopathic spontaneous preterm birth. . Placenta , 32 (5) , 386-90.
  • Plunkett, J., Doniger, S., Morgan, T., Haataja, R., Hallman, M., Puttonen, H., Menon, R., Kuczynski, E., Norwitz, E., Snegovskikh, V., Palotie, A., Peltonen, L., Fellman, V., DeFranco, E. A., Chaudhari, B. P., Oates, J., Boutaud, O., McGregor, T. L., McElroy, J. J., Teramo, K., Borecki, I., Fay, J. C., & Muglia, L. J. (2010). Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth. . BMC Medical Genomics , 3 , 62.
  • Loftin, R. W., Habli, M., Snyder, C. C., Cormier, C. M., Lewis, D. F., & Defranco, E. A. (2010). Late preterm birth. . Reviews in Obstetrics and Gynecology , 3 (1) , 10-9.
  • Defranco, E. A., Chang, J. J., Macones, G. A., & Muglia, L. J. (2009). The correlation in birth timing between singleton and twin gestations in the same mother. . The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians , 22 (2) , 106-10.
  • Plunkett, J., Feitosa, M. F., Trusgnich, M., Wangler, M. F., Palomar, L., Kistka, Z. A., DeFranco, E. A., Shen, T. T., Stormo, A. E. D., Puttonen, H., Hallman, M., Haataja, R., Luukkonen, A., Fellman, V., Peltonen, L., Palotie, A., Daw, E. W., An, P., Teramo, K., Borecki, I., & Muglia, L. J. (2009). Mother's genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. . Human Heredity , 68 (3) , 209-19.
  • O'Brien, J. M., Defranco, E. A., Adair, C. D., Lewis, D. F., Hall, D. R., How, H., Bsharat, M., & Creasy, G. W. (2009). Effect of progesterone on cervical shortening in women at risk for preterm birth: secondary analysis from a multinational, randomized, double-blind, placebo-controlled trial. . Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology , 34 (6) , 653-9.
  • Shen, T. T., DeFranco, E. A., Stamilio, D. M., Chang, J. J., & Muglia, L. J. (2008). A population-based study of race-specific risk for preterm premature rupture of membranes. . American Journal of Obstetrics and Gynecology , 199 (4) , 373.e1-7.
  • DeFranco, E. A., Lian, M., Muglia, L. A., & Schootman, M. (2008). Area-level poverty and preterm birth risk: a population-based multilevel analysis. . BMC Public Health , 8 , 316.
  • Shen, T. T., DeFranco, E. A., Stamilio, D. M., Chang, J. J., & Muglia, L. J. (2008). A population-based study of race-specific risk for placental abruption. . BMC Pregnancy and Childbirth , 8 , 43.
  • DeFranco, E., Gross, G., Shanks, A., Johnson, T., & Shen, T. (2008). Prenatal exposure to anti-D immune globulin and autism risk: Croen et al. . American Journal of Obstetrics and Gynecology , 199 (3) , 322-3.
  • Purisch, S. E., DeFranco, E. A., Muglia, L. J., Odibo, A. O., & Stamilio, D. M. (2008). Preterm birth in pregnancies complicated by major congenital malformations: a population-based study. . American Journal of Obstetrics and Gynecology , 199 (3) , 287.e1-8.
  • DeFranco, E., Gross, G., Shanks, A., Johnson, T., & Shen, T. (2008). Discussion: Prenatal exposure to anti-D immune globulin and autism risk by Croen et al. . American Journal of Obstetrics and Gynecology , 199 (3) , e1-4.
  • Kistka, Z. A., DeFranco, E. A., Ligthart, L., Willemsen, G., Plunkett, J., Muglia, L. J., & Boomsma, D. I. (2008). Heritability of parturition timing: an extended twin design analysis. . American Journal of Obstetrics and Gynecology , 199 (1) , 43.e1-5.
  • Odibo, A., DeFranco, E., Krings, K., Hoff, J., & Stout, M. (2008). Predicting congenital cytomegalovirus infection: Guerra et al. . American Journal of Obstetrics and Gynecology , 198 (4) , 480-1; discussion e1.
  • Chaudhari, B. P., Plunkett, J., Ratajczak, C. K., Shen, T. T., DeFranco, E. A., & Muglia, L. J. (2008). The genetics of birth timing: insights into a fundamental component of human development. . Clinical Genetics , 74 (6) , 493-501.
  • Stamilio, D. M., DeFranco, E., Paré, E., Odibo, A. O., Peipert, J. F., Allsworth, J. E., Stevens, E., & Macones, G. A. (2007). Short interpregnancy interval: risk of uterine rupture and complications of vaginal birth after cesarean delivery. . Obstetrics and Gynecology , 110 (5) , 1075-82.
  • DeFranco, E. A., Rampersad, R., Atkins, K. L., Odibo, A. O., Stevens, E. J., Peipert, J. F., Stamilio, D. M., & Macones, G. A. (2007). Do vaginal birth after cesarean outcomes differ based on hospital setting? . American Journal of Obstetrics and Gynecology , 197 (4) , 400.e1-6.
  • DeFranco, E. A., Stamilio, D. M., Boslaugh, S. E., Gross, G. A., & Muglia, L. J. (2007). A short interpregnancy interval is a risk factor for preterm birth and its recurrence. . American Journal of Obstetrics and Gynecology , 197 (3) , 264.e1-6.
  • Palomar, L., DeFranco, E. A., Lee, K. A., Allsworth, J. E., & Muglia, L. J. (2007). Paternal race is a risk factor for preterm birth. . American Journal of Obstetrics and Gynecology , 197 (2) , 152.e1-7.
  • Kistka, Z. A., Palomar, L., Boslaugh, S. E., DeBaun, M. R., DeFranco, E. A., & Muglia, L. J. (2007). Risk for postterm delivery after previous postterm delivery. . American Journal of Obstetrics and Gynecology , 196 (3) , 241.e1-6.
  • Stamilio, D. M., Gross, G. A., Shanks, A., DeFranco, E., & Chang, J. J. (2007). Discussion: 'racial disparity in preterm birth' by Kistka et Al. . American Journal of Obstetrics and Gynecology , 196 (2) , e1-5; discussion 189.
  • DeFranco, E., Teramo, K., & Muglia, L. (2007). Genetic influences on preterm birth. . Seminars in Reproductive Medicine , 25 (1) , 40-51.
  • O'Brien, J. M., Adair, C. D., Lewis, D. F., Hall, D. R., Defranco, E. A., Fusey, S., Soma-Pillay, P., Porter, K., How, H., Schackis, R., Eller, D., Trivedi, Y., Vanburen, G., Khandelwal, M., Trofatter, K., Vidyadhari, D., Vijayaraghavan, J., Weeks, J., Dattel, B., Newton, E., Chazotte, C., Valenzuela, G., Calda, P., Bsharat, M., & Creasy, G. W. (2007). Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double-blind, placebo-controlled trial. . Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology , 30 (5) , 687-96.
  • DeFranco, E. A., O'Brien, J. M., Adair, C. D., Lewis, D. F., Hall, D. R., Fusey, S., Soma-Pillay, P., Porter, K., How, H., Schakis, R., Eller, D., Trivedi, Y., Vanburen, G., Khandelwal, M., Trofatter, K., Vidyadhari, D., Vijayaraghavan, J., Weeks, J., Dattel, B., Newton, E., Chazotte, C., Valenzuela, G., Calda, P., Bsharat, M., & Creasy, G. W. (2007). Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. . Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology , 30 (5) , 697-705.
  • Fontenot, M. T., Lewis, D. F., Frederick, J. B., Wang, Y., DeFranco, E. A., Groome, L. J., & Evans, A. T. (2005). A prospective randomized trial of magnesium sulfate in severe preeclampsia: use of diuresis as a clinical parameter to determine the duration of postpartum therapy. . American Journal of Obstetrics and Gynecology , 192 (6) , 1788-93; discussion .
  • Regan J, Thompson A, DeFranco E (11/27/2012). (In Press). The Influence of Mode of Delivery on Breastfeeding Initiation in Women with a Prior Cesarean Delivery: A Population-Based Study. . Breastfeed Med , [Epub ahead of print].

    Research Grants:

  • SRS 007609 Cincinnati Children's Hospital Medical Center. Progesterone for Preterm Birth Prevention: Effect on Uterine Blood Flow Dynamics, PI, Active.

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