Today is Thursday, Sep. 21, 2017

Department of

Neurosurgery

Neurovascular Lab

Research in the Neurovascular laboratory focuses on the cerebrovascular responses to blood in the brain, either from spontaneous intracranial hemorrhage or trauma.

The lab's primary research focus is on the cerebrovascular signaling pathways involved in cerebral vasospasm after subarachnoid hemorrhage.

The lab also has a particular interest in the discovery, validation and theranostic utility of cerebrospinal fluid (CSF) and blood biomarkers in patients with acute neurological injury.

To this end, Gail Pyne-Geithman, DPhil, has established and maintains a CSF and blood sample repository from this patient population, which is funded by the Point of Care Center for Emerging Neurotechnologies (POCCENT).

To date, the research team has largely focused on large-vessel spasm and animal models. However, small vessel spasm and cortical spreading depolarization have become more of a focus in our field, and collaboration with Jed Hartings, PhD, will allow the team to explore these aspects in the near future.

The team is also interested in the formation of aneurysms. In collaboration with Todd Abruzzo, MD, and stroke fellow Sharyl Martini, MD, PhD, the team is investigating changes in gene expression in a basilar artery flow-loading model in the rat.

The lab's aim is to identify gene products involved in early aneurysm formation and compare our data with genetic profiles of human cerebral aneurysm patients and their families (Familial Intracranial Aneurysm Study). This will give valuable insight into the molecular and vascular changes that contribute to intracranial hemorrhage and subarachnoid hemorrhage.

Major specialized equipment and expertise available in this facility include:

  • Force measurement machine for vessel preparations 
  • Isolated perfused pressurized vessel system
  • High-resolution respirometery for metabolic analyses
  • Biomarker discovery, identification, quantification and validation
  • Quantification method development and validation
  • Vascular smooth muscle physiology and biochemistry

Our overall mission is to provide a basic science resource, both of physical space and equipment, but more importantly, to provide mentorship, teaching, training and intellectual support for undergraduate, graduate and medical students as well as residents, fellows and clinical faculty.

Personnel

Gail Pyne-Geithman, DPhil, Research Associate Professor
Eric Mahoney, MS, Senior Research Assistant

Research_Lab

More Information

University of Cincinnati
Department of Neurosurgery

Office Location:
Stetson Office Building
260 Stetson Street, Suite 2200
Cincinnati, Ohio 45219
Phone: 513-558-5387

Gail Pyne-Geithman, DPhil
Department of Neurosurgery
5210 Medical Sciences Building, ML 0517
Cincinnati, OH 45267
Phone: 513-558-7358
pynegj@ucmail.uc.edu